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OPENSEQ.org
PAAX - Transcriptional repressor PaaX
UniProt: P76086 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13746
Length: 316 (302)
Sequences: 337
Seq/Len: 1.12
PAAX
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_Y 260_A 2.912 1.00
29_D 229_Q 2.053 0.97
196_N 256_A 1.708 0.90
234_H 237_R 1.652 0.87
209_L 228_I 1.644 0.87
29_D 268_Y 1.642 0.87
295_S 299_Q 1.492 0.79
6_T 13_N 1.479 0.78
251_L 255_W 1.439 0.76
9_Q 14_A 1.406 0.73
23_I 57_V 1.398 0.73
21_S 99_Y 1.397 0.73
84_S 198_M 1.39 0.72
41_G 78_R 1.389 0.72
234_H 241_L 1.385 0.72
51_G 112_L 1.382 0.71
237_R 241_L 1.382 0.71
124_A 236_Y 1.379 0.71
2_S 9_Q 1.371 0.70
14_A 295_S 1.358 0.69
98_I 238_R 1.357 0.69
130_L 135_F 1.342 0.68
99_Y 257_G 1.324 0.67
143_M 202_F 1.323 0.67
2_S 292_A 1.321 0.66
29_D 79_S 1.311 0.65
97_K 230_L 1.307 0.65
27_Y 57_V 1.297 0.64
69_W 241_L 1.295 0.64
22_L 135_F 1.291 0.64
5_D 13_N 1.278 0.63
27_Y 36_G 1.272 0.62
39_W 78_R 1.272 0.62
222_P 277_A 1.268 0.62
291_P 297_Y 1.267 0.62
100_R 161_G 1.267 0.62
59_T 279_V 1.266 0.62
11_A 14_A 1.26 0.61
6_T 9_Q 1.26 0.61
2_S 6_T 1.255 0.61
36_G 61_L 1.254 0.60
201_T 253_A 1.251 0.60
285_T 291_P 1.249 0.60
98_I 126_V 1.244 0.59
128_K 145_S 1.241 0.59
69_W 99_Y 1.239 0.59
25_S 234_H 1.229 0.58
109_K 172_Q 1.229 0.58
99_Y 234_H 1.223 0.58
207_R 259_T 1.217 0.57
2_S 13_N 1.214 0.57
69_W 234_H 1.214 0.57
9_Q 13_N 1.211 0.56
40_L 81_Y 1.21 0.56
40_L 57_V 1.203 0.56
39_W 42_S 1.2 0.55
94_A 240_V 1.199 0.55
2_S 15_V 1.198 0.55
47_L 261_R 1.193 0.55
29_D 77_R 1.19 0.54
22_L 157_L 1.186 0.54
136_G 145_S 1.185 0.54
185_R 195_Q 1.184 0.54
292_A 296_L 1.182 0.54
29_D 234_H 1.18 0.53
295_S 298_F 1.179 0.53
114_L 139_A 1.178 0.53
194_E 266_N 1.17 0.53
27_Y 61_L 1.166 0.52
7_F 14_A 1.161 0.52
61_L 83_L 1.161 0.52
76_G 80_F 1.158 0.51
108_G 252_P 1.153 0.51
298_F 303_G 1.15 0.51
114_L 142_L 1.149 0.51
11_A 297_Y 1.142 0.50
24_S 64_L 1.141 0.50
59_T 268_Y 1.138 0.49
83_L 201_T 1.138 0.49
136_G 202_F 1.136 0.49
229_Q 268_Y 1.135 0.49
99_Y 237_R 1.13 0.49
24_S 241_L 1.128 0.49
294_G 298_F 1.125 0.48
2_S 287_V 1.118 0.48
61_L 72_V 1.117 0.47
69_W 160_A 1.116 0.47
26_L 106_W 1.115 0.47
207_R 212_L 1.112 0.47
5_D 9_Q 1.111 0.47
107_D 250_L 1.11 0.47
287_V 292_A 1.11 0.47
66_K 175_L 1.11 0.47
132_W 255_W 1.108 0.47
7_F 11_A 1.105 0.46
274_A 277_A 1.103 0.46
36_G 210_V 1.103 0.46
94_A 132_W 1.103 0.46
21_S 234_H 1.1 0.46
9_Q 287_V 1.096 0.45
3_K 292_A 1.093 0.45
60_A 237_R 1.089 0.45
218_D 249_E 1.087 0.45
5_D 14_A 1.087 0.45
43_L 74_R 1.085 0.44
28_G 237_R 1.084 0.44
98_I 236_Y 1.082 0.44
17_V 38_I 1.082 0.44
2_S 116_E 1.081 0.44
76_G 79_S 1.079 0.44
9_Q 292_A 1.078 0.44
64_L 241_L 1.077 0.44
84_S 155_T 1.077 0.44
25_S 100_R 1.076 0.44
61_L 70_L 1.075 0.43
94_A 234_H 1.075 0.43
2_S 5_D 1.073 0.43
195_Q 256_A 1.072 0.43
103_Q 201_T 1.071 0.43
27_Y 62_F 1.071 0.43
42_S 250_L 1.07 0.43
25_S 175_L 1.07 0.43
99_Y 241_L 1.068 0.43
69_W 90_L 1.062 0.42
40_L 77_R 1.059 0.42
59_T 94_A 1.057 0.42
91_T 94_A 1.057 0.42
11_A 293_P 1.057 0.42
3_K 10_H 1.052 0.41
94_A 268_Y 1.051 0.41
79_S 268_Y 1.05 0.41
13_N 292_A 1.049 0.41
287_V 295_S 1.049 0.41
294_G 299_Q 1.048 0.41
163_A 197_A 1.048 0.41
2_S 14_A 1.045 0.41
13_N 297_Y 1.045 0.41
11_A 227_H 1.043 0.40
37_E 108_G 1.042 0.40
81_Y 225_A 1.042 0.40
153_V 240_V 1.041 0.40
208_P 212_L 1.037 0.40
263_L 268_Y 1.036 0.40
7_F 16_P 1.035 0.40
26_L 257_G 1.035 0.40
32_S 98_I 1.034 0.40
94_A 136_G 1.028 0.39
40_L 61_L 1.027 0.39
41_G 48_E 1.026 0.39
138_L 232_L 1.026 0.39
161_G 270_R 1.022 0.39
231_L 241_L 1.018 0.38
29_D 69_W 1.017 0.38
25_S 30_S 1.017 0.38
23_I 79_S 1.016 0.38
104_P 230_L 1.015 0.38
83_L 136_G 1.014 0.38
21_S 69_W 1.014 0.38
26_L 48_E 1.012 0.38
113_L 129_Q 1.012 0.38
87_G 129_Q 1.01 0.37
287_V 293_P 1.01 0.37
272_A 275_A 1.01 0.37
4_L 13_N 1.005 0.37
65_N 70_L 1.005 0.37
10_H 296_L 1.004 0.37
46_L 226_F 1.002 0.37
175_L 201_T 1 0.37
94_A 115_S 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kfwX10.77221000.38Contact Map0.201
3l09A40.81651000.414Contact Map0.246
3cuoA40.294397.50.911Contact Map0.297
2co5A20.300697.40.911Contact Map0.309
3jthA20.294397.40.912Contact Map0.283
3pqkA60.303897.30.914Contact Map0.342
1hsjA20.310197.20.915Contact Map0.33
4fx0A20.414697.10.917Contact Map0.4
2e1nA20.3544970.918Contact Map0.37
2pexA20.382996.90.918Contact Map0.321
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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