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OPENSEQ.org
YFCC - Uncharacterized protein YfcC
UniProt: P39263 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12607
Length: 506 (487)
Sequences: 519
Seq/Len: 1.07
YFCC
Paralog alert: 0.24 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_M 360_V 3.296 1.00
302_W 307_N 3.192 1.00
159_S 236_W 3.124 1.00
434_D 440_R 2.994 1.00
475_F 479_L 2.579 1.00
41_F 386_N 2.55 0.99
121_G 346_F 2.441 0.99
159_S 240_T 2.386 0.99
155_F 247_T 2.204 0.98
242_I 492_M 2.203 0.98
326_G 342_M 2.197 0.98
462_A 466_A 2.191 0.98
152_P 248_M 2.152 0.98
329_G 337_M 2.149 0.98
43_S 382_N 2.122 0.97
433_G 443_T 2.064 0.97
128_R 341_T 2.055 0.97
257_N 260_L 1.954 0.95
483_A 487_G 1.954 0.95
408_Q 425_T 1.88 0.94
418_G 451_D 1.875 0.94
415_V 424_L 1.87 0.94
338_T 341_T 1.862 0.93
170_E 212_F 1.853 0.93
29_T 370_V 1.849 0.93
221_A 430_A 1.834 0.93
348_E 351_R 1.828 0.93
412_N 451_D 1.812 0.92
236_W 240_T 1.753 0.90
134_N 286_D 1.738 0.90
202_I 243_G 1.72 0.89
235_V 496_V 1.717 0.89
61_D 65_F 1.699 0.89
259_L 264_H 1.689 0.88
179_A 470_V 1.679 0.88
222_G 430_A 1.645 0.86
191_T 254_V 1.642 0.86
289_V 329_G 1.641 0.86
42_D 66_R 1.634 0.86
292_V 328_I 1.618 0.85
385_L 424_L 1.616 0.85
215_V 226_L 1.591 0.84
430_A 440_R 1.584 0.83
162_G 171_A 1.584 0.83
173_A 176_I 1.581 0.83
93_M 320_T 1.577 0.83
495_V 499_G 1.576 0.83
221_A 440_R 1.576 0.83
252_S 256_K 1.575 0.83
233_I 237_V 1.574 0.83
204_F 418_G 1.57 0.83
213_C 418_G 1.534 0.81
135_G 157_L 1.527 0.80
408_Q 421_Q 1.519 0.80
163_A 208_W 1.506 0.79
267_D 271_R 1.505 0.79
412_N 421_Q 1.492 0.78
204_F 451_D 1.491 0.78
161_G 167_M 1.482 0.77
296_V 321_M 1.481 0.77
115_F 170_E 1.451 0.75
23_F 27_I 1.449 0.75
288_L 291_I 1.422 0.73
219_G 423_A 1.421 0.73
379_S 437_G 1.414 0.72
285_G 336_G 1.41 0.72
409_A 454_S 1.408 0.72
188_D 250_Y 1.383 0.70
386_N 390_N 1.381 0.70
287_W 480_K 1.375 0.69
169_E 212_F 1.375 0.69
451_D 455_H 1.37 0.69
461_S 465_M 1.368 0.69
499_G 503_M 1.367 0.69
28_L 253_R 1.366 0.69
91_G 94_N 1.362 0.68
182_M 192_T 1.36 0.68
373_G 380_V 1.355 0.68
410_V 414_F 1.351 0.68
156_I 240_T 1.339 0.67
156_I 244_L 1.338 0.66
34_W 373_G 1.335 0.66
465_M 475_F 1.333 0.66
215_V 225_V 1.326 0.65
115_F 212_F 1.325 0.65
350_A 358_L 1.323 0.65
191_T 369_L 1.32 0.65
98_E 372_N 1.317 0.65
412_N 418_G 1.309 0.64
151_I 199_A 1.306 0.64
117_L 354_I 1.304 0.63
406_L 410_V 1.301 0.63
439_N 442_V 1.288 0.62
396_D 399_V 1.288 0.62
453_F 486_L 1.286 0.62
35_V 295_A 1.281 0.61
251_A 254_V 1.278 0.61
370_V 380_V 1.276 0.61
