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OPENSEQ.org

CTNNB1_armadillo

ID: 1402405892 Query Sequence

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 550 (513)
Sequences: 1561 (1362.3)
Seq/Len: 3.043
Nf(neff/√len): 60.1

Jackhmmer Results: (2014_04_16)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 3.043).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
96_S101_V2.7811.00
102_L138_K2.6561.00
205_P208_V2.4241.00
410_F414_V2.3801.00
61_A96_S2.2881.00
496_S501_V2.0411.00
461_Q496_S2.0371.00
138_K143_F2.0201.00
408_Q411_V1.9140.99
416_M419_I1.8590.99
90_L93_M1.8400.99
205_P209_E1.8360.99
397_T401_T1.8320.99
410_F415_R1.7840.99
63_C67_T1.7260.99
423_C430_L1.7140.99
63_C70_N1.6820.98
404_G409_Q1.6320.98
261_S266_V1.6210.98
58_V63_C1.5990.97
331_A334_A1.5890.97
503_T506_A1.5820.97
499_E506_A1.5750.97
63_C66_G1.5680.97
371_P377_L1.5600.97
421_E425_G1.5470.97
446_I449_F1.5440.97
464_A467_V1.5210.96
397_T400_R1.5040.96
401_T404_G1.5030.96
416_M431_A1.4860.95
416_M422_G1.4840.95
405_G408_Q1.4800.95
438_I441_R1.4770.95
411_V415_R1.4690.95
12_D17_V1.4590.95
410_F413_G1.4590.95
404_G408_Q1.4400.94
449_F452_L1.4400.94
423_C429_I1.4390.94
408_Q413_G1.4390.94
511_R514_E1.4370.94
504_Y507_A1.4340.94
407_Q410_F1.4330.94
441_R449_F1.4240.94
408_Q412_E1.4170.94
106_I110_H1.4000.93
506_A510_F1.3990.93
23_V27_Q1.3930.93
22_A26_H1.3880.93
60_T63_C1.3860.93
23_V31_K1.3850.93
65_A73_H1.3850.93
422_G425_G1.3830.93
400_R407_Q1.3750.92
102_L143_F1.3750.92
18_V24_M1.3690.92
504_Y510_F1.3690.92
404_G413_G1.3680.92
423_C431_A1.3550.92
419_I423_C1.3490.91
89_A93_M1.3480.91
403_M407_Q1.3460.91
58_V62_R1.3390.91
492_E496_S1.3330.91
8_K12_D1.3280.91
26_H29_S1.3280.91
58_V61_A1.3210.90
20_K27_Q1.3150.90
400_R403_M1.3090.90
404_G407_Q1.3070.90
55_T61_A1.3030.89
399_R405_G1.3010.89
405_G411_V1.2940.89
228_V231_C1.2910.89
404_G415_R1.2890.89
24_M29_S1.2860.89
466_G470_E1.2820.88
62_R66_G1.2800.88
402_S410_F1.2700.88
399_R407_Q1.2580.87
398_Q401_T1.2570.87
416_M429_I1.2570.87
404_G410_F1.2550.87
19_N23_V1.2510.87
59_E63_C1.2490.87
22_A27_Q1.2480.87
319_R322_T1.2480.87
370_C383_I1.2470.86
491_T496_S1.2460.86
217_G220_L1.2460.86
198_S237_N1.2420.86
416_M425_G1.2410.86
407_Q411_V1.2370.86
406_T411_V1.2360.86
167_A171_P1.2350.86
19_N26_H1.2340.86
155_A189_T1.2310.86
79_L82_F1.2290.85
318_L322_T1.2270.85
507_A510_F1.2190.85
510_F513_S1.2170.85
442_G449_F1.2130.84
66_G70_N1.2110.84
271_A314_A1.2080.84
470_E473_Q1.2060.84
22_A25_V1.2030.84
404_G411_V1.2000.84
503_T507_A1.1960.83
59_E62_R1.1950.83
16_V19_N1.1920.83
165_I170_G1.1870.83
66_G73_H1.1860.83
419_I425_G1.1860.83
409_Q415_R1.1850.82
416_M423_C1.1850.82
100_S110_H1.1830.82
442_G445_T1.1830.82
485_G491_T1.1800.82
128_G132_M1.1780.82
93_M101_V1.1760.82
466_G469_C1.1740.82
15_Q18_V1.1740.82
144_L149_D1.1730.82
194_L234_T1.1730.82
59_E67_T1.1720.81
286_M289_C1.1720.81
425_G429_I1.1690.81
58_V67_T1.1680.81
502_A506_A1.1660.81
398_Q403_M1.1650.81
481_I486_A1.1610.81
371_P376_P1.1610.81
487_T490_L1.1580.80
339_Y342_P1.1580.80
267_V270_A1.1570.80
