| acrb |
| ID: | 1499794483 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 1000 (992) | ||
| Sequences: | 4576 (2701.7) | ||
| Seq/Len: | 4.613 | ||
| Nf(neff/√len): | 85.8 |
HHblits Results: (2016_02)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 4.613).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 959_G | 962_E | 4.890 | 1.00 |
| 244_E | 247_G | 4.639 | 1.00 |
| 309_E | 312_K | 4.599 | 1.00 |
| 304_A | 334_K | 4.223 | 1.00 |
| 169_T | 305_A | 4.166 | 1.00 |
| 591_L | 625_G | 4.151 | 1.00 |
| 247_G | 263_R | 4.052 | 1.00 |
| 62_T | 88_V | 4.034 | 1.00 |
| 142_V | 158_V | 3.758 | 1.00 |
| 154_I | 321_L | 3.590 | 1.00 |
| 47_A | 88_V | 3.581 | 1.00 |
| 65_I | 69_M | 3.445 | 1.00 |
| 165_A | 309_E | 3.365 | 1.00 |
| 76_M | 93_T | 3.363 | 1.00 |
| 311_A | 314_E | 3.338 | 1.00 |
| 193_L | 198_L | 3.305 | 1.00 |
| 680_F | 829_G | 3.266 | 1.00 |
| 736_A | 746_I | 3.245 | 1.00 |
| 75_L | 92_L | 3.155 | 1.00 |
| 58_Q | 823_P | 3.130 | 1.00 |
| 248_K | 263_R | 3.128 | 1.00 |
| 730_D | 808_R | 3.083 | 1.00 |
| 742_S | 745_D | 3.073 | 1.00 |
| 760_N | 771_V | 3.020 | 1.00 |
| 345_V | 349_I | 3.003 | 1.00 |
| 65_I | 90_I | 2.980 | 1.00 |
| 282_N | 608_S | 2.972 | 1.00 |
| 307_R | 328_D | 2.959 | 1.00 |
| 186_I | 207_I | 2.910 | 1.00 |
| 450_S | 479_A | 2.857 | 1.00 |
| 69_M | 90_I | 2.835 | 1.00 |
| 251_L | 265_V | 2.835 | 1.00 |
| 3_N | 7_D | 2.799 | 1.00 |
| 691_G | 694_K | 2.781 | 1.00 |
| 314_E | 322_K | 2.707 | 1.00 |
| 61_V | 122_V | 2.659 | 1.00 |
| 193_L | 265_V | 2.610 | 1.00 |
| 247_G | 268_I | 2.609 | 1.00 |
| 209_A | 737_Q | 2.600 | 1.00 |
| 949_A | 964_T | 2.584 | 1.00 |
| 598_Y | 651_A | 2.516 | 1.00 |
| 62_T | 82_S | 2.495 | 1.00 |
| 633_D | 636_D | 2.462 | 1.00 |
| 10_I | 889_A | 2.461 | 1.00 |
| 188_M | 203_V | 2.439 | 1.00 |
| 732_D | 806_S | 2.408 | 1.00 |
| 731_I | 736_A | 2.408 | 1.00 |
| 262_L | 268_I | 2.406 | 1.00 |
| 301_D | 305_A | 2.384 | 1.00 |
| 182_Y | 270_L | 2.383 | 1.00 |
| 14_V | 886_L | 2.366 | 1.00 |
| 588_Q | 592_N | 2.310 | 1.00 |
| 388_F | 472_I | 2.292 | 1.00 |
| 342_K | 346_E | 2.282 | 1.00 |
| 189_N | 192_E | 2.268 | 1.00 |
| 732_D | 735_K | 2.244 | 1.00 |
