| UniProt: | P45563 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG20250 | ||
| Length: | 277 (269) | ||
| Sequences: | 1789 | ||
| Seq/Len: | 6.65 |
| XAPA
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 165_D | 230_K | 4.394 | 1.00 | |
| 173_Q | 185_E | 3.452 | 1.00 | |
| 189_V | 210_G | 3.236 | 1.00 | |
| 131_V | 212_V | 3.041 | 1.00 | |
| 204_M | 208_I | 2.994 | 1.00 | |
| 189_V | 205_M | 2.916 | 1.00 | |
| 172_L | 232_V | 2.572 | 1.00 | |
| 178_E | 275_K | 2.406 | 1.00 | |
| 191_Y | 205_M | 2.387 | 1.00 | |
| 167_E | 230_K | 2.355 | 1.00 | |
| 122_R | 211_D | 2.257 | 1.00 | |
| 178_E | 271_G | 2.247 | 1.00 | |
| 71_L | 80_V | 2.228 | 1.00 | |
| 112_L | 229_L | 2.205 | 1.00 | |
| 163_A | 221_V | 2.199 | 1.00 | |
| 212_V | 237_I | 2.155 | 1.00 | |
| 27_R | 77_V | 2.12 | 1.00 | |
| 98_T | 223_S | 2.061 | 1.00 | |
| 172_L | 272_F | 2.011 | 1.00 | |
| 27_R | 110_E | 2.005 | 1.00 | |
| 126_G | 129_S | 1.973 | 1.00 | |
| 271_G | 274_R | 1.945 | 1.00 | |
| 174_K | 275_K | 1.942 | 1.00 | |
| 129_S | 184_T | 1.94 | 1.00 | |
| 188_F | 214_G | 1.916 | 1.00 | |
| 197_E | 239_N | 1.84 | 1.00 | |
| 132_A | 183_L | 1.808 | 1.00 | |
| 149_N | 226_H | 1.785 | 1.00 | |
| 12_F | 56_G | 1.782 | 1.00 | |
| 93_G | 96_I | 1.781 | 1.00 | |
| 143_T | 195_N | 1.766 | 1.00 | |
| 73_H | 78_P | 1.762 | 1.00 | |
| 27_R | 78_P | 1.731 | 1.00 | |
| 170_A | 174_K | 1.721 | 1.00 | |
| 137_I | 210_G | 1.697 | 1.00 | |
| 69_L | 80_V | 1.686 | 1.00 | |
| 43_I | 81_C | 1.649 | 1.00 | |
| 202_I | 241_A | 1.633 | 1.00 | |
| 31_I | 114_C | 1.632 | 1.00 | |
| 128_G | 257_A | 1.628 | 1.00 | |
| 69_L | 103_T | 1.625 | 1.00 | |
| 256_A | 260_L | 1.621 | 1.00 | |
| 176_A | 183_L | 1.618 | 1.00 | |
| 140_M | 190_S | 1.598 | 1.00 | |
| 31_I | 101_I | 1.579 | 1.00 | |
| 15_D | 19_T | 1.569 | 0.99 | |
| 202_I | 239_N | 1.563 | 0.99 | |
| 116_N | 235_S | 1.555 | 0.99 | |
| 162_N | 199_A | 1.554 | 0.99 | |
| 105_K | 227_C | 1.553 | 0.99 | |
| 131_V | 237_I | 1.532 | 0.99 | |
| 123_P | 206_Q | 1.525 | 0.99 | |
| 29_A | 104_F | 1.492 | 0.99 | |
| 13_C | 99_D | 1.492 | 0.99 | |
| 179_E | 271_G | 1.473 | 0.99 | |
| 196_F | 254_T | 1.471 | 0.99 | |
| 75_Q | 270_C | 1.451 | 0.99 | |
| 120_S | 237_I | 1.443 | 0.99 | |
| 28_V | 273_L | 1.437 | 0.99 | |
| 17_I | 49_I | 1.436 | 0.99 | |
| 48_A | 68_E | 1.433 | 0.99 | |
| 62_V | 251_H | 1.423 | 0.99 | |
| 202_I | 243_G | 1.418 | 0.99 | |
| 55_P | 66_A | 1.402 | 0.99 | |
| 13_C | 56_G | 1.396 | 0.99 | |
| 73_H | 76_G | 1.388 | 0.98 | |
| 146_V | 192_P | 1.351 | 0.98 | |
| 132_A | 173_Q | 1.348 | 0.98 | |
| 141_P | 192_P | 1.343 | 0.98 | |
| 111_L | 168_Y | 1.332 | 0.98 | |
| 64_G | 251_H | 1.329 | 0.98 | |
