| TRPA1_s -force run |
| ID: | 1438061531 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 992 (988) | ||
| Sequences: | 90 (61.8) | ||
| Seq/Len: | 0.091 | ||
| Nf(neff/√len): | 2.0 |
HHblits Results: (2013_03)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 0.091).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 670_L | 682_K | 1.696 | 0.26 |
| 557_H | 568_V | 1.683 | 0.25 |
| 494_S | 526_F | 1.676 | 0.25 |
| 678_Y | 842_L | 1.655 | 0.24 |
| 40_H | 43_A | 1.618 | 0.23 |
| 852_L | 919_F | 1.617 | 0.23 |
| 932_A | 935_D | 1.612 | 0.23 |
| 251_A | 777_N | 1.605 | 0.23 |
| 409_V | 415_S | 1.587 | 0.22 |
| 106_P | 110_A | 1.585 | 0.22 |
| 129_D | 193_G | 1.581 | 0.22 |
| 609_L | 835_L | 1.578 | 0.22 |
| 829_G | 856_F | 1.577 | 0.22 |
| 107_L | 110_A | 1.539 | 0.20 |
| 568_V | 605_C | 1.513 | 0.20 |
| 860_F | 863_L | 1.506 | 0.19 |
| 950_M | 954_L | 1.488 | 0.19 |
| 763_Q | 771_Y | 1.487 | 0.19 |
| 461_A | 538_L | 1.481 | 0.19 |
| 654_P | 706_T | 1.477 | 0.18 |
| 389_L | 538_L | 1.475 | 0.18 |
| 458_L | 525_H | 1.474 | 0.18 |
| 670_L | 930_G | 1.472 | 0.18 |
| 833_V | 849_F | 1.470 | 0.18 |
| 505_I | 941_K | 1.465 | 0.18 |
| 222_G | 260_V | 1.463 | 0.18 |
| 426_A | 429_G | 1.461 | 0.18 |
| 845_S | 852_L | 1.457 | 0.18 |
| 939_V | 959_E | 1.457 | 0.18 |
| 494_S | 922_I | 1.450 | 0.18 |
| 531_G | 556_L | 1.444 | 0.18 |
| 536_V | 567_V | 1.444 | 0.18 |
| 321_A | 679_L | 1.440 | 0.17 |
| 74_L | 94_A | 1.437 | 0.17 |
| 142_I | 145_C | 1.436 | 0.17 |
| 37_F | 92_R | 1.436 | 0.17 |
| 355_V | 888_I | 1.429 | 0.17 |
| 438_L | 472_L | 1.429 | 0.17 |
| 822_L | 842_L | 1.427 | 0.17 |
| 522_T | 559_A | 1.422 | 0.17 |
| 760_E | 777_N | 1.419 | 0.17 |
| 289_S | 813_F | 1.416 | 0.17 |
| 682_K | 834_M | 1.416 | 0.17 |
| 13_E | 18_G | 1.413 | 0.17 |
| 780_E | 807_G | 1.413 | 0.17 |
| 77_A | 89_L | 1.413 | 0.17 |
| 883_M | 916_F | 1.412 | 0.17 |
| 390_H | 423_H | 1.396 | 0.16 |
| 251_A | 603_P | 1.395 | 0.16 |
| 25_Q | 972_Q | 1.390 | 0.16 |
| 35_D | 78_V | 1.388 | 0.16 |
| 679_L | 683_W | 1.386 | 0.16 |
| 211_K | 940_Q | 1.379 | 0.16 |
| 701_G | 708_L | 1.378 | 0.16 |
| 820_L | 841_T | 1.375 | 0.16 |
| 814_Y | 919_F | 1.375 | 0.16 |
| 760_E | 771_Y | 1.375 | 0.16 |
| 141_V | 153_L | 1.374 | 0.16 |
| 682_K | 815_W | 1.371 | 0.16 |
| 916_F | 932_A | 1.365 | 0.15 |
| 835_L | 932_A | 1.362 | 0.15 |
| 32_D | 42_A | 1.361 | 0.15 |
| 930_G | 933_V | 1.357 | 0.15 |