| 280_E | 588_Q | 2.220 | 1.00 |
| 382_V | 476_S | 2.219 | 1.00 |
| 578_L | 582_A | 2.201 | 1.00 |
| 371_A | 484_V | 2.194 | 1.00 |
| 34_Q | 569_Q | 2.191 | 1.00 |
| 243_T | 247_G | 2.184 | 1.00 |
| 45_I | 69_M | 2.150 | 1.00 |
| 787_G | 802_S | 2.150 | 1.00 |
| 408_D | 940_K | 2.147 | 1.00 |
| 183_A | 772_Y | 2.146 | 1.00 |
| 952_L | 956_E | 2.140 | 1.00 |
| 415_N | 418_R | 2.139 | 1.00 |
| 188_M | 200_P | 2.129 | 1.00 |
| 267_K | 776_E | 2.121 | 1.00 |
| 280_E | 595_T | 2.114 | 1.00 |
| 713_L | 716_V | 2.079 | 1.00 |
| 605_N | 642_N | 2.070 | 1.00 |
| 76_M | 95_E | 2.057 | 1.00 |
| 979_S | 983_I | 2.054 | 1.00 |
| 561_S | 838_G | 2.048 | 1.00 |
| 741_V | 804_F | 2.041 | 1.00 |
| 586_R | 589_K | 2.036 | 1.00 |
| 696_T | 700_N | 2.033 | 1.00 |
| 3_N | 432_R | 2.022 | 1.00 |
| 731_I | 746_I | 2.016 | 1.00 |
| 741_V | 791_V | 2.009 | 1.00 |
| 606_V | 629_V | 2.002 | 1.00 |
| 4_F | 11_F | 1.996 | 1.00 |
| 784_D | 787_G | 1.991 | 1.00 |
| 62_T | 80_S | 1.990 | 1.00 |
| 77_Y | 820_N | 1.990 | 1.00 |
| 782_L | 785_D | 1.989 | 1.00 |
| 587_T | 625_G | 1.980 | 1.00 |
| 699_R | 718_P | 1.970 | 1.00 |
| 55_K | 59_D | 1.967 | 1.00 |
| 694_K | 697_Q | 1.958 | 1.00 |
| 429_E | 433_K | 1.957 | 1.00 |
| 82_S | 88_V | 1.946 | 1.00 |
| 572_F | 651_A | 1.946 | 1.00 |
| 338_H | 342_K | 1.914 | 1.00 |
| 378_G | 480_L | 1.911 | 1.00 |
| 698_A | 855_V | 1.911 | 1.00 |
| 69_M | 92_L | 1.883 | 1.00 |
| 642_N | 650_R | 1.866 | 1.00 |
| 57_V | 61_V | 1.861 | 1.00 |
| 74_N | 98_T | 1.854 | 1.00 |
| 199_T | 792_R | 1.833 | 1.00 |
| 736_A | 741_V | 1.822 | 1.00 |
| 242_S | 245_E | 1.815 | 1.00 |
| 20_M | 377_L | 1.813 | 1.00 |
| 952_L | 958_K | 1.810 | 1.00 |
| 204_I | 773_V | 1.806 | 1.00 |
| 78_M | 92_L | 1.805 | 1.00 |
| 43_V | 104_Q | 1.805 | 1.00 |
| 729_I | 805_S | 1.790 | 1.00 |
| 115_M | 124_Q | 1.785 | 1.00 |
| 65_I | 114_A | 1.784 | 1.00 |
| 45_I | 65_I | 1.783 | 1.00 |
| 120_Q | 124_Q | 1.783 | 1.00 |
| 426_P | 429_E | 1.780 | 1.00 |
| 613_N | 625_G | 1.764 | 1.00 |
| 193_L | 196_F | 1.756 | 1.00 |
| 594_V | 655_F | 1.755 | 1.00 |
| 684_L | 702_L | 1.751 | 1.00 |
| 47_A | 62_T | 1.745 | 1.00 |
| 190_P | 779_Y | 1.739 | 1.00 |
