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OPENSEQ.org
YHCM - Uncharacterized protein YhcM
UniProt: P64612 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12819
Length: 375 (369)
Sequences: 1056
Seq/Len: 2.86
YHCM
Paralog alert: 0.13 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_D 199_K 7.46 1.00
95_L 139_V 4.146 1.00
274_S 302_D 3.606 1.00
131_D 166_R 3.391 1.00
33_E 37_Q 3.253 1.00
269_Q 296_H 3.226 1.00
34_I 38_E 2.976 1.00
31_R 203_D 2.847 1.00
303_V 333_V 2.771 1.00
196_D 199_K 2.478 1.00
229_H 232_T 2.453 1.00
134_K 168_I 2.397 1.00
280_V 313_E 2.325 1.00
274_S 277_T 2.3 1.00
272_A 301_F 2.198 1.00
11_L 26_K 2.196 1.00
115_E 132_R 2.162 1.00
185_G 188_R 2.118 1.00
255_E 260_P 2.08 1.00
236_M 299_M 2.048 1.00
224_W 335_A 2.047 1.00
6_P 36_Y 1.84 0.99
182_Y 185_G 1.817 0.99
146_F 176_I 1.815 0.99
182_Y 188_R 1.794 0.99
180_E 183_R 1.784 0.99
320_L 324_F 1.761 0.99
236_M 334_S 1.743 0.99
300_L 331_L 1.732 0.98
291_L 298_V 1.731 0.98
224_W 333_V 1.726 0.98
21_P 26_K 1.725 0.98
305_V 337_V 1.722 0.98
289_I 323_E 1.704 0.98
112_V 155_L 1.674 0.98
116_L 126_L 1.629 0.97
163_L 168_I 1.627 0.97
101_Q 111_R 1.626 0.97
92_Y 100_K 1.611 0.97
339_L 356_L 1.593 0.97
111_R 115_E 1.59 0.97
298_V 324_F 1.561 0.96
235_Q 239_L 1.553 0.96
277_T 281_D 1.552 0.96
178_P 204_V 1.534 0.96
279_C 320_L 1.519 0.96
192_L 196_D 1.516 0.96
99_R 138_D 1.509 0.95
253_T 260_P 1.506 0.95
237_D 272_A 1.481 0.95
115_E 136_E 1.476 0.95
7_T 11_L 1.468 0.94
77_W 177_P 1.464 0.94
261_L 291_L 1.454 0.94
9_Q 13_A 1.449 0.94
263_T 273_V 1.447 0.94
243_L 299_M 1.445 0.94
147_V 156_L 1.439 0.94
176_I 350_F 1.426 0.93
235_Q 238_K 1.402 0.93
236_M 301_F 1.4 0.92
113_H 152_D 1.396 0.92
96_P 100_K 1.372 0.91
276_T 280_V 1.363 0.91
254_L 295_F 1.353 0.91
278_L 300_L 1.347 0.90
290_A 293_R 1.338 0.90
85_T 326_E 1.338 0.90
335_A 342_I 1.337 0.90
42_S 71_V 1.329 0.90
300_L 320_L 1.319 0.89
142_F 172_A 1.307 0.89
124_D 158_G 1.306 0.89
137_T 140_L 1.298 0.88
5_T 33_E 1.294 0.88
225_L 232_T 1.293 0.88
282_A 326_E 1.291 0.88
338_P 341_E 1.282 0.87
78_G 81_G 1.281 0.87
343_Y 351_E 1.269 0.87
354_R 357_S 1.269 0.87
354_R 358_R 1.269 0.87
111_R 136_E 1.266 0.86
265_G 272_A 1.265 0.86
145_F 172_A 1.257 0.86
315_R 351_E 1.254 0.86
253_T 262_A 1.241 0.85
233_R 302_D 1.232 0.84
106_H 197_A 1.231 0.84
337_V 341_E 1.216 0.83
304_P 313_E 1.206 0.83
101_Q 136_E 1.199 0.82
170_L 202_C 1.196 0.82
14_L 21_P 1.186 0.81
270_T 296_H 1.183 0.81
160_M 194_A 1.173 0.80
266_V 295_F 1.171 0.80
364_S 367_Y 1.168 0.80
22_D 25_Q 1.167 0.80
13_A 19_H 1.166 0.80
131_D 162_A 1.163 0.79
318_I 352_F 1.163 0.79
318_I 348_L 1.159 0.79
32_L 74_L 1.153 0.78
108_F 141_C 1.149 0.78
182_Y 187_Q 1.148 0.78
263_T 302_D 1.144 0.78
7_T 30_S 1.133 0.77
78_G 83_G 1.133 0.77
88_M 173_T 1.131 0.77
85_T 176_I 1.131 0.77
35_I 169_T 1.123 0.76
311_E 346_D 1.123 0.76
51_G 59_L 1.113 0.75
328_H 370_R 1.113 0.75
261_L 277_T 1.108 0.74
30_S 33_E 1.107 0.74
39_L 140_L 1.106 0.74
101_Q 140_L 1.105 0.74
59_L 63_R 1.101 0.74
88_M 141_C 1.1 0.74
292_S 324_F 1.097 0.73
231_E 234_A 1.083 0.72
167_G 198_I 1.08 0.72
152_D 159_L 1.076 0.71
237_D 301_F 1.075 0.71
218_L 221_A 1.074 0.71
157_G 197_A 1.074 0.71
13_A 86_W 1.072 0.71
109_M 362_M 1.071 0.71
5_T 8_S 1.068 0.71
177_P 180_E 1.067 0.70
51_G 56_V 1.066 0.70
92_Y 359_L 1.066 0.70
11_L 21_P 1.062 0.70
251_S 262_A 1.061 0.70
9_Q 12_K 1.056 0.69
89_D 102_R 1.055 0.69
115_E 285_Q 1.051 0.69
297_T 330_K 1.048 0.68
356_L 360_Q 1.045 0.68
118_A 276_T 1.04 0.68
335_A 339_L 1.038 0.67
272_A 326_E 1.031 0.67
269_Q 297_T 1.027 0.66
82_R 343_Y 1.026 0.66
146_F 319_A 1.026 0.66
28_A 79_G 1.026 0.66
361_E 367_Y 1.011 0.64
244_A 270_T 1.008 0.64
34_I 203_D 1.008 0.64
12_K 231_E 1.007 0.64
153_A 182_Y 1.007 0.64
112_V 129_I 1.006 0.64
92_Y 141_C 1.006 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2w58A20.4899.70.868Contact Map0.628
4m4wJ60.562799.60.874Contact Map0.565
3ec2A10.453399.60.881Contact Map0.39
2qgzA10.557399.50.882Contact Map0.587
3bosA20.57699.10.907Contact Map0.594
1u0jA10.538798.80.916Contact Map0.457
1tueA60.517398.70.919Contact Map0.674
2qz4A10.64898.70.92Contact Map0.267
3n70A80.38498.70.92Contact Map0.408
1lv7A10.605398.70.92Contact Map0.194
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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