| 930_G | 935_D | 1.357 | 0.15 |
| 451_D | 916_F | 1.348 | 0.15 |
| 823_Q | 851_F | 1.345 | 0.15 |
| 84_E | 274_V | 1.344 | 0.15 |
| 598_M | 602_L | 1.342 | 0.15 |
| 107_L | 123_L | 1.333 | 0.15 |
| 771_Y | 777_N | 1.331 | 0.15 |
| 64_H | 148_N | 1.327 | 0.14 |
| 248_I | 274_V | 1.327 | 0.14 |
| 81_N | 115_N | 1.327 | 0.14 |
| 106_P | 344_D | 1.327 | 0.14 |
| 848_V | 863_L | 1.320 | 0.14 |
| 54_I | 58_S | 1.318 | 0.14 |
| 808_A | 863_L | 1.318 | 0.14 |
| 284_M | 505_I | 1.316 | 0.14 |
| 812_Y | 855_A | 1.316 | 0.14 |
| 505_I | 513_T | 1.303 | 0.14 |
| 852_L | 913_L | 1.301 | 0.14 |
| 804_W | 807_G | 1.301 | 0.14 |
| 20_Q | 23_N | 1.301 | 0.14 |
| 932_A | 943_A | 1.300 | 0.14 |
| 421_P | 573_R | 1.299 | 0.14 |
| 670_L | 932_A | 1.296 | 0.14 |
| 698_Y | 706_T | 1.294 | 0.14 |
| 64_H | 96_P | 1.293 | 0.14 |
| 670_L | 933_V | 1.292 | 0.14 |
| 670_L | 935_D | 1.292 | 0.14 |
| 283_T | 286_H | 1.287 | 0.14 |
| 933_V | 943_A | 1.287 | 0.14 |
| 935_D | 943_A | 1.287 | 0.14 |
| 123_L | 768_K | 1.286 | 0.13 |
| 598_M | 613_C | 1.282 | 0.13 |
| 74_L | 679_L | 1.279 | 0.13 |
| 322_T | 598_M | 1.275 | 0.13 |
| 396_G | 423_H | 1.272 | 0.13 |
| 457_P | 470_V | 1.272 | 0.13 |
| 458_L | 473_L | 1.263 | 0.13 |
| 137_G | 819_L | 1.262 | 0.13 |
| 930_G | 936_I | 1.262 | 0.13 |
| 520_G | 543_N | 1.262 | 0.13 |
| 214_P | 538_L | 1.260 | 0.13 |
| 835_L | 933_V | 1.259 | 0.13 |
| 835_L | 935_D | 1.259 | 0.13 |
| 599_I | 603_P | 1.258 | 0.13 |
| 74_L | 144_A | 1.253 | 0.13 |
| 258_E | 574_S | 1.253 | 0.13 |
| 11_V | 22_F | 1.248 | 0.13 |
| 67_D | 100_N | 1.246 | 0.13 |
| 51_M | 755_F | 1.245 | 0.13 |
| 451_D | 883_M | 1.244 | 0.13 |
| 823_Q | 842_L | 1.242 | 0.13 |
| 936_I | 951_Q | 1.242 | 0.13 |
| 251_A | 599_I | 1.242 | 0.13 |
| 459_H | 465_G | 1.239 | 0.12 |
| 227_I | 446_L | 1.236 | 0.12 |
| 251_A | 886_G | 1.236 | 0.12 |
| 22_F | 928_L | 1.236 | 0.12 |
| 219_V | 963_P | 1.235 | 0.12 |
| 10_V | 13_E | 1.235 | 0.12 |
| 32_D | 40_H | 1.234 | 0.12 |
| 73_P | 777_N | 1.234 | 0.12 |
| 338_A | 423_H | 1.234 | 0.12 |
| 187_E | 191_R | 1.232 | 0.12 |
| 916_F | 933_V | 1.231 | 0.12 |
| 916_F | 935_D | 1.231 | 0.12 |
| 532_H | 556_L | 1.229 | 0.12 |
| 830_I | 841_T | 1.229 | 0.12 |
| 219_V | 426_A | 1.229 | 0.12 |
| 325_A | 506_L | 1.228 | 0.12 |
| 235_A | 540_L | 1.227 | 0.12 |
| 763_Q | 777_N | 1.225 | 0.12 |
| 119_M | 214_P | 1.225 | 0.12 |
| 429_G | 459_H | 1.225 | 0.12 |
