OPENSEQ.org - PAAD - ECOLI GREMLIN

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PAAD - Putative 1,2-phenylacetyl-CoA epoxidase, subunit D

UniProt:	P76080	Sequence MQRLATIAPPQVHEIWALLSQIPDPEIPVLTITDLGMVRNVTQMGEGWVIGFTPTYSGCPATEHLIGAIREAMTTNGFTPVQVVLQLDPAWTTDWMTPDARERLREYGISPPAGHSCHAHLPPEVRCPRCASVHTTLISEFGSTACKALYRCDSCREPFDYFKCI	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG13738
Length:	165 (157)
Sequences:	332
Seq/Len:	2.11

PAAD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
134_H	154_S	3.003	1.00
143_S	160_D	2.752	1.00
37_M	65_L	2.381	1.00
34_D	103_R	2.258	1.00
30_L	37_M	2.239	1.00
137_L	140_E	1.904	0.99
32_I	65_L	1.898	0.99
136_T	151_R	1.881	0.98
29_V	107_Y	1.876	0.98
32_I	38_V	1.795	0.98
136_T	153_D	1.738	0.97
19_L	38_V	1.719	0.97
102_E	105_R	1.703	0.97
44_M	49_V	1.696	0.96
34_D	100_A	1.659	0.96
52_F	69_I	1.656	0.96
27_I	107_Y	1.64	0.96
52_F	62_T	1.632	0.95
33_T	38_V	1.559	0.94
18_L	72_A	1.492	0.92
100_A	129_R	1.48	0.91
102_E	106_E	1.463	0.91
143_S	162_F	1.427	0.89
32_I	52_F	1.412	0.88
49_V	82_Q	1.403	0.88
97_T	100_A	1.4	0.88
49_V	84_V	1.386	0.87
143_S	147_K	1.376	0.87
30_L	96_M	1.373	0.86
18_L	76_N	1.361	0.86
32_I	86_Q	1.355	0.85
17_A	21_Q	1.352	0.85
99_D	103_R	1.325	0.84
134_H	153_D	1.294	0.82
147_K	160_D	1.286	0.81
118_H	121_L	1.264	0.79
19_L	33_T	1.26	0.79
75_T	97_T	1.254	0.79
114_G	119_A	1.251	0.78
39_R	53_T	1.236	0.77
57_S	95_W	1.212	0.75
21_Q	72_A	1.203	0.75
39_R	95_W	1.178	0.72
115_H	121_L	1.16	0.71
20_S	99_D	1.156	0.70
40_N	51_G	1.155	0.70
66_I	85_L	1.147	0.69
53_T	95_W	1.134	0.68
93_T	160_D	1.129	0.68
37_M	52_F	1.123	0.67
47_G	82_Q	1.103	0.65
15_I	18_L	1.099	0.65
18_L	65_L	1.082	0.63
19_L	31_T	1.077	0.62
56_Y	139_S	1.069	0.62
53_T	157_E	1.067	0.61
147_K	162_F	1.067	0.61
115_H	119_A	1.064	0.61
69_I	164_C	1.058	0.60
92_T	95_W	1.056	0.60
68_A	97_T	1.055	0.60
57_S	147_K	1.055	0.60
70_R	74_T	1.054	0.60
27_I	63_E	1.048	0.59
39_R	57_S	1.048	0.59
34_D	42_T	1.046	0.59
89_P	157_E	1.046	0.59
13_H	17_A	1.036	0.58
23_P	72_A	1.027	0.57
68_A	71_E	1.026	0.57
18_L	78_F	1.021	0.56
147_K	157_E	1.019	0.56
52_F	90_A	1.018	0.56
126_R	133_V	1.017	0.56
104_L	111_P	1.009	0.55
53_T	56_Y	1.008	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3lnoA	6	0.6182	99.9	0.683	Contact Map	0.465
3cq1A	1	0.6182	99.9	0.692	Contact Map	0.474
1uwdA	1	0.6061	99.9	0.693	Contact Map	0.346
3ux2A	1	0.7212	99.9	0.722	Contact Map	0.194
4esjA	2	0.4303	90.9	0.931	Contact Map	0.332
1k81A	1	0.2182	77	0.943	Contact Map	0.19
1wiiA	1	0.3697	62	0.949	Contact Map	0.216
1qypA	1	0.2848	59.4	0.949	Contact Map	0.451
1tfiA	1	0.2667	58.9	0.949	Contact Map	0.775
1k82A	4	0.6182	53.3	0.951	Contact Map	0.211

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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