| cftr_model |
| ID: | 1445522248 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 1000 (974) | ||
| Sequences: | 5398 (3356.7) | ||
| Seq/Len: | 5.542 | ||
| Nf(neff/√len): | 107.6 |
HHblits Results: (2015_06)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 5.542).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 824_S | 827_Q | 5.089 | 1.00 |
| 803_D | 818_N | 5.062 | 1.00 |
| 805_T | 818_N | 4.952 | 1.00 |
| 800_T | 822_S | 4.926 | 1.00 |
| 801_V | 804_L | 4.560 | 1.00 |
| 798_Q | 822_S | 4.492 | 1.00 |
| 342_G | 346_E | 4.207 | 1.00 |
| 420_L | 428_I | 4.188 | 1.00 |
| 363_I | 372_I | 4.139 | 1.00 |
| 364_K | 369_E | 3.970 | 1.00 |
| 802_K | 855_E | 3.951 | 1.00 |
| 978_K | 998_E | 3.756 | 1.00 |
| 356_E | 360_R | 3.730 | 1.00 |
| 345_K | 380_N | 3.553 | 1.00 |
| 119_H | 122_W | 3.542 | 1.00 |
| 308_S | 317_L | 3.485 | 1.00 |
| 367_Q | 427_E | 3.389 | 1.00 |
| 805_T | 814_A | 3.284 | 1.00 |
| 334_S | 653_T | 3.244 | 1.00 |
| 129_A | 133_G | 3.207 | 1.00 |
| 900_S | 903_E | 3.138 | 1.00 |
| 359_Y | 379_D | 3.025 | 1.00 |
| 909_D | 914_R | 2.941 | 1.00 |
| 862_S | 865_S | 2.931 | 1.00 |
| 988_L | 999_C | 2.926 | 1.00 |
| 847_L | 957_L | 2.903 | 1.00 |
| 659_R | 662_Y | 2.899 | 1.00 |
| 928_L | 935_L | 2.899 | 1.00 |
| 801_V | 821_F | 2.889 | 1.00 |
| 858_I | 955_I | 2.876 | 1.00 |
| 404_V | 432_C | 2.872 | 1.00 |
| 914_R | 924_L | 2.867 | 1.00 |
| 595_A | 599_V | 2.802 | 1.00 |
| 890_R | 901_D | 2.772 | 1.00 |
| 471_W | 507_I | 2.721 | 1.00 |
| 572_L | 752_V | 2.699 | 1.00 |
| 802_K | 857_Q | 2.664 | 1.00 |
| 666_L | 670_A | 2.613 | 1.00 |
| 344_I | 398_I | 2.590 | 1.00 |
| 867_T | 870_Q | 2.500 | 1.00 |
| 104_L | 644_L | 2.497 | 1.00 |
| 298_V | 309_L | 2.490 | 1.00 |
| 349_I | 354_Y | 2.487 | 1.00 |
| 823_I | 829_V | 2.476 | 1.00 |
| 81_Y | 647_S | 2.467 | 1.00 |
| 400_L | 413_L | 2.450 | 1.00 |
| 893_L | 904_I | 2.442 | 1.00 |
| 975_R | 979_Q | 2.431 | 1.00 |
| 310_L | 412_L | 2.414 | 1.00 |
| 798_Q | 824_S | 2.409 | 1.00 |
| 312_V | 317_L | 2.409 | 1.00 |
| 843_L | 957_L | 2.392 | 1.00 |
| 753_F | 757_D | 2.390 | 1.00 |
| 290_I | 296_L | 2.373 | 1.00 |
| 890_R | 925_D | 2.354 | 1.00 |
| 856_I | 863_W | 2.346 | 1.00 |
| 889_F | 943_M | 2.345 | 1.00 |
| 797_G | 859_D | 2.341 | 1.00 |
| 855_E | 862_S | 2.340 | 1.00 |
| 291_E | 294_Q | 2.338 | 1.00 |
| 799_M | 955_I | 2.327 | 1.00 |
| 831_L | 987_I | 2.309 | 1.00 |
| 798_Q | 825_P | 2.297 | 1.00 |
