May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YLII - Soluble aldose sugar dehydrogenase YliI
UniProt: P75804 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13480
Length: 371 (347)
Sequences: 2399
Seq/Len: 6.91
YLII
Paralog alert: 0.36 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
187_T 191_E 4.409 1.00
99_R 119_Y 4.188 1.00
117_V 162_I 3.974 1.00
91_A 97_S 3.784 1.00
307_K 320_V 3.507 1.00
210_S 213_I 3.263 1.00
248_K 278_E 3.262 1.00
222_N 227_A 3.018 1.00
43_L 50_L 2.946 1.00
155_D 161_F 2.899 1.00
348_G 354_Y 2.821 1.00
309_F 353_L 2.799 1.00
159_Y 187_T 2.642 1.00
245_Q 248_K 2.632 1.00
42_F 349_P 2.497 1.00
221_M 228_L 2.376 1.00
348_G 352_Y 2.188 1.00
25_V 301_F 2.164 1.00
222_N 225_S 2.161 1.00
28_E 368_S 2.147 1.00
53_L 57_E 2.109 1.00
307_K 322_S 2.097 1.00
47_H 60_H 2.078 1.00
297_N 347_T 2.039 1.00
58_L 102_L 1.935 1.00
255_A 279_Q 1.926 1.00
192_I 195_D 1.922 1.00
183_L 230_L 1.889 1.00
118_G 132_F 1.883 1.00
134_T 137_R 1.881 1.00
230_L 244_P 1.869 1.00
241_I 308_L 1.825 1.00
93_D 96_Q 1.824 1.00
117_V 152_L 1.817 1.00
91_A 188_D 1.815 1.00
155_D 159_Y 1.802 1.00
223_P 295_F 1.8 1.00
296_Y 309_F 1.77 1.00
255_A 274_V 1.76 1.00
102_L 120_G 1.709 1.00
156_G 221_M 1.676 1.00
227_A 243_I 1.667 1.00
255_A 277_T 1.665 1.00
93_D 97_S 1.655 1.00
174_Q 249_N 1.653 1.00
300_K 369_P 1.632 1.00
51_I 61_W 1.624 1.00
295_F 308_L 1.584 1.00
294_A 345_V 1.557 1.00
317_D 333_R 1.552 0.99
119_Y 133_R 1.543 0.99
92_P 154_F 1.539 0.99
356_L 364_L 1.536 0.99
219_M 230_L 1.529 0.99
299_D 305_Q 1.523 0.99
216_P 230_L 1.504 0.99
164_L 184_V 1.502 0.99
103_S 150_G 1.491 0.99
310_I 321_M 1.474 0.99
135_V 138_Q 1.472 0.99
153_V 221_M 1.449 0.99
163_A 219_M 1.449 0.99
210_S 244_P 1.448 0.99
25_V 334_I 1.446 0.99
159_Y 185_R 1.444 0.99
233_H 289_A 1.444 0.99
53_L 59_R 1.442 0.99
176_L 211_Y 1.435 0.99
355_V 367_V 1.429 0.99
99_R 121_R 1.427 0.99
40_L 356_L 1.417 0.99
29_V 32_D 1.417 0.99
322_S 329_T 1.416 0.99
40_L 346_R 1.411 0.99
42_F 49_M 1.408 0.99
241_I 310_I 1.4 0.99
293_M 308_L 1.388 0.99
30_L 364_L 1.384 0.99
222_N 295_F 1.379 0.99
312_A 315_D 1.378 0.99
37_P 53_L 1.369 0.98
161_F 228_L 1.365 0.98
318_V 345_V 1.363 0.98
213_I 232_E 1.361 0.98
59_R 70_P 1.348 0.98
121_R 131_D 1.346 0.98
42_F 354_Y 1.345 0.98
294_A 347_T 1.344 0.98
89_V 152_L 1.34 0.98
29_V 363_E 1.339 0.98
42_F 346_R 1.328 0.98
26_N 368_S 1.328 0.98
353_L 367_V 1.325 0.98
