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OPENSEQ.org
QUEE - 7-carboxy-7-deazaguanine synthase
UniProt: P64554 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13034
Length: 223 (219)
Sequences: 1116
Seq/Len: 5.10
QUEE
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_P 120_S 3.01 1.00
78_V 81_R 2.649 1.00
80_G 111_N 2.479 1.00
73_E 107_L 2.378 1.00
37_W 163_G 2.246 1.00
91_I 108_L 2.071 1.00
77_A 111_N 2.021 1.00
23_A 90_V 1.988 1.00
187_A 211_R 1.969 1.00
215_Q 218_K 1.951 1.00
91_I 100_D 1.922 1.00
62_K 223_A 1.895 1.00
63_E 67_W 1.884 1.00
71_S 74_D 1.844 1.00
109_E 131_T 1.767 1.00
163_G 191_I 1.754 1.00
119_T 135_V 1.71 1.00
189_Q 215_Q 1.687 1.00
74_D 77_A 1.669 0.99
21_V 114_S 1.655 0.99
10_Q 22_P 1.652 0.99
8_M 78_V 1.65 0.99
88_H 116_Q 1.645 0.99
37_W 136_S 1.64 0.99
165_V 169_E 1.61 0.99
32_P 122_T 1.599 0.99
17_Y 187_A 1.573 0.99
33_V 120_S 1.568 0.99
156_N 184_R 1.554 0.99
18_F 88_H 1.549 0.99
89_V 108_L 1.545 0.99
188_L 204_T 1.529 0.99
202_I 220_L 1.506 0.99
41_K 44_W 1.501 0.99
17_Y 157_E 1.494 0.99
28_L 101_L 1.492 0.98
107_L 111_N 1.485 0.98
26_I 79_I 1.483 0.98
19_T 216_T 1.46 0.98
106_D 109_E 1.436 0.98
23_A 116_Q 1.432 0.98
23_A 88_H 1.425 0.98
63_E 223_A 1.417 0.98
97_C 125_V 1.414 0.98
103_P 107_L 1.411 0.98
21_V 211_R 1.394 0.97
2_Q 66_K 1.38 0.97
28_L 91_I 1.344 0.97
138_K 164_R 1.343 0.97
199_R 203_E 1.34 0.96
4_P 99_H 1.339 0.96
90_V 116_Q 1.338 0.96
149_S 177_T 1.332 0.96
40_T 43_T 1.319 0.96
133_V 156_N 1.291 0.95
70_A 75_L 1.282 0.95
166_R 169_E 1.271 0.95
59_A 62_K 1.264 0.95
8_M 26_I 1.263 0.95
24_I 79_I 1.262 0.95
62_K 67_W 1.257 0.94
136_S 163_G 1.248 0.94
63_E 78_V 1.246 0.94
125_V 134_T 1.241 0.94
204_T 208_R 1.229 0.94
21_V 88_H 1.216 0.93
179_T 182_K 1.215 0.93
87_R 113_F 1.213 0.93
106_D 110_K 1.206 0.93
105_T 109_E 1.193 0.92
30_G 108_L 1.192 0.92
168_I 172_D 1.183 0.92
205_C 212_L 1.178 0.92
90_V 136_S 1.174 0.91
203_E 207_A 1.143 0.90
30_G 189_Q 1.133 0.89
3_Y 28_L 1.131 0.89
26_I 89_V 1.126 0.89
73_E 111_N 1.125 0.89
23_A 136_S 1.125 0.89
125_V 152_L 1.121 0.89
213_S 216_T 1.11 0.88
210_W 213_S 1.096 0.87
138_K 163_G 1.092 0.87
76_L 111_N 1.087 0.87
173_E 176_A 1.082 0.86
189_Q 213_S 1.081 0.86
10_Q 86_A 1.073 0.86
168_I 178_L 1.068 0.85
173_E 177_T 1.061 0.85
8_M 24_I 1.057 0.84
12_L 222_I 1.056 0.84
90_V 213_S 1.053 0.84
136_S 191_I 1.053 0.84
32_P 123_H 1.052 0.84
81_R 129_P 1.05 0.84
189_Q 192_S 1.048 0.84
12_L 220_L 1.04 0.83
77_A 81_R 1.04 0.83
214_M 218_K 1.038 0.83
76_L 107_L 1.036 0.83
73_E 77_A 1.028 0.82
11_T 223_A 1.021 0.81
154_R 182_K 1.012 0.81
18_F 116_Q 1.011 0.81
18_F 157_E 1.005 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c8fA10.847599.80.73Contact Map0.409
1tv8A20.887999.50.781Contact Map0.491
3rfaA20.887999.50.787Contact Map0.305
2yx0A10.919399.40.792Contact Map0.605
2z2uA10.919399.40.799Contact Map0.601
2qgqA80.816199.10.818Contact Map0.557
1oltA10.910399.10.821Contact Map0.384
2a5hA40.896999.10.821Contact Map0.393
4k36A20.843990.831Contact Map0.454
4jc0A20.896998.80.84Contact Map0.486
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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