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OPENSEQ.org
YGBK - Uncharacterized protein YgbK
UniProt: Q46889 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13105
Length: 388 (387)
Sequences: 832
Seq/Len: 2.15
YGBK
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_A 152_S 2.871 1.00
175_E 205_H 2.687 1.00
8_A 14_A 2.628 1.00
103_M 111_T 2.368 1.00
103_M 108_T 2.261 1.00
185_L 196_A 2.22 1.00
124_V 129_L 2.114 0.99
127_G 168_V 2.031 0.99
96_G 161_Q 2.005 0.99
91_A 160_A 1.997 0.99
198_L 209_Q 1.961 0.99
119_V 203_E 1.958 0.99
184_E 188_L 1.951 0.99
99_T 220_T 1.818 0.98
131_V 136_L 1.814 0.98
55_C 63_Q 1.804 0.98
221_G 225_L 1.802 0.98
127_G 199_D 1.786 0.98
84_C 87_F 1.765 0.97
141_M 147_N 1.748 0.97
253_V 356_F 1.732 0.97
302_L 351_E 1.719 0.97
84_C 88_D 1.714 0.97
173_V 180_A 1.707 0.97
27_P 44_D 1.704 0.97
254_V 357_I 1.688 0.96
73_Q 372_G 1.685 0.96
293_Y 296_E 1.669 0.96
181_V 208_I 1.66 0.96
141_M 144_H 1.649 0.96
16_D 260_S 1.641 0.96
86_T 260_S 1.64 0.96
68_L 102_L 1.629 0.95
210_G 228_G 1.596 0.95
83_Y 220_T 1.584 0.94
171_A 175_E 1.566 0.94
6_V 17_I 1.563 0.94
283_R 296_E 1.556 0.94
297_L 312_V 1.554 0.94
80_Y 225_L 1.524 0.93
84_C 89_S 1.518 0.93
125_Y 201_L 1.514 0.93
145_P 148_P 1.491 0.92
155_P 168_V 1.485 0.92
363_T 385_A 1.469 0.91
174_F 212_A 1.452 0.90
202_T 205_H 1.449 0.90
11_F 378_I 1.438 0.90
312_V 346_A 1.426 0.89
69_S 105_A 1.424 0.89
276_A 313_F 1.423 0.89
21_L 226_A 1.422 0.89
82_K 221_G 1.419 0.89
104_D 163_T 1.414 0.89
301_V 312_V 1.412 0.89
173_V 184_E 1.406 0.88
80_Y 226_A 1.396 0.88
342_S 348_L 1.386 0.87
65_L 105_A 1.385 0.87
21_L 45_A 1.383 0.87
100_D 162_S 1.362 0.86
16_D 221_G 1.353 0.86
18_A 362_E 1.352 0.86
151_D 156_R 1.351 0.86
170_S 173_V 1.351 0.86
19_S 381_T 1.346 0.85
117_L 381_T 1.344 0.85
16_D 223_S 1.34 0.85
110_F 196_A 1.334 0.85
139_S 142_R 1.324 0.84
61_T 101_A 1.313 0.83
80_Y 221_G 1.311 0.83
18_A 47_V 1.307 0.83
253_V 348_L 1.304 0.83
113_F 195_Y 1.299 0.82
181_V 209_Q 1.299 0.82
100_D 164_G 1.298 0.82
136_L 139_S 1.297 0.82
144_H 149_M 1.29 0.82
61_T 104_D 1.289 0.82
358_V 364_S 1.281 0.81
65_L 101_A 1.276 0.81
174_F 177_G 1.27 0.80
142_R 152_S 1.264 0.80
5_G 71_L 1.262 0.80
187_R 191_E 1.255 0.79
9_D 13_G 1.251 0.79
183_Q 324_I 1.242 0.78
261_Q 265_R 1.238 0.78
221_G 385_A 1.233 0.78
135_L 138_E 1.228 0.77
124_V 200_A 1.219 0.76
116_A 200_A 1.214 0.76
58_V 62_Q 1.208 0.76
125_Y 130_F 1.205 0.75
82_K 224_G 1.204 0.75