| 177_E | 211_T | 2.287 | 1.00 |
| 548_A | 758_M | 2.283 | 1.00 |
| 365_A | 436_L | 2.257 | 1.00 |
| 762_G | 867_T | 2.252 | 1.00 |
| 806_A | 850_L | 2.248 | 1.00 |
| 636_G | 674_H | 2.244 | 1.00 |
| 799_M | 858_I | 2.230 | 1.00 |
| 990_E | 995_A | 2.226 | 1.00 |
| 803_D | 820_S | 2.226 | 1.00 |
| 970_Y | 978_K | 2.216 | 1.00 |
| 506_Y | 510_G | 2.186 | 1.00 |
| 905_W | 909_D | 2.174 | 1.00 |
| 970_Y | 974_R | 2.144 | 1.00 |
| 843_L | 989_C | 2.125 | 1.00 |
| 799_M | 987_I | 2.122 | 1.00 |
| 847_L | 875_F | 2.105 | 1.00 |
| 687_W | 691_R | 2.074 | 1.00 |
| 362_V | 366_C | 2.067 | 1.00 |
| 8_L | 12_E | 2.053 | 1.00 |
| 190_Q | 554_N | 2.002 | 1.00 |
| 360_R | 369_E | 2.001 | 1.00 |
| 190_Q | 550_M | 1.990 | 1.00 |
| 629_L | 684_T | 1.987 | 1.00 |
| 316_E | 655_R | 1.986 | 1.00 |
| 598_A | 605_F | 1.935 | 1.00 |
| 800_T | 857_Q | 1.909 | 1.00 |
| 564_R | 568_D | 1.905 | 1.00 |
| 503_Y | 507_I | 1.894 | 1.00 |
| 847_L | 877_V | 1.883 | 1.00 |
| 364_K | 431_S | 1.869 | 1.00 |
| 806_A | 841_T | 1.869 | 1.00 |
| 345_K | 354_Y | 1.867 | 1.00 |
| 831_L | 842_L | 1.856 | 1.00 |
| 799_M | 823_I | 1.848 | 1.00 |
| 816_L | 819_I | 1.829 | 1.00 |
| 544_S | 760_T | 1.829 | 1.00 |
| 310_L | 445_V | 1.813 | 1.00 |
| 390_L | 398_I | 1.808 | 1.00 |
| 903_E | 952_K | 1.801 | 1.00 |
| 210_Q | 535_K | 1.799 | 1.00 |
| 375_F | 381_I | 1.798 | 1.00 |
| 199_E | 869_Q | 1.797 | 1.00 |
| 848_R | 851_N | 1.792 | 1.00 |
| 384_G | 387_G | 1.780 | 1.00 |
| 314_M | 332_F | 1.775 | 1.00 |
| 139_L | 259_T | 1.768 | 1.00 |
| 291_E | 296_L | 1.763 | 1.00 |
| 252_I | 255_K | 1.763 | 1.00 |
| 213_L | 535_K | 1.756 | 1.00 |
| 396_A | 418_G | 1.754 | 1.00 |
| 337_S | 396_A | 1.749 | 1.00 |
| 361_S | 364_K | 1.745 | 1.00 |
| 307_T | 311_M | 1.734 | 1.00 |
| 427_E | 431_S | 1.733 | 1.00 |
| 833_G | 838_G | 1.712 | 1.00 |
| 424_T | 835_T | 1.707 | 1.00 |
| 406_K | 411_Y | 1.691 | 1.00 |
| 863_W | 871_W | 1.685 | 1.00 |
| 734_W | 737_N | 1.682 | 1.00 |
| 407_D | 440_K | 1.674 | 1.00 |
| 938_G | 941_Q | 1.674 | 1.00 |
| 298_V | 443_I | 1.652 | 1.00 |
| 308_S | 312_V | 1.651 | 1.00 |
| 346_E | 380_N | 1.635 | 0.99 |
| 507_I | 510_G | 1.634 | 0.99 |
| 906_K | 910_E | 1.633 | 0.99 |
| 537_L | 572_L | 1.633 | 0.99 |
| 409_D | 440_K | 1.623 | 0.99 |
| 907_V | 911_V | 1.620 | 0.99 |
| 905_W | 914_R | 1.611 | 0.99 |
| 391_S | 394_Q | 1.604 | 0.99 |
| 426_K | 430_E | 1.596 | 0.99 |
| 833_G | 836_G | 1.570 | 0.99 |