| 841_T | 936_I | 1.219 | 0.12 |
| 386_C | 491_H | 1.219 | 0.12 |
| 98_L | 140_A | 1.217 | 0.12 |
| 94_A | 305_A | 1.212 | 0.12 |
| 678_Y | 822_L | 1.210 | 0.12 |
| 74_L | 89_L | 1.210 | 0.12 |
| 73_P | 89_L | 1.210 | 0.12 |
| 173_P | 215_L | 1.205 | 0.12 |
| 283_T | 870_F | 1.205 | 0.12 |
| 883_M | 932_A | 1.205 | 0.12 |
| 75_H | 465_G | 1.205 | 0.12 |
| 235_A | 320_L | 1.204 | 0.12 |
| 832_I | 835_L | 1.204 | 0.12 |
| 915_S | 919_F | 1.203 | 0.12 |
| 190_L | 814_Y | 1.203 | 0.12 |
| 491_H | 929_I | 1.201 | 0.12 |
| 841_T | 931_L | 1.201 | 0.12 |
| 9_K | 16_A | 1.200 | 0.12 |
| 925_M | 930_G | 1.200 | 0.12 |
| 5_K | 20_Q | 1.198 | 0.12 |
| 73_P | 760_E | 1.197 | 0.12 |
| 108_H | 525_H | 1.197 | 0.12 |
| 74_L | 392_A | 1.193 | 0.11 |
| 520_G | 636_Q | 1.191 | 0.11 |
| 763_Q | 817_N | 1.191 | 0.11 |
| 318_L | 321_A | 1.191 | 0.11 |
| 259_I | 348_R | 1.190 | 0.11 |
| 139_T | 286_H | 1.187 | 0.11 |
| 931_L | 935_D | 1.187 | 0.11 |
| 885_L | 929_I | 1.187 | 0.11 |
| 753_S | 791_V | 1.184 | 0.11 |
| 757_Y | 764_I | 1.183 | 0.11 |
| 628_I | 832_I | 1.183 | 0.11 |
| 683_W | 829_G | 1.180 | 0.11 |
| 227_I | 314_G | 1.180 | 0.11 |
| 925_M | 936_I | 1.180 | 0.11 |
| 322_T | 377_L | 1.179 | 0.11 |
| 916_F | 920_V | 1.177 | 0.11 |
| 385_G | 388_P | 1.177 | 0.11 |
| 804_W | 810_A | 1.176 | 0.11 |
| 74_L | 389_L | 1.174 | 0.11 |
| 566_E | 878_I | 1.174 | 0.11 |
| 883_M | 922_I | 1.174 | 0.11 |
| 73_P | 771_Y | 1.173 | 0.11 |
| 105_A | 174_I | 1.173 | 0.11 |
| 539_L | 559_A | 1.171 | 0.11 |
| 197_G | 300_L | 1.170 | 0.11 |
| 387_T | 461_A | 1.169 | 0.11 |
| 931_L | 943_A | 1.169 | 0.11 |
| 506_L | 544_A | 1.169 | 0.11 |
| 35_D | 40_H | 1.167 | 0.11 |
| 498_Y | 970_V | 1.167 | 0.11 |
| 89_L | 333_L | 1.166 | 0.11 |
| 46_G | 607_K | 1.163 | 0.11 |
| 918_I | 929_I | 1.162 | 0.11 |
| 459_H | 493_A | 1.162 | 0.11 |
| 752_S | 780_E | 1.162 | 0.11 |
| 678_Y | 929_I | 1.160 | 0.11 |
| 212_A | 482_S | 1.160 | 0.11 |
| 594_P | 603_P | 1.157 | 0.11 |
| 524_L | 527_A | 1.157 | 0.11 |
| 40_H | 54_I | 1.156 | 0.11 |
| 70_G | 603_P | 1.156 | 0.11 |
| 295_E | 474_L | 1.156 | 0.11 |
| 72_T | 94_A | 1.156 | 0.11 |
| 73_P | 333_L | 1.153 | 0.11 |
| 321_A | 470_V | 1.152 | 0.11 |
| 216_H | 318_L | 1.152 | 0.11 |
| 108_H | 216_H | 1.150 | 0.11 |
| 939_V | 951_Q | 1.149 | 0.11 |
| 404_L | 928_L | 1.147 | 0.11 |
| 669_L | 682_K | 1.147 | 0.11 |
| 883_M | 933_V | 1.146 | 0.11 |
