May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
NORV - Anaerobic nitric oxide reductase flavorubredoxin
UniProt: Q46877 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12963
Length: 479 (393)
Sequences: 735
Seq/Len: 1.87
NORV
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
4_V 7_N 4.085 1.00
46_V 132_I 4.064 1.00
75_I 88_L 3.621 1.00
143_T 153_M 3.157 1.00
180_D 232_R 3.134 1.00
139_I 157_T 2.993 1.00
44_K 73_D 2.957 1.00
160_A 219_P 2.948 1.00
138_L 154_T 2.913 1.00
99_P 122_N 2.84 1.00
207_T 246_A 2.826 1.00
131_D 135_G 2.75 1.00
64_R 94_Q 2.69 1.00
6_K 221_D 2.628 1.00
268_M 385_C 2.542 1.00
275_G 389_G 2.517 1.00
75_I 98_T 2.478 1.00
78_N 154_T 2.261 1.00
155_Y 160_A 2.23 1.00
160_A 221_D 2.212 1.00
45_N 72_I 2.202 0.99
255_T 305_S 2.183 0.99
311_G 343_F 2.172 0.99
9_I 161_V 2.15 0.99
42_E 135_G 2.142 0.99
208_P 211_T 2.126 0.99
288_F 301_N 2.08 0.99
290_V 298_I 2.034 0.99
136_K 159_D 2.019 0.99
389_G 393_A 1.981 0.99
131_D 137_Q 1.97 0.99
9_I 40_I 1.955 0.99
178_F 232_R 1.937 0.98
103_T 106_A 1.934 0.98
243_L 247_A 1.921 0.98
102_C 106_A 1.848 0.98
103_T 152_M 1.842 0.98
39_L 47_L 1.837 0.98
310_V 323_I 1.833 0.98
151_S 165_N 1.777 0.97
211_T 243_L 1.754 0.97
40_I 48_I 1.749 0.96
207_T 243_L 1.725 0.96
279_T 390_R 1.706 0.96
307_G 392_I 1.704 0.96
358_T 361_Q 1.679 0.95
129_T 137_Q 1.675 0.95
253_R 305_S 1.63 0.94
381_A 384_L 1.613 0.94
75_I 100_I 1.607 0.94
69_L 95_I 1.598 0.93
90_E 93_A 1.595 0.93
264_N 345_S 1.59 0.93
10_H 41_R 1.585 0.93
14_Q 55_F 1.584 0.93
111_N 118_E 1.574 0.93
101_Y 122_N 1.561 0.92
383_K 386_R 1.559 0.92
45_N 73_D 1.55 0.92
254_I 276_I 1.548 0.92
76_V 130_L 1.547 0.92
9_I 156_L 1.544 0.92
165_N 226_S 1.539 0.92
74_Y 101_Y 1.536 0.91
101_Y 130_L 1.527 0.91
358_T 362_D 1.513 0.91
40_I 138_L 1.488 0.90
39_L 63_L 1.488 0.90
48_I 138_L 1.479 0.89
378_D 381_A 1.478 0.89
40_I 46_V 1.471 0.89
128_D 131_D 1.464 0.89
290_V 323_I 1.456 0.88
48_I 78_N 1.453 0.88
91_L 98_T 1.452 0.88
48_I 163_F 1.44 0.87
156_L 163_F 1.439 0.87
92_M 100_I 1.434 0.87
275_G 386_R 1.407 0.86
276_I 309_L 1.403 0.86
99_P 120_N 1.399 0.85
90_E 94_Q 1.393 0.85
240_E 244_K 1.388 0.85
105_N 108_D 1.385 0.85
15_R 173_C 1.379 0.84
371_L 388_H 1.379 0.84
6_K 159_D 1.371 0.84
191_C 238_I 1.368 0.84
126_T 212_E 1.363 0.83
385_C 389_G 1.359 0.83
214_L 243_L 1.353 0.83
