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OPENSEQ.org
DCYD - D-cysteine desulfhydrase
UniProt: P76316 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14038
Length: 328 (322)
Sequences: 842
Seq/Len: 2.61
DCYD
Paralog alert: 0.11 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
256_Y 297_D 3.896 1.00
88_A 95_C 3.887 1.00
34_E 309_P 3.527 1.00
37_I 281_I 3.091 1.00
72_T 84_T 3.012 1.00
40_D 53_R 2.635 1.00
21_L 311_L 2.465 1.00
297_D 301_Q 2.324 1.00
176_I 311_L 2.273 1.00
144_T 147_E 2.248 1.00
59_A 70_L 2.21 1.00
30_Y 278_L 2.181 1.00
63_L 93_L 2.135 1.00
199_H 217_G 2.132 1.00
291_A 312_F 1.987 0.99
256_Y 301_Q 1.973 0.99
61_D 65_E 1.968 0.99
38_K 53_R 1.943 0.99
186_I 311_L 1.904 0.99
219_T 252_L 1.809 0.99
81_V 97_A 1.771 0.98
72_T 80_H 1.77 0.98
81_V 99_L 1.766 0.98
161_S 197_G 1.752 0.98
173_A 206_L 1.741 0.98
68_D 151_F 1.74 0.98
314_H 317_G 1.735 0.98
78_S 81_V 1.727 0.98
218_V 294_G 1.722 0.98
6_L 9_F 1.687 0.98
193_S 199_H 1.68 0.98
144_T 148_A 1.664 0.97
283_L 292_M 1.629 0.97
295_L 312_F 1.626 0.97
188_S 216_I 1.616 0.97
223_S 226_D 1.613 0.97
97_A 124_T 1.593 0.96
305_K 308_G 1.588 0.96
71_I 155_V 1.574 0.96
269_M 273_K 1.559 0.96
61_D 154_Y 1.558 0.96
33_R 307_E 1.546 0.95
147_E 153_P 1.53 0.95
58_L 162_N 1.514 0.95
255_D 301_Q 1.503 0.94
192_A 288_T 1.493 0.94
56_E 175_E 1.484 0.94
130_D 133_T 1.464 0.93
206_L 215_L 1.462 0.93
140_E 144_T 1.439 0.93
143_A 155_V 1.438 0.93
312_F 315_T 1.428 0.92
80_H 160_G 1.422 0.92
94_H 151_F 1.421 0.92
190_V 218_V 1.416 0.92
68_D 152_R 1.408 0.92
37_I 292_M 1.399 0.91
85_A 122_F 1.385 0.91
193_S 217_G 1.385 0.91
19_T 38_K 1.379 0.90
198_T 315_T 1.375 0.90
80_H 84_T 1.374 0.90
272_V 289_G 1.362 0.90
231_V 252_L 1.36 0.90
188_S 308_G 1.35 0.89
298_G 303_R 1.345 0.89
76_I 101_N 1.338 0.89
7_T 243_E 1.331 0.88
23_Y 36_F 1.331 0.88
276_A 321_L 1.33 0.88
22_E 90_K 1.329 0.88
260_G 263_V 1.327 0.88
52_L 83_Q 1.324 0.88
100_E 134_D 1.309 0.87
189_V 313_I 1.308 0.87
67_A 154_Y 1.3 0.87
23_Y 34_E 1.291 0.86
20_P 38_K 1.285 0.86
146_V 151_F 1.266 0.85
271_A 293_A 1.257 0.84
180_C 186_I 1.251 0.84
275_L 292_M 1.244 0.83
61_D 64_R 1.24 0.83
65_E 152_R 1.239 0.83
71_I 143_A 1.228 0.82
21_L 36_F 1.215 0.81
33_R 299_I 1.212 0.81
115_N 118_L 1.211 0.81
258_A 265_N 1.197 0.80
178_Q 182_G 1.196 0.80
70_L 88_A 1.195 0.80
94_H 125_Q 1.195 0.80
12_L 91_L 1.18 0.78
116_R 119_L 1.177 0.78
54_K 80_H 1.17 0.77
288_T 315_T 1.169 0.77
177_A 209_L 1.168 0.77
199_H 203_A 1.165 0.77
45_M 87_V 1.164 0.77
266_D 284_D 1.164 0.77
7_T 10_P 1.162 0.77
220_V 261_Y 1.151 0.76
61_D 164_L 1.143 0.75
69_T 96_V 1.136 0.75
58_L 61_D 1.118 0.73
162_N 197_G 1.112 0.72
154_Y 162_N 1.11 0.72
83_Q 319_P 1.1 0.71
189_V 311_L 1.098 0.71
256_Y 294_G 1.092 0.70
296_I 300_S 1.09 0.70
89_A 95_C 1.088 0.70
75_A 83_Q 1.077 0.69
96_V 127_E 1.073 0.68
268_G 272_V 1.065 0.68
26_R 278_L 1.065 0.68
145_R 149_Q 1.061 0.67
270_E 300_S 1.058 0.67
59_A 87_V 1.058 0.67
62_A 93_L 1.056 0.67
285_P 321_L 1.054 0.66
196_A 231_V 1.052 0.66
190_V 295_L 1.049 0.66
33_R 308_G 1.048 0.66
170_V 204_V 1.046 0.66
53_R 175_E 1.044 0.65
75_A 100_E 1.043 0.65
114_G 118_L 1.042 0.65
24_L 279_E 1.04 0.65
26_R 29_D 1.038 0.65
214_E 248_A 1.037 0.65
89_A 122_F 1.033 0.64
68_D 153_P 1.032 0.64
101_N 104_G 1.03 0.64
174_L 281_I 1.029 0.64
266_D 270_E 1.025 0.63
75_A 221_S 1.024 0.63
200_A 231_V 1.022 0.63
85_A 95_C 1.018 0.62
46_A 83_Q 1.016 0.62
288_T 314_H 1.016 0.62
139_L 143_A 1.014 0.62
75_A 158_V 1.014 0.62
96_V 125_Q 1.014 0.62
16_G 42_V 1.012 0.62
40_D 220_V 1.01 0.62
222_R 257_F 1.007 0.61
38_K 175_E 1.005 0.61
40_D 169_Y 1.004 0.61
225_A 229_P 1.001 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1f2dA40.98781000.44Contact Map0.741
4d9bA411000.452Contact Map0.786
1tzjA40.99091000.454Contact Map0.807
1j0aA30.96341000.484Contact Map0.779
3aeyA20.93291000.58Contact Map0.651
2d1fA20.9361000.585Contact Map0.681
2gn0A40.92681000.585Contact Map0.618
2zsjA40.93291000.587Contact Map0.635
3l6bA10.92681000.59Contact Map0.535
4h27A10.93291000.591Contact Map0.581
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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