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OPENSEQ.org

MalT

ID: 1426770552 Query Sequence

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 901 (889)
Sequences: 3773 (3352.9)
Seq/Len: 4.244
Nf(neff/√len): 112.5

Jackhmmer Results: (2015_01_07)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 4.244).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
665_D668_A5.3141.00
585_R588_E5.2451.00
624_D627_N5.1251.00
703_E706_P4.2341.00
464_N467_E4.1091.00
344_H363_H3.9301.00
424_R427_E3.8771.00
49_I158_L3.7511.00
543_F546_T3.5761.00
503_E506_R3.5661.00
871_I875_Y3.5111.00
191_A222_L3.3261.00
264_D300_E3.3031.00
795_A798_I3.1901.00
847_I856_I3.1801.00
93_C96_M3.0261.00
792_Q795_A3.0251.00
590_E622_R2.8921.00
851_Y859_E2.7851.00
187_T190_E2.7241.00
799_L802_I2.7191.00
795_A799_L2.6641.00
195_F226_A2.6521.00
53_A126_V2.5841.00
839_R842_Q2.5351.00
361_I364_A2.5111.00
743_R746_D2.5091.00
277_L347_A2.4921.00
92_I97_A2.4901.00
27_S55_G2.4791.00
130_Y157_V2.4691.00
795_A806_H2.4311.00
798_I802_I2.3901.00
715_N734_L2.3731.00
657_V673_L2.3411.00
841_W845_G2.3201.00
798_I806_H2.2611.00
795_A803_N2.2491.00
799_L803_N2.2481.00
274_S320_Y2.2461.00
128_D158_L2.2291.00
580_L592_S2.1521.00
552_E576_R2.1351.00
792_Q803_N2.1291.00
93_C97_A2.1251.00
188_H209_S2.1221.00
818_V822_L2.1131.00
844_L874_L2.1001.00
26_L52_W2.0951.00
360_A364_A2.0891.00
619_S624_D2.0791.00
134_T137_V2.0621.00
105_L108_L2.0551.00
149_Q153_L2.0391.00
594_R615_L2.0381.00
795_A807_R2.0281.00
580_L585_R2.0141.00
795_A804_Q2.0091.00
840_E877_K1.9931.00
23_L51_Q1.9911.00
787_L791_E1.9881.00
52_W156_V1.9591.00
783_Q786_T1.9481.00
191_A212_C1.9421.00
267_T300_E1.9361.00
636_E656_R1.9321.00
92_I96_M1.9291.00
712_E734_L1.9061.00
795_A805_H1.8881.00
629_R663_T1.8741.00
62_Y66_E1.8731.00
767_F771_G1.8701.00
660_W668_A1.8581.00
89_H93_C1.8511.00
794_R798_I1.8401.00
436_E455_R1.8381.00
849_S859_E1.8181.00
792_Q799_L1.8131.00
813_F818_V1.8121.00
345_R349_E1.8111.00
268_R272_L1.8041.00
795_A802_I1.7931.00
535_S551_Q1.7921.00
264_D267_T1.7771.00
660_W665_D1.7721.00
276_I329_R1.7680.99
587_D622_R1.7650.99
90_C93_C1.7570.99
619_S627_N1.7550.99
89_H92_I1.7550.99
590_E594_R1.7470.99
865_T872_R1.7350.99
548_W583_W1.7270.99
61_W66_E1.7230.99
869_T873_N1.7200.99
728_N758_A1.7200.99
788_P792_Q1.7180.99
862_V867_I1.7130.99
597_I615_L1.7100.99
47_T51_Q1.7050.99
49_I126_V1.7030.99
619_S631_Q1.6940.99
814_D822_L1.6920.99
182_Q186_F1.6840.99
16_T47_T1.6780.99
580_L588_E1.6770.99
577_A593_A1.6690.99
596_G611_C1.6670.99
660_W672_W1.6610.99
803_N806_H1.6570.99
37_I49_I1.6570.99
360_A363_H1.6520.99
39_S43_Y1.6480.99
333_Q337_A1.6270.99
875_Y880_V1.6170.99
802_I806_H1.6080.99
814_D818_V1.6020.99
325_G329_R1.6010.99
495_G511_M1.5980.99
89_H97_A1.5770.99
182_Q185_A1.5750.99
593_A615_L1.5690.99
332_C343_I1.5560.98
548_W552_E1.5450.98
456_A472_A1.5430.98
794_R797_R1.5390.98
276_I343_I1.5350.98
755_L770_E1.5340.98
802_I807_R1.5340.98
77_Y133_I1.5320.98
661_Q669_A1.5230.98
188_H212_C1.5200.98
538_L550_T1.5190.98
267_T301_I1.5170.98
271_L301_I1.5170.98
625_L663_T1.5080.98
811_A815_E1.5030.98
94_E97_A1.4990.98
881_A885_D1.4980.98
224_L258_E1.4880.98
