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1BE9_A PDZ trimmed to 311-393 Return to Main Page
Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 0.6 -0.3 1.2 0.8 1.1 -0.3 -0.8 -0.3 -0.9 0.7 -0.7 -0.2 -0.5 -0.8 -0.6 0.2 0.8 -0.9 1 -0.3
0002 -0.8 0.3 0.2 0.5 0.8 -0.2 -0.8 0.2 -0.5 -0.5 1.3 1.5 0.8 -0.7 0.7 -0.2 -0.3 -1.2 -1 -0.2
0003 -0.4 -0.4 0.4 0.5 0.8 -0.4 -1.4 -0.4 0.7 1.6 0.4 0.3 0.2 0 -0.1 0.2 1.8 -1.3 -0.9 -0.8
0004 0.4 0.4 1.7 1.1 2.1 -0.1 -0.8 0.2 -0.8 -0.8 -0.8 -0.5 -0.7 -0.8 -0.8 0.1 0.4 -0.8 -0.8 1.3
0005 -0.2 -0.5 0.5 0 1.1 -0.9 -1.9 -0.5 0.3 1.6 0.7 0.3 0.1 0 0.4 0.7 1.6 -1.6 -0.3 -0.7
0006 -0.2 1.1 3.1 3.3 2.7 1.1 -0.9 -0.6 -0.9 -0.9 -0.8 -0.9 -0.9 -0.4 -0.9 -0.9 -0.8 -0.9 -0.9 -0.4
0007 -0.1 -0.6 0 -0.1 1.1 -0.9 -1.5 -0.3 0 1.1 1.1 0.5 0.6 0.7 0.6 0.4 0.8 -1.2 -0.2 -0.8
0008 -0.4 -1 -1.1 -0.6 -0.6 -0.3 -0.2 -0.8 -0.1 -0.2 3.2 2.4 0 0.3 -0.1 -0.6 0.4 0.2 0.1 0.2
0009 0.5 -1.2 -0.4 -0.6 -0.5 -1.1 -1.4 -1.1 1.6 1.1 0.5 0.2 -0.3 0.6 0.2 1.4 0.8 1.6 -0.1 -0.9
0010 0.3 -0.7 -1 -0.9 -0.1 -1.2 -1.3 -0.6 0.8 0.9 0.6 0 0.3 1 0 1.2 0.2 2.3 -0.6 -0.5
0011 0 -1 -1.1 -0.2 0.3 -0.5 -1.4 -0.5 0.6 1.2 0.9 0.4 -0.4 0.4 0.6 0.7 0.2 2.1 -0.7 -0.5
0012 0.2 -0.1 -0.2 -0.5 -0.2 -0.8 -0.8 -0.8 0.3 0.6 0.7 0.7 -0.3 0.5 -0.1 0.6 0 0.8 0.3 -0.3
0013 -0.4 1.3 1 2.2 0.5 0.5 0.2 1.2 -0.5 -0.2 -0.7 -0.7 -0.3 -0.5 -0.7 -0.7 -0.4 -0.6 -0.3 -0.2
0014 0.5 -0.6 -0.6 -0.4 -0.4 -0.6 -0.6 -0.6 0.5 -0.3 -0.6 -0.6 -0.6 1.3 -0.6 0.6 -0.6 5.2 -0.6 -0.1
0015 0.2 2.1 1.6 2.3 1.6 0.8 -0.7 -0.3 -0.7 -0.7 -0.7 -0.7 -0.7 -0.5 -0.7 -0.7 -0.7 -0.7 -0.7 0
0016 0.4 -0.1 -0.8 -0.9 0.5 -0.7 -1.8 -0.4 -0.3 0.1 0.4 0.8 0.6 1 0.3 2.7 1.7 0.5 -1.4 -0.7
0017 0 0.8 1.4 3.1 2.1 0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.4 -0.1 -0.6 -0.6 -0.6
0018 0.5 -0.6 0.6 0.1 1.1 -0.2 -1.2 -0.7 0.1 0.5 0.7 0.2 -0.7 -0.1 0 0.5 0.5 0.7 -1 -0.1
0019 0.8 -1.3 -0.3 -0.6 -0.4 -0.8 -1.4 -0.4 0.8 0.8 0.2 0.2 -0.7 0 0 1.3 0.2 2 0.7 -0.1
