| ScerevisiaeSte6 |
| ID: | 1400817483 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 1290 (1263) | ||
| Sequences: | 2907 (2083) | ||
| Seq/Len: | 2.302 | ||
| Nf(neff/√len): | 58.6 |
HHblits Results: (2013_03)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 2.302).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 1269_G | 1273_T | 5.350 | 1.00 |
| 1058_T | 1072_N | 4.474 | 1.00 |
| 361_N | 377_N | 4.444 | 1.00 |
| 1056_N | 1072_N | 3.867 | 1.00 |
| 1053_S | 1076_D | 3.856 | 1.00 |
| 1081_Q | 1256_S | 3.701 | 1.00 |
| 1171_H | 1181_L | 3.578 | 1.00 |
| 1055_Q | 1110_K | 3.561 | 1.00 |
| 1078_F | 1081_Q | 3.336 | 1.00 |
| 1054_I | 1057_L | 3.324 | 1.00 |
| 447_D | 451_K | 3.290 | 1.00 |
| 359_F | 362_V | 3.174 | 1.00 |
| 1166_K | 1171_H | 3.149 | 1.00 |
| 243_I | 246_C | 3.047 | 1.00 |
| 485_D | 495_L | 3.026 | 1.00 |
| 587_Q | 598_F | 2.990 | 1.00 |
| 383_S | 386_Q | 2.952 | 1.00 |
| 358_T | 381_N | 2.882 | 1.00 |
| 239_F | 243_I | 2.862 | 1.00 |
| 1145_R | 1158_E | 2.844 | 1.00 |
| 380_L | 574_Y | 2.801 | 1.00 |
| 450_R | 496_E | 2.788 | 1.00 |
| 376_K | 580_E | 2.788 | 1.00 |
| 1110_K | 1117_D | 2.777 | 1.00 |
| 1051_I | 1076_D | 2.760 | 1.00 |
| 382_F | 388_T | 2.758 | 1.00 |
| 400_T | 409_Y | 2.731 | 1.00 |
| 1157_L | 1160_E | 2.720 | 1.00 |
| 572_Y | 584_S | 2.714 | 1.00 |
| 386_Q | 572_Y | 2.710 | 1.00 |
| 1148_L | 1161_M | 2.657 | 1.00 |
| 360_A | 415_S | 2.629 | 1.00 |
| 1271_F | 1281_L | 2.542 | 1.00 |
| 1052_V | 1242_M | 2.538 | 1.00 |
| 919_A | 922_H | 2.497 | 1.00 |
| 586_T | 589_E | 2.472 | 1.00 |
| 469_N | 473_H | 2.460 | 1.00 |
| 536_L | 544_L | 2.456 | 1.00 |
| 1266_V | 1280_E | 2.449 | 1.00 |
| 863_K | 975_E | 2.438 | 1.00 |
| 1075_F | 1258_A | 2.344 | 1.00 |
| 484_L | 487_F | 2.325 | 1.00 |
| 888_K | 891_T | 2.313 | 1.00 |
| 243_I | 247_N | 2.277 | 1.00 |
| 439_E | 913_T | 2.275 | 1.00 |
| 1117_D | 1120_D | 2.268 | 1.00 |
| 476_K | 488_I | 2.250 | 1.00 |
| 449_L | 514_V | 2.248 | 1.00 |
| 1233_K | 1253_S | 2.245 | 1.00 |
| 1052_V | 1210_I | 2.240 | 1.00 |
| 363_S | 377_N | 2.213 | 1.00 |
| 1243_V | 1254_C | 2.202 | 1.00 |
| 453_I | 479_C | 2.200 | 1.00 |
| 1145_R | 1182_D | 2.199 | 1.00 |
| 1258_A | 1265_V | 2.195 | 1.00 |
| 1278_R | 1282_F | 2.159 | 1.00 |
| 1072_N | 1264_K | 2.129 | 1.00 |
| 1245_T | 1250_M | 2.124 | 1.00 |
| 832_L | 1015_I | 2.120 | 1.00 |
| 402_S | 528_F | 2.085 | 1.00 |
| 1113_I | 1210_I | 2.073 | 0.99 |
| 737_T | 741_L | 2.057 | 0.99 |
| 761_K | 765_L | 2.045 | 0.99 |
| 1057_L | 1106_C | 2.037 | 0.99 |