751_L774_M1.4850.98
810_F813_F1.4840.98
802_I805_H1.4840.98
854_E864_A1.4810.98
272_L339_E1.4810.98
50_S63_S1.4800.98
378_L410_Q1.4790.98
792_Q798_I1.4770.98
804_Q807_R1.4750.98
59_I62_Y1.4750.98
798_I801_E1.4740.98
732_L736_Q1.4730.98
748_Q752_L1.4680.97
844_L886_A1.4630.97
601_S634_R1.4600.97
753_D757_L1.4600.97
798_I803_N1.4550.97
20_E190_E1.4510.97
813_F817_F1.4510.97
852_S855_Q1.4440.97
632_L656_R1.4430.97
51_Q54_A1.4420.97
468_A472_A1.4420.97
429_N433_A1.4400.97
419_M427_E1.4390.97
519_R527_A1.4360.97
698_Q706_P1.4300.97
41_A160_R1.4300.97
548_W580_L1.4280.97
273_K347_A1.4230.97
774_M778_L1.4200.97
92_I98_Q1.4170.97
329_R340_L1.4150.97
181_S185_A1.4140.97
538_L546_T1.4120.97
21_R24_A1.4060.96
798_I805_H1.4050.96
362_H366_A1.4040.96
444_E447_M1.4020.96
90_C97_A1.4020.96
796_Q800_R1.4010.96
732_L766_H1.4000.96
627_N631_Q1.3910.96
398_K427_E1.3870.96
59_I124_Y1.3860.96
880_V889_H1.3810.96
889_H892_Q1.3800.96
708_E712_E1.3780.96
181_S184_L1.3750.96
183_Q186_F1.3750.96
799_L804_Q1.3740.96
586_L622_R1.3720.96
62_Y70_Q1.3660.96
89_H96_M1.3630.96
704_F708_E1.3590.95
792_Q804_Q1.3590.95
482_G487_R1.3540.95
866_T870_H1.3520.95
470_R474_L1.3510.95
144_F148_H1.3480.95
389_E392_L1.3480.95
77_Y80_A1.3470.95
408_N412_V1.3450.95
130_Y133_I1.3360.95
754_A770_E1.3300.95
865_T868_K1.3250.95
153_L158_L1.3230.95
433_A455_R1.3200.94
60_G64_L1.3190.94
70_Q73_R1.3110.94
243_L246_I1.3070.94
586_L618_C1.3000.94
126_V158_L1.2990.94
711_L715_N1.2970.94
743_R747_A1.2940.94
817_F820_R1.2920.94
342_E346_A1.2890.93
97_A100_R1.2860.93
269_H339_E1.2840.93
192_K208_S1.2840.93
210_R214_D1.2830.93
393_L400_L1.2830.93
272_L332_C1.2800.93
211_I222_L1.2790.93
666_K697_A1.2770.93
844_L880_V1.2760.93
190_E193_Q1.2760.93
590_E615_L1.2730.93
64_L80_A1.2660.93
204_E207_E1.2650.93
484_F487_R1.2640.93
792_Q802_I1.2640.93
698_Q703_E1.2640.93
686_F691_W1.2620.93
731_L753_D1.2580.92
752_L774_M1.2580.92
160_R321_H1.2570.92
43_Y219_A1.2520.92
263_V267_T1.2510.92
685_H688_Q1.2500.92
810_F817_F1.2500.92
73_R76_S1.2500.92
299_E303_R1.2490.92
753_D756_K1.2430.92
288_V350_S1.2400.92
90_C96_M1.2400.92
695_A699_I1.2390.92
193_Q197_C1.2330.91
62_Y65_D1.2320.91
612_L634_R1.2310.91
276_I347_A1.2290.91
459_A464_N1.2270.91
112_L116_L1.2270.91
473_K494_L1.2260.91
671_N675_H1.2260.91
746_D749_R1.2250.91
803_N807_R1.2230.91
667_A701_L1.2230.91
216_S322_P1.2210.91
799_L805_H1.2200.91
576_R580_L1.2190.91
77_Y81_A1.2150.91
629_R660_W1.2120.90
128_D131_H1.2120.90
348_A364_A1.2100.90
181_S186_F1.2090.90
792_Q806_H1.2050.90
91_A94_E1.2040.90
36_L159_S1.2030.90
817_F822_L1.2020.90
844_L890_A1.1990.90
818_V821_L1.1940.90
491_T510_L1.1930.89
506_R509_A1.1890.89
538_L543_F1.1850.89
60_G121_S1.1820.89
556_Q560_E1.1810.89
765_S769_I1.1810.89
882_H885_D1.1790.89
40_P43_Y1.1790.89
358_S364_A1.1770.89
847_I874_L1.1740.88
747_A751_L1.1730.88
806_H809_K1.1710.88
128_D322_P1.1690.88
64_L67_G1.1690.88
758_A767_F1.1690.88
653_N672_W1.1680.88
284_L350_S1.1680.88
813_F822_L1.1670.88
135_N138_I1.1650.88
629_R633_N1.1650.88
593_A618_C1.1630.88
873_N876_Q1.1620.88
127_I142_M1.1600.88
352_M372_M1.1540.87
618_C622_R1.1520.87
452_N471_L1.1500.87
853_N868_K1.1490.87
