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OPENSEQ.org

YEFM - Antitoxin YefM
UniProt: P69346 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12844
Length: 83 (83)
Sequences: 491
Seq/Len: 5.92

YEFM
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_H 44_E 2.895 1.00
42_L 46_N 2.336 1.00
36_A 42_L 2.269 1.00
7_S 10_R 2.222 1.00
9_A 16_T 2.196 1.00
17_M 37_C 2.14 1.00
29_I 39_L 1.913 1.00
48_L 52_A 1.761 1.00
45_Y 48_L 1.724 1.00
9_A 13_L 1.695 1.00
9_A 29_I 1.695 1.00
52_A 56_R 1.597 0.99
17_M 39_L 1.517 0.99
10_R 14_S 1.486 0.99
19_K 23_D 1.433 0.98
40_M 45_Y 1.404 0.98
61_A 64_L 1.375 0.98
54_L 60_N 1.373 0.98
79_K 82_I 1.362 0.98
18_M 31_R 1.357 0.98
69_D 73_S 1.345 0.97
12_N 15_A 1.308 0.97
59_A 63_R 1.245 0.96
60_N 64_L 1.232 0.95
10_R 32_Q 1.225 0.95
66_D 70_S 1.206 0.94
28_L 42_L 1.205 0.94
38_V 41_S 1.205 0.94
22_E 35_E 1.203 0.94
71_L 76_G 1.195 0.94
26_P 45_Y 1.188 0.94
2_R 47_S 1.168 0.93
2_R 42_L 1.159 0.93
29_I 37_C 1.157 0.93
4_I 9_A 1.156 0.93
78_E 83_E 1.145 0.92
55_L 61_A 1.132 0.92
38_V 45_Y 1.125 0.91
47_S 51_T 1.118 0.91
60_N 63_R 1.088 0.89
24_H 43_E 1.074 0.88
57_S 60_N 1.043 0.86
54_L 61_A 1.021 0.85
3_T 28_L 1.014 0.84
4_I 8_E 1.006 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a6qA4199.80.297Contact Map0.784
3d55A40.975999.80.304Contact Map0.835
3g5oA2199.70.359Contact Map0.725
2odkA40.927799.50.455Contact Map0.749
3hryA30.867599.20.548Contact Map0.815
3hs2A80.6988990.57Contact Map0.748
3k6qA40.9759990.582Contact Map0.695
3dboA10.939898.80.603Contact Map0.451
4m7cA20.433790.911Contact Map0.381
3bpqA20.56638.30.912Contact Map0.893

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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