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OPENSEQ.org
QUEC - 7-cyano-7-deazaguanine synthase
UniProt: P77756 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13252
Length: 231 (217)
Sequences: 1111
Seq/Len: 5.12
QUEC
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
171_L 174_Y 2.988 1.00
34_D 40_R 2.959 1.00
118_A 157_E 2.889 1.00
208_N 212_H 2.658 1.00
167_E 170_A 2.642 1.00
32_T 43_I 2.63 1.00
141_A 145_A 2.498 1.00
124_C 168_T 2.436 1.00
34_D 62_D 2.395 1.00
3_R 27_E 2.392 1.00
30_C 55_A 2.342 1.00
41_A 186_L 2.193 1.00
52_K 184_E 2.186 1.00
207_A 211_N 2.071 1.00
5_V 116_A 2.056 1.00
32_T 58_H 2.016 1.00
136_D 140_K 1.979 1.00
73_S 93_N 1.962 1.00
20_Q 171_L 1.933 1.00
108_A 146_V 1.774 1.00
123_V 139_V 1.774 1.00
23_Q 174_Y 1.713 1.00
12_Q 169_W 1.686 1.00
83_D 190_N 1.682 0.99
44_D 47_R 1.681 0.99
196_G 207_A 1.634 0.99
170_A 174_Y 1.603 0.99
63_V 106_L 1.593 0.99
108_A 142_L 1.581 0.99
24_Q 120_I 1.579 0.99
33_F 103_F 1.566 0.99
24_Q 157_E 1.564 0.99
59_K 110_Y 1.563 0.99
15_T 49_L 1.552 0.99
29_H 110_Y 1.54 0.99
163_I 171_L 1.504 0.99
20_Q 24_Q 1.503 0.99
47_R 60_V 1.491 0.99
97_P 112_Y 1.481 0.98
102_L 109_I 1.469 0.98
164_D 167_E 1.438 0.98
110_Y 114_V 1.41 0.98
118_A 155_R 1.406 0.98
41_A 191_G 1.394 0.97
79_I 93_N 1.387 0.97
47_R 51_L 1.38 0.97
19_V 53_L 1.373 0.97
101_I 138_F 1.358 0.97
48_E 184_E 1.341 0.97
131_Y 134_C 1.341 0.97
18_L 30_C 1.335 0.96
8_F 30_C 1.313 0.96
186_L 209_G 1.309 0.96
59_K 114_V 1.304 0.96
98_G 101_I 1.295 0.96
70_A 76_R 1.286 0.95
140_K 144_H 1.27 0.95
20_Q 120_I 1.256 0.94
72_S 75_T 1.255 0.94
16_T 182_R 1.252 0.94
48_E 51_L 1.25 0.94
83_D 199_H 1.238 0.94
82_P 93_N 1.232 0.94
142_L 145_A 1.225 0.93
6_V 28_V 1.213 0.93
30_C 50_A 1.205 0.93
31_V 107_A 1.194 0.92
125_E 136_D 1.192 0.92
25_Y 118_A 1.192 0.92
143_N 155_R 1.19 0.92
117_E 157_E 1.161 0.91
16_T 172_A 1.155 0.91
25_Y 157_E 1.155 0.91
64_T 67_N 1.149 0.90
97_P 152_K 1.14 0.90
6_V 18_L 1.135 0.89
128_F 135_R 1.129 0.89
59_K 68_E 1.11 0.88
180_L 185_T 1.109 0.88
46_A 58_H 1.109 0.88
112_Y 150_M 1.108 0.88
136_D 162_W 1.105 0.88
127_D 134_C 1.105 0.88
40_R 44_D 1.103 0.88
179_D 183_N 1.102 0.88
73_S 94_T 1.102 0.88
172_A 182_R 1.102 0.88
50_A 55_A 1.1 0.87
94_T 131_Y 1.088 0.87
104_L 121_T 1.088 0.87
139_V 158_T 1.086 0.87
98_G 109_I 1.084 0.86
18_L 28_V 1.08 0.86
29_H 114_V 1.08 0.86
145_A 149_G 1.071 0.86
84_Y 88_A 1.068 0.85
27_E 56_R 1.067 0.85
52_K 183_N 1.057 0.84
186_L 191_G 1.047 0.84
96_V 189_Y 1.044 0.83
92_P 130_G 1.035 0.83
50_A 54_G 1.033 0.83
142_L 156_F 1.03 0.82
39_H 191_G 1.027 0.82
130_G 205_L 1.022 0.82
18_L 53_L 1.017 0.81
142_L 146_V 1.012 0.81
127_D 131_Y 1.009 0.81
164_D 212_H 1.003 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pg3A111000.38Contact Map0.59
3bl5A60.92211000.546Contact Map0.741
1vl2A40.900499.90.712Contact Map0.627
3k32A60.822599.90.725Contact Map0.645
3rjzA10.783599.90.728Contact Map0.527
1k92A10.917799.90.734Contact Map0.548
2hmaA10.909199.80.744Contact Map0.551
2o8vA10.844299.80.747Contact Map0.529
3uowA20.883199.80.748Contact Map0.503
1korA40.891899.80.749Contact Map0.641
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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