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OPENSEQ.org
YEGL - Uncharacterized protein YegL
UniProt: P76396 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14055
Length: 219 (215)
Sequences: 257
Seq/Len: 1.20
YEGL
Paralog alert: 0.21 [within 20: 0.10] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_D 144_K 2.849 1.00
133_A 165_D 2.337 0.99
69_G 95_P 2.215 0.99
107_V 154_F 2.127 0.98
139_Q 171_Q 2.096 0.98
19_R 200_S 1.546 0.84
23_I 103_A 1.541 0.84
108_E 153_R 1.49 0.81
66_V 99_A 1.478 0.80
57_A 191_W 1.474 0.80
68_F 96_M 1.407 0.75
20_C 23_I 1.403 0.75
99_A 128_L 1.384 0.73
103_A 108_E 1.368 0.72
114_Y 121_Y 1.356 0.71
98_A 107_V 1.311 0.68
25_L 127_F 1.306 0.67
101_T 137_E 1.296 0.66
43_G 191_W 1.288 0.66
130_T 150_E 1.287 0.65
195_S 200_S 1.274 0.64
19_R 121_Y 1.264 0.63
23_I 107_V 1.257 0.63
135_T 200_S 1.257 0.63
85_P 130_T 1.253 0.62
54_D 58_L 1.251 0.62
69_G 93_D 1.246 0.62
188_L 196_L 1.239 0.61
43_G 57_A 1.228 0.60
163_G 178_L 1.227 0.60
9_T 219_V 1.201 0.58
27_D 31_S 1.2 0.57
96_M 128_L 1.198 0.57
163_G 172_I 1.197 0.57
214_K 217_T 1.194 0.57
96_M 100_I 1.193 0.57
41_N 202_S 1.187 0.56
138_W 168_T 1.184 0.56
203_T 206_T 1.183 0.56
46_T 172_I 1.181 0.56
6_T 9_T 1.175 0.55
64_G 122_Y 1.169 0.55
10_S 13_A 1.167 0.54
75_Q 83_F 1.166 0.54
18_P 56_L 1.155 0.53
95_P 138_W 1.145 0.52
53_A 206_T 1.137 0.51
9_T 218_S 1.135 0.51
62_E 114_Y 1.134 0.51
5_I 10_S 1.129 0.51
97_G 164_A 1.128 0.51
77_F 111_K 1.127 0.50
97_G 136_D 1.126 0.50
41_N 185_F 1.117 0.49
12_F 149_E 1.114 0.49
145_V 197_R 1.11 0.49
71_V 206_T 1.109 0.49
66_V 86_P 1.109 0.49
7_F 10_S 1.108 0.49
101_T 105_D 1.108 0.49
57_A 61_V 1.107 0.48
72_H 109_E 1.106 0.48
5_I 8_A 1.104 0.48
123_R 195_S 1.101 0.48
95_P 135_T 1.1 0.48
38_N 197_R 1.098 0.48
86_P 203_T 1.083 0.46
44_L 129_I 1.08 0.46
8_A 218_S 1.08 0.46
129_I 161_V 1.08 0.46
95_P 99_A 1.078 0.46
43_G 189_F 1.077 0.46
150_E 189_F 1.076 0.45
166_M 179_P 1.072 0.45
189_F 193_S 1.064 0.44
50_E 53_A 1.061 0.44
203_T 209_V 1.059 0.44
47_F 67_T 1.058 0.44
69_G 168_T 1.057 0.44
44_L 86_P 1.057 0.44
175_R 193_S 1.056 0.44
19_R 180_L 1.055 0.43
40_L 71_V 1.052 0.43
123_R 149_E 1.051 0.43
43_G 188_L 1.048 0.43
104_L 141_A 1.045 0.42
63_L 89_F 1.044 0.42
88_L 160_G 1.044 0.42
50_E 127_F 1.041 0.42
10_S 219_V 1.04 0.42
5_I 9_T 1.04 0.42
45_V 197_R 1.038 0.42
6_T 219_V 1.038 0.42
43_G 180_L 1.033 0.41
21_P 27_D 1.03 0.41
154_F 213_P 1.026 0.41
21_P 24_L 1.025 0.41
160_G 180_L 1.025 0.41
108_E 152_K 1.024 0.41
143_N 147_R 1.024 0.41
118_G 182_G 1.02 0.40
97_G 169_L 1.019 0.40
38_N 50_E 1.019 0.40
18_P 200_S 1.017 0.40
9_T 214_K 1.014 0.40
85_P 171_Q 1.009 0.39
48_R 215_G 1.008 0.39
209_V 212_A 1.006 0.39
79_S 107_V 1.005 0.39
80_A 155_A 1.005 0.39
153_R 167_K 1.005 0.39
8_A 11_D 1.004 0.39
47_F 189_F 1.003 0.39
50_E 181_Q 1.001 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2odpA10.940699.90.706Contact Map0.265
1q0pA10.876799.80.712Contact Map0.258
1ijbA10.840299.80.716Contact Map0.312
4fx5A10.917899.80.716Contact Map0.242
1mjnA10.739799.80.717Contact Map0.293
1rrkA10.881399.80.717Contact Map0.261
1mf7A10.794599.80.72Contact Map0.286
3k6sA40.931599.80.721Contact Map0.275
4f1jA20.817499.80.722Contact Map0.344
3zqkA30.849399.80.723Contact Map0.281
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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