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OPENSEQ.org

YAFQ - mRNA interferase YafQ
UniProt: Q47149 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13154
Length: 92 (88)
Sequences: 569
Seq/Len: 6.47

YAFQ
Paralog alert: 0.18 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_D 69_I 4.018 1.00
49_D 60_R 3.999 1.00
15_D 83_R 3.858 1.00
28_K 65_E 3.25 1.00
49_D 72_Y 2.583 1.00
68_W 84_T 2.285 1.00
35_L 44_P 2.134 1.00
62_A 70_L 1.998 1.00
4_R 40_T 1.995 1.00
59_Y 73_K 1.831 1.00
51_P 60_R 1.783 1.00
40_T 74_L 1.72 1.00
33_M 81_F 1.665 1.00
22_R 89_A 1.641 1.00
32_L 62_A 1.629 1.00
84_T 89_A 1.534 0.99
8_Y 13_S 1.518 0.99
6_I 38_N 1.506 0.99
61_D 91_F 1.453 0.99
60_R 72_Y 1.43 0.99
43_L 49_D 1.287 0.97
6_I 81_F 1.271 0.97
59_Y 82_E 1.188 0.95
83_R 90_L 1.129 0.93
73_K 80_R 1.127 0.93
37_I 44_P 1.113 0.92
33_M 38_N 1.099 0.91
56_W 59_Y 1.087 0.91
32_L 47_Y 1.08 0.90
69_I 91_F 1.076 0.90
12_Y 29_L 1.074 0.90
35_L 41_L 1.068 0.90
29_L 68_W 1.056 0.89
49_D 74_L 1.043 0.88
44_P 47_Y 1.026 0.87
10_G 17_K 1.018 0.86
24_K 65_E 1.013 0.86
75_T 78_L 1.009 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2otrA10.967499.80.397Contact Map0.54
1z8mA10.956599.70.419Contact Map0.561
3oeiC80.934899.70.452Contact Map0.815
3g5oB20.91399.40.547Contact Map0.602
2a6sA40.902299.40.556Contact Map0.779
1wmiA20.934899.20.583Contact Map0.741
3bpqB20.902299.20.592Contact Map0.656
4fxiA30.902299.10.6Contact Map0.596
2kheA10.91399.10.602Contact Map0.545
3kxeA20.91394.80.811Contact Map0.723

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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