| 730_D | 806_S | 1.737 | 1.00 |
| 591_L | 613_N | 1.734 | 1.00 |
| 987_M | 991_I | 1.732 | 1.00 |
| 706_A | 844_M | 1.730 | 0.99 |
| 181_Q | 273_E | 1.727 | 0.99 |
| 75_L | 78_M | 1.727 | 0.99 |
| 68_N | 114_A | 1.725 | 0.99 |
| 650_R | 654_A | 1.723 | 0.99 |
| 904_V | 942_A | 1.722 | 0.99 |
| 202_D | 792_R | 1.719 | 0.99 |
| 592_N | 595_T | 1.718 | 0.99 |
| 8_R | 893_E | 1.717 | 0.99 |
| 591_L | 611_A | 1.712 | 0.99 |
| 339_E | 342_K | 1.711 | 0.99 |
| 189_N | 267_K | 1.711 | 0.99 |
| 562_S | 924_D | 1.708 | 0.99 |
| 205_T | 208_K | 1.708 | 0.99 |
| 479_A | 483_L | 1.706 | 0.99 |
| 958_K | 966_D | 1.706 | 0.99 |
| 845_E | 867_R | 1.705 | 0.99 |
| 241_T | 245_E | 1.704 | 0.99 |
| 597_Y | 654_A | 1.697 | 0.99 |
| 697_Q | 701_Q | 1.694 | 0.99 |
| 7_D | 428_K | 1.694 | 0.99 |
| 145_T | 322_K | 1.688 | 0.99 |
| 203_V | 265_V | 1.686 | 0.99 |
| 297_A | 302_T | 1.677 | 0.99 |
| 593_E | 597_Y | 1.664 | 0.99 |
| 305_A | 308_A | 1.647 | 0.99 |
| 574_T | 629_V | 1.642 | 0.99 |
| 445_I | 482_V | 1.623 | 0.99 |
| 836_S | 839_E | 1.622 | 0.99 |
| 379_T | 477_A | 1.616 | 0.99 |
| 53_D | 56_T | 1.614 | 0.99 |
| 419_V | 437_Q | 1.614 | 0.99 |
| 776_E | 779_Y | 1.603 | 0.99 |
| 207_I | 249_I | 1.602 | 0.99 |
| 19_I | 378_G | 1.601 | 0.99 |
| 607_E | 632_K | 1.587 | 0.99 |
| 245_E | 248_K | 1.583 | 0.99 |
| 976_L | 980_L | 1.577 | 0.99 |
| 643_K | 646_A | 1.574 | 0.99 |
| 24_G | 28_L | 1.564 | 0.99 |
| 952_L | 966_D | 1.563 | 0.99 |
| 609_V | 627_A | 1.558 | 0.99 |
| 175_V | 289_L | 1.554 | 0.99 |
| 572_F | 648_T | 1.553 | 0.99 |
| 244_E | 248_K | 1.542 | 0.99 |
| 703_L | 716_V | 1.542 | 0.99 |
| 13_W | 895_W | 1.541 | 0.99 |
| 305_A | 309_E | 1.534 | 0.99 |
| 307_R | 325_Y | 1.534 | 0.99 |
| 423_E | 433_K | 1.532 | 0.98 |
| 188_M | 193_L | 1.530 | 0.98 |
| 14_V | 890_A | 1.529 | 0.98 |
| 885_F | 889_A | 1.528 | 0.98 |
| 593_E | 596_H | 1.527 | 0.98 |
| 715_S | 830_Q | 1.523 | 0.98 |
| 262_L | 266_A | 1.520 | 0.98 |
| 632_K | 636_D | 1.513 | 0.98 |
| 746_I | 804_F | 1.505 | 0.98 |
| 218_Q | 231_N | 1.505 | 0.98 |
| 172_V | 291_I | 1.504 | 0.98 |
| 196_F | 260_V | 1.501 | 0.98 |
| 702_L | 848_A | 1.501 | 0.98 |