| 883_M | 935_D | 1.146 | 0.11 |
| 25_Q | 30_R | 1.146 | 0.11 |
| 222_G | 812_Y | 1.145 | 0.11 |
| 75_H | 89_L | 1.145 | 0.11 |
| 58_S | 409_V | 1.145 | 0.11 |
| 40_H | 75_H | 1.143 | 0.11 |
| 230_C | 319_I | 1.143 | 0.11 |
| 271_V | 582_K | 1.142 | 0.11 |
| 560_L | 778_V | 1.140 | 0.10 |
| 208_N | 505_I | 1.139 | 0.10 |
| 93_G | 301_I | 1.138 | 0.10 |
| 557_H | 862_I | 1.138 | 0.10 |
| 134_G | 823_Q | 1.138 | 0.10 |
| 670_L | 815_W | 1.138 | 0.10 |
| 922_I | 928_L | 1.136 | 0.10 |
| 543_N | 872_S | 1.136 | 0.10 |
| 172_F | 939_V | 1.135 | 0.10 |
| 358_P | 783_I | 1.135 | 0.10 |
| 535_A | 838_I | 1.135 | 0.10 |
| 882_S | 929_I | 1.133 | 0.10 |
| 462_A | 649_D | 1.133 | 0.10 |
| 532_H | 559_A | 1.133 | 0.10 |
| 813_F | 831_F | 1.133 | 0.10 |
| 593_C | 636_Q | 1.133 | 0.10 |
| 860_F | 883_M | 1.132 | 0.10 |
| 44_A | 65_E | 1.132 | 0.10 |
| 491_H | 678_Y | 1.132 | 0.10 |
| 682_K | 930_G | 1.132 | 0.10 |
| 115_N | 167_N | 1.132 | 0.10 |
| 603_P | 777_N | 1.132 | 0.10 |
| 11_V | 21_N | 1.130 | 0.10 |
| 698_Y | 760_E | 1.130 | 0.10 |
| 860_F | 864_L | 1.130 | 0.10 |
| 698_Y | 771_Y | 1.130 | 0.10 |
| 227_I | 509_N | 1.130 | 0.10 |
| 141_V | 154_Q | 1.129 | 0.10 |
| 426_A | 454_G | 1.128 | 0.10 |
| 339_Q | 764_I | 1.128 | 0.10 |
| 494_S | 963_P | 1.126 | 0.10 |
| 687_G | 931_L | 1.126 | 0.10 |
| 155_I | 334_L | 1.123 | 0.10 |
| 451_D | 930_G | 1.123 | 0.10 |
| 490_L | 493_A | 1.123 | 0.10 |
| 182_S | 230_C | 1.122 | 0.10 |
| 208_N | 887_D | 1.122 | 0.10 |
| 249_H | 311_D | 1.122 | 0.10 |
| 51_M | 54_I | 1.122 | 0.10 |
| 456_T | 679_L | 1.122 | 0.10 |
| 325_A | 354_T | 1.121 | 0.10 |
| 84_E | 119_M | 1.121 | 0.10 |
| 378_V | 693_M | 1.121 | 0.10 |
| 832_I | 844_R | 1.119 | 0.10 |
| 458_L | 461_A | 1.119 | 0.10 |
| 349_N | 945_L | 1.118 | 0.10 |
| 158_K | 769_R | 1.118 | 0.10 |
| 389_L | 392_A | 1.118 | 0.10 |
| 437_L | 860_F | 1.118 | 0.10 |
| 457_P | 881_F | 1.116 | 0.10 |
| 674_V | 861_Y | 1.116 | 0.10 |
| 204_I | 225_E | 1.115 | 0.10 |
| 25_Q | 31_C | 1.115 | 0.10 |
| 216_H | 249_H | 1.114 | 0.10 |
| 319_I | 414_K | 1.114 | 0.10 |
| 140_A | 566_E | 1.112 | 0.10 |
| 752_S | 845_S | 1.111 | 0.10 |
| 695_L | 871_S | 1.111 | 0.10 |
| 465_G | 927_L | 1.111 | 0.10 |
| 401_V | 565_K | 1.111 | 0.10 |
| 160_G | 540_L | 1.109 | 0.10 |
| 217_L | 462_A | 1.108 | 0.10 |
| 863_L | 866_L | 1.108 | 0.10 |
| 223_D | 313_E | 1.106 | 0.10 |
| 457_P | 461_A | 1.105 | 0.10 |