| 314_M | 656_A | 1.568 | 0.99 |
| 971_Q | 975_R | 1.565 | 0.99 |
| 908_A | 924_L | 1.564 | 0.99 |
| 163_M | 166_K | 1.561 | 0.99 |
| 343_T | 346_E | 1.558 | 0.99 |
| 897_E | 925_D | 1.557 | 0.99 |
| 340_M | 347_N | 1.549 | 0.99 |
| 193_K | 198_E | 1.535 | 0.99 |
| 833_G | 839_K | 1.533 | 0.99 |
| 974_R | 992_R | 1.528 | 0.99 |
| 136_W | 144_F | 1.526 | 0.99 |
| 471_W | 475_N | 1.522 | 0.99 |
| 383_L | 389_T | 1.521 | 0.99 |
| 189_I | 553_L | 1.511 | 0.99 |
| 204_M | 891_K | 1.508 | 0.99 |
| 557_K | 560_G | 1.499 | 0.99 |
| 404_V | 437_M | 1.496 | 0.99 |
| 627_Q | 743_D | 1.492 | 0.99 |
| 961_P | 990_E | 1.491 | 0.99 |
| 888_T | 891_K | 1.484 | 0.99 |
| 848_R | 868_L | 1.472 | 0.99 |
| 366_C | 404_V | 1.472 | 0.99 |
| 344_I | 372_I | 1.471 | 0.99 |
| 361_S | 365_A | 1.470 | 0.99 |
| 970_Y | 992_R | 1.469 | 0.99 |
| 928_L | 932_G | 1.468 | 0.99 |
| 844_S | 850_L | 1.463 | 0.99 |
| 568_D | 751_R | 1.462 | 0.99 |
| 541_M | 752_V | 1.460 | 0.99 |
| 203_K | 207_N | 1.454 | 0.98 |
| 340_M | 663_F | 1.452 | 0.98 |
| 845_A | 856_I | 1.450 | 0.98 |
| 370_E | 373_S | 1.442 | 0.98 |
| 81_Y | 663_F | 1.437 | 0.98 |
| 170_Q | 215_L | 1.436 | 0.98 |
| 295_L | 429_F | 1.427 | 0.98 |
| 809_T | 812_G | 1.424 | 0.98 |
| 643_H | 670_A | 1.421 | 0.98 |
| 974_R | 978_K | 1.419 | 0.98 |
| 908_A | 917_I | 1.416 | 0.98 |
| 136_W | 143_A | 1.416 | 0.98 |
| 348_I | 366_C | 1.415 | 0.98 |
| 935_L | 943_M | 1.409 | 0.98 |
| 331_S | 408_A | 1.406 | 0.98 |
| 688_F | 692_I | 1.405 | 0.98 |
| 144_F | 148_G | 1.399 | 0.98 |
| 990_E | 996_M | 1.398 | 0.98 |
| 560_G | 638_S | 1.397 | 0.98 |
| 936_S | 941_Q | 1.394 | 0.98 |
| 981_F | 984_C | 1.393 | 0.98 |
| 393_G | 397_R | 1.392 | 0.98 |
| 192_V | 201_M | 1.389 | 0.98 |
| 550_M | 554_N | 1.380 | 0.98 |
| 73_R | 77_F | 1.367 | 0.97 |
| 836_G | 839_K | 1.364 | 0.97 |
| 185_M | 205_I | 1.361 | 0.97 |
| 396_A | 400_L | 1.358 | 0.97 |
| 27_A | 254_R | 1.355 | 0.97 |
| 362_V | 365_A | 1.354 | 0.97 |
| 758_M | 761_E | 1.353 | 0.97 |
| 992_R | 995_A | 1.353 | 0.97 |
| 936_S | 939_H | 1.351 | 0.97 |
| 109_N | 113_E | 1.348 | 0.97 |
| 330_I | 410_L | 1.342 | 0.97 |
| 956_L | 984_C | 1.341 | 0.97 |
| 181_I | 208_L | 1.340 | 0.97 |
| 876_G | 953_A | 1.340 | 0.97 |
| 910_E | 980_A | 1.334 | 0.97 |
| 837_S | 841_T | 1.334 | 0.97 |
| 893_L | 908_A | 1.334 | 0.97 |
| 186_I | 545_V | 1.324 | 0.97 |
| 686_R | 737_N | 1.324 | 0.97 |