670_A701_L1.1490.87
370_A377_L1.1440.87
37_I181_S1.1430.87
799_L807_R1.1420.87
47_T223_Q1.1420.87
220_T321_H1.1400.86
847_I871_I1.1390.86
515_E534_Q1.1340.86
817_F821_L1.1330.86
554_A557_L1.1320.86
369_D372_M1.1320.86
531_L553_K1.1320.86
689_G692_R1.1290.86
273_K339_E1.1280.86
814_D817_F1.1250.85
64_L69_N1.1200.85
616_I655_V1.1190.85
579_L583_W1.1180.85
775_A782_I1.1170.85
889_H893_L1.1140.85
277_L280_M1.1130.85
802_I810_F1.1130.85
872_R876_Q1.1130.85
854_E858_G1.1120.85
559_N595_S1.1110.84
807_R810_F1.1110.84
731_L750_V1.1090.84
415_Q419_M1.1090.84
738_Y742_G1.1090.84
333_Q339_E1.1070.84
559_N569_H1.1060.84
487_R491_T1.1050.84
508_L541_Q1.1030.84
474_L477_E1.1030.84
685_H690_Q1.1030.84
757_L760_R1.1010.84
89_H94_E1.1010.84
711_L730_N1.0990.84
494_L498_L1.0980.84
472_A476_L1.0960.83
61_W65_D1.0960.83
589_A618_C1.0930.83
487_R513_Q1.0930.83
871_I886_A1.0920.83
795_A801_E1.0890.83
35_A154_T1.0840.82
358_S383_S1.0840.82
364_A372_M1.0830.82
449_A475_A1.0820.82
60_G123_L1.0810.82
656_R672_W1.0800.82
738_Y750_V1.0780.82
427_E431_L1.0770.82
727_L731_L1.0720.81
498_L510_L1.0720.81
60_G66_E1.0690.81
141_S145_F1.0680.81
45_K220_T1.0660.81
29_A35_A1.0640.81
179_I186_F1.0640.81
300_E304_Q1.0620.81
419_M431_L1.0620.81
694_I698_Q1.0620.81
657_V693_N1.0620.81
576_R592_S1.0610.81
76_S80_A1.0600.80
797_R801_E1.0590.80
416_A435_A1.0590.80
404_S407_E1.0590.80
577_A589_A1.0570.80
358_S363_H1.0560.80
766_H769_I1.0550.80
130_Y139_H1.0540.80
265_L268_R1.0530.80
220_T224_L1.0520.80
64_L77_Y1.0510.80
755_L767_F1.0490.79
361_I373_L1.0470.79
812_H816_N1.0470.79
752_L756_K1.0460.79
49_I128_D1.0460.79
619_S622_R1.0440.79
316_E320_Y1.0430.79
37_I158_L1.0430.79
371_L375_D1.0410.79
535_S547_A1.0410.79
449_A479_L1.0400.79
593_A611_C1.0390.79
130_Y159_S1.0390.79
18_V22_L1.0390.79
546_T549_E1.0390.79
615_L631_Q1.0350.78
53_A63_S1.0350.78
590_E619_S1.0340.78
512_Q516_Q1.0340.78
270_F285_I1.0310.78
590_E618_C1.0310.78
71_Q81_A1.0300.78
429_N462_D1.0300.78
329_R344_H1.0260.77
696_R699_I1.0260.77
512_Q534_Q1.0260.77
581_W586_L1.0250.77
573_V595_S1.0250.77
195_F222_L1.0240.77
779_R817_F1.0240.77
843_V870_H1.0210.77
104_S112_L1.0200.77
273_K343_I1.0170.76
659_Y663_T1.0170.76
66_E70_Q1.0170.76
548_W576_R1.0160.76
552_E556_Q1.0160.76
756_K759_N1.0150.76
554_A572_L1.0140.76
872_R875_Y1.0130.76
865_T869_T1.0100.76
639_L643_K1.0090.76
656_R660_W1.0090.76
105_L109_F1.0070.75
750_V753_D1.0070.75
774_M777_Q1.0060.75
633_N656_R1.0060.75
415_Q431_L1.0060.75
542_G725_S1.0060.75
275_A329_R1.0060.75
761_T764_I1.0050.75
733_L737_L1.0040.75
51_Q55_G1.0020.75
93_C98_Q1.0000.75
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features
HHsearch Results: (31Jan15)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
1z6tA40.47721000.756Contact Map
2a5yB20.3841000.806Contact Map
1hz4A10.40621000.819Contact Map
2fnaA20.34399.90.841Contact Map
2qenA10.350799.90.858Contact Map
3c57A20.056699.90.86Contact Map
2rnjA10.074499.90.861Contact Map
1fnnA20.354199.80.865Contact Map
3c3wA20.233199.80.865Contact Map
3sf4A30.375199.80.871Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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