| 757_Y | 780_E | 1.105 | 0.10 |
| 235_A | 749_V | 1.102 | 0.10 |
| 20_Q | 26_K | 1.101 | 0.10 |
| 426_A | 849_F | 1.101 | 0.10 |
| 174_I | 263_M | 1.101 | 0.10 |
| 32_D | 73_P | 1.099 | 0.10 |
| 252_A | 847_V | 1.099 | 0.10 |
| 676_K | 842_L | 1.099 | 0.10 |
| 167_N | 701_G | 1.099 | 0.10 |
| 819_L | 939_V | 1.099 | 0.10 |
| 382_D | 687_G | 1.098 | 0.10 |
| 13_E | 23_N | 1.098 | 0.10 |
| 3_D | 12_F | 1.097 | 0.10 |
| 251_A | 300_L | 1.097 | 0.10 |
| 831_F | 834_M | 1.097 | 0.10 |
| 157_L | 754_I | 1.097 | 0.10 |
| 940_Q | 966_F | 1.097 | 0.10 |
| 819_L | 823_Q | 1.095 | 0.10 |
| 142_I | 408_N | 1.094 | 0.10 |
| 807_G | 815_W | 1.094 | 0.10 |
| 497_G | 931_L | 1.092 | 0.10 |
| 296_L | 387_T | 1.092 | 0.10 |
| 122_L | 870_F | 1.092 | 0.10 |
| 158_K | 772_F | 1.092 | 0.10 |
| 929_I | 941_K | 1.091 | 0.10 |
| 662_V | 666_R | 1.091 | 0.10 |
| 126_R | 131_N | 1.089 | 0.10 |
| 284_M | 599_I | 1.089 | 0.10 |
| 74_L | 321_A | 1.089 | 0.10 |
| 211_K | 844_R | 1.089 | 0.10 |
| 490_L | 506_L | 1.088 | 0.10 |
| 352_H | 842_L | 1.088 | 0.10 |
| 392_A | 396_G | 1.087 | 0.10 |
| 713_K | 852_L | 1.087 | 0.10 |
| 163_P | 223_D | 1.087 | 0.10 |
| 595_I | 844_R | 1.087 | 0.10 |
| 493_A | 505_I | 1.087 | 0.10 |
| 841_T | 950_M | 1.087 | 0.10 |
| 210_G | 489_A | 1.085 | 0.10 |
| 378_V | 401_V | 1.085 | 0.10 |
| 75_H | 936_I | 1.085 | 0.10 |
| 236_Q | 505_I | 1.084 | 0.10 |
| 887_D | 920_V | 1.082 | 0.09 |
| 449_E | 876_S | 1.082 | 0.09 |
| 119_M | 177_A | 1.081 | 0.09 |
| 232_D | 620_D | 1.081 | 0.09 |
| 128_I | 783_I | 1.081 | 0.09 |
| 409_V | 941_K | 1.081 | 0.09 |
| 355_V | 803_Q | 1.080 | 0.09 |
| 131_N | 140_A | 1.080 | 0.09 |
| 951_Q | 954_L | 1.080 | 0.09 |
| 172_F | 594_P | 1.080 | 0.09 |
| 251_A | 288_A | 1.078 | 0.09 |
| 709_V | 844_R | 1.078 | 0.09 |
| 404_L | 408_N | 1.077 | 0.09 |
| 89_L | 106_P | 1.075 | 0.09 |
| 187_E | 214_P | 1.075 | 0.09 |
| 455_M | 483_D | 1.075 | 0.09 |
| 245_C | 378_V | 1.075 | 0.09 |
| 207_M | 754_I | 1.074 | 0.09 |
| 465_G | 661_M | 1.074 | 0.09 |
| 212_A | 382_D | 1.074 | 0.09 |
| 39_L | 810_A | 1.074 | 0.09 |
| 258_E | 401_V | 1.074 | 0.09 |
| 822_L | 903_L | 1.073 | 0.09 |
| 848_V | 852_L | 1.073 | 0.09 |
| 916_F | 930_G | 1.073 | 0.09 |
| 231_L | 780_E | 1.073 | 0.09 |
| 105_A | 123_L | 1.071 | 0.09 |
| 611_D | 901_N | 1.071 | 0.09 |
| 382_D | 456_T | 1.070 | 0.09 |
| 67_D | 234_G | 1.070 | 0.09 |
| 207_M | 469_V | 1.070 | 0.09 |
