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OPENSEQ.org
YHET - Putative esterase YheT
UniProt: P45524 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12904
Length: 340 (322)
Sequences: 949
Seq/Len: 2.95
YHET
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
268_I 272_T 3.731 1.00
28_H 199_Y 3.25 1.00
163_L 175_A 3.149 1.00
47_W 61_A 3.063 1.00
161_C 264_M 2.977 1.00
149_A 159_L 2.961 1.00
174_A 334_Y 2.923 1.00
75_L 97_A 2.887 1.00
301_Q 326_R 2.622 1.00
60_L 105_V 2.599 1.00
53_P 133_W 2.518 1.00
49_R 59_D 2.497 1.00
313_G 325_S 2.45 1.00
51_E 118_R 2.393 1.00
176_V 331_L 2.358 1.00
149_A 172_V 2.242 1.00
94_V 104_G 2.24 1.00
161_C 165_K 2.209 1.00
250_A 254_D 2.193 1.00
160_A 272_T 2.166 1.00
59_D 113_S 2.137 1.00
239_D 256_Y 2.105 1.00
249_Y 258_Q 2.003 1.00
128_T 165_K 1.945 0.99
157_N 161_C 1.876 0.99
132_S 166_E 1.854 0.99
180_A 261_A 1.813 0.99
128_T 161_C 1.809 0.99
48_Q 62_W 1.785 0.99
61_A 85_L 1.768 0.99
157_N 261_A 1.768 0.99
160_A 177_I 1.762 0.99
76_V 135_L 1.748 0.99
254_D 258_Q 1.745 0.99
161_C 164_A 1.721 0.98
49_R 57_F 1.693 0.98
48_Q 141_E 1.691 0.98
59_D 115_E 1.638 0.98
79_H 112_C 1.626 0.98
148_A 331_L 1.604 0.97
175_A 270_K 1.579 0.97
278_K 304_E 1.576 0.97
62_W 105_V 1.546 0.96
85_L 108_H 1.537 0.96
18_F 21_M 1.533 0.96
240_D 251_D 1.529 0.96
84_S 87_S 1.514 0.96
164_A 264_M 1.492 0.95
49_R 113_S 1.477 0.95
57_F 118_R 1.462 0.95
239_D 243_T 1.461 0.95
168_N 269_A 1.447 0.94
100_R 329_D 1.447 0.94
77_V 90_A 1.445 0.94
78_F 159_L 1.436 0.94
18_F 30_Q 1.401 0.93
132_S 136_R 1.395 0.93
242_I 246_I 1.38 0.92
126_G 165_K 1.378 0.92
49_R 115_E 1.371 0.92
240_D 252_A 1.368 0.92
177_I 180_A 1.366 0.92
31_T 307_G 1.363 0.92
307_G 310_G 1.343 0.91
303_T 311_F 1.34 0.91
79_H 274_I 1.34 0.91
152_Y 309_V 1.326 0.90
78_F 109_F 1.325 0.90
179_S 311_F 1.322 0.90
92_G 324_E 1.312 0.89
234_R 237_E 1.302 0.89
176_V 327_I 1.277 0.88
38_R 92_G 1.276 0.88
186_A 284_D 1.27 0.87
236_R 253_I 1.267 0.87
244_A 252_A 1.26 0.87
121_R 127_E 1.26 0.87
27_C 276_H 1.26 0.87
61_A 106_V 1.256 0.86
124_H 249_Y 1.241 0.86
52_L 58_V 1.239 0.85
175_A 272_T 1.238 0.85
47_W 59_D 1.221 0.84
204_L 208_K 1.221 0.84
125_S 184_L 1.22 0.84
30_Q 279_D 1.219 0.84
111_G 116_P 1.212 0.84
77_V 94_V 1.212 0.84
170_L 270_K 1.211 0.84
82_E 210_N 1.207 0.83
283_M 287_V 1.206 0.83
178_V 275_I 1.197 0.83
156_G 180_A 1.191 0.82
156_G 261_A 1.182 0.82
185_E 253_I 1.18 0.81
132_S 165_K 1.172 0.81
78_F 158_M 1.152 0.79
147_T 172_V 1.151 0.79
161_C 261_A 1.141 0.78
109_F 123_Y 1.141 0.78
232_V 237_E 1.139 0.78
80_G 89_Y 1.131 0.77
103_L 145_A 1.131 0.77
143_G 147_T 1.13 0.77
78_F 131_A 1.117 0.76
82_E 112_C 1.116 0.76
154_L 260_S 1.112 0.76
57_F 115_E 1.11 0.76
52_L 133_W 1.104 0.75
323_L 327_I 1.104 0.75
186_A 286_Q 1.094 0.74
132_S 162_L 1.091 0.74
169_D 233_R 1.089 0.74
38_R 324_E 1.089 0.74
50_L 133_W 1.087 0.73
163_L 322_W 1.086 0.73
314_G 317_L 1.085 0.73
273_L 330_W 1.084 0.73
45_P 85_L 1.083 0.73
114_G 123_Y 1.083 0.73
131_A 158_M 1.081 0.73
207_L 238_F 1.079 0.73
184_L 260_S 1.078 0.72
249_Y 259_C 1.077 0.72
78_F 107_M 1.076 0.72
56_D 59_D 1.075 0.72
47_W 85_L 1.074 0.72
195_F 198_V 1.074 0.72
79_H 83_G 1.072 0.72
57_F 113_S 1.069 0.72
85_L 106_V 1.067 0.71
156_G 207_L 1.06 0.71
54_D 121_R 1.051 0.70
100_R 332_T 1.05 0.70
235_I 277_A 1.05 0.70
178_V 327_I 1.047 0.69
126_G 259_C 1.045 0.69
81_L 207_L 1.039 0.68
192_E 200_Q 1.035 0.68
163_L 270_K 1.034 0.68
97_A 327_I 1.033 0.68
176_V 275_I 1.031 0.68
49_R 56_D 1.029 0.67
74_R 103_L 1.026 0.67
97_A 164_A 1.025 0.67
203_L 219_P 1.024 0.67
117_N 214_K 1.023 0.67
154_L 255_Y 1.023 0.67
107_M 134_F 1.023 0.67
72_K 103_L 1.023 0.67
226_L 229_L 1.023 0.67
24_F 33_L 1.019 0.66
54_D 62_W 1.016 0.66
137_W 141_E 1.012 0.65
160_A 274_I 1.007 0.65
321_M 324_E 1.007 0.65
73_P 167_G 1.004 0.65
20_P 305_H 1.001 0.64
157_N 184_L 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iiiA10.879499.90.754Contact Map0.558
1k8qA20.923599.90.756Contact Map0.638
3hjuA20.908899.90.761Contact Map0.601
1lnsA10.952999.90.764Contact Map0.461
3k6kA40.847199.90.764Contact Map0.614
2wtmA40.726599.90.77Contact Map0.72
2y6uA10.897199.90.772Contact Map0.642
3vdxA30.814799.90.775Contact Map0.651
3i2kA10.864799.90.775Contact Map0.522
3u1tA20.832499.90.776Contact Map0.585
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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