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OPENSEQ.org

YOEA - Putative uncharacterized protein YoeA
UniProt: P76356 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14308
Length: 167 (132)
Sequences: 3817
Seq/Len: 28.92

YOEA
Paralog alert: 0.86 [within 20: 0.13] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_L 162_F 3.67 1.00
63_D 66_T 3.441 1.00
64_Q 68_Q 3.389 1.00
64_Q 165_K 3.293 1.00
139_R 163_I 3.126 1.00
138_E 165_K 2.981 1.00
82_I 142_V 2.673 1.00
138_E 166_K 2.667 1.00
60_Q 144_K 2.667 1.00
67_L 78_N 2.438 1.00
112_I 117_V 2.307 1.00
74_S 77_D 2.295 1.00
38_E 41_L 2.243 1.00
65_Q 68_Q 2.127 1.00
109_L 116_E 2.079 1.00
133_D 136_A 2.05 1.00
61_V 141_E 2.002 1.00
65_Q 69_N 1.991 1.00
112_I 164_T 1.931 1.00
116_E 154_Q 1.896 1.00
51_N 54_E 1.74 1.00
85_V 100_I 1.665 1.00
78_N 134_E 1.641 1.00
61_V 139_R 1.605 1.00
143_V 147_Y 1.584 1.00
64_Q 138_E 1.571 1.00
84_G 144_K 1.567 1.00
72_N 78_N 1.553 1.00
111_L 161_N 1.519 1.00
70_S 81_D 1.492 1.00
99_R 104_A 1.491 1.00
66_T 69_N 1.417 1.00
73_A 77_D 1.415 1.00
98_I 160_V 1.39 0.99
113_D 164_T 1.369 0.99
104_A 107_R 1.362 0.99
44_T 163_I 1.33 0.99
109_L 155_A 1.33 0.99
103_E 107_R 1.22 0.98
62_I 78_N 1.202 0.98
141_E 161_N 1.202 0.98
111_L 163_I 1.163 0.97
100_I 158_G 1.148 0.97
75_I 162_F 1.146 0.97
46_N 50_S 1.137 0.97
103_E 157_G 1.132 0.97
151_Y 159_I 1.062 0.95
110_I 128_V 1.052 0.95
140_V 162_F 1.033 0.94
136_A 164_T 1.029 0.94
85_V 98_I 1.026 0.94
77_D 80_Q 1.026 0.94
138_E 163_I 1.022 0.93
72_N 81_D 1.02 0.93
112_I 137_L 1.012 0.93
83_P 144_K 1.012 0.93
58_T 144_K 1.002 0.92
114_G 161_N 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fhhA10.76051000.186Contact Map0.645
3v8xA10.92221000.205Contact Map0.701
2hdiA10.79641000.208Contact Map0.84
1fepA10.80841000.246Contact Map0.72
2gufA10.79641000.251Contact Map0.843
4epaA10.79041000.263Contact Map0.692
1qfgA10.91621000.268Contact Map0.742
1xkwA10.76651000.279Contact Map0.839
4b7oA10.95211000.281Contact Map0.698
3qlbA20.94011000.281Contact Map0.805

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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