| 1054_I | 1075_F | 2.007 | 0.99 |
| 406_L | 437_V | 2.007 | 0.99 |
| 472_R | 495_L | 2.006 | 0.99 |
| 180_I | 185_P | 1.992 | 0.99 |
| 1162_Y | 1166_K | 1.987 | 0.99 |
| 224_Q | 808_M | 1.984 | 0.99 |
| 1085_I | 1242_M | 1.981 | 0.99 |
| 1267_E | 1274_L | 1.979 | 0.99 |
| 887_Q | 891_T | 1.966 | 0.99 |
| 76_M | 80_A | 1.963 | 0.99 |
| 886_L | 890_E | 1.963 | 0.99 |
| 1256_S | 1268_R | 1.962 | 0.99 |
| 378_V | 581_V | 1.958 | 0.99 |
| 516_I | 529_L | 1.944 | 0.99 |
| 1161_M | 1205_L | 1.943 | 0.99 |
| 1050_P | 1114_D | 1.938 | 0.99 |
| 239_F | 246_C | 1.931 | 0.99 |
| 1282_F | 1286_S | 1.928 | 0.99 |
| 890_E | 893_Y | 1.917 | 0.99 |
| 499_I | 505_T | 1.914 | 0.99 |
| 1077_M | 1083_L | 1.905 | 0.99 |
| 1053_S | 1112_K | 1.898 | 0.99 |
| 239_F | 247_N | 1.895 | 0.99 |
| 523_D | 555_K | 1.893 | 0.99 |
| 478_A | 551_W | 1.888 | 0.99 |
| 174_W | 178_L | 1.884 | 0.99 |
| 1225_S | 1233_K | 1.882 | 0.99 |
| 1230_E | 1234_K | 1.876 | 0.99 |
| 764_L | 767_L | 1.874 | 0.99 |
| 1270_N | 1273_T | 1.872 | 0.99 |
| 377_N | 580_E | 1.868 | 0.99 |
| 1158_E | 1162_Y | 1.857 | 0.99 |
| 824_L | 828_D | 1.848 | 0.99 |
| 1148_L | 1165_L | 1.845 | 0.98 |
| 442_C | 512_Q | 1.842 | 0.98 |
| 114_A | 119_K | 1.831 | 0.98 |
| 585_G | 590_L | 1.831 | 0.98 |
| 483_L | 487_F | 1.813 | 0.98 |
| 1052_V | 1077_M | 1.811 | 0.98 |
| 1025_T | 1122_N | 1.810 | 0.98 |
| 1101_T | 1132_V | 1.807 | 0.98 |
| 1055_Q | 1112_K | 1.806 | 0.98 |
| 1101_T | 1212_I | 1.803 | 0.98 |
| 465_D | 468_T | 1.799 | 0.98 |
| 1163_D | 1167_Y | 1.799 | 0.98 |
| 1122_N | 1125_S | 1.794 | 0.98 |
| 500_G | 503_G | 1.789 | 0.98 |
| 1059_F | 1104_Y | 1.789 | 0.98 |
| 583_E | 590_L | 1.786 | 0.98 |
| 167_G | 171_Y | 1.781 | 0.98 |
| 944_A | 948_G | 1.763 | 0.98 |
| 1058_T | 1068_F | 1.763 | 0.98 |
| 224_Q | 812_S | 1.762 | 0.98 |
| 525_P | 555_K | 1.758 | 0.98 |
| 888_K | 892_D | 1.741 | 0.98 |
| 1051_I | 1079_C | 1.739 | 0.98 |
| 357_L | 558_I | 1.736 | 0.98 |
| 1260_L | 1265_V | 1.734 | 0.98 |
| 885_I | 888_K | 1.732 | 0.97 |
| 388_T | 572_Y | 1.730 | 0.97 |
| 516_I | 544_L | 1.729 | 0.97 |
| 289_N | 292_D | 1.724 | 0.97 |
| 1111_I | 1118_V | 1.724 | 0.97 |
| 479_C | 495_L | 1.711 | 0.97 |
| 1052_V | 1113_I | 1.710 | 0.97 |
| 886_L | 892_D | 1.707 | 0.97 |
| 390_I | 401_L | 1.701 | 0.97 |
| 583_E | 596_T | 1.689 | 0.97 |
| 359_F | 405_L | 1.679 | 0.97 |
| 235_E | 1150_Y | 1.672 | 0.97 |
| 1083_L | 1258_A | 1.663 | 0.97 |
| 886_L | 891_T | 1.660 | 0.97 |
| 82_G | 958_C | 1.656 | 0.96 |