52_T 88_V 1.322 0.98
49_M 354_Y 1.321 0.98
51_I 364_L 1.313 0.98
296_Y 347_T 1.31 0.98
318_V 355_V 1.303 0.98
182_K 208_I 1.302 0.98
232_E 240_E 1.302 0.98
208_I 211_Y 1.302 0.98
198_F 211_Y 1.301 0.98
41_A 90_L 1.3 0.98
25_V 304_W 1.293 0.98
63_A 67_L 1.275 0.97
26_N 370_R 1.273 0.97
28_E 366_K 1.263 0.97
282_F 321_M 1.254 0.97
104_Y 118_G 1.24 0.97
47_H 62_Q 1.239 0.97
254_L 277_T 1.237 0.97
40_L 49_M 1.225 0.96
39_A 344_D 1.223 0.96
274_V 277_T 1.218 0.96
82_Q 85_L 1.217 0.96
300_K 352_Y 1.215 0.96
231_N 293_M 1.212 0.96
117_V 135_V 1.21 0.96
352_Y 366_K 1.209 0.96
260_N 264_F 1.208 0.96
74_V 77_V 1.2 0.96
31_Q 61_W 1.191 0.95
242_N 250_Y 1.19 0.95
185_R 207_E 1.19 0.95
34_L 37_P 1.189 0.95
194_D 202_S 1.187 0.95
209_W 246_K 1.186 0.95
58_L 88_V 1.183 0.95
67_L 70_P 1.181 0.95
220_A 295_F 1.177 0.95
335_L 367_V 1.164 0.95
257_W 283_Y 1.163 0.95
153_V 219_M 1.153 0.94
120_G 132_F 1.148 0.94
27_V 365_L 1.143 0.94
176_L 204_A 1.142 0.94
296_Y 302_P 1.138 0.94
155_D 221_M 1.134 0.94
232_E 242_N 1.13 0.93
229_W 281_V 1.123 0.93
63_A 66_G 1.113 0.93
117_V 186_L 1.108 0.93
151_R 163_A 1.108 0.93
335_L 355_V 1.107 0.92
231_N 241_I 1.102 0.92
95_A 98_R 1.098 0.92
285_K 288_P 1.093 0.92
324_N 327_K 1.084 0.91
147_H 214_R 1.083 0.91
103_S 117_V 1.081 0.91
42_F 348_G 1.076 0.91
222_N 297_N 1.065 0.90
101_W 188_D 1.065 0.90
293_M 310_I 1.064 0.90
96_Q 194_D 1.062 0.90
31_Q 51_I 1.058 0.90
311_G 345_V 1.058 0.90
234_G 240_E 1.051 0.90
296_Y 301_F 1.051 0.90
94_F 98_R 1.05 0.90
333_R 336_T 1.048 0.90
114_G 137_R 1.047 0.89
201_E 204_A 1.04 0.89
116_A 134_T 1.039 0.89
178_K 182_K 1.038 0.89
183_L 219_M 1.036 0.89
298_S 347_T 1.033 0.89
106_E 137_R 1.032 0.89
50_L 90_L 1.029 0.88
304_W 309_F 1.025 0.88
27_V 367_V 1.023 0.88
209_W 244_P 1.018 0.88
91_A 98_R 1.017 0.88
50_L 100_I 1.008 0.87
43_L 47_H 1.006 0.87
187_T 200_K 1.006 0.87
161_F 209_W 1.005 0.87
269_A 272_E 1.004 0.87
37_P 51_I 1.001 0.86
228_L 244_P 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1cruA20.95961000.301Contact Map0.805
2wg3C20.86791000.324Contact Map0.66
2g8sA20.94881000.327Contact Map0.796
3a9gA10.91911000.428Contact Map0.818
2ismA20.89761000.466Contact Map0.874
3dasA10.87871000.5Contact Map0.777
1rwiB20.698199.70.813Contact Map0.763
3s94A20.81499.70.813Contact Map0.769
1pjxA10.754799.60.817Contact Map0.794
4hw6A40.81499.60.825Contact Map0.81
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.9207 seconds.