0020 0.1 -0.3 0.2 -0.1 0.3 -0.4 -0.9 0 0.6 0 0.7 0.2 -0.6 -0.1 -0.3 0.4 0.3 0.3 0 0.1
0021 0.8 -1.2 -0.1 0.4 0.9 -1.2 -2.2 -0.8 0.9 0.9 1.4 1 -0.5 0.8 0.2 0.6 0.4 -0.5 0.3 -0.6
0022 0.3 -0.5 -0.6 -0.1 -0.3 -0.7 -1.3 -0.2 0.5 0.6 0.1 0.1 -0.2 0.4 0.3 0.8 0.4 1.3 -0.3 -0.9
0023 -0.1 -1.1 -1 -1 -0.5 -1.2 -1.6 -1.4 1.6 0.9 1.2 0.7 -0.7 0.6 0.5 1.1 0.6 1.6 -0.3 -1.3
0024 0.3 -1.5 -1.2 0.5 -0.4 -0.4 -1.9 -1.2 0.5 1.1 0.6 0.5 -0.1 0.3 0.5 1.1 0.6 0.5 1.5 -0.3
0025 0.8 0.2 -0.8 0.4 0.4 -0.6 -1.3 -0.3 -0.1 -0.6 -0.2 0.3 -0.6 -0.4 0.1 0.8 -0.4 2.3 0.9 -0.1
0026 0.3 0.4 1.3 1.7 1.9 -0.1 -0.8 0.1 -1.1 -0.9 -0.3 -0.7 0 -1 -0.8 0.2 0.7 -1.1 0.8 -0.1
0027 -0.4 1.2 0.9 0.9 1.5 0.1 -0.7 1.6 -1.5 -0.8 0.1 1 0.1 -1.3 0.2 -0.3 1 -1.5 -1.2 -0.1
0028 -0.1 0.3 1.9 1.4 1.6 0.5 -0.5 -0.2 -0.5 -0.5 -0.3 -0.2 -0.3 -0.3 -0.5 -0.3 -0.4 -0.3 -0.5 -0.2
0029 0.6 -0.7 -0.2 0 0.6 -0.5 -0.9 -0.5 -0.1 0 0.7 0.5 0.1 0.1 0.2 0.9 0.7 0.3 -1 -0.2
0030 0.6 -0.8 -1 -0.5 -0.8 -0.7 -0.7 -0.7 1.3 0.9 0.2 0.3 0.8 0.7 0.5 1.5 0.4 0.7 -1 -0.8
- A F I L V M W Y D E K R H N Q S T G P C
0031 0 0.1 2.5 1.4 2.8 0.3 -0.6 -0.6 -0.6 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 -0.5 -0.2 -0.6 -0.3 0.3
0032 0.5 0.1 0.1 1.1 1.1 -0.4 -1 -0.7 0.3 0.9 0.7 0.5 -0.2 0.6 0.2 0.4 0.3 -0.9 -1.1 -1.2
0033 1.3 -1.2 -1 -0.7 -0.4 -1.1 -1.5 -1 1.6 1.8 1.2 0.7 -0.2 0.2 0.8 1.1 0.1 -1 2.2 -1.4
0034 0.3 -1.6 -1.2 -0.9 -0.7 -1.3 -1.4 -1.4 1.9 0.9 0.7 0.3 0.1 1.7 0.3 0.6 -0.2 2.9 -0.8 -1.4
0035 0.3 -0.6 -0.7 0.1 0 -0.4 -0.8 -0.8 0.2 -0.4 0.1 0.1 -0.3 -0.2 0.1 1.2 0.6 1.5 -0.2 -0.3
0036 1.4 -1 1.1 1.1 1.5 -0.5 -1.1 -0.4 -0.5 -0.3 -0.6 -0.4 -0.9 -0.5 -0.4 0.4 0.5 -0.5 1.5 -0.4
0037 0.8 -0.2 0.6 1 0.8 -0.5 -0.5 -0.5 -0.7 -0.5 -0.5 0 -0.3 -0.2 -0.1 0.5 0.3 0 0.3 0.4
0038 1.5 0.1 0 -0.4 -0.5 -0.1 -0.6 0.2 0 1.4 -0.1 -0.2 -0.3 -0.3 0 0.8 -0.6 0.3 -0.9 -0.1
0039 0.5 -1.5 -0.1 1.2 0.1 -0.1 -1.5 -1.3 -0.5 0.7 1.6 2.1 0 -0.3 1.2 0.5 0.1 -0.2 -1.7 -0.9
0040 0.3 -0.8 -0.6 -0.1 0.1 -0.5 -0.7 -0.4 -0.5 0.6 -0.6 -0.3 0.1 0.5 0.5 1 0.6 0.2 -0.1 0.4