| 266_F | 270_T | 1.652 | 0.96 |
| 1280_E | 1283_Q | 1.638 | 0.96 |
| 1258_A | 1268_R | 1.637 | 0.96 |
| 362_V | 411_G | 1.634 | 0.96 |
| 404_L | 409_Y | 1.633 | 0.96 |
| 1225_S | 1229_N | 1.632 | 0.96 |
| 1051_I | 1078_F | 1.624 | 0.96 |
| 1056_N | 1074_N | 1.622 | 0.96 |
| 1101_T | 1130_I | 1.620 | 0.96 |
| 476_K | 480_Q | 1.614 | 0.96 |
| 704_I | 707_M | 1.613 | 0.96 |
| 415_S | 422_N | 1.604 | 0.96 |
| 1165_L | 1181_L | 1.604 | 0.96 |
| 861_G | 976_Y | 1.600 | 0.95 |
| 512_Q | 534_S | 1.594 | 0.95 |
| 985_F | 989_L | 1.592 | 0.95 |
| 116_L | 119_K | 1.591 | 0.95 |
| 887_Q | 890_E | 1.586 | 0.95 |
| 136_Q | 140_C | 1.585 | 0.95 |
| 954_M | 958_C | 1.584 | 0.95 |
| 147_S | 320_G | 1.580 | 0.95 |
| 76_M | 83_A | 1.578 | 0.95 |
| 1097_V | 1244_I | 1.578 | 0.95 |
| 389_F | 570_D | 1.573 | 0.95 |
| 855_I | 859_V | 1.571 | 0.95 |
| 799_V | 1015_I | 1.563 | 0.95 |
| 1216_C | 1245_T | 1.558 | 0.95 |
| 1071_K | 1264_K | 1.556 | 0.94 |
| 475_I | 478_A | 1.549 | 0.94 |
| 888_K | 893_Y | 1.548 | 0.94 |
| 885_I | 890_E | 1.544 | 0.94 |
| 438_V | 512_Q | 1.534 | 0.94 |
| 180_I | 189_F | 1.530 | 0.94 |
| 1162_Y | 1171_H | 1.527 | 0.94 |
| 361_N | 379_S | 1.525 | 0.94 |
| 885_I | 892_D | 1.522 | 0.94 |
| 1102_K | 1105_N | 1.520 | 0.94 |
| 327_I | 331_L | 1.511 | 0.93 |
| 197_M | 200_V | 1.508 | 0.93 |
| 475_I | 479_C | 1.503 | 0.93 |
| 28_M | 32_I | 1.503 | 0.93 |
| 886_L | 893_Y | 1.502 | 0.93 |
| 885_I | 891_T | 1.500 | 0.93 |
| 1131_S | 1208_S | 1.496 | 0.93 |
| 1259_V | 1267_E | 1.492 | 0.93 |
| 765_L | 768_G | 1.492 | 0.93 |
| 1193_G | 1196_Q | 1.490 | 0.93 |
| 196_R | 200_V | 1.490 | 0.93 |
| 705_K | 709_K | 1.484 | 0.92 |
| 1097_V | 1212_I | 1.478 | 0.92 |
| 1261_K | 1266_V | 1.476 | 0.92 |
| 483_L | 486_R | 1.471 | 0.92 |
| 890_E | 895_T | 1.471 | 0.92 |
| 764_L | 768_G | 1.468 | 0.92 |
| 1269_G | 1279_G | 1.468 | 0.92 |
| 361_N | 413_N | 1.468 | 0.92 |
| 512_Q | 516_I | 1.460 | 0.92 |
| 422_N | 425_T | 1.456 | 0.92 |
| 817_K | 820_E | 1.454 | 0.91 |
| 362_V | 404_L | 1.452 | 0.91 |
| 1149_T | 1161_M | 1.449 | 0.91 |
| 1211_L | 1260_L | 1.449 | 0.91 |
| 870_S | 873_P | 1.448 | 0.91 |
| 383_S | 572_Y | 1.447 | 0.91 |
| 886_L | 895_T | 1.446 | 0.91 |
| 1160_E | 1207_K | 1.445 | 0.91 |
| 408_F | 915_K | 1.444 | 0.91 |
| 402_S | 560_L | 1.443 | 0.91 |
| 115_Y | 327_I | 1.443 | 0.91 |
| 987_L | 991_T | 1.434 | 0.91 |
| 1258_A | 1269_G | 1.433 | 0.91 |
| 223_A | 811_F | 1.433 | 0.91 |
| 1059_F | 1095_T | 1.427 | 0.90 |
| 1247_S | 1250_M | 1.424 | 0.90 |