| 170_Q | 218_K | 1.323 | 0.97 |
| 547_Q | 760_T | 1.319 | 0.97 |
| 174_K | 211_T | 1.313 | 0.97 |
| 28_S | 40_A | 1.313 | 0.97 |
| 133_G | 137_E | 1.312 | 0.97 |
| 807_K | 814_A | 1.312 | 0.97 |
| 956_L | 986_V | 1.304 | 0.96 |
| 974_R | 995_A | 1.301 | 0.96 |
| 425_E | 448_K | 1.298 | 0.96 |
| 866_I | 871_W | 1.291 | 0.96 |
| 411_Y | 440_K | 1.285 | 0.96 |
| 804_L | 821_F | 1.284 | 0.96 |
| 354_Y | 359_Y | 1.283 | 0.96 |
| 798_Q | 860_G | 1.281 | 0.96 |
| 358_R | 362_V | 1.279 | 0.96 |
| 332_F | 335_Q | 1.277 | 0.96 |
| 429_F | 433_V | 1.277 | 0.96 |
| 973_I | 976_T | 1.275 | 0.96 |
| 510_G | 514_T | 1.274 | 0.96 |
| 333_C | 403_A | 1.273 | 0.96 |
| 830_G | 990_E | 1.269 | 0.96 |
| 184_E | 886_S | 1.268 | 0.96 |
| 591_I | 595_A | 1.265 | 0.95 |
| 48_C | 701_I | 1.263 | 0.95 |
| 174_K | 215_L | 1.262 | 0.95 |
| 506_Y | 509_V | 1.262 | 0.95 |
| 861_V | 866_I | 1.253 | 0.95 |
| 333_C | 396_A | 1.249 | 0.95 |
| 633_E | 637_R | 1.249 | 0.95 |
| 965_L | 973_I | 1.247 | 0.95 |
| 627_Q | 631_Q | 1.242 | 0.95 |
| 392_G | 419_Y | 1.241 | 0.95 |
| 59_H | 689_Q | 1.220 | 0.94 |
| 391_S | 397_R | 1.220 | 0.94 |
| 806_A | 845_A | 1.216 | 0.94 |
| 312_V | 315_G | 1.210 | 0.94 |
| 303_G | 307_T | 1.207 | 0.94 |
| 206_E | 539_H | 1.207 | 0.94 |
| 549_P | 553_L | 1.202 | 0.94 |
| 507_I | 511_V | 1.201 | 0.94 |
| 339_I | 398_I | 1.195 | 0.93 |
| 76_M | 80_I | 1.194 | 0.93 |
| 974_R | 990_E | 1.192 | 0.93 |
| 545_V | 565_F | 1.191 | 0.93 |
| 345_K | 349_I | 1.191 | 0.93 |
| 653_T | 657_F | 1.184 | 0.93 |
| 345_K | 379_D | 1.183 | 0.93 |
| 254_R | 258_T | 1.181 | 0.93 |
| 819_I | 842_L | 1.179 | 0.93 |
| 544_S | 756_I | 1.178 | 0.93 |
| 902_Q | 906_K | 1.178 | 0.93 |
| 344_I | 348_I | 1.177 | 0.93 |
| 338_W | 650_G | 1.172 | 0.92 |
| 798_Q | 859_D | 1.172 | 0.92 |
| 393_G | 421_D | 1.172 | 0.92 |
| 746_M | 749_V | 1.172 | 0.92 |
| 804_L | 852_T | 1.171 | 0.92 |
| 394_Q | 397_R | 1.166 | 0.92 |
| 300_G | 306_K | 1.164 | 0.92 |
| 835_T | 838_G | 1.161 | 0.92 |
| 357_Y | 361_S | 1.161 | 0.92 |
| 643_H | 647_S | 1.160 | 0.92 |
| 633_E | 674_H | 1.156 | 0.92 |
| 188_N | 883_F | 1.155 | 0.92 |
| 293_G | 296_L | 1.154 | 0.92 |
| 418_G | 447_S | 1.151 | 0.91 |
| 509_V | 513_D | 1.151 | 0.91 |
| 105_S | 641_F | 1.150 | 0.91 |
| 390_L | 394_Q | 1.146 | 0.91 |
| 331_S | 335_Q | 1.141 | 0.91 |
| 603_Y | 606_V | 1.140 | 0.91 |
| 392_G | 397_R | 1.138 | 0.91 |
| 890_R | 894_D | 1.137 | 0.91 |