| 472_I | 476_S | 1.497 | 0.98 |
| 582_A | 586_R | 1.497 | 0.98 |
| 537_S | 540_R | 1.494 | 0.98 |
| 605_N | 632_K | 1.493 | 0.98 |
| 187_W | 269_E | 1.490 | 0.98 |
| 169_T | 309_E | 1.490 | 0.98 |
| 170_S | 305_A | 1.480 | 0.98 |
| 11_F | 890_A | 1.479 | 0.98 |
| 916_A | 927_F | 1.479 | 0.98 |
| 897_I | 950_K | 1.474 | 0.98 |
| 547_I | 551_G | 1.472 | 0.98 |
| 473_T | 477_A | 1.469 | 0.98 |
| 62_T | 90_I | 1.469 | 0.98 |
| 339_E | 1000_Q | 1.469 | 0.98 |
| 142_V | 323_I | 1.466 | 0.98 |
| 703_L | 707_A | 1.460 | 0.98 |
| 418_R | 970_M | 1.459 | 0.98 |
| 328_D | 331_P | 1.459 | 0.98 |
| 156_D | 160_A | 1.450 | 0.98 |
| 112_Q | 115_M | 1.450 | 0.98 |
| 533_G | 537_S | 1.448 | 0.98 |
| 185_R | 774_M | 1.445 | 0.98 |
| 92_L | 107_V | 1.444 | 0.98 |
| 598_Y | 606_V | 1.440 | 0.98 |
| 686_D | 855_V | 1.440 | 0.98 |
| 45_I | 92_L | 1.437 | 0.97 |
| 576_V | 625_G | 1.432 | 0.97 |
| 301_D | 304_A | 1.431 | 0.97 |
| 98_T | 106_Q | 1.430 | 0.97 |
| 835_K | 839_E | 1.430 | 0.97 |
| 606_V | 609_V | 1.425 | 0.97 |
| 576_V | 594_V | 1.423 | 0.97 |
| 66_E | 818_R | 1.421 | 0.97 |
| 835_K | 843_L | 1.415 | 0.97 |
| 528_T | 969_R | 1.413 | 0.97 |
| 370_I | 492_L | 1.411 | 0.97 |
| 694_K | 698_A | 1.407 | 0.97 |
| 57_V | 82_S | 1.406 | 0.97 |
| 334_K | 338_H | 1.402 | 0.97 |
| 198_L | 202_D | 1.395 | 0.97 |
| 199_T | 202_D | 1.393 | 0.97 |
| 683_E | 824_S | 1.393 | 0.97 |
| 578_L | 587_T | 1.389 | 0.97 |
| 699_R | 825_M | 1.384 | 0.97 |
| 13_W | 17_I | 1.384 | 0.97 |
| 713_L | 840_A | 1.384 | 0.97 |
| 163_K | 167_S | 1.383 | 0.97 |
| 711_D | 835_K | 1.381 | 0.97 |
| 684_L | 699_R | 1.379 | 0.97 |
| 172_V | 302_T | 1.379 | 0.97 |
| 590_V | 593_E | 1.377 | 0.96 |
| 642_N | 647_I | 1.373 | 0.96 |
| 594_V | 658_I | 1.369 | 0.96 |
| 99_D | 102_I | 1.368 | 0.96 |
| 593_E | 660_D | 1.365 | 0.96 |
| 142_V | 154_I | 1.364 | 0.96 |
| 143_I | 322_K | 1.362 | 0.96 |
| 698_A | 851_L | 1.360 | 0.96 |
| 22_A | 381_A | 1.360 | 0.96 |
| 441_A | 951_D | 1.359 | 0.96 |
| 352_F | 369_T | 1.357 | 0.96 |
| 972_L | 976_L | 1.355 | 0.96 |
| 26_A | 384_A | 1.355 | 0.96 |
| 148_T | 320_G | 1.350 | 0.96 |
| 240_L | 246_F | 1.344 | 0.96 |
