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OPENSEQ.org
YEIH - UPF0324 inner membrane protein YeiH
UniProt: P62723 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12027
Length: 349 (328)
Sequences: 1128
Seq/Len: 3.44
YEIH
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
193_S 196_T 2.953 1.00
119_A 138_G 2.952 1.00
123_G 134_S 2.873 1.00
270_L 273_V 2.679 1.00
50_A 304_A 2.582 1.00
119_A 329_L 2.521 1.00
216_H 223_E 2.314 1.00
83_L 86_I 2.179 1.00
90_F 274_V 2.167 1.00
269_I 273_V 2.163 1.00
215_G 226_A 2.132 1.00
194_P 219_S 2.07 1.00
143_I 240_F 1.985 1.00
139_A 152_T 1.947 1.00
152_T 244_L 1.882 1.00
174_G 210_Q 1.827 0.99
208_V 234_V 1.784 0.99
219_S 223_E 1.767 0.99
132_H 162_K 1.729 0.99
20_L 76_A 1.725 0.99
140_G 149_V 1.711 0.99
205_V 214_A 1.678 0.99
121_F 126_V 1.665 0.99
219_S 222_A 1.661 0.99
215_G 223_E 1.628 0.98
154_P 158_A 1.557 0.98
174_G 207_E 1.556 0.97
118_L 332_W 1.542 0.97
149_V 166_A 1.523 0.97
79_Y 83_L 1.492 0.97
122_L 126_V 1.468 0.96
86_I 274_V 1.462 0.96
142_S 244_L 1.449 0.96
201_I 205_V 1.431 0.95
197_F 214_A 1.417 0.95
130_D 162_K 1.406 0.95
146_A 209_A 1.406 0.95
88_Y 147_A 1.402 0.95
107_I 203_S 1.4 0.95
76_A 80_L 1.396 0.94
119_A 142_S 1.385 0.94
113_S 117_L 1.385 0.94
46_A 300_A 1.383 0.94
185_Y 197_F 1.381 0.94
26_I 304_A 1.366 0.94
277_F 289_N 1.362 0.93
149_V 170_V 1.359 0.93
117_L 121_F 1.359 0.93
221_D 224_N 1.353 0.93
28_G 32_W 1.352 0.93
147_A 207_E 1.351 0.93
142_S 152_T 1.347 0.93
109_V 113_S 1.342 0.93
37_P 40_A 1.341 0.93
272_I 322_P 1.327 0.92
147_A 171_V 1.32 0.92
206_H 299_L 1.31 0.92
146_A 207_E 1.301 0.91
274_V 277_F 1.298 0.91
184_I 187_L 1.286 0.91
49_L 53_L 1.283 0.90
146_A 206_H 1.28 0.90
26_I 53_L 1.275 0.90
197_F 218_I 1.262 0.89
277_F 282_L 1.247 0.89
21_A 25_V 1.225 0.88
207_E 303_M 1.222 0.87
192_F 196_T 1.221 0.87
88_Y 268_A 1.221 0.87
79_Y 86_I 1.218 0.87
100_V 228_I 1.212 0.87
283_L 288_V 1.211 0.87
194_P 221_D 1.211 0.87
93_T 279_S 1.209 0.87
146_A 171_V 1.207 0.87
97_I 275_A 1.203 0.86
134_S 325_M 1.2 0.86
220_P 224_N 1.19 0.85
175_T 299_L 1.182 0.85
86_I 270_L 1.177 0.85
84_G 244_L 1.177 0.85
200_Y 204_T 1.175 0.84
98_A 102_I 1.169 0.84
107_I 112_L 1.168 0.84
174_G 234_V 1.165 0.84
115_T 142_S 1.162 0.84
273_V 277_F 1.159 0.83
261_K 266_W 1.157 0.83
200_Y 334_I 1.153 0.83
283_L 287_V 1.15 0.83
147_A 303_M 1.147 0.82
285_Q 289_N 1.142 0.82
210_Q 234_V 1.14 0.82
85_I 140_G 1.139 0.82
114_S 332_W 1.135 0.82
234_V 306_L 1.133 0.81
86_I 133_T 1.126 0.81
146_A 299_L 1.123 0.81
273_V 276_I 1.123 0.81
210_Q 237_L 1.121 0.80
172_I 315_L 1.112 0.80
175_T 206_H 1.1 0.79
172_I 327_L 1.099 0.79
264_I 269_I 1.098 0.78
33_G 49_L 1.09 0.78
81_L 136_L 1.089 0.78
207_E 210_Q 1.087 0.78
313_S 316_K 1.087 0.78
129_L 325_M 1.086 0.77
331_A 335_V 1.085 0.77
30_A 53_L 1.084 0.77
94_F 276_I 1.083 0.77
90_F 146_A 1.083 0.77
152_T 241_L 1.082 0.77
24_A 301_M 1.079 0.77
178_I 213_A 1.078 0.77
20_L 253_G 1.077 0.77
34_G 184_I 1.077 0.77
177_A 205_V 1.077 0.77
313_S 317_K 1.076 0.77
33_G 184_I 1.073 0.76
23_S 73_V 1.073 0.76
305_A 310_T 1.07 0.76
146_A 234_V 1.069 0.76
141_S 330_F 1.069 0.76
299_L 303_M 1.068 0.76
93_T 275_A 1.067 0.76
147_A 151_A 1.066 0.76
206_H 209_A 1.064 0.75
137_I 325_M 1.064 0.75
128_G 132_H 1.061 0.75
122_L 328_V 1.057 0.75
93_T 241_L 1.056 0.75
166_A 326_A 1.054 0.74
228_I 264_I 1.051 0.74
82_R 146_A 1.048 0.74
177_A 330_F 1.048 0.74
142_S 169_T 1.046 0.74
146_A 239_P 1.045 0.74
100_V 310_T 1.045 0.74
17_I 56_V 1.043 0.73
50_A 54_G 1.042 0.73
85_I 233_R 1.037 0.73
103_S 127_F 1.037 0.73
80_L 297_F 1.034 0.72
50_A 57_L 1.033 0.72
206_H 233_R 1.032 0.72
127_F 324_L 1.03 0.72
147_A 227_V 1.029 0.72
171_V 210_Q 1.024 0.71
123_G 325_M 1.02 0.71
275_A 278_N 1.02 0.71
27_T 31_L 1.018 0.71
57_L 99_D 1.017 0.71
90_F 270_L 1.016 0.70
171_V 209_A 1.013 0.70
206_H 234_V 1.013 0.70
186_P 218_I 1.012 0.70
196_T 228_I 1.01 0.70
51_I 162_K 1.001 0.69
114_S 118_L 1 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zuxA10.782295.20.933Contact Map0.179
4bwzA10.810994.90.934Contact Map0.273
1zcdA20.524470.974Contact Map0.137
2nwlA30.26932.20.98Contact Map0.406
1pw4A10.72492.10.98Contact Map0.15
3tijA10.34381.80.98Contact Map0.151
3dh4A40.29511.50.981Contact Map0.716
4h44G10.10031.20.982Contact Map0.001
2ls4A10.06881.10.983Contact Map0.007
1q90G10.10030.90.984Contact Map0.051
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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