| 638_S | 641_F | 1.137 | 0.91 |
| 993_I | 996_M | 1.137 | 0.91 |
| 363_I | 367_Q | 1.135 | 0.91 |
| 800_T | 860_G | 1.131 | 0.91 |
| 828_R | 999_C | 1.130 | 0.90 |
| 16_A | 131_L | 1.127 | 0.90 |
| 966_D | 969_T | 1.126 | 0.90 |
| 808_Y | 816_L | 1.126 | 0.90 |
| 990_E | 993_I | 1.126 | 0.90 |
| 802_K | 820_S | 1.125 | 0.90 |
| 7_F | 11_G | 1.122 | 0.90 |
| 941_Q | 947_R | 1.119 | 0.90 |
| 889_F | 926_F | 1.118 | 0.90 |
| 453_I | 456_L | 1.118 | 0.90 |
| 545_V | 553_L | 1.117 | 0.90 |
| 182_T | 538_H | 1.117 | 0.90 |
| 104_L | 641_F | 1.116 | 0.90 |
| 889_F | 935_L | 1.116 | 0.90 |
| 960_E | 991_H | 1.113 | 0.90 |
| 26_I | 29_Y | 1.113 | 0.90 |
| 385_E | 558_A | 1.112 | 0.90 |
| 253_L | 476_T | 1.112 | 0.90 |
| 295_L | 433_V | 1.110 | 0.89 |
| 938_G | 947_R | 1.109 | 0.89 |
| 169_D | 173_G | 1.108 | 0.89 |
| 792_I | 795_S | 1.107 | 0.89 |
| 290_I | 443_I | 1.107 | 0.89 |
| 358_R | 436_L | 1.106 | 0.89 |
| 414_D | 421_D | 1.106 | 0.89 |
| 542_L | 565_F | 1.105 | 0.89 |
| 412_L | 445_V | 1.104 | 0.89 |
| 174_K | 208_L | 1.104 | 0.89 |
| 372_I | 379_D | 1.103 | 0.89 |
| 959_D | 962_S | 1.103 | 0.89 |
| 762_G | 851_N | 1.101 | 0.89 |
| 300_G | 305_G | 1.099 | 0.89 |
| 391_S | 421_D | 1.096 | 0.89 |
| 904_I | 950_L | 1.095 | 0.89 |
| 42_Y | 46_G | 1.089 | 0.88 |
| 146_G | 263_C | 1.089 | 0.88 |
| 547_Q | 867_T | 1.088 | 0.88 |
| 466_S | 592_G | 1.087 | 0.88 |
| 810_E | 813_N | 1.086 | 0.88 |
| 337_S | 653_T | 1.085 | 0.88 |
| 367_Q | 431_S | 1.081 | 0.88 |
| 628_Q | 635_E | 1.080 | 0.88 |
| 802_K | 854_G | 1.078 | 0.88 |
| 936_S | 966_D | 1.076 | 0.87 |
| 402_R | 414_D | 1.075 | 0.87 |
| 383_L | 388_I | 1.075 | 0.87 |
| 145_C | 244_P | 1.074 | 0.87 |
| 343_T | 380_N | 1.074 | 0.87 |
| 839_K | 880_Q | 1.070 | 0.87 |
| 835_T | 839_K | 1.069 | 0.87 |
| 303_G | 306_K | 1.069 | 0.87 |
| 288_F | 454_W | 1.066 | 0.87 |
| 138_L | 258_T | 1.065 | 0.87 |
| 990_E | 998_E | 1.065 | 0.87 |
| 631_Q | 750_S | 1.064 | 0.87 |
| 513_D | 517_A | 1.062 | 0.86 |
| 347_N | 350_F | 1.059 | 0.86 |
| 885_F | 892_N | 1.059 | 0.86 |
| 870_Q | 874_A | 1.058 | 0.86 |
| 293_G | 441_T | 1.057 | 0.86 |
| 202_E | 543_H | 1.057 | 0.86 |
| 387_G | 391_S | 1.056 | 0.86 |
| 358_R | 407_D | 1.056 | 0.86 |
| 838_G | 841_T | 1.056 | 0.86 |
| 82_K | 668_H | 1.054 | 0.86 |
| 45_I | 49_L | 1.054 | 0.86 |
| 970_Y | 998_E | 1.054 | 0.86 |
| 938_G | 966_D | 1.053 | 0.86 |
| 530_L | 577_P | 1.050 | 0.86 |