| 890_E | 894_K | 1.422 | 0.90 |
| 986_T | 989_L | 1.420 | 0.90 |
| 926_T | 930_L | 1.413 | 0.90 |
| 471_N | 523_D | 1.405 | 0.89 |
| 520_F | 547_A | 1.405 | 0.89 |
| 149_A | 152_S | 1.402 | 0.89 |
| 359_F | 364_F | 1.399 | 0.89 |
| 140_C | 143_E | 1.399 | 0.89 |
| 1160_E | 1205_L | 1.397 | 0.89 |
| 1251_M | 1257_I | 1.394 | 0.89 |
| 1164_A | 1168_V | 1.389 | 0.89 |
| 803_L | 825_V | 1.389 | 0.89 |
| 507_S | 510_Q | 1.387 | 0.89 |
| 892_D | 895_T | 1.385 | 0.89 |
| 436_T | 524_T | 1.385 | 0.89 |
| 1267_E | 1279_G | 1.384 | 0.89 |
| 321_G | 325_E | 1.383 | 0.88 |
| 220_M | 803_L | 1.383 | 0.88 |
| 364_F | 409_Y | 1.381 | 0.88 |
| 1179_Q | 1183_T | 1.377 | 0.88 |
| 375_L | 378_V | 1.374 | 0.88 |
| 1174_V | 1177_S | 1.367 | 0.88 |
| 767_L | 771_A | 1.358 | 0.87 |
| 18_V | 23_D | 1.357 | 0.87 |
| 1118_V | 1126_L | 1.354 | 0.87 |
| 328_M | 332_K | 1.353 | 0.87 |
| 1185_I | 1190_L | 1.352 | 0.87 |
| 573_L | 587_Q | 1.351 | 0.87 |
| 243_I | 250_F | 1.349 | 0.87 |
| 497_T | 500_G | 1.347 | 0.87 |
| 962_I | 966_Y | 1.343 | 0.86 |
| 1059_F | 1099_L | 1.337 | 0.86 |
| 359_F | 401_L | 1.334 | 0.86 |
| 357_L | 526_I | 1.334 | 0.86 |
| 314_I | 448_T | 1.332 | 0.86 |
| 1163_D | 1166_K | 1.331 | 0.86 |
| 116_L | 121_M | 1.329 | 0.86 |
| 997_S | 1000_S | 1.329 | 0.86 |
| 1167_Y | 1235_G | 1.327 | 0.86 |
| 516_I | 536_L | 1.327 | 0.86 |
| 1091_T | 1095_T | 1.326 | 0.86 |
| 1144_I | 1190_L | 1.323 | 0.85 |
| 1229_N | 1247_S | 1.319 | 0.85 |
| 574_Y | 584_S | 1.318 | 0.85 |
| 359_F | 380_L | 1.317 | 0.85 |
| 383_S | 388_T | 1.312 | 0.85 |
| 1269_G | 1274_L | 1.311 | 0.85 |
| 510_Q | 513_R | 1.310 | 0.85 |
| 508_G | 513_R | 1.309 | 0.85 |
| 385_G | 556_T | 1.308 | 0.84 |
| 36_A | 39_L | 1.308 | 0.84 |
| 1081_Q | 1268_R | 1.308 | 0.84 |
| 986_T | 990_F | 1.304 | 0.84 |
| 453_I | 475_I | 1.304 | 0.84 |
| 137_I | 140_C | 1.302 | 0.84 |
| 382_F | 558_I | 1.302 | 0.84 |
| 1034_R | 1125_S | 1.300 | 0.84 |
| 1077_M | 1085_I | 1.300 | 0.84 |
| 131_L | 134_F | 1.297 | 0.84 |
| 1016_Y | 1020_D | 1.294 | 0.84 |
| 53_D | 289_N | 1.294 | 0.84 |
| 1062_P | 1066_T | 1.293 | 0.84 |
| 1191_S | 1196_Q | 1.292 | 0.83 |
| 738_F | 741_L | 1.292 | 0.83 |
| 471_N | 474_L | 1.291 | 0.83 |
| 360_A | 379_S | 1.291 | 0.83 |
| 1174_V | 1180_G | 1.288 | 0.83 |
| 359_F | 378_V | 1.287 | 0.83 |
| 359_F | 416_I | 1.285 | 0.83 |
| 206_N | 209_T | 1.285 | 0.83 |
| 1165_L | 1174_V | 1.284 | 0.83 |
| 966_Y | 970_L | 1.282 | 0.83 |
| 1154_D | 1182_D | 1.281 | 0.83 |
| 795_L | 832_L | 1.272 | 0.82 |