| 889_N | 948_I | 1.070 | 0.09 |
| 528_A | 554_S | 1.068 | 0.09 |
| 842_L | 956_T | 1.067 | 0.09 |
| 219_V | 292_D | 1.067 | 0.09 |
| 224_L | 862_I | 1.065 | 0.09 |
| 814_Y | 915_S | 1.065 | 0.09 |
| 352_H | 929_I | 1.065 | 0.09 |
| 108_H | 425_A | 1.065 | 0.09 |
| 334_L | 531_G | 1.064 | 0.09 |
| 423_H | 426_A | 1.064 | 0.09 |
| 325_A | 768_K | 1.064 | 0.09 |
| 355_V | 552_Q | 1.064 | 0.09 |
| 296_L | 609_L | 1.063 | 0.09 |
| 263_M | 285_L | 1.063 | 0.09 |
| 302_S | 821_Y | 1.063 | 0.09 |
| 316_S | 671_N | 1.063 | 0.09 |
| 659_N | 838_I | 1.061 | 0.09 |
| 322_T | 415_S | 1.061 | 0.09 |
| 554_S | 595_I | 1.060 | 0.09 |
| 11_V | 24_K | 1.058 | 0.09 |
| 522_T | 906_P | 1.058 | 0.09 |
| 10_V | 21_N | 1.058 | 0.09 |
| 343_K | 906_P | 1.058 | 0.09 |
| 813_F | 915_S | 1.057 | 0.09 |
| 598_M | 894_F | 1.057 | 0.09 |
| 140_A | 246_T | 1.057 | 0.09 |
| 574_S | 839_L | 1.056 | 0.09 |
| 425_A | 473_L | 1.056 | 0.09 |
| 452_L | 941_K | 1.056 | 0.09 |
| 382_D | 386_C | 1.054 | 0.09 |
| 493_A | 497_G | 1.054 | 0.09 |
| 488_T | 577_W | 1.053 | 0.09 |
| 154_Q | 847_V | 1.053 | 0.09 |
| 297_A | 314_G | 1.051 | 0.09 |
| 466_H | 673_P | 1.051 | 0.09 |
| 835_L | 930_G | 1.051 | 0.09 |
| 458_L | 477_G | 1.051 | 0.09 |
| 812_Y | 952_V | 1.051 | 0.09 |
| 259_I | 761_A | 1.050 | 0.09 |
| 156_L | 160_G | 1.050 | 0.09 |
| 818_F | 887_D | 1.049 | 0.09 |
| 157_L | 581_L | 1.047 | 0.09 |
| 255_G | 810_A | 1.047 | 0.09 |
| 536_V | 540_L | 1.047 | 0.09 |
| 831_F | 837_V | 1.047 | 0.09 |
| 234_G | 848_V | 1.047 | 0.09 |
| 805_Q | 870_F | 1.047 | 0.09 |
| 451_D | 925_M | 1.047 | 0.09 |
| 843_L | 872_S | 1.047 | 0.09 |
| 488_T | 531_G | 1.046 | 0.09 |
| 96_P | 148_N | 1.046 | 0.09 |
| 247_A | 250_F | 1.044 | 0.09 |
| 338_A | 396_G | 1.044 | 0.09 |
| 772_F | 847_V | 1.044 | 0.09 |
| 93_G | 321_A | 1.044 | 0.09 |
| 649_D | 695_L | 1.043 | 0.09 |
| 250_F | 349_N | 1.043 | 0.09 |
| 882_S | 913_L | 1.043 | 0.09 |
| 174_I | 833_V | 1.040 | 0.09 |
| 834_M | 856_F | 1.040 | 0.09 |
| 670_L | 931_L | 1.040 | 0.09 |
| 672_H | 933_V | 1.040 | 0.09 |
| 672_H | 935_D | 1.040 | 0.09 |
| 841_T | 954_L | 1.040 | 0.09 |
| 54_I | 148_N | 1.040 | 0.09 |
| 451_D | 932_A | 1.039 | 0.09 |
| 930_G | 943_A | 1.039 | 0.09 |
| 74_L | 781_W | 1.039 | 0.09 |
| 251_A | 286_H | 1.039 | 0.09 |
| 817_N | 841_T | 1.039 | 0.09 |
| 761_A | 769_R | 1.037 | 0.09 |
| 595_I | 609_L | 1.037 | 0.09 |