| 337_S | 399_S | 1.049 | 0.86 |
| 300_G | 303_G | 1.049 | 0.86 |
| 259_T | 263_C | 1.048 | 0.85 |
| 952_K | 984_C | 1.046 | 0.85 |
| 631_Q | 743_D | 1.046 | 0.85 |
| 665_T | 669_K | 1.045 | 0.85 |
| 573_D | 576_L | 1.044 | 0.85 |
| 734_W | 738_S | 1.044 | 0.85 |
| 371_D | 379_D | 1.043 | 0.85 |
| 866_I | 870_Q | 1.043 | 0.85 |
| 941_Q | 966_D | 1.041 | 0.85 |
| 351_G | 662_Y | 1.041 | 0.85 |
| 666_L | 669_K | 1.038 | 0.85 |
| 576_L | 742_V | 1.037 | 0.85 |
| 417_F | 420_L | 1.037 | 0.85 |
| 372_I | 398_I | 1.036 | 0.85 |
| 844_S | 849_L | 1.034 | 0.84 |
| 882_V | 944_C | 1.034 | 0.84 |
| 172_A | 175_I | 1.033 | 0.84 |
| 366_C | 379_D | 1.029 | 0.84 |
| 904_I | 917_I | 1.028 | 0.84 |
| 135_I | 259_T | 1.028 | 0.84 |
| 195_Y | 944_C | 1.027 | 0.84 |
| 345_K | 359_Y | 1.025 | 0.84 |
| 416_P | 428_I | 1.019 | 0.83 |
| 858_I | 863_W | 1.017 | 0.83 |
| 413_L | 442_R | 1.016 | 0.83 |
| 969_T | 976_T | 1.015 | 0.83 |
| 690_M | 694_M | 1.014 | 0.83 |
| 215_L | 218_K | 1.014 | 0.83 |
| 429_F | 445_V | 1.013 | 0.83 |
| 368_L | 371_D | 1.013 | 0.83 |
| 319_P | 324_I | 1.012 | 0.83 |
| 263_C | 266_L | 1.012 | 0.83 |
| 121_V | 125_P | 1.012 | 0.83 |
| 922_G | 926_F | 1.011 | 0.83 |
| 552_T | 755_F | 1.010 | 0.82 |
| 906_K | 952_K | 1.010 | 0.82 |
| 960_E | 966_D | 1.010 | 0.82 |
| 245_Y | 255_K | 1.009 | 0.82 |
| 861_V | 865_S | 1.008 | 0.82 |
| 188_N | 885_F | 1.008 | 0.82 |
| 806_A | 844_S | 1.007 | 0.82 |
| 567_K | 570_A | 1.007 | 0.82 |
| 202_E | 546_L | 1.005 | 0.82 |
| 910_E | 979_Q | 1.004 | 0.82 |
| 209_R | 212_E | 1.003 | 0.82 |
| 329_R | 409_D | 1.003 | 0.82 |
| 360_R | 363_I | 1.002 | 0.82 |
| 704_T | 722_L | 1.001 | 0.82 |
| 206_E | 210_Q | 1.000 | 0.82 |
| 540_K | 756_I | 1.000 | 0.82 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- See coupling matrix (for protein design or mutagenesis)
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4f4cA | 1 | 0.959 | 100 | 0.357 | Contact Map |
| 4q9hA | 1 | 0.959 | 100 | 0.377 | Contact Map |
| 4ry2A | 2 | 0 | 100 | 0.624 | Contact Map |
| 4a82A | 4 | 0.538 | 100 | 0.626 | Contact Map |
| 3wmgA | 1 | 0.534 | 100 | 0.642 | Contact Map |
| 4q4hB | 1 | 0.543 | 100 | 0.643 | Contact Map |
| 3zdqA | 1 | 0.538 | 100 | 0.649 | Contact Map |
| 3b60A | 4 | 0.531 | 100 | 0.65 | Contact Map |
| 3b5xA | 2 | 0.531 | 100 | 0.651 | Contact Map |
| 4q4hA | 1 | 0.533 | 100 | 0.652 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)