319_M 355_R 1.351 0.83
59_F 91_L 1.341 0.82
310_V 327_V 1.336 0.82
243_L 246_A 1.332 0.81
19_V 29_T 1.316 0.80
309_L 392_I 1.297 0.79
179_N 237_Q 1.292 0.78
327_V 356_L 1.275 0.77
46_V 76_V 1.269 0.77
357_S 370_S 1.269 0.77
276_I 389_G 1.269 0.77
12_V 47_L 1.266 0.76
384_L 387_E 1.26 0.76
12_V 63_L 1.259 0.76
213_I 218_L 1.253 0.75
42_E 131_D 1.252 0.75
9_I 48_I 1.239 0.74
272_I 385_C 1.238 0.74
137_Q 158_G 1.218 0.72
391_E 394_R 1.216 0.72
204_R 208_P 1.214 0.72
8_N 136_K 1.213 0.72
179_N 233_D 1.196 0.71
78_N 152_M 1.195 0.70
46_V 131_D 1.191 0.70
89_T 110_I 1.19 0.70
279_T 389_G 1.188 0.70
207_T 247_A 1.187 0.70
286_K 301_N 1.183 0.69
256_I 273_A 1.18 0.69
102_C 107_I 1.178 0.69
129_T 154_T 1.177 0.69
153_M 167_A 1.172 0.68
311_G 350_G 1.167 0.68
40_I 130_L 1.166 0.68
387_E 391_E 1.16 0.67
48_I 156_L 1.155 0.67
4_V 10_H 1.151 0.66
271_A 274_Q 1.148 0.66
266_R 270_D 1.145 0.66
136_K 156_L 1.142 0.65
9_I 163_F 1.137 0.65
103_T 142_E 1.135 0.65
269_A 343_F 1.132 0.64
44_K 74_Y 1.125 0.64
257_F 290_V 1.116 0.63
5_V 222_M 1.113 0.62
351_G 372_K 1.111 0.62
106_A 142_E 1.111 0.62
58_E 62_N 1.11 0.62
253_R 304_R 1.11 0.62
275_G 393_A 1.108 0.62
136_K 158_G 1.107 0.62
357_S 361_Q 1.089 0.60
309_L 388_H 1.088 0.60
195_Y 203_S 1.075 0.58
130_L 138_L 1.071 0.58
31_R 190_Q 1.069 0.58
129_T 157_T 1.068 0.58
137_Q 157_T 1.068 0.58
40_I 132_I 1.066 0.57
161_V 222_M 1.062 0.57
271_A 275_G 1.061 0.57
155_Y 219_P 1.059 0.57
8_N 41_R 1.053 0.56
126_T 142_E 1.048 0.56
129_T 139_I 1.047 0.55
104_A 125_K 1.043 0.55
236_T 240_E 1.042 0.55
383_K 387_E 1.04 0.55
92_M 98_T 1.036 0.54
108_D 374_K 1.035 0.54
41_R 63_L 1.034 0.54
156_L 159_D 1.034 0.54
38_Y 230_V 1.033 0.54
171_H 315_M 1.029 0.53
195_Y 246_A 1.024 0.53
77_I 100_I 1.022 0.53
107_I 121_F 1.017 0.52
16_D 35_Y 1.013 0.52
257_F 302_V 1.01 0.51
57_R 90_E 1.01 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ycgA40.82251000.574Contact Map0.781
4dikA20.79961000.584Contact Map0.733
1e5dA20.83091000.601Contact Map0.757
2q9uA20.83511000.612Contact Map0.742
2ohhA40.81631000.616Contact Map0.824
2vw8A10.55741000.769Contact Map0.652
3hnnA40.5241000.777Contact Map0.699
2cfuA10.8811000.806Contact Map0.519
2xr1A20.85391000.854Contact Map0.456
2yheA60.88311000.856Contact Map0.651
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.4834 seconds.