0041 0.2 -1.3 -1.1 -0.8 -1.1 -1.3 -1.1 -0.9 0.9 0 1.1 0.7 -0.2 0.9 0.5 0.5 0.1 3.8 0.3 -0.9
0042 0 -1 0 0.3 0.3 -0.8 -1.3 -1.1 -0.3 -0.3 1.6 0.7 -0.7 0.6 0.4 0.3 0.3 1 -0.2 -0.8
0043 -0.1 0.8 1.8 2.2 2.2 1.2 -0.7 -0.7 -0.7 -0.7 -0.5 -0.4 -0.7 -0.3 -0.7 -0.7 -0.5 -0.4 -0.7 -0.6
0044 0.2 -0.1 -0.5 0.3 -0.1 -0.3 -1.2 -0.7 -1 0.4 2 1.8 1 0 1.6 0.5 -0.4 -0.7 -1.3 -0.2
0045 0.8 -0.8 0.7 0.6 1 -0.5 -1.2 -0.7 -0.3 1 0.6 0 -0.4 0.1 0.1 -0.2 0.3 -1 1.3 -0.3
0046 0 -0.6 -0.9 -0.2 -0.9 -0.5 -0.5 -0.2 0.6 0.5 0 0 0.6 1.6 0.7 0.2 -0.8 2.9 -0.9 -0.9
0047 -0.5 -0.6 -0.5 -0.1 -0.3 0.9 -0.7 -0.6 3.4 1.5 -0.6 -0.6 0.1 -0.1 0.6 0.1 -0.1 0 -0.7 -0.7
0048 -0.2 -0.1 1.2 0.3 1.1 -1 -0.8 -0.1 -1.2 1.6 -0.1 1.1 0.5 -0.6 1.7 -0.4 0 -1.1 -1.2 0.3
0049 -0.2 -0.6 3.3 4.2 2.4 -0.2 -0.6 -0.2 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.4 -0.5 -0.6 -0.6 -0.6
0050 -0.7 -0.2 2.3 3.3 2.7 1.1 -1 -0.5 -1 -0.3 -0.5 -0.5 0 -1 -0.9 -0.2 0.3 -1 -1 -0.1
0051 1.8 0.1 -1.2 -0.4 -0.5 0.1 -1 -0.2 -0.5 1.7 0.8 0.8 -0.7 -0.4 1.2 1.7 0 -0.1 -1.4 -0.7
0052 0.8 0.4 3.2 1.3 3.6 0.3 -0.6 0.8 -0.9 -0.9 -0.9 -0.7 -0.9 -0.9 -0.9 -0.6 -0.9 -0.7 -0.9 -0.1
0053 -0.3 -0.7 -0.8 -0.8 -0.8 -0.8 -0.8 -0.6 2 0.4 -0.2 0.1 0.1 3 0.2 0.4 -0.3 1.6 -0.8 0.2
0054 0 -1 -0.8 -0.7 -1 -1 -1 -0.7 1.5 1.4 -0.1 0 0.2 1.6 0.4 1 0.5 2.7 -1 -0.7
0055 0.2 -0.7 1.1 0.5 1.5 0 -1.3 -0.7 0.1 0.9 0.7 0.1 0.2 -0.3 1.1 -0.1 1.4 -1 -1.6 -0.3
0056 0.1 -0.8 -0.7 0.2 0.1 -0.4 -0.8 -0.6 1.4 0.1 -0.1 0.1 0 0.9 -0.3 1.5 -0.1 -0.5 1 0.1
0057 0.5 0.9 1.1 1.5 1.8 1.5 -0.8 -0.5 -0.8 -0.8 -0.8 -0.8 -0.7 -0.8 -0.8 -0.2 0.8 -0.5 -0.5 0.4
0058 0.6 -1.1 -0.2 0.4 0.5 -0.3 -1.6 -0.3 1 1.2 0.7 1.1 0.1 -0.1 0.7 0.7 0.7 -0.6 -1 -0.8
0059 0.2 -1.3 -1 -0.8 -1.1 -1 -1.4 -0.3 1.9 1 0.3 0 0.6 2 0.1 0.8 0.2 2.7 -1 -0.6
0060 0.4 0.2 1 1.8 0.8 0.8 -0.7 0.3 -0.7 0 0.3 -0.2 -0.6 -0.9 -0.1 0.2 -0.1 -0.7 -1.1 0.1
- A F I L V M W Y D E K R H N Q S T G P C
0061 0.3 -1.4 -1.1 -0.7 -0.9 -1 -1.5 -1.1 1.5 0.6 -0.1 -0.1 -0.6 0.7 -0.6 2.6 2.8 0.4 1.4 -0.2
