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OPENSEQ.org
NAGZ - Beta-hexosaminidase
UniProt: P75949 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13433
Length: 341 (290)
Sequences: 1974
Seq/Len: 6.81
NAGZ
Paralog alert: 0.18 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_L 146_A 4.382 1.00
185_P 188_E 3.709 1.00
233_T 237_Q 3.248 1.00
98_Q 151_D 3.069 1.00
162_G 206_L 3.008 1.00
231_L 245_I 2.993 1.00
190_R 238_E 2.978 1.00
105_A 156_A 2.86 1.00
186_Q 190_R 2.715 1.00
154_H 160_T 2.601 1.00
150_I 160_T 2.579 1.00
121_L 162_G 2.521 1.00
154_H 207_D 2.464 1.00
76_T 107_E 2.453 1.00
260_S 263_E 2.405 1.00
98_Q 155_E 2.391 1.00
247_S 273_C 2.365 1.00
228_P 233_T 2.342 1.00
115_I 208_A 2.115 1.00
175_S 180_P 2.037 1.00
161_T 208_A 2.025 1.00
211_P 225_S 2.004 1.00
46_V 59_V 1.925 1.00
101_G 149_F 1.921 1.00
59_V 113_I 1.919 1.00
97_A 145_I 1.916 1.00
250_L 276_I 1.848 1.00
228_P 232_K 1.819 1.00
186_Q 238_E 1.781 1.00
231_L 273_C 1.747 1.00
19_E 23_H 1.742 1.00
18_R 48_Q 1.723 1.00
27_G 275_M 1.709 1.00
5_M 60_A 1.692 1.00
136_H 141_K 1.683 1.00
268_S 273_C 1.654 1.00
168_H 175_S 1.592 1.00
153_M 160_T 1.582 1.00
117_F 277_L 1.577 1.00
184_R 188_E 1.558 0.99
148_R 152_G 1.539 0.99
95_K 98_Q 1.488 0.99
211_P 231_L 1.487 0.99
266_Q 291_N 1.472 0.99
162_G 209_I 1.463 0.99
176_H 252_M 1.459 0.99
204_N 241_F 1.458 0.99
44_E 48_Q 1.457 0.99
190_R 198_S 1.44 0.99
247_S 268_S 1.428 0.99
229_Y 233_T 1.425 0.99
281_N 284_G 1.423 0.99
29_L 49_I 1.423 0.99
82_Q 86_A 1.416 0.99
31_L 46_V 1.412 0.99
176_H 213_H 1.396 0.99
117_F 246_F 1.385 0.99
201_I 204_N 1.382 0.99
116_S 153_M 1.378 0.98
101_G 153_M 1.371 0.98
105_A 153_M 1.364 0.98
102_W 156_A 1.356 0.98
255_A 264_R 1.354 0.98
201_I 239_L 1.353 0.98
50_R 57_L 1.351 0.98
209_I 235_L 1.347 0.98
149_F 153_M 1.335 0.98
201_I 209_I 1.329 0.98
160_T 207_D 1.325 0.98
107_E 110_A 1.322 0.98
150_I 206_L 1.319 0.98
60_A 117_F 1.315 0.98
123_V 142_A 1.312 0.98
140_Q 195_S 1.297 0.97
151_D 203_E 1.291 0.97
147_S 203_E 1.289 0.97
198_S 239_L 1.288 0.97
229_Y 234_V 1.275 0.97
82_Q 124_G 1.27 0.97
185_P 218_D 1.266 0.97
129_A 168_H 1.263 0.97
266_Q 270_D 1.26 0.97
43_R 47_R 1.255 0.97
263_E 267_A 1.254 0.97
50_R 53_S 1.252 0.97
37_H 41_Q 1.251 0.97
36_Y 42_L 1.25 0.97
60_A 115_I 1.244 0.97
127_S 171_V 1.242 0.97
11_Y 37_H 1.231 0.96
198_S 202_R 1.226 0.96
220_D 229_Y 1.225 0.96
143_L 199_S 1.224 0.96
199_S 202_R 1.199 0.96
46_V 113_I 1.197 0.95
140_Q 144_A 1.19 0.95
130_I 168_H 1.173 0.95
265_G 276_I 1.169 0.95
50_R 56_R 1.166 0.95
18_R 22_A 1.165 0.95
40_A 44_E 1.158 0.94
195_S 199_S 1.146 0.94
28_G 277_L 1.144 0.94
269_L 292_L 1.139 0.94
87_L 145_I 1.138 0.94
124_G 128_A 1.138 0.94
67_R 132_E 1.134 0.93
146_A 197_F 1.132 0.93
259_G 267_A 1.132 0.93
138_D 141_K 1.131 0.93
87_L 96_L 1.13 0.93
49_I 57_L 1.129 0.93
168_H 212_A 1.125 0.93
187_A 191_A 1.121 0.93
42_L 111_M 1.119 0.93
40_A 43_R 1.119 0.93
5_M 275_M 1.118 0.93
84_F 100_A 1.11 0.92
220_D 227_S 1.105 0.92
213_H 252_M 1.103 0.92
7_D 249_D 1.092 0.92
98_Q 102_W 1.09 0.92
147_S 150_I 1.09 0.92
78_L 100_A 1.085 0.91
194_M 234_V 1.085 0.91
224_A 230_W 1.076 0.91
152_G 156_A 1.068 0.90
21_L 53_S 1.061 0.90
75_F 111_M 1.056 0.90
123_V 192_K 1.054 0.90
102_W 155_E 1.054 0.90
253_E 257_I 1.051 0.89
150_I 154_H 1.046 0.89
141_K 144_A 1.046 0.89
222_R 267_A 1.041 0.89
143_L 147_S 1.037 0.89
123_V 139_P 1.023 0.88
159_K 207_D 1.02 0.88
179_T 215_I 1.02 0.88
246_F 275_M 1.017 0.87
199_S 203_E 1.015 0.87
102_W 106_S 1.014 0.87
39_P 75_F 1.011 0.87
150_I 200_L 1.008 0.87
162_G 200_L 1.008 0.87
237_Q 240_G 1.008 0.87
173_A 178_E 1.006 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gvfA211000.146Contact Map0.762
2oxnA10.97951000.182Contact Map0.731
4g6cA20.96481000.211Contact Map0.712
3tevA20.94131000.218Contact Map0.734
3bmxA20.97951000.252Contact Map0.814
3sqlA20.97651000.278Contact Map0.744
1x38A10.94131000.346Contact Map0.681
3rrxA10.93841000.369Contact Map0.6
3u48A20.9151000.38Contact Map0.652
4i3gA20.9151000.445Contact Map0.724
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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