| 7_D | 432_R | 1.343 | 0.96 |
| 924_D | 927_F | 1.343 | 0.96 |
| 651_A | 655_F | 1.342 | 0.96 |
| 701_Q | 705_E | 1.338 | 0.96 |
| 231_N | 276_D | 1.336 | 0.96 |
| 115_M | 123_Q | 1.335 | 0.96 |
| 425_L | 433_K | 1.333 | 0.96 |
| 43_V | 107_V | 1.332 | 0.96 |
| 595_T | 609_V | 1.332 | 0.96 |
| 310_L | 323_I | 1.331 | 0.96 |
| 158_V | 162_M | 1.330 | 0.95 |
| 74_N | 95_E | 1.330 | 0.95 |
| 592_N | 596_H | 1.327 | 0.95 |
| 304_A | 308_A | 1.324 | 0.95 |
| 482_V | 981_A | 1.323 | 0.95 |
| 792_R | 798_M | 1.322 | 0.95 |
| 47_A | 65_I | 1.320 | 0.95 |
| 142_V | 162_M | 1.315 | 0.95 |
| 204_I | 208_K | 1.314 | 0.95 |
| 140_V | 325_Y | 1.313 | 0.95 |
| 202_D | 205_T | 1.313 | 0.95 |
| 303_A | 330_T | 1.310 | 0.95 |
| 137_L | 303_A | 1.305 | 0.95 |
| 572_F | 629_V | 1.303 | 0.95 |
| 841_M | 863_S | 1.300 | 0.95 |
| 741_V | 746_I | 1.300 | 0.95 |
| 157_Y | 321_L | 1.294 | 0.95 |
| 897_I | 900_S | 1.290 | 0.94 |
| 446_A | 482_V | 1.289 | 0.94 |
| 562_S | 922_T | 1.289 | 0.94 |
| 162_M | 313_M | 1.288 | 0.94 |
| 711_D | 843_L | 1.284 | 0.94 |
| 412_V | 435_M | 1.284 | 0.94 |
| 273_E | 770_K | 1.277 | 0.94 |
| 433_K | 436_G | 1.273 | 0.94 |
| 728_K | 808_R | 1.271 | 0.94 |
| 522_K | 526_H | 1.271 | 0.94 |
| 141_G | 281_F | 1.270 | 0.94 |
| 984_L | 987_M | 1.264 | 0.94 |
| 47_A | 122_V | 1.261 | 0.94 |
| 791_V | 804_F | 1.261 | 0.94 |
| 576_V | 591_L | 1.258 | 0.93 |
| 842_E | 845_E | 1.256 | 0.93 |
| 239_R | 763_I | 1.254 | 0.93 |
| 647_I | 650_R | 1.248 | 0.93 |
| 26_A | 381_A | 1.245 | 0.93 |
| 58_Q | 816_L | 1.242 | 0.93 |
| 549_V | 553_A | 1.239 | 0.93 |
| 449_L | 940_K | 1.239 | 0.93 |
| 681_D | 826_E | 1.238 | 0.93 |
| 158_V | 289_L | 1.237 | 0.93 |
| 317_F | 323_I | 1.237 | 0.93 |
| 68_N | 113_L | 1.236 | 0.93 |
| 102_I | 105_V | 1.235 | 0.93 |
| 728_K | 810_E | 1.233 | 0.92 |
| 705_E | 847_L | 1.232 | 0.92 |
| 542_L | 546_L | 1.230 | 0.92 |
| 702_L | 827_I | 1.228 | 0.92 |
| 361_N | 417_E | 1.225 | 0.92 |
| 735_K | 738_A | 1.225 | 0.92 |
| 207_I | 759_V | 1.224 | 0.92 |
| 27_I | 390_I | 1.224 | 0.92 |
| 349_I | 353_L | 1.224 | 0.92 |
| 382_V | 386_F | 1.223 | 0.92 |
| 234_I | 754_W | 1.221 | 0.92 |