0062 0.4 0 0.2 1.4 0.6 0 -0.7 0.5 -0.4 0.3 0.2 -0.7 0.2 -0.2 -0.1 0.3 -0.1 -0.7 0.1 -1
0063 0.9 -0.9 -0.9 0.2 -0.6 -1 -1.8 -0.5 1.3 2.2 0.3 0.3 0.3 0.3 1.2 1 0.3 0.2 -0.6 -0.5
0064 0.5 -0.6 -0.7 0 0.1 -0.5 -1.6 -0.1 2.2 2.2 0.6 0.4 0 0 1.6 0.3 0.4 -0.4 -1.3 -1.6
0065 2.6 -0.3 1.7 1.2 2.8 -0.2 -0.9 -0.9 -0.9 -0.9 -0.9 -0.7 -0.9 -0.8 -0.9 0.6 1.1 -0.4 -0.9 0.7
0066 0.8 -0.8 0.9 1.3 1.1 0.3 -0.8 -0.3 -1.1 -0.2 0.1 0.9 -0.6 -0.2 1.1 0.1 0.4 -0.7 -1 -0.4
0067 1.1 -1.6 -1 -0.6 -0.7 -0.7 -1.4 -0.6 1.1 1.3 0.8 1.1 -0.3 0.8 1.4 1.2 0.7 0.3 -0.4 -1.1
0068 0.8 0.3 1.3 2 1.2 1.3 -0.9 0 -1.3 0.6 0.1 0.2 -0.2 -0.9 -0.3 -0.6 0 -0.7 -1.3 -0.5
0069 -0.1 1.1 2.6 2.1 1.5 1 -0.7 -0.4 -0.7 -0.7 -0.5 -0.4 -0.7 -0.7 -0.7 -0.7 -0.3 -0.7 -0.7 -0.1
0070 1 -1.6 -0.9 0.6 -0.5 -0.6 -1.4 -1.4 0.1 0.1 2.5 2.4 0.4 0.1 2 0.7 0.5 -0.2 -1.3 -1
0071 1.2 -1.6 -1 -0.4 -0.7 -0.7 -1.9 -1.1 0.4 1.1 1.3 0.6 0 1.3 1.5 1.9 0.8 0.9 -1.4 -0.7
0072 1.6 -0.3 0.4 0.6 0.3 -0.5 -1.2 -0.3 -0.6 -0.7 -0.3 -0.6 -0.3 0.3 0.3 1.5 -0.1 -0.2 0.1 0.6
0073 0.9 -0.9 -1.2 -0.3 -0.6 -0.4 -1.3 -0.9 0.6 0.8 0.5 0.4 -0.2 -0.1 0.2 0.8 0.8 0.9 1.2 -0.3
0074 -0.3 -1.4 -0.9 -0.1 -0.3 -1.1 -1.8 -1 1.4 1.2 0.5 -0.2 -0.3 0.9 0.7 0.9 0.1 2.2 0.8 -1.7
0075 -0.3 -0.6 0.3 0.1 0.7 -0.8 -1.1 -0.5 0.1 0.8 0.5 1 0.4 0.4 0.3 0.7 0.7 -1.1 0.5 -0.6
0076 1 0.5 2.2 1.9 2.4 0.3 -1 -0.6 -0.8 -0.7 -0.6 -0.6 -0.5 -0.9 -0.8 -0.2 0.4 -0.6 -0.8 0.6
0077 -0.5 -1 -0.1 0.3 0.7 -0.7 -1.3 -0.5 0.4 0.7 0.8 1 0.2 0.5 0.6 1.1 1.6 -1.1 -0.9 -0.4
0078 0.5 1.3 2.2 2.7 2 1.4 -0.8 -0.4 -0.8 -0.6 -0.6 -0.8 -0.8 -0.6 -0.8 -0.6 -0.4 -0.8 -0.8 -0.6
0079 -0.2 -0.9 1 1.6 2.1 -0.7 -1.1 -0.9 -0.6 0.7 0.7 0.5 0 -1.3 0.5 0.3 1.6 0.7 -1.6 -0.6
0080 0.7 0.5 1.3 1.4 1.3 0.1 -0.7 -0.2 -0.5 -0.7 -0.7 -0.7 -0.6 -0.7 -0.7 -0.6 1.6 -0.4 -0.4 0.6
0081 1.2 -1.2 0.9 1.2 1.2 -0.2 -0.9 -0.8 -1.3 0.1 0.2 1.4 -0.7 -1.2 1 1 0.3 -0.1 -1.6 0.5
0082 -0.1 -0.3 -0.7 -1.1 -0.1 -0.9 -1.1 0.2 0.3 0 1.3 2 0 -0.3 1 0.3 -0.1 -0.1 0.6 -0.7