10_D 13_G 1.199 0.75
99_T 195_Y 1.195 0.74
28_T 47_V 1.192 0.74
113_F 158_V 1.19 0.74
284_C 341_F 1.188 0.74
81_F 98_V 1.179 0.73
269_H 272_Q 1.177 0.73
16_D 82_K 1.176 0.73
186_A 372_G 1.176 0.73
23_E 381_T 1.175 0.73
164_G 194_R 1.171 0.72
11_F 141_M 1.167 0.72
359_A 364_S 1.161 0.71
99_T 158_V 1.147 0.70
97_P 101_A 1.147 0.70
17_I 20_F 1.144 0.70
149_M 362_E 1.141 0.69
179_D 183_Q 1.132 0.69
3_K 246_R 1.115 0.67
68_L 105_A 1.115 0.67
9_D 12_T 1.113 0.67
255_L 345_A 1.113 0.67
158_V 195_Y 1.113 0.67
96_G 158_V 1.108 0.66
158_V 162_S 1.103 0.66
221_G 226_A 1.099 0.65
169_V 198_L 1.098 0.65
171_A 205_H 1.096 0.65
256_S 263_T 1.095 0.65
86_T 147_N 1.095 0.65
47_V 148_P 1.089 0.64
49_S 376_F 1.089 0.64
320_A 323_A 1.089 0.64
271_R 276_A 1.085 0.64
98_V 144_H 1.083 0.64
62_Q 66_A 1.078 0.63
295_H 346_A 1.077 0.63
144_H 260_S 1.075 0.63
65_L 69_S 1.072 0.62
47_V 51_K 1.069 0.62
109_P 189_Q 1.069 0.62
152_S 376_F 1.068 0.62
174_F 372_G 1.068 0.62
84_C 90_T 1.064 0.62
11_F 368_T 1.06 0.61
102_L 206_L 1.056 0.61
86_T 91_A 1.056 0.61
169_V 209_Q 1.055 0.61
131_V 135_L 1.047 0.60
129_L 144_H 1.047 0.60
84_C 149_M 1.044 0.59
38_K 77_K 1.04 0.59
111_T 220_T 1.037 0.59
15_T 373_I 1.035 0.58
141_M 149_M 1.034 0.58
69_S 243_K 1.034 0.58
183_Q 186_A 1.033 0.58
162_S 166_C 1.032 0.58
47_V 94_N 1.03 0.58
293_Y 344_L 1.029 0.58
16_D 224_G 1.028 0.58
188_L 196_A 1.026 0.57
197_V 256_S 1.025 0.57
139_S 144_H 1.022 0.57
298_A 347_R 1.022 0.57
57_V 61_T 1.019 0.57
153_Y 156_R 1.019 0.57
112_V 213_L 1.019 0.57
349_A 356_F 1.017 0.56
264_N 267_V 1.015 0.56
256_S 359_A 1.014 0.56
174_F 214_R 1.012 0.56
292_A 296_E 1.012 0.56
108_T 217_P 1.011 0.56
131_V 366_V 1.011 0.56
64_S 81_F 1.011 0.56
218_L 267_V 1.01 0.56
145_P 260_S 1.008 0.55
221_G 224_G 1.007 0.55
304_Q 307_V 1.007 0.55
8_A 16_D 1.007 0.55
105_A 242_R 1.006 0.55
284_C 314_A 1.006 0.55
82_K 118_P 1 0.54
20_F 270_Y 1 0.54
82_K 385_A 1 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dqqA20.99741000.069Contact Map0.57
1yzyA20.9821000.076Contact Map0.612
2zayA20.353128.70.968Contact Map0.305
3snkA10.3041270.969Contact Map0.37
2a9oA10.301526.90.969Contact Map0.334
4h60A10.29924.20.969Contact Map0.38
3i42A10.314423.60.969Contact Map0.374
2gnpA10.237123.30.97Contact Map0.605
3c3mA10.342820.80.97Contact Map0.386
3hp4A10.386620.30.97Contact Map0.18
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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