| 299_S | 306_T | 1.272 | 0.82 |
| 399_S | 403_N | 1.272 | 0.82 |
| 541_R | 563_E | 1.272 | 0.82 |
| 806_K | 1021_E | 1.269 | 0.82 |
| 535_A | 1216_C | 1.267 | 0.82 |
| 762_W | 765_L | 1.266 | 0.82 |
| 1207_K | 1239_L | 1.260 | 0.81 |
| 575_L | 585_G | 1.259 | 0.81 |
| 410_D | 424_Q | 1.259 | 0.81 |
| 896_S | 934_M | 1.259 | 0.81 |
| 80_A | 83_A | 1.258 | 0.81 |
| 1191_S | 1194_Q | 1.257 | 0.81 |
| 1196_Q | 1221_D | 1.256 | 0.81 |
| 1087_G | 1092_G | 1.256 | 0.81 |
| 380_L | 581_V | 1.256 | 0.81 |
| 509_G | 513_R | 1.256 | 0.81 |
| 1196_Q | 1202_R | 1.256 | 0.81 |
| 1073_M | 1265_V | 1.255 | 0.81 |
| 365_S | 412_Y | 1.254 | 0.81 |
| 119_K | 122_E | 1.254 | 0.81 |
| 1053_S | 1115_G | 1.251 | 0.81 |
| 763_S | 766_V | 1.250 | 0.81 |
| 1097_V | 1132_V | 1.249 | 0.80 |
| 796_R | 825_V | 1.249 | 0.80 |
| 1112_K | 1117_D | 1.248 | 0.80 |
| 1083_L | 1268_R | 1.244 | 0.80 |
| 1145_R | 1149_T | 1.243 | 0.80 |
| 1114_D | 1117_D | 1.239 | 0.80 |
| 364_F | 400_T | 1.237 | 0.80 |
| 1257_I | 1270_N | 1.236 | 0.80 |
| 211_K | 245_N | 1.234 | 0.79 |
| 1174_V | 1181_L | 1.234 | 0.79 |
| 989_L | 994_S | 1.233 | 0.79 |
| 585_G | 589_E | 1.231 | 0.79 |
| 882_Y | 886_L | 1.230 | 0.79 |
| 1085_I | 1096_L | 1.228 | 0.79 |
| 533_V | 536_L | 1.226 | 0.79 |
| 113_E | 116_L | 1.226 | 0.79 |
| 278_F | 281_A | 1.226 | 0.79 |
| 507_S | 513_R | 1.225 | 0.79 |
| 1229_N | 1245_T | 1.224 | 0.79 |
| 989_L | 995_C | 1.224 | 0.79 |
| 522_R | 527_L | 1.223 | 0.79 |
| 391_V | 575_L | 1.223 | 0.79 |
| 400_T | 404_L | 1.221 | 0.78 |
| 728_G | 735_S | 1.221 | 0.78 |
| 561_T | 566_Q | 1.219 | 0.78 |
| 590_L | 598_F | 1.214 | 0.78 |
| 1261_K | 1280_E | 1.213 | 0.78 |
| 895_T | 898_A | 1.211 | 0.78 |
| 364_F | 411_G | 1.211 | 0.78 |
| 891_T | 894_K | 1.210 | 0.78 |
| 1056_N | 1108_V | 1.209 | 0.77 |
| 520_F | 552_R | 1.208 | 0.77 |
| 139_R | 143_E | 1.208 | 0.77 |
| 356_D | 381_N | 1.205 | 0.77 |
| 1245_T | 1251_M | 1.204 | 0.77 |
| 1229_N | 1250_M | 1.204 | 0.77 |
| 508_G | 535_A | 1.201 | 0.77 |
| 1025_T | 1105_N | 1.199 | 0.77 |
| 1052_V | 1083_L | 1.198 | 0.77 |
| 802_K | 1023_H | 1.198 | 0.77 |
| 395_G | 399_S | 1.197 | 0.76 |
| 426_I | 430_L | 1.196 | 0.76 |
| 1215_E | 1246_H | 1.195 | 0.76 |
| 737_T | 742_L | 1.194 | 0.76 |
| 985_F | 988_L | 1.194 | 0.76 |
| 356_D | 384_A | 1.193 | 0.76 |
| 112_L | 119_K | 1.189 | 0.76 |
| 355_S | 419_N | 1.186 | 0.76 |
| 218_W | 1141_N | 1.184 | 0.75 |
| 16_R | 332_K | 1.184 | 0.75 |
| 819_S | 824_L | 1.181 | 0.75 |
| 24_Y | 28_M | 1.181 | 0.75 |
