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OPENSEQ.org
PAAK - Phenylacetate-coenzyme A ligase
UniProt: P76085 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13745
Length: 437 (425)
Sequences: 3992
Seq/Len: 9.39
PAAK
Paralog alert: 0.51 [within 20: 0.07] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
202_D 206_C 4.458 1.00
287_L 308_T 4.047 1.00
286_E 303_R 4.041 1.00
272_N 277_T 3.469 1.00
177_Q 207_S 3.319 1.00
173_I 207_S 2.891 1.00
267_Y 290_T 2.888 1.00
171_Q 175_D 2.868 1.00
130_D 179_D 2.791 1.00
87_V 104_G 2.776 1.00
224_K 228_R 2.668 1.00
333_I 338_N 2.509 1.00
272_N 275_D 2.493 1.00
42_R 46_A 2.43 1.00
34_Y 45_D 2.327 1.00
353_H 395_Q 2.326 1.00
133_H 178_P 2.238 1.00
196_E 229_R 2.217 1.00
15_V 19_Q 2.21 1.00
270_I 308_T 2.193 1.00
269_E 278_P 2.179 1.00
23_T 57_L 2.17 1.00
272_N 283_E 2.162 1.00
186_S 216_E 2.152 1.00
271_V 288_L 2.15 1.00
284_H 307_L 2.098 1.00
126_G 180_M 2.083 1.00
280_A 283_E 2.072 1.00
269_E 288_L 2.066 1.00
252_C 260_T 2.049 1.00
263_E 319_R 1.96 1.00
350_K 399_R 1.957 1.00
31_K 35_E 1.903 1.00
50_H 53_D 1.903 1.00
350_K 403_M 1.9 1.00
130_D 209_R 1.875 1.00
393_C 397_R 1.854 1.00
69_Q 73_D 1.836 1.00
23_T 27_K 1.814 1.00
268_P 287_L 1.791 1.00
269_E 290_T 1.79 1.00
310_L 321_M 1.783 1.00
174_R 201_G 1.758 1.00
60_L 267_Y 1.739 1.00
272_N 279_L 1.734 1.00
398_H 402_S 1.73 1.00
83_P 86_Q 1.69 1.00
351_F 399_R 1.675 1.00
179_D 209_R 1.668 1.00
233_T 256_T 1.66 1.00
113_W 245_G 1.658 1.00
363_N 431_L 1.646 1.00
309_R 322_D 1.624 1.00
308_T 324_I 1.618 1.00
34_Y 51_P 1.616 1.00
269_E 301_R 1.615 1.00
67_T 70_D 1.612 1.00
287_L 321_M 1.581 1.00
111_D 153_R 1.568 1.00
32_H 36_N 1.567 1.00
17_E 20_A 1.558 1.00
151_A 158_V 1.556 1.00
45_D 50_H 1.546 1.00
183_V 188_C 1.536 1.00
268_P 289_F 1.525 1.00
290_T 301_R 1.516 1.00
219_T 222_M 1.515 1.00
345_E 427_R 1.512 1.00
54_F 63_F 1.497 1.00
132_I 151_A 1.492 1.00
354_L 396_L 1.485 1.00
19_Q 58_S 1.483 1.00
15_V 263_E 1.472 1.00
41_R 45_D 1.468 1.00
391_Q 395_Q 1.467 1.00
348_I 373_V 1.466 1.00
92_A 102_V 1.465 1.00
270_I 285_G 1.423 0.99
419_P 422_E 1.419 0.99
270_I 287_L 1.417 0.99
374_K 411_M 1.41 0.99
108_N 295_E 1.406 0.99
211_G 232_I 1.402 0.99
331_M 340_F 1.4 0.99
131_K 159_I 1.399 0.99
372_S 411_M 1.39 0.99
115_N 153_R 1.386 0.99
87_V 296_A 1.385 0.99
370_S 409_D 1.384 0.99
194_E 198_Q 1.383 0.99
129_K 179_D 1.382 0.99
65_C 271_V 1.381 0.99
39_M 43_K 1.376 0.99
14_S 17_E 1.374 0.99
10_I 13_A 1.373 0.99
391_Q 394_H 1.372 0.99
390_C 393_C 1.371 0.99
284_H 309_R 1.369 0.99
31_K 52_D 1.368 0.99
126_G 156_A 1.364 0.99
159_I 178_P 1.363 0.99
418_I 425_A 1.363 0.99
225_E 229_R 1.358 0.99
273_P 286_E 1.349 0.99
28_W 32_H 1.347 0.99
394_H 398_H 1.346 0.99
281_D 312_P 1.337 0.99
132_I 156_A 1.33 0.99
108_N 112_N 1.329 0.99
161_M 168_K 1.328 0.99