| 106_L | 153_F | 1.327 | 0.98 | |
| 121_L | 202_I | 1.324 | 0.98 | |
| 111_L | 230_K | 1.305 | 0.97 | |
| 175_V | 271_G | 1.294 | 0.97 | |
| 42_Q | 270_C | 1.281 | 0.97 | |
| 164_Y | 217_V | 1.278 | 0.97 | |
| 102_R | 106_L | 1.268 | 0.97 | |
| 132_A | 169_R | 1.265 | 0.97 | |
| 114_C | 221_V | 1.262 | 0.97 | |
| 136_H | 160_L | 1.257 | 0.97 | |
| 133_L | 233_A | 1.256 | 0.97 | |
| 127_A | 240_M | 1.253 | 0.97 | |
| 68_E | 83_K | 1.232 | 0.96 | |
| 39_L | 74_L | 1.22 | 0.96 | |
| 205_M | 210_G | 1.21 | 0.96 | |
| 11_L | 15_D | 1.21 | 0.96 | |
| 169_R | 185_E | 1.198 | 0.95 | |
| 75_Q | 274_R | 1.187 | 0.95 | |
| 137_I | 204_M | 1.18 | 0.95 | |
| 252_A | 256_A | 1.176 | 0.95 | |
| 171_L | 275_K | 1.137 | 0.93 | |
| 18_K | 25_T | 1.136 | 0.93 | |
| 257_A | 261_S | 1.135 | 0.93 | |
| 202_I | 242_E | 1.135 | 0.93 | |
| 171_L | 174_K | 1.125 | 0.93 | |
| 162_N | 166_A | 1.125 | 0.93 | |
| 218_V | 221_V | 1.124 | 0.93 | |
| 29_A | 109_C | 1.124 | 0.93 | |
| 137_I | 189_V | 1.121 | 0.93 | |
| 169_R | 173_Q | 1.118 | 0.92 | |
| 234_V | 268_L | 1.118 | 0.92 | |
| 109_C | 229_L | 1.118 | 0.92 | |
| 257_A | 260_L | 1.108 | 0.92 | |
| 88_F | 94_M | 1.108 | 0.92 | |
| 99_D | 103_T | 1.089 | 0.91 | |
| 67_G | 85_R | 1.082 | 0.91 | |
| 202_I | 244_L | 1.068 | 0.90 | |
| 199_A | 239_N | 1.059 | 0.90 | |
| 125_V | 131_V | 1.059 | 0.90 | |
| 197_E | 202_I | 1.058 | 0.89 | |
| 101_I | 227_C | 1.054 | 0.89 | |
| 20_Y | 53_K | 1.049 | 0.89 | |
| 239_N | 243_G | 1.048 | 0.89 | |
| 105_K | 110_E | 1.04 | 0.88 | |
| 242_E | 249_L | 1.034 | 0.88 | |
| 175_V | 275_K | 1.03 | 0.88 | |
| 11_L | 14_I | 1.027 | 0.88 | |
| 38_A | 266_I | 1.026 | 0.87 | |
| 179_E | 267_N | 1.024 | 0.87 | |
| 134_K | 169_R | 1.022 | 0.87 | |
| 80_V | 104_F | 1.022 | 0.87 | |
| 137_I | 208_I | 1.016 | 0.87 | |
| 232_V | 272_F | 1.015 | 0.87 | |
| 50_S | 68_E | 1.009 | 0.86 | |
| 251_H | 254_T | 1.008 | 0.86 | |
| 28_V | 77_V | 1.007 | 0.86 | |
| 50_S | 53_K | 1.006 | 0.86 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3la8A | 1 | 0.9819 | 100 | 0.265 | Contact Map | 0.766 |
| 2p4sA | 3 | 0.9964 | 100 | 0.269 | Contact Map | 0.791 |
| 1vmkA | 3 | 0.9747 | 100 | 0.272 | Contact Map | 0.806 |
| 4earA | 3 | 0.9964 | 100 | 0.274 | Contact Map | 0.786 |
| 4m1eA | 6 | 0.9964 | 100 | 0.277 | Contact Map | 0.822 |
| 3odgA | 1 | 1 | 100 | 0.287 | Contact Map | 0.681 |
| 3khsA | 4 | 0.9856 | 100 | 0.291 | Contact Map | 0.828 |
| 1g2oA | 3 | 0.9567 | 100 | 0.296 | Contact Map | 0.751 |
| 1tcvA | 3 | 0.9964 | 100 | 0.296 | Contact Map | 0.818 |
| 3fucA | 3 | 0.9964 | 100 | 0.307 | Contact Map | 0.788 |
Sequence Conservation (Image Generated using WebLogo v3)