| 1274_L | 1281_L | 1.181 | 0.75 |
| 216_L | 825_V | 1.180 | 0.75 |
| 360_A | 417_S | 1.180 | 0.75 |
| 358_T | 417_S | 1.179 | 0.75 |
| 1159_I | 1163_D | 1.177 | 0.75 |
| 563_E | 566_Q | 1.176 | 0.75 |
| 450_R | 454_L | 1.176 | 0.75 |
| 540_H | 544_L | 1.176 | 0.75 |
| 170_F | 177_T | 1.174 | 0.74 |
| 925_L | 929_D | 1.171 | 0.74 |
| 888_K | 895_T | 1.170 | 0.74 |
| 1087_G | 1090_G | 1.170 | 0.74 |
| 1248_E | 1251_M | 1.167 | 0.74 |
| 1279_G | 1284_I | 1.167 | 0.74 |
| 270_T | 767_L | 1.166 | 0.74 |
| 1143_T | 1146_D | 1.165 | 0.74 |
| 887_Q | 893_Y | 1.165 | 0.74 |
| 828_D | 1014_W | 1.163 | 0.73 |
| 1062_P | 1065_P | 1.162 | 0.73 |
| 254_C | 785_D | 1.162 | 0.73 |
| 185_P | 189_F | 1.161 | 0.73 |
| 180_I | 183_S | 1.159 | 0.73 |
| 485_D | 489_L | 1.158 | 0.73 |
| 796_R | 800_M | 1.158 | 0.73 |
| 540_H | 545_M | 1.157 | 0.73 |
| 202_S | 206_N | 1.157 | 0.73 |
| 1190_L | 1198_L | 1.156 | 0.73 |
| 1046_K | 1050_P | 1.156 | 0.73 |
| 477_D | 485_D | 1.155 | 0.73 |
| 1196_Q | 1203_A | 1.155 | 0.73 |
| 867_V | 966_Y | 1.155 | 0.73 |
| 70_Q | 73_Q | 1.154 | 0.73 |
| 1281_L | 1284_I | 1.154 | 0.73 |
| 112_L | 116_L | 1.151 | 0.72 |
| 491_L | 497_T | 1.149 | 0.72 |
| 541_R | 566_Q | 1.149 | 0.72 |
| 453_I | 514_V | 1.149 | 0.72 |
| 140_C | 144_L | 1.148 | 0.72 |
| 1026_L | 1029_E | 1.147 | 0.72 |
| 1169_G | 1227_I | 1.146 | 0.72 |
| 464_A | 468_T | 1.145 | 0.72 |
| 470_E | 474_L | 1.143 | 0.72 |
| 461_V | 464_A | 1.142 | 0.72 |
| 586_T | 590_L | 1.142 | 0.72 |
| 76_M | 79_M | 1.140 | 0.71 |
| 1248_E | 1284_I | 1.139 | 0.71 |
| 1144_I | 1198_L | 1.137 | 0.71 |
| 138_N | 143_E | 1.134 | 0.71 |
| 449_L | 499_I | 1.131 | 0.70 |
| 1171_H | 1175_I | 1.131 | 0.70 |
| 1259_V | 1274_L | 1.126 | 0.70 |
| 512_Q | 1219_A | 1.126 | 0.70 |
| 527_L | 555_K | 1.124 | 0.70 |
| 1028_V | 1034_R | 1.123 | 0.70 |
| 235_E | 243_I | 1.122 | 0.70 |
| 479_C | 488_I | 1.120 | 0.69 |
| 1083_L | 1256_S | 1.119 | 0.69 |
| 990_F | 995_C | 1.117 | 0.69 |
| 1060_A | 1107_E | 1.117 | 0.69 |
| 1082_T | 1254_C | 1.116 | 0.69 |
| 203_E | 207_S | 1.115 | 0.69 |
| 1235_G | 1239_L | 1.115 | 0.69 |
| 1228_I | 1239_L | 1.113 | 0.69 |
| 962_I | 965_Y | 1.112 | 0.69 |
| 1084_G | 1101_T | 1.112 | 0.69 |
| 1213_L | 1219_A | 1.111 | 0.69 |
| 1280_E | 1284_I | 1.110 | 0.68 |
| 483_L | 543_L | 1.109 | 0.68 |
| 110_Q | 113_E | 1.106 | 0.68 |
| 812_S | 1069_V | 1.105 | 0.68 |
| 1098_L | 1104_Y | 1.104 | 0.68 |
| 573_L | 590_L | 1.103 | 0.68 |
| 13_H | 16_R | 1.102 | 0.68 |
| 235_E | 246_C | 1.102 | 0.68 |
