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OPENSEQ.org
MMUM - Homocysteine S-methyltransferase
UniProt: Q47690 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13343
Length: 310 (303)
Sequences: 2034
Seq/Len: 6.71
MMUM
Paralog alert: 0.27 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_R 101_K 5.543 1.00
59_Y 66_A 4.12 1.00
89_K 159_D 3.183 1.00
56_L 105_A 3.136 1.00
40_S 95_S 3.096 1.00
75_P 152_P 3.039 1.00
94_K 97_E 2.867 1.00
122_V 154_V 2.837 1.00
100_R 104_E 2.825 1.00
65_C 119_A 2.75 1.00
52_R 105_A 2.722 1.00
56_L 60_R 2.699 1.00
304_A 308_A 2.65 1.00
158_L 189_A 2.524 1.00
167_C 183_L 2.508 1.00
142_S 145_A 2.485 1.00
87_Q 90_A 2.396 1.00
53_E 57_D 2.38 1.00
301_A 304_A 2.256 1.00
52_R 56_L 2.227 1.00
30_R 53_E 2.191 1.00
147_Q 185_A 2.18 1.00
119_A 164_L 2.165 1.00
282_P 286_A 2.141 1.00
154_V 186_Y 2.125 1.00
56_L 102_A 2.07 1.00
52_R 102_A 2.068 1.00
70_S 95_S 2.068 1.00
96_V 160_A 2.004 1.00
151_R 185_A 1.928 1.00
93_G 159_D 1.907 1.00
151_R 186_Y 1.899 1.00
72_Q 77_G 1.897 1.00
305_A 308_A 1.884 1.00
184_T 188_R 1.868 1.00
65_C 164_L 1.867 1.00
192_W 224_A 1.86 1.00
93_G 97_E 1.84 1.00
59_Y 116_L 1.802 1.00
154_V 183_L 1.795 1.00
224_A 251_V 1.785 1.00
89_K 93_G 1.775 1.00
210_R 241_H 1.767 1.00
92_I 153_R 1.74 1.00
176_I 193_F 1.729 1.00
47_N 50_L 1.727 1.00
121_S 253_Y 1.704 1.00
217_A 247_V 1.704 1.00
27_L 51_I 1.676 1.00
89_K 155_E 1.651 1.00
282_P 309_R 1.632 1.00
10_L 15_D 1.621 1.00
151_R 155_E 1.611 1.00
18_L 307_K 1.608 1.00
89_K 156_A 1.603 1.00
294_G 298_T 1.577 1.00
120_G 162_A 1.565 0.99
154_V 165_L 1.5 0.99
165_L 183_L 1.476 0.99
213_V 247_V 1.469 0.99
103_R 118_V 1.449 0.99
27_L 54_V 1.441 0.99
156_A 160_A 1.438 0.99
9_A 14_Q 1.434 0.99
79_A 85_E 1.428 0.99
100_R 103_R 1.421 0.99
82_G 85_E 1.414 0.99
194_S 251_V 1.396 0.99
78_F 83_L 1.393 0.99
77_G 126_G 1.39 0.99
11_L 223_V 1.379 0.98
120_G 157_L 1.376 0.98
122_V 153_R 1.368 0.98
239_L 250_L 1.367 0.98
208_P 211_D 1.362 0.98
26_E 57_D 1.354 0.98
251_V 291_L 1.347 0.98
167_C 180_A 1.346 0.98
68_T 96_V 1.345 0.98
236_T 283_Q 1.336 0.98
10_L 117_L 1.336 0.98
216_L 225_L 1.335 0.98
32_C 50_L 1.33 0.98
96_V 157_L 1.33 0.98
29_A 301_A 1.33 0.98
180_A 222_V 1.327 0.98
60_R 106_Y 1.323 0.98
9_A 13_K 1.318 0.98
213_V 248_L 1.317 0.98
10_L 14_Q 1.317 0.98
10_L 17_L 1.316 0.98
147_Q 181_E 1.316 0.98
74_T 77_G 1.314 0.98
59_Y 103_R 1.309 0.98
136_R 139_Y 1.298 0.97
22_A 25_T 1.297 0.97
30_R 50_L 1.293 0.97
19_L 291_L 1.289 0.97
49_E 53_E 1.288 0.97
155_E 186_Y 1.288 0.97
56_L 106_Y 1.286 0.97
75_P 149_F 1.282 0.97
65_C 291_L 1.278 0.97
57_D 60_R 1.273 0.97
197_L 238_A 1.255 0.97
52_R 98_L 1.226 0.96
240_Q 287_A 1.22 0.96
170_L 176_I 1.21 0.96
97_E 101_K 1.2 0.95
209_L 227_I 1.197 0.95
305_A 309_R 1.195 0.95
88_S 156_A 1.189 0.95
167_C 179_L 1.187 0.95
232_L 269_H 1.183 0.95
289_A 292_I 1.182 0.95
18_L 306_L 1.177 0.95
99_A 118_V 1.161 0.94
224_A 291_L 1.16 0.94
278_A 305_A 1.159 0.94
107_L 111_P 1.158 0.94
252_V 289_A 1.138 0.93
83_L 87_Q 1.135 0.93
57_D 300_P 1.124 0.93
258_E 297_R 1.122 0.93
73_A 91_L 1.12 0.93
30_R 57_D 1.115 0.92
125_Y 146_F 1.109 0.92
269_H 276_Q 1.103 0.92
23_M 54_V 1.1 0.92
89_K 152_P 1.095 0.92
177_E 215_L 1.094 0.92
26_E 29_A 1.093 0.91
209_L 238_A 1.091 0.91
217_A 246_T 1.077 0.91
67_I 166_A 1.061 0.90
158_L 186_Y 1.059 0.90
45_V 91_L 1.047 0.89
143_V 181_E 1.043 0.89
270_H 276_Q 1.042 0.89
166_A 253_Y 1.038 0.88
6_P 9_A 1.036 0.88
122_V 165_L 1.029 0.88
169_T 228_N 1.026 0.88
26_E 30_R 1.026 0.88
76_A 149_F 1.026 0.88
225_L 246_T 1.014 0.87
102_A 105_A 1.013 0.87
26_E 58_Y 1.012 0.87
213_V 245_L 1.011 0.87
11_L 249_P 1.01 0.87
55_H 63_A 1.008 0.86
281_L 292_I 1.007 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q7zA20.91941000.139Contact Map0.795
4cczA10.96771000.146Contact Map0.621
1lt8A20.93231000.176Contact Map0.722
3eooA160.838793.80.935Contact Map0.387
2e6fA20.538793.60.936Contact Map0.513
3w9zA10.493592.10.939Contact Map0.482
1zlpA20.845291.50.94Contact Map0.421
3hgjA40.603290.50.941Contact Map0.512
2nuwA20.589.60.942Contact Map0.676
3gr7A20.616189.50.942Contact Map0.471
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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