| 393_C | 713_K | 1.037 | 0.09 |
| 815_W | 933_V | 1.037 | 0.09 |
| 815_W | 935_D | 1.037 | 0.09 |
| 521_N | 549_N | 1.036 | 0.09 |
| 554_S | 593_C | 1.036 | 0.09 |
| 208_N | 354_T | 1.036 | 0.09 |
| 451_D | 933_V | 1.036 | 0.09 |
| 451_D | 935_D | 1.036 | 0.09 |
| 495_M | 836_E | 1.036 | 0.09 |
| 811_V | 815_W | 1.036 | 0.09 |
| 255_G | 497_G | 1.034 | 0.09 |
| 780_E | 783_I | 1.034 | 0.09 |
| 189_I | 231_L | 1.034 | 0.09 |
| 251_A | 283_T | 1.033 | 0.09 |
| 852_L | 906_P | 1.033 | 0.09 |
| 157_L | 594_P | 1.033 | 0.09 |
| 976_I | 982_P | 1.033 | 0.09 |
| 497_G | 808_A | 1.033 | 0.09 |
| 3_D | 7_S | 1.033 | 0.09 |
| 750_F | 787_G | 1.032 | 0.09 |
| 481_L | 695_L | 1.032 | 0.09 |
| 674_V | 684_L | 1.030 | 0.09 |
| 549_N | 934_G | 1.030 | 0.09 |
| 927_L | 936_I | 1.030 | 0.09 |
| 12_F | 16_A | 1.029 | 0.09 |
| 539_L | 883_M | 1.029 | 0.09 |
| 333_L | 338_A | 1.029 | 0.09 |
| 962_L | 971_D | 1.029 | 0.09 |
| 94_A | 248_I | 1.029 | 0.09 |
| 389_L | 438_L | 1.027 | 0.09 |
| 403_N | 407_F | 1.027 | 0.09 |
| 812_Y | 853_L | 1.027 | 0.09 |
| 751_L | 787_G | 1.026 | 0.09 |
| 778_V | 809_I | 1.026 | 0.09 |
| 15_S | 22_F | 1.026 | 0.09 |
| 842_L | 955_H | 1.026 | 0.09 |
| 10_V | 762_G | 1.023 | 0.09 |
| 49_E | 892_E | 1.023 | 0.09 |
| 924_L | 929_I | 1.023 | 0.09 |
| 828_C | 845_S | 1.022 | 0.09 |
| 107_L | 168_K | 1.022 | 0.09 |
| 264_I | 560_L | 1.022 | 0.09 |
| 393_C | 938_E | 1.022 | 0.09 |
| 15_S | 24_K | 1.022 | 0.09 |
| 682_K | 933_V | 1.020 | 0.08 |
| 682_K | 935_D | 1.020 | 0.08 |
| 835_L | 931_L | 1.020 | 0.08 |
| 936_I | 945_L | 1.020 | 0.08 |
| 490_L | 559_A | 1.020 | 0.08 |
| 830_I | 930_G | 1.020 | 0.08 |
| 133_E | 581_L | 1.019 | 0.08 |
| 10_V | 20_Q | 1.019 | 0.08 |
| 577_W | 804_W | 1.019 | 0.08 |
| 86_V | 591_N | 1.019 | 0.08 |
| 654_P | 860_F | 1.019 | 0.08 |
| 772_F | 912_Q | 1.019 | 0.08 |
| 705_M | 923_V | 1.019 | 0.08 |
| 31_C | 56_R | 1.017 | 0.08 |
| 706_T | 860_F | 1.016 | 0.08 |
| 815_W | 834_M | 1.016 | 0.08 |
| 554_S | 657_A | 1.016 | 0.08 |
| 763_Q | 766_Q | 1.016 | 0.08 |
| 672_H | 932_A | 1.016 | 0.08 |
| 260_V | 653_E | 1.015 | 0.08 |
| 753_S | 882_S | 1.015 | 0.08 |
| 670_L | 687_G | 1.013 | 0.08 |
| 771_Y | 815_W | 1.013 | 0.08 |
| 423_H | 477_G | 1.013 | 0.08 |
| 188_I | 191_R | 1.013 | 0.08 |
| 610_L | 661_M | 1.013 | 0.08 |
| 706_T | 760_E | 1.013 | 0.08 |
| 669_L | 933_V | 1.012 | 0.08 |
| 669_L | 935_D | 1.012 | 0.08 |