| 1192_G | 1218_S | 1.102 | 0.68 |
| 1192_G | 1197_R | 1.101 | 0.68 |
| 501_T | 818_A | 1.099 | 0.67 |
| 582_V | 597_T | 1.099 | 0.67 |
| 530_D | 537_D | 1.097 | 0.67 |
| 531_E | 1197_R | 1.097 | 0.67 |
| 1070_Y | 1073_M | 1.096 | 0.67 |
| 764_L | 771_A | 1.096 | 0.67 |
| 29_I | 32_I | 1.095 | 0.67 |
| 119_K | 123_W | 1.094 | 0.67 |
| 1272_D | 1276_N | 1.094 | 0.67 |
| 80_A | 84_A | 1.093 | 0.67 |
| 913_T | 917_L | 1.092 | 0.67 |
| 858_L | 865_S | 1.090 | 0.66 |
| 887_Q | 894_K | 1.090 | 0.66 |
| 113_E | 119_K | 1.090 | 0.66 |
| 1060_A | 1068_F | 1.088 | 0.66 |
| 587_Q | 591_L | 1.086 | 0.66 |
| 1055_Q | 1074_N | 1.085 | 0.66 |
| 886_L | 889_C | 1.085 | 0.66 |
| 573_L | 586_T | 1.084 | 0.66 |
| 233_R | 1124_T | 1.084 | 0.66 |
| 1243_V | 1253_S | 1.083 | 0.66 |
| 1217_T | 1221_D | 1.081 | 0.65 |
| 1161_M | 1182_D | 1.081 | 0.65 |
| 115_Y | 119_K | 1.081 | 0.65 |
| 805_R | 1122_N | 1.080 | 0.65 |
| 1082_T | 1238_A | 1.079 | 0.65 |
| 462_R | 465_D | 1.079 | 0.65 |
| 891_T | 895_T | 1.078 | 0.65 |
| 449_L | 453_I | 1.078 | 0.65 |
| 1271_F | 1274_L | 1.077 | 0.65 |
| 1243_V | 1251_M | 1.076 | 0.65 |
| 540_H | 543_L | 1.076 | 0.65 |
| 1220_L | 1228_I | 1.075 | 0.65 |
| 802_K | 1019_L | 1.073 | 0.65 |
| 488_I | 495_L | 1.071 | 0.64 |
| 173_S | 288_L | 1.071 | 0.64 |
| 231_T | 1150_Y | 1.070 | 0.64 |
| 44_T | 55_L | 1.069 | 0.64 |
| 362_V | 366_Y | 1.069 | 0.64 |
| 577_K | 582_V | 1.068 | 0.64 |
| 38_G | 42_A | 1.067 | 0.64 |
| 394_S | 400_T | 1.067 | 0.64 |
| 155_T | 317_L | 1.066 | 0.64 |
| 1193_G | 1202_R | 1.065 | 0.64 |
| 990_F | 994_S | 1.065 | 0.64 |
| 227_R | 232_Q | 1.064 | 0.64 |
| 1223_V | 1226_S | 1.063 | 0.64 |
| 520_F | 551_W | 1.062 | 0.63 |
| 461_V | 468_T | 1.060 | 0.63 |
| 1052_V | 1056_N | 1.060 | 0.63 |
| 885_I | 893_Y | 1.058 | 0.63 |
| 831_D | 1011_A | 1.058 | 0.63 |
| 803_L | 811_F | 1.057 | 0.63 |
| 1087_G | 1093_K | 1.055 | 0.63 |
| 278_F | 282_M | 1.054 | 0.63 |
| 945_T | 948_G | 1.054 | 0.63 |
| 116_L | 907_I | 1.053 | 0.62 |
| 515_A | 913_T | 1.053 | 0.62 |
| 279_G | 293_V | 1.052 | 0.62 |
| 111_I | 114_A | 1.052 | 0.62 |
| 376_K | 578_E | 1.052 | 0.62 |
| 662_Q | 665_S | 1.051 | 0.62 |
| 1232_V | 1236_P | 1.051 | 0.62 |
| 411_G | 418_I | 1.051 | 0.62 |
| 358_T | 415_S | 1.051 | 0.62 |
| 527_L | 552_R | 1.049 | 0.62 |
| 450_R | 495_L | 1.049 | 0.62 |
| 391_V | 400_T | 1.049 | 0.62 |
| 1059_F | 1260_L | 1.048 | 0.62 |
| 445_F | 452_N | 1.048 | 0.62 |
| 738_F | 742_L | 1.048 | 0.62 |
| 442_C | 515_A | 1.046 | 0.62 |