121_L 212_V 1.319 0.99
279_L 283_E 1.298 0.99
270_I 279_L 1.297 0.99
130_D 156_A 1.296 0.99
59_D 62_K 1.296 0.99
174_R 202_D 1.291 0.99
23_T 54_F 1.284 0.99
220_Q 224_K 1.282 0.99
284_H 325_S 1.253 0.98
15_V 18_L 1.252 0.98
131_K 179_D 1.249 0.98
20_A 24_Q 1.249 0.98
141_F 144_G 1.248 0.98
290_T 300_I 1.248 0.98
121_L 126_G 1.248 0.98
19_Q 23_T 1.236 0.98
16_D 19_Q 1.235 0.98
218_W 234_A 1.232 0.98
271_V 278_P 1.228 0.98
279_L 282_G 1.226 0.98
13_A 18_L 1.225 0.98
180_M 210_V 1.221 0.98
82_V 86_Q 1.219 0.98
201_G 206_C 1.21 0.98
106_T 109_D 1.206 0.98
309_R 323_R 1.201 0.98
170_A 191_L 1.189 0.97
291_T 296_A 1.186 0.97
131_K 157_T 1.179 0.97
67_T 305_R 1.178 0.97
268_P 308_T 1.175 0.97
53_D 62_K 1.17 0.97
107_Q 111_D 1.169 0.97
23_T 56_E 1.167 0.97
88_V 107_Q 1.167 0.97
29_T 33_A 1.16 0.97
372_S 413_V 1.152 0.97
374_K 430_D 1.149 0.97
240_L 304_T 1.148 0.97
359_Q 429_F 1.143 0.97
127_S 130_D 1.134 0.96
360_L 371_L 1.131 0.96
11_E 316_R 1.13 0.96
30_L 300_I 1.13 0.96
24_Q 28_W 1.124 0.96
174_R 206_C 1.122 0.96
347_E 404_V 1.12 0.96
174_R 205_G 1.12 0.96
140_L 144_G 1.119 0.96
240_L 248_V 1.117 0.96
43_K 46_A 1.113 0.96
143_G 146_G 1.107 0.96
260_T 315_A 1.105 0.96
399_R 402_S 1.102 0.96
265_H 293_T 1.101 0.96
15_V 319_R 1.089 0.95
361_E 374_K 1.087 0.95
363_N 372_S 1.081 0.95
80_F 104_G 1.073 0.95
331_M 338_N 1.07 0.95
101_T 241_S 1.069 0.94
136_Y 182_M 1.069 0.94
288_L 301_R 1.066 0.94
208_L 211_G 1.066 0.94
393_C 412_I 1.065 0.94
203_A 206_C 1.065 0.94
173_I 178_P 1.062 0.94
43_K 70_D 1.062 0.94
87_V 106_T 1.06 0.94
27_K 55_R 1.054 0.94
43_K 47_A 1.052 0.94
332_L 371_L 1.05 0.94
133_H 169_Q 1.047 0.94
178_P 207_S 1.044 0.94
34_Y 41_R 1.041 0.93
122_R 127_S 1.04 0.93
305_R 328_S 1.039 0.93
28_W 31_K 1.038 0.93
357_H 420_R 1.036 0.93
13_A 17_E 1.035 0.93
131_K 178_P 1.034 0.93
363_N 370_S 1.029 0.93
359_Q 374_K 1.027 0.93
374_K 413_V 1.025 0.93
353_H 378_K 1.023 0.93
34_Y 50_H 1.023 0.93
168_K 171_Q 1.023 0.93
93_S 103_V 1.023 0.93
13_A 21_L 1.021 0.93
376_E 418_I 1.018 0.92
124_A 212_V 1.017 0.92
334_I 339_V 1.015 0.92
55_R 59_D 1.015 0.92
262_W 318_M 1.014 0.92
165_Q 171_Q 1.014 0.92
214_G 237_I 1.012 0.92
91_H 241_S 1.01 0.92
33_A 300_I 1.008 0.92
151_A 156_A 1.007 0.92
109_D 244_M 1.006 0.92
167_E 201_G 1.002 0.92
364_R 369_D 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2y27A20.9841000.228Contact Map0.791
2y4oA20.99311000.23Contact Map0.779
3qovA40.98631000.235Contact Map0.794
3tsyA10.93141000.461Contact Map0.737
3ni2A10.94741000.462Contact Map0.716
3etcA20.92221000.463Contact Map0.782
2v7bA20.92221000.466Contact Map0.681
4lgcA10.90851000.47Contact Map0.686
1pg4A20.93591000.471Contact Map0.724
1mdbA10.93821000.471Contact Map0.709
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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