| 408_D | 981_A | 1.217 | 0.92 |
| 166_I | 175_V | 1.217 | 0.92 |
| 309_E | 313_M | 1.212 | 0.92 |
| 29_K | 384_A | 1.207 | 0.91 |
| 79_S | 93_T | 1.205 | 0.91 |
| 94_F | 107_V | 1.202 | 0.91 |
| 415_N | 437_Q | 1.199 | 0.91 |
| 145_T | 148_T | 1.196 | 0.91 |
| 65_I | 111_L | 1.194 | 0.91 |
| 254_N | 258_S | 1.193 | 0.91 |
| 280_E | 592_N | 1.191 | 0.91 |
| 698_A | 701_Q | 1.191 | 0.91 |
| 50_P | 123_Q | 1.190 | 0.91 |
| 713_L | 829_G | 1.188 | 0.91 |
| 383_L | 388_F | 1.186 | 0.90 |
| 77_Y | 93_T | 1.182 | 0.90 |
| 522_K | 525_H | 1.181 | 0.90 |
| 98_T | 103_A | 1.181 | 0.90 |
| 786_I | 807_S | 1.175 | 0.90 |
| 218_Q | 276_D | 1.173 | 0.90 |
| 528_T | 532_G | 1.171 | 0.90 |
| 439_Q | 443_V | 1.169 | 0.90 |
| 81_N | 91_T | 1.168 | 0.90 |
| 416_V | 493_C | 1.168 | 0.90 |
| 42_A | 91_T | 1.166 | 0.89 |
| 726_Q | 812_G | 1.166 | 0.89 |
| 1_M | 5_F | 1.166 | 0.89 |
| 140_V | 289_L | 1.165 | 0.89 |
| 701_Q | 704_A | 1.164 | 0.89 |
| 307_R | 330_T | 1.164 | 0.89 |
| 379_T | 476_S | 1.163 | 0.89 |
| 819_Y | 860_T | 1.163 | 0.89 |
| 46_S | 89_Q | 1.162 | 0.89 |
| 2_P | 435_M | 1.160 | 0.89 |
| 800_P | 803_A | 1.160 | 0.89 |
| 603_K | 654_A | 1.157 | 0.89 |
| 193_L | 203_V | 1.156 | 0.89 |
| 184_M | 762_F | 1.155 | 0.89 |
| 163_K | 177_L | 1.154 | 0.89 |
| 961_I | 965_L | 1.153 | 0.89 |
| 573_M | 628_F | 1.153 | 0.89 |
| 729_I | 807_S | 1.152 | 0.89 |
| 685_I | 858_D | 1.150 | 0.89 |
| 445_I | 981_A | 1.146 | 0.88 |
| 745_D | 748_T | 1.145 | 0.88 |
| 31_P | 389_S | 1.145 | 0.88 |
| 699_R | 703_L | 1.145 | 0.88 |
| 216_A | 750_L | 1.143 | 0.88 |
| 793_A | 797_Q | 1.142 | 0.88 |
| 590_V | 658_I | 1.141 | 0.88 |
| 922_T | 927_F | 1.140 | 0.88 |
| 404_L | 982_F | 1.139 | 0.88 |
| 157_Y | 161_N | 1.139 | 0.88 |
| 680_F | 844_M | 1.137 | 0.88 |
| 58_Q | 818_R | 1.137 | 0.88 |
| 386_F | 476_S | 1.136 | 0.88 |
| 428_K | 432_R | 1.135 | 0.88 |
| 347_A | 351_V | 1.134 | 0.88 |
| 700_N | 703_L | 1.133 | 0.88 |
| 449_L | 478_M | 1.130 | 0.87 |
| 785_D | 788_D | 1.130 | 0.87 |
| 574_T | 598_Y | 1.129 | 0.87 |
| 839_E | 842_E | 1.129 | 0.87 |
| 595_T | 611_A | 1.124 | 0.87 |
| 886_L | 890_A | 1.124 | 0.87 |