| 707_M | 710_S | 1.045 | 0.62 |
| 290_I | 449_L | 1.045 | 0.62 |
| 382_F | 556_T | 1.045 | 0.62 |
| 1113_I | 1126_L | 1.045 | 0.62 |
| 1263_G | 1274_L | 1.044 | 0.61 |
| 49_G | 55_L | 1.044 | 0.61 |
| 30_M | 34_T | 1.044 | 0.61 |
| 235_E | 239_F | 1.043 | 0.61 |
| 583_E | 587_Q | 1.043 | 0.61 |
| 1026_L | 1032_N | 1.043 | 0.61 |
| 944_A | 953_N | 1.042 | 0.61 |
| 1217_T | 1228_I | 1.042 | 0.61 |
| 31_I | 34_T | 1.041 | 0.61 |
| 137_I | 143_E | 1.039 | 0.61 |
| 531_E | 1192_G | 1.039 | 0.61 |
| 818_A | 1072_N | 1.036 | 0.61 |
| 771_A | 775_I | 1.035 | 0.60 |
| 373_A | 376_K | 1.034 | 0.60 |
| 442_C | 913_T | 1.034 | 0.60 |
| 46_I | 172_Y | 1.034 | 0.60 |
| 449_L | 803_L | 1.033 | 0.60 |
| 564_L | 585_G | 1.031 | 0.60 |
| 1090_G | 1093_K | 1.030 | 0.60 |
| 108_R | 112_L | 1.028 | 0.60 |
| 404_L | 407_R | 1.027 | 0.60 |
| 1208_S | 1239_L | 1.026 | 0.59 |
| 988_L | 991_T | 1.026 | 0.59 |
| 886_L | 894_K | 1.024 | 0.59 |
| 1219_A | 1249_Q | 1.023 | 0.59 |
| 202_S | 209_T | 1.022 | 0.59 |
| 175_S | 287_K | 1.020 | 0.59 |
| 532_A | 544_L | 1.020 | 0.59 |
| 575_L | 590_L | 1.017 | 0.58 |
| 130_L | 134_F | 1.017 | 0.58 |
| 1026_L | 1122_N | 1.017 | 0.58 |
| 768_G | 772_A | 1.016 | 0.58 |
| 1057_L | 1096_L | 1.015 | 0.58 |
| 1267_E | 1271_F | 1.015 | 0.58 |
| 139_R | 142_E | 1.015 | 0.58 |
| 31_I | 156_F | 1.014 | 0.58 |
| 418_I | 431_L | 1.014 | 0.58 |
| 222_A | 1140_F | 1.011 | 0.58 |
| 1086_I | 1259_V | 1.011 | 0.58 |
| 812_S | 1137_P | 1.010 | 0.58 |
| 482_A | 487_F | 1.010 | 0.58 |
| 112_L | 121_M | 1.008 | 0.57 |
| 27_L | 30_M | 1.007 | 0.57 |
| 541_R | 545_M | 1.006 | 0.57 |
| 1051_I | 1115_G | 1.004 | 0.57 |
| 298_H | 301_I | 1.004 | 0.57 |
| 1215_E | 1221_D | 1.004 | 0.57 |
| 889_C | 892_D | 1.002 | 0.57 |
| 23_D | 53_D | 1.002 | 0.57 |
| 1216_C | 1251_M | 1.001 | 0.57 |
| 1187_T | 1195_A | 1.001 | 0.57 |
| 406_L | 916_C | 1.001 | 0.57 |
| 174_W | 177_T | 1.001 | 0.57 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4f4cA | 1 | 0.9163 | 100 | 0.329 | Contact Map |
| 3g5uA | 2 | 0.9039 | 100 | 0.34 | Contact Map |
| 4a82A | 4 | 0.4434 | 100 | 0.656 | Contact Map |
| 3qf4A | 1 | 0.4403 | 100 | 0.663 | Contact Map |
| 2yl4A | 1 | 0.4349 | 100 | 0.67 | Contact Map |
| 3b5xA | 2 | 0.4419 | 100 | 0.671 | Contact Map |
| 3qf4B | 1 | 0.4504 | 100 | 0.672 | Contact Map |
| 3b60A | 4 | 0.4411 | 100 | 0.674 | Contact Map |
| 3wmgA | 1 | 0.4488 | 100 | 0.677 | Contact Map |
| 4mrsA | 2 | 0.4519 | 100 | 0.679 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)