| 662_V | 951_Q | 1.012 | 0.08 |
| 841_T | 932_A | 1.012 | 0.08 |
| 493_A | 527_A | 1.012 | 0.08 |
| 815_W | 932_A | 1.012 | 0.08 |
| 682_K | 931_L | 1.012 | 0.08 |
| 171_C | 280_C | 1.012 | 0.08 |
| 150_S | 289_S | 1.010 | 0.08 |
| 231_L | 844_R | 1.010 | 0.08 |
| 555_F | 908_L | 1.010 | 0.08 |
| 459_H | 928_L | 1.010 | 0.08 |
| 296_L | 536_V | 1.010 | 0.08 |
| 311_D | 884_M | 1.010 | 0.08 |
| 416_K | 574_S | 1.010 | 0.08 |
| 461_A | 683_W | 1.010 | 0.08 |
| 26_K | 57_D | 1.010 | 0.08 |
| 100_N | 929_I | 1.010 | 0.08 |
| 415_S | 851_F | 1.009 | 0.08 |
| 828_C | 869_P | 1.009 | 0.08 |
| 370_Q | 564_R | 1.009 | 0.08 |
| 258_E | 790_F | 1.008 | 0.08 |
| 477_G | 927_L | 1.008 | 0.08 |
| 153_L | 301_I | 1.008 | 0.08 |
| 143_I | 275_N | 1.008 | 0.08 |
| 131_N | 248_I | 1.008 | 0.08 |
| 298_D | 434_C | 1.006 | 0.08 |
| 698_Y | 949_A | 1.006 | 0.08 |
| 834_M | 841_T | 1.006 | 0.08 |
| 271_V | 504_V | 1.006 | 0.08 |
| 177_A | 262_L | 1.006 | 0.08 |
| 756_G | 787_G | 1.006 | 0.08 |
| 251_A | 333_L | 1.006 | 0.08 |
| 754_I | 918_I | 1.006 | 0.08 |
| 334_L | 893_S | 1.005 | 0.08 |
| 16_A | 22_F | 1.005 | 0.08 |
| 16_A | 29_K | 1.005 | 0.08 |
| 67_D | 70_G | 1.005 | 0.08 |
| 947_R | 950_M | 1.003 | 0.08 |
| 153_L | 296_L | 1.003 | 0.08 |
| 486_G | 692_M | 1.003 | 0.08 |
| 324_S | 835_L | 1.003 | 0.08 |
| 174_I | 186_M | 1.003 | 0.08 |
| 669_L | 886_G | 1.003 | 0.08 |
| 106_P | 218_A | 1.002 | 0.08 |
| 215_L | 318_L | 1.002 | 0.08 |
| 141_V | 592_K | 1.002 | 0.08 |
| 18_G | 23_N | 1.002 | 0.08 |
| 423_H | 924_L | 1.002 | 0.08 |
| 20_Q | 982_P | 1.000 | 0.08 |
| 491_H | 941_K | 1.000 | 0.08 |
| 494_S | 805_Q | 1.000 | 0.08 |
| 393_C | 852_L | 1.000 | 0.08 |
| 830_I | 943_A | 1.000 | 0.08 |
| 9_K | 20_Q | 1.000 | 0.08 |
| 286_H | 603_P | 1.000 | 0.08 |
| 340_V | 405_L | 1.000 | 0.08 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4rlvA | 1 | 0.5837 | 100 | 0.702 | Contact Map |
| 4cj9A | 2 | 0.5565 | 100 | 0.712 | Contact Map |
| 1n11A | 1 | 0.4073 | 100 | 0.782 | Contact Map |
| 3j5pB | 4 | 0.5534 | 100 | 0.784 | Contact Map |
| 4oavB | 2 | 0.5635 | 100 | 0.837 | Contact Map |
| 3ljnA | 1 | 0.2742 | 100 | 0.839 | Contact Map |
| 3utmA | 2 | 0.3196 | 100 | 0.839 | Contact Map |
| 4rlyA | 1 | 0.3044 | 100 | 0.845 | Contact Map |
| 4ot9A | 1 | 0.2843 | 100 | 0.854 | Contact Map |
| 1wdyA | 1 | 0.2802 | 100 | 0.858 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)