| 735_K | 739_L | 1.124 | 0.87 |
| 95_E | 98_T | 1.123 | 0.87 |
| 278_I | 613_N | 1.123 | 0.87 |
| 139_V | 290_G | 1.122 | 0.87 |
| 543_V | 550_V | 1.121 | 0.87 |
| 759_V | 773_V | 1.121 | 0.87 |
| 904_V | 907_L | 1.121 | 0.87 |
| 200_P | 752_A | 1.121 | 0.87 |
| 684_L | 827_I | 1.116 | 0.87 |
| 843_L | 847_L | 1.115 | 0.86 |
| 5_F | 12_A | 1.114 | 0.86 |
| 192_E | 196_F | 1.114 | 0.86 |
| 278_I | 588_Q | 1.113 | 0.86 |
| 155_S | 180_S | 1.109 | 0.86 |
| 899_F | 903_L | 1.107 | 0.86 |
| 912_A | 931_L | 1.107 | 0.86 |
| 816_L | 823_P | 1.106 | 0.86 |
| 6_I | 432_R | 1.104 | 0.86 |
| 958_K | 962_E | 1.100 | 0.85 |
| 16_A | 19_I | 1.100 | 0.85 |
| 591_L | 627_A | 1.099 | 0.85 |
| 923_N | 927_F | 1.097 | 0.85 |
| 550_V | 553_A | 1.095 | 0.85 |
| 706_A | 713_L | 1.091 | 0.85 |
| 703_L | 827_I | 1.091 | 0.85 |
| 746_I | 801_F | 1.091 | 0.85 |
| 597_Y | 651_A | 1.090 | 0.85 |
| 206_A | 249_I | 1.089 | 0.85 |
| 145_T | 320_G | 1.089 | 0.85 |
| 415_N | 419_V | 1.088 | 0.85 |
| 684_L | 855_V | 1.088 | 0.85 |
| 709_H | 843_L | 1.088 | 0.85 |
| 146_D | 320_G | 1.087 | 0.84 |
| 529_D | 533_G | 1.087 | 0.84 |
| 578_L | 590_V | 1.086 | 0.84 |
| 840_A | 843_L | 1.085 | 0.84 |
| 432_R | 436_G | 1.084 | 0.84 |
| 313_M | 317_F | 1.083 | 0.84 |
| 442_L | 482_V | 1.080 | 0.84 |
| 203_V | 773_V | 1.080 | 0.84 |
| 465_A | 468_R | 1.079 | 0.84 |
| 843_L | 846_Q | 1.079 | 0.84 |
| 69_M | 75_L | 1.078 | 0.84 |
| 47_A | 125_Q | 1.077 | 0.84 |
| 831_A | 840_A | 1.075 | 0.84 |
| 915_A | 919_R | 1.075 | 0.84 |
| 47_A | 82_S | 1.075 | 0.84 |
| 383_L | 472_I | 1.073 | 0.83 |
| 518_R | 522_K | 1.071 | 0.83 |
| 246_F | 262_L | 1.070 | 0.83 |
| 388_F | 475_V | 1.068 | 0.83 |
| 693_E | 696_T | 1.067 | 0.83 |
| 76_M | 864_Y | 1.066 | 0.83 |
| 163_K | 175_V | 1.065 | 0.83 |
| 20_M | 24_G | 1.063 | 0.83 |
| 462_S | 563_F | 1.061 | 0.82 |
| 388_F | 469_Q | 1.060 | 0.82 |
| 178_F | 290_G | 1.057 | 0.82 |
| 150_T | 153_D | 1.056 | 0.82 |
| 214_V | 747_N | 1.056 | 0.82 |
| 205_T | 209_A | 1.056 | 0.82 |
| 70_N | 821_G | 1.055 | 0.82 |
| 649_M | 652_T | 1.052 | 0.82 |
| 720_G | 825_M | 1.051 | 0.82 |
| 41_P | 94_F | 1.051 | 0.82 |
| 980_L | 984_L | 1.051 | 0.82 |