0083 0.3 -1 -0.8 0.2 -0.4 -0.8 -1.5 -0.5 0.7 0.7 1 1.3 -0.5 0.3 0.6 0.4 -0.4 1 1.2 -1.3
Select residue pair below:
i_j Score Prob
0043_0080 3.957 1.00
0034_0038 2.739 1.00
0002_0082 2.634 1.00
0051_0079 2.608 1.00
0026_0065 2.406 1.00
0005_0077 2.017 1.00
0005_0075 1.905 1.00
0057_0065 1.841 1.00
0062_0066 1.748 1.00
0003_0079 1.718 1.00
0044_0082 1.643 1.00
0020_0062 1.538 1.00
0018_0029 1.502 1.00
0057_0060 1.439 1.00
0033_0038 1.414 1.00
0019_0062 1.390 0.99
0028_0043 1.387 0.99
0056_0059 1.339 0.99
0067_0071 1.299 0.99
0051_0054 1.296 0.99
0060_0064 1.296 0.99
0027_0048 1.285 0.99
0012_0036 1.279 0.99
0012_0015 1.254 0.99
0047_0082 1.230 0.98
0030_0045 1.216 0.98
0055_0068 1.212 0.98
0048_0083 1.209 0.98
0061_0064 1.186 0.98
0048_0081 1.186 0.98
0025_0048 1.172 0.98
0001_0050 1.155 0.97
0003_0077 1.150 0.97
0051_0056 1.112 0.96
0060_0065 1.109 0.96
0067_0070 1.097 0.96
0015_0037 1.093 0.96
0020_0026 1.024 0.93
0057_0068 1.023 0.93
0026_0062 1.016 0.93
0018_0062 0.989 0.92
0016_0030 0.989 0.92
0011_0039 0.989 0.92
0052_0057 0.948 0.89
0031_0038 0.942 0.89
0007_0075 0.940 0.89
0006_0037 0.926 0.88
0029_0045 0.908 0.87
0052_0068 0.908 0.87
0032_0045 0.908 0.87
0013_0069 0.903 0.86
0069_0078 0.892 0.85
0029_0069 0.888 0.85
0018_0045 0.872 0.83
0060_0063 0.868 0.83
0013_0057 0.854 0.82
0004_0028 0.848 0.81
0013_0076 0.835 0.80
0056_0060 0.835 0.80
0002_0042 0.832 0.79
0017_0066 0.831 0.79
0054_0077 0.828 0.79
0029_0032 0.827 0.79
0001_0081 0.826 0.79
0009_0012 0.817 0.77
0018_0066 0.797 0.75
0008_0072 0.791 0.74
0008_0062 0.787 0.74
0036_0053 0.785 0.73
0006_0040 0.770 0.71
0063_0067 0.765 0.71
0062_0070 0.763 0.70
0001_0082 0.763 0.70
0035_0040 0.756 0.69
0009_0036 0.754 0.69
0004_0042 0.754 0.69
0001_0079 0.740 0.67
0072_0076 0.738 0.67
0031_0037 0.730 0.65
0046_0050 0.725 0.65
0018_0032 0.725 0.65
0002_0080 0.722 0.64
0068_0072 0.720 0.64
0017_0062 0.702 0.61
0018_0022 0.701 0.61
0017_0029 0.701 0.61
0054_0075 0.700 0.61