24_M27_Q1.1570.80
494_L506_A1.1570.80
475_K481_I1.1560.80
286_M290_Q1.1550.80
267_V276_N1.1520.80
396_D399_R1.1510.80
20_K24_M1.1510.80
416_M428_H1.1490.80
396_D401_T1.1480.80
496_S502_A1.1460.79
427_L430_L1.1460.79
488_A495_H1.1440.79
18_V22_A1.1430.79
15_Q20_K1.1420.79
274_L367_L1.1420.79
504_Y508_V1.1380.79
170_G179_R1.1330.78
375_A378_R1.1320.78
406_T409_Q1.1300.78
212_G217_G1.1280.78
492_E498_N1.1240.78
500_G504_Y1.1240.78
501_V504_Y1.1220.77
61_A70_N1.1220.77
425_G428_H1.1220.77
322_T335_V1.1200.77
470_E507_A1.1150.77
417_E420_V1.1150.77
467_V470_E1.1140.77
485_G489_P1.1140.77
148_T190_T1.1130.77
504_Y511_R1.1110.76
141_V146_I1.1100.76
62_R71_L1.1090.76
67_T70_N1.1080.76
499_E510_F1.1070.76
148_T193_V1.1060.76
424_T431_A1.1060.76
76_E83_K1.1050.76
476_E480_A1.1040.76
425_G431_A1.1040.76
15_Q24_M1.1030.76
58_V66_G1.1020.76
502_A505_A1.1020.76
20_K23_V1.0990.75
417_E429_I1.0970.75
41_S44_M1.0970.75
489_P496_S1.0940.75
444_N448_L1.0910.75
377_L380_Q1.0900.74
417_E457_I1.0890.74
24_M32_E1.0870.74
194_L250_G1.0860.74
45_V49_V1.0850.74
445_T452_L1.0800.74
420_V428_H1.0800.74
486_A491_T1.0790.73
107_T114_L1.0770.73
405_G410_F1.0760.73
420_V423_C1.0730.73
501_V507_A1.0720.73
283_K288_V1.0720.73
103_F110_H1.0720.73
409_Q412_E1.0710.73
10_L22_A1.0690.72
222_D227_L1.0690.72
416_M430_L1.0670.72
397_T407_Q1.0670.72
18_V25_V1.0660.72
112_L149_D1.0660.72
45_V62_R1.0650.72
500_G510_F1.0630.72
357_I360_T1.0610.72
201_S471_L1.0600.72
484_E492_E1.0600.72
499_E507_A1.0570.71
406_T412_E1.0560.71
63_C69_H1.0530.71
62_R69_H1.0510.71
78_L81_I1.0500.71
445_T450_V1.0490.70
65_A70_N1.0470.70
508_V511_R1.0470.70
485_G496_S1.0460.70
25_V29_S1.0460.70
18_V21_A1.0430.70
462_R466_G1.0430.70
27_Q30_K1.0430.70
452_L460_I1.0420.70
502_A510_F1.0380.69
60_T67_T1.0360.69
402_S407_Q1.0310.69
407_Q414_V1.0300.68
449_F454_Y1.0300.68
180_T186_L1.0290.68
412_E415_R1.0270.68
79_L83_K1.0270.68
503_T511_R1.0230.68
475_K478_A1.0220.68
108_T111_N1.0220.68
499_E503_T1.0210.67
486_A495_H1.0210.67
250_G253_G1.0200.67
396_D400_R1.0180.67
52_M64_T1.0180.67
475_K479_E1.0150.67
503_T508_V1.0130.67
404_G414_V1.0110.66
460_I465_A1.0110.66
495_H499_E1.0100.66
57_D66_G1.0090.66
104_Y111_N1.0090.66
145_A149_D1.0090.66
486_A489_P1.0070.66
468_L481_I1.0060.66
161_S165_I1.0060.66
17_V71_L1.0060.66
418_E429_I1.0050.66
256_V260_G1.0030.65
225_Q255_L1.0030.65
8_K13_E1.0030.65
313_P316_C1.0020.65
177_I180_T1.0010.65
318_L325_H1.0010.65
204_K209_E1.0010.65
513_S516_K1.0000.65
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features
HHsearch Results: (07Jun14)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
2z6hA10.96551000.293Contact Map
2z6gA10.95641000.316Contact Map
4ev8A10.89451000.339Contact Map
3nowA10.88551000.48Contact Map
4i2zA10.84551000.491Contact Map
1wa5B10.73821000.528Contact Map
4b8jA10.72911000.529Contact Map
2jdqA20.73821000.535Contact Map
1b3uA20.84551000.544Contact Map
3tpoA10.73271000.545Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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