| 877_Y | 935_I | 1.050 | 0.82 |
| 288_G | 610_F | 1.050 | 0.82 |
| 201_V | 745_D | 1.049 | 0.82 |
| 960_L | 964_T | 1.049 | 0.82 |
| 335_I | 338_H | 1.046 | 0.81 |
| 110_K | 113_L | 1.045 | 0.81 |
| 192_E | 735_K | 1.043 | 0.81 |
| 352_F | 372_V | 1.042 | 0.81 |
| 594_V | 627_A | 1.042 | 0.81 |
| 703_L | 718_P | 1.042 | 0.81 |
| 874_P | 878_A | 1.042 | 0.81 |
| 169_T | 302_T | 1.041 | 0.81 |
| 211_N | 760_N | 1.041 | 0.81 |
| 404_L | 981_A | 1.040 | 0.81 |
| 941_N | 979_S | 1.040 | 0.81 |
| 30_L | 390_I | 1.040 | 0.81 |
| 304_A | 307_R | 1.039 | 0.81 |
| 279_A | 288_G | 1.037 | 0.80 |
| 683_E | 819_Y | 1.037 | 0.80 |
| 832_A | 835_K | 1.036 | 0.80 |
| 979_S | 982_F | 1.036 | 0.80 |
| 880_S | 932_L | 1.036 | 0.80 |
| 291_I | 306_I | 1.034 | 0.80 |
| 144_N | 320_G | 1.032 | 0.80 |
| 367_I | 492_L | 1.032 | 0.80 |
| 69_M | 107_V | 1.032 | 0.80 |
| 382_V | 480_L | 1.031 | 0.80 |
| 166_I | 309_E | 1.031 | 0.80 |
| 603_K | 647_I | 1.030 | 0.80 |
| 419_V | 433_K | 1.027 | 0.80 |
| 201_V | 205_T | 1.027 | 0.80 |
| 558_R | 917_T | 1.025 | 0.79 |
| 366_L | 496_M | 1.024 | 0.79 |
| 374_V | 488_L | 1.023 | 0.79 |
| 417_E | 421_A | 1.022 | 0.79 |
| 447_M | 887_C | 1.019 | 0.79 |
| 702_L | 847_L | 1.018 | 0.79 |
| 646_A | 650_R | 1.017 | 0.79 |
| 530_S | 533_G | 1.015 | 0.78 |
| 48_S | 87_T | 1.014 | 0.78 |
| 360_Q | 517_N | 1.014 | 0.78 |
| 593_E | 658_I | 1.014 | 0.78 |
| 250_L | 259_R | 1.014 | 0.78 |
| 78_M | 821_G | 1.013 | 0.78 |
| 835_K | 840_A | 1.012 | 0.78 |
| 729_I | 750_L | 1.010 | 0.78 |
| 713_L | 844_M | 1.004 | 0.77 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4k0jA | 6 | 0.928 | 100 | 0.281 | Contact Map |
| 4mt1A | 1 | 0.975 | 100 | 0.34 | Contact Map |
| 3ne5A | 1 | 0.96 | 100 | 0.351 | Contact Map |
| 3w9iA | 6 | 0.996 | 100 | 0.351 | Contact Map |
| 4dx5A | 3 | 0.994 | 100 | 0.364 | Contact Map |
| 4r86A | 2 | 0.29 | 100 | 0.759 | Contact Map |
| 3aqpA | 2 | 0.665 | 100 | 0.781 | Contact Map |
| 2ew9A | 1 | 0.149 | 72.1 | 0.985 | Contact Map |
| 4n8nA | 4 | 0.101 | 65.2 | 0.986 | Contact Map |
| 4q2lA | 1 | 0.064 | 61.5 | 0.986 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)