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OPENSEQ.org
HIS1 - ATP phosphoribosyltransferase
UniProt: P60757 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10449
Length: 299 (289)
Sequences: 742
Seq/Len: 2.57
HIS1
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
123_N 145_S 4.001 1.00
98_R 192_K 2.953 1.00
139_L 146_F 2.943 1.00
233_A 241_V 2.842 1.00
119_P 138_Y 2.692 1.00
236_E 261_Q 2.648 1.00
122_L 166_A 2.637 1.00
235_T 263_V 2.553 1.00
237_R 240_E 2.524 1.00
238_L 265_M 2.363 1.00
258_G 261_Q 2.126 1.00
127_I 139_L 2.114 1.00
135_L 168_C 2.095 1.00
96_L 197_Q 2.067 1.00
137_R 141_Q 2.015 0.99
74_E 95_T 1.957 0.99
117_D 121_S 1.943 0.99
92_R 199_D 1.924 0.99
234_P 237_R 1.794 0.99
208_Q 283_A 1.784 0.98
187_V 190_R 1.78 0.98
100_D 192_K 1.773 0.98
58_I 169_D 1.771 0.98
62_V 196_I 1.76 0.98
112_V 181_G 1.701 0.98
95_T 194_C 1.687 0.98
24_L 217_I 1.624 0.97
232_H 249_E 1.622 0.97
233_A 265_M 1.619 0.97
207_Q 211_D 1.611 0.97
136_K 140_D 1.566 0.96
30_I 43_A 1.554 0.95
230_M 266_H 1.554 0.95
155_V 171_V 1.551 0.95
139_L 168_C 1.543 0.95
107_S 184_E 1.501 0.94
113_D 183_R 1.455 0.93
81_L 137_R 1.446 0.93
105_R 184_E 1.428 0.92
235_T 261_Q 1.41 0.91
107_S 171_V 1.399 0.91
243_A 283_A 1.396 0.91
171_V 216_R 1.376 0.90
104_C 191_S 1.372 0.90
110_T 114_E 1.369 0.90
13_K 154_S 1.365 0.90
240_E 243_A 1.344 0.89
280_K 283_A 1.343 0.88
106_L 170_L 1.332 0.88
240_E 280_K 1.331 0.88
108_L 122_L 1.329 0.88
108_L 138_Y 1.321 0.87
273_L 276_E 1.317 0.87
14_S 21_S 1.3 0.86
140_D 145_S 1.287 0.85
109_A 177_L 1.287 0.85
148_S 217_I 1.277 0.85
94_F 200_G 1.271 0.85
133_H 136_K 1.262 0.84
10_A 14_S 1.253 0.83
241_V 284_L 1.248 0.83
119_P 144_I 1.247 0.83
110_T 183_R 1.244 0.83
250_R 256_L 1.243 0.83
114_E 125_K 1.24 0.82
154_S 209_L 1.225 0.81
226_S 270_S 1.221 0.81
173_T 184_E 1.22 0.81
291_V 295_E 1.214 0.81
50_I 58_I 1.206 0.80
72_I 75_N 1.196 0.79
77_L 93_Y 1.19 0.79
119_P 142_K 1.185 0.78
91_P 144_I 1.183 0.78
12_Q 75_N 1.183 0.78
6_R 13_K 1.18 0.78
69_L 195_L 1.175 0.78
19_D 23_E 1.166 0.77
159_P 180_N 1.148 0.75
22_R 26_A 1.145 0.75
138_Y 186_E 1.14 0.74
118_G 121_S 1.132 0.74
248_A 288_S 1.132 0.74
74_E 98_R 1.118 0.72
227_K 295_E 1.115 0.72
228_Y 266_H 1.113 0.72
196_I 253_I 1.113 0.72
47_P 209_L 1.111 0.72
130_S 155_V 1.108 0.71
103_G 127_I 1.103 0.71
55_D 72_I 1.101 0.71
276_E 280_K 1.098 0.70
129_T 158_A 1.094 0.70
142_K 188_I 1.09 0.70
56_D 76_V 1.087 0.69
139_L 142_K 1.086 0.69
249_E 287_S 1.085 0.69
74_E 194_C 1.083 0.69
130_S 171_V 1.062 0.67
115_A 183_R 1.061 0.67
10_A 15_G 1.055 0.66
32_I 41_A 1.051 0.66
32_I 50_I 1.049 0.65
37_Q 179_A 1.044 0.65
168_C 188_I 1.044 0.65
155_V 216_R 1.04 0.64
128_A 149_C 1.037 0.64
55_D 106_L 1.033 0.64
31_K 62_V 1.03 0.63
162_G 176_T 1.028 0.63
90_D 260_Q 1.023 0.63
103_G 141_Q 1.022 0.62
119_P 186_E 1.022 0.62
16_R 79_E 1.02 0.62
98_R 194_C 1.015 0.62
94_F 199_D 1.014 0.62
12_Q 55_D 1.009 0.61
49_D 175_A 1.006 0.61
11_M 28_C 1.006 0.61
141_Q 240_E 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h3dA111000.081Contact Map0.548
1nh8A10.96321000.107Contact Map0.499
2vd3A20.95651000.108Contact Map0.593
2vd2A10.70231000.362Contact Map0.43
1z7mE40.68231000.373Contact Map0.49
1o63A20.73241000.377Contact Map0.478
1ve4A10.68561000.378Contact Map0.478
3qslA20.949898.90.89Contact Map0.428
4eswA20.899798.90.891Contact Map0.462
3ix1A20.879698.60.902Contact Map0.503
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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