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OPENSEQ.org
MURQ - N-acetylmuramic acid 6-phosphate etherase
UniProt: P76535 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14162
Length: 298 (296)
Sequences: 815
Seq/Len: 2.75
MURQ
Paralog alert: 0.13 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_S 252_Q 4.521 1.00
51_A 162_V 3.71 1.00
23_T 53_D 3.576 1.00
30_I 195_M 3.481 1.00
155_R 177_E 3.395 1.00
35_K 42_E 3.013 1.00
88_Y 195_M 3.006 1.00
58_Q 160_R 2.91 1.00
182_P 204_V 2.798 1.00
129_L 135_V 2.792 1.00
120_G 150_G 2.738 1.00
78_I 106_I 2.688 1.00
117_R 152_E 2.574 1.00
38_P 203_L 2.543 1.00
256_A 271_V 2.528 1.00
66_I 127_I 2.525 1.00
68_L 150_G 2.428 1.00
18_I 214_I 2.383 1.00
151_L 161_T 2.339 1.00
88_Y 189_V 2.319 1.00
152_E 175_T 2.227 1.00
123_D 146_Y 2.162 1.00
52_I 211_G 2.094 1.00
58_Q 134_V 2.087 1.00
103_E 107_Q 2.083 1.00
269_V 291_I 2.027 1.00
27_C 52_I 2.009 1.00
153_Y 156_Q 1.982 0.99
24_L 49_A 1.966 0.99
276_D 279_E 1.932 0.99
54_V 178_F 1.901 0.99
24_L 28_R 1.806 0.99
18_I 189_V 1.786 0.99
55_I 208_L 1.76 0.99
236_V 250_A 1.757 0.98
53_D 215_K 1.721 0.98
23_T 215_K 1.717 0.98
48_I 204_V 1.713 0.98
26_M 211_G 1.689 0.98
24_L 45_L 1.677 0.98
59_V 216_S 1.655 0.98
59_V 94_L 1.646 0.97
236_V 240_N 1.631 0.97
84_C 90_V 1.629 0.97
218_K 226_D 1.626 0.97
170_S 173_S 1.614 0.97
184_V 197_A 1.611 0.97
44_V 48_I 1.604 0.97
136_V 208_L 1.59 0.97
151_L 172_V 1.568 0.96
121_V 125_K 1.551 0.96
35_K 39_L 1.538 0.96
243_K 250_A 1.529 0.96
21_V 29_I 1.491 0.95
54_V 160_R 1.482 0.94
51_A 208_L 1.468 0.94
14_A 36_T 1.464 0.94
38_P 41_V 1.458 0.94
122_N 126_N 1.451 0.94
162_V 208_L 1.45 0.94
12_N 15_S 1.427 0.93
160_R 178_F 1.424 0.93
27_C 45_L 1.4 0.92
236_V 239_V 1.391 0.92
44_V 180_I 1.38 0.91
15_S 29_I 1.369 0.91
227_V 241_I 1.368 0.91
7_I 168_P 1.356 0.90
124_L 153_Y 1.353 0.90
122_N 125_K 1.353 0.90
68_L 120_G 1.346 0.90
17_E 20_R 1.338 0.89
263_N 266_T 1.325 0.89
119_G 123_D 1.321 0.89
153_Y 157_L 1.307 0.88
65_L 136_V 1.305 0.88
110_V 113_A 1.301 0.88
163_G 179_A 1.295 0.87
255_A 259_A 1.295 0.87
242_V 268_I 1.294 0.87
44_V 47_D 1.289 0.87
96_V 127_I 1.276 0.86
260_C 270_M 1.273 0.86
173_S 181_T 1.27 0.86
44_V 182_P 1.268 0.86
33_E 36_T 1.256 0.85
84_C 226_D 1.255 0.85
277_A 281_K 1.248 0.84
137_G 147_V 1.245 0.84
32_D 35_K 1.243 0.84
84_C 95_V 1.243 0.84
51_A 55_I 1.225 0.83
76_L 205_L 1.212 0.82
60_S 288_G 1.195 0.81
82_S 106_I 1.19 0.80
61_G 132_Q 1.19 0.80
27_C 49_A 1.183 0.80
49_A 53_D 1.177 0.79
51_A 180_I 1.177 0.79
118_E 122_N 1.171 0.79
26_M 214_I 1.16 0.78
82_S 85_P 1.157 0.78
68_L 98_L 1.157 0.78
163_G 173_S 1.155 0.78
66_I 96_V 1.148 0.77
120_G 149_A 1.122 0.75
270_M 277_A 1.119 0.74
121_V 149_A 1.117 0.74
254_E 258_I 1.114 0.74
29_I 188_V 1.109 0.73
242_V 257_L 1.093 0.72
37_V 203_L 1.086 0.71
163_G 172_V 1.083 0.71
15_S 188_V 1.076 0.70
31_N 34_D 1.073 0.70
212_L 216_S 1.071 0.70
93_G 96_V 1.069 0.70
238_Q 264_C 1.068 0.69
245_A 268_I 1.063 0.69
129_L 153_Y 1.051 0.68
19_D 292_R 1.047 0.67
34_D 203_L 1.045 0.67
11_S 223_L 1.041 0.67
283_R 287_H 1.031 0.65
22_S 25_E 1.031 0.65
59_V 212_L 1.023 0.65
155_R 175_T 1.022 0.64
116_S 119_G 1.021 0.64
266_T 275_L 1.016 0.64
229_A 242_V 1.011 0.63
60_S 216_S 1.003 0.62
48_I 180_I 1.003 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3w0lB20.99331000.396Contact Map0.517
4bb9A10.99331000.398Contact Map0.612
1nriA10.99661000.4Contact Map0.669
1tk9A40.630999.90.81Contact Map0.74
3trjA40.661199.80.823Contact Map0.686
2xblA40.654499.80.83Contact Map0.659
2yvaA20.647799.80.83Contact Map0.554
2i2wA40.691399.80.839Contact Map0.66
1x92A20.654499.80.84Contact Map0.706
2bplA30.879299.70.841Contact Map0.589
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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