0022_0053 0.699 0.60
0012_0047 0.695 0.60
0017_0046 0.687 0.58
0037_0043 0.685 0.58
0017_0020 0.682 0.58
0020_0046 0.681 0.57
0015_0035 0.678 0.57
0020_0048 0.674 0.56
0032_0038 0.672 0.56
0004_0040 0.669 0.55
0050_0056 0.666 0.55
0064_0067 0.654 0.53
0001_0059 0.648 0.52
0052_0073 0.648 0.52
0014_0080 0.648 0.52
0051_0077 0.644 0.51
0028_0049 0.641 0.51
0044_0074 0.641 0.51
0040_0043 0.640 0.50
0058_0081 0.639 0.50
0048_0066 0.639 0.50
0038_0044 0.638 0.50
0012_0066 0.634 0.49
0032_0035 0.633 0.49
0008_0073 0.632 0.49
0031_0053 0.631 0.49
0017_0069 0.630 0.49
0007_0011 0.629 0.49
0028_0047 0.626 0.48
0017_0072 0.624 0.48
0011_0038 0.622 0.47
0031_0045 0.615 0.46
0018_0069 0.615 0.46
0022_0029 0.611 0.46
0015_0030 0.611 0.46
0004_0049 0.608 0.45
Local Interactions:
i_j Score Prob
0040_0042 5.178 1.00
0056_0058 3.646 1.00
0019_0020 3.156 1.00
0009_0010 1.946 1.00
0025_0027 1.869 1.00
0073_0074 1.709 1.00
0023_0024 1.598 1.00
0011_0012 1.447 1.00
0076_0078 1.256 0.99
0040_0041 1.151 0.97
0081_0082 1.132 0.97
0010_0012 1.109 0.96
0029_0030 1.072 0.95
0078_0080 1.054 0.95
0038_0039 1.013 0.93
0013_0015 1.009 0.93
0002_0004 1.004 0.93
0009_0011 1.001 0.92
0035_0036 0.991 0.92
0072_0073 0.966 0.91
0059_0060 0.955 0.90
0030_0032 0.917 0.87
0026_0027 0.879 0.84
0074_0075 0.878 0.84
0010_0011 0.871 0.83
0021_0022 0.870 0.83
0054_0055 0.829 0.79
0071_0072 0.828 0.79
0053_0054 0.800 0.75
0075_0077 0.798 0.75
0073_0075 0.795 0.75
0022_0023 0.755 0.69
0002_0003 0.746 0.68
0001_0002 0.744 0.68
0035_0037 0.713 0.63
0036_0038 0.712 0.63
0008_0010 0.712 0.63
0030_0031 0.685 0.58
0001_0003 0.679 0.57
0022_0024 0.677 0.57
0041_0042 0.671 0.56
0058_0059 0.670 0.56
0020_0022 0.662 0.54
0005_0007 0.659 0.54
0012_0013 0.649 0.52
0045_0046 0.648 0.52
0025_0026 0.647 0.52
0033_0035 0.640 0.50
0055_0056 0.634 0.49
0029_0031 0.618 0.47
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: P R R I V ...
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