284_F 288_L 1.27 0.60
125_I 322_G 1.264 0.60
264_H 429_L 1.263 0.60
221_A 434_D 1.258 0.59
16_P 261_S 1.238 0.58
96_P 385_L 1.237 0.57
404_M 429_L 1.229 0.57
411_F 415_V 1.226 0.56
474_D 477_N 1.225 0.56
170_E 217_A 1.223 0.56
187_Y 248_M 1.222 0.56
302_W 306_V 1.222 0.56
230_G 234_V 1.222 0.56
188_D 254_V 1.216 0.55
20_V 339_V 1.216 0.55
146_N 184_R 1.211 0.55
194_L 247_T 1.208 0.55
139_L 187_Y 1.204 0.54
129_T 289_V 1.203 0.54
22_I 314_I 1.202 0.54
451_D 454_S 1.201 0.54
194_L 199_A 1.199 0.54
421_Q 451_D 1.199 0.54
36_V 214_V 1.192 0.53
120_G 349_G 1.191 0.53
412_N 454_S 1.191 0.53
33_T 373_G 1.183 0.52
145_G 161_G 1.181 0.52
240_T 244_L 1.178 0.52
13_W 16_P 1.173 0.51
297_M 300_V 1.172 0.51
27_I 31_L 1.164 0.51
100_L 114_M 1.163 0.51
125_I 193_V 1.157 0.50
153_A 499_G 1.154 0.50
217_A 426_M 1.154 0.50
246_F 488_L 1.152 0.49
370_V 496_V 1.151 0.49
26_A 369_L 1.151 0.49
497_V 501_Q 1.15 0.49
369_L 373_G 1.146 0.49
353_M 356_P 1.145 0.49
291_I 295_A 1.143 0.49
170_E 310_F 1.142 0.49
120_G 466_A 1.14 0.48
115_F 310_F 1.134 0.48
162_G 204_F 1.133 0.48
198_I 359_L 1.132 0.48
245_I 249_V 1.127 0.47
136_I 151_I 1.127 0.47
124_G 161_G 1.124 0.47
147_E 161_G 1.124 0.47
116_M 176_I 1.124 0.47
146_N 196_T 1.123 0.47
181_L 229_S 1.122 0.47
40_M 379_S 1.121 0.47
300_V 317_Q 1.119 0.46
162_G 170_E 1.117 0.46
102_S 364_K 1.116 0.46
245_I 488_L 1.113 0.46
429_L 443_T 1.108 0.45
402_W 494_S 1.101 0.45
314_I 425_T 1.099 0.44
187_Y 255_K 1.096 0.44
19_L 360_V 1.094 0.44
426_M 433_G 1.093 0.44
100_L 361_G 1.092 0.44
161_G 346_F 1.092 0.44
30_S 34_W 1.092 0.44
249_V 253_R 1.086 0.43
298_V 390_N 1.083 0.43
25_V 164_V 1.082 0.43
482_G 486_L 1.082 0.43
412_N 441_Q 1.079 0.43
217_A 444_V 1.076 0.42
212_F 217_A 1.075 0.42
213_C 451_D 1.074 0.42
389_A 435_L 1.073 0.42
198_I 482_G 1.071 0.42
227_S 441_Q 1.07 0.42
265_E 474_D 1.066 0.41
135_G 426_M 1.065 0.41
18_T 463_S 1.065 0.41
491_I 498_I 1.065 0.41
59_V 495_V 1.064 0.41
177_I 252_S 1.063 0.41
188_D 261_S 1.061 0.41
170_E 211_P 1.06 0.41
27_I 92_L 1.055 0.40
326_G 329_G 1.055 0.40
430_A 434_D 1.05 0.40
169_E 187_Y 1.05 0.40
241_L 338_T 1.05 0.40
265_E 477_N 1.05 0.40
289_V 324_V 1.044 0.39
297_M 301_I 1.04 0.39
485_L 488_L 1.038 0.39
148_I 252_S 1.037 0.39
57_R 64_S 1.036 0.39
234_V 499_G 1.033 0.38
314_I 481_V 1.031 0.38
191_T 247_T 1.03 0.38
366_I 373_G 1.028 0.38
58_K 222_G 1.027 0.38
154_L 178_I 1.027 0.38
227_S 450_G 1.026 0.38
173_A 360_V 1.026 0.38
417_S 420_G 1.025 0.38
216_V 447_F 1.024 0.38
326_G 337_M 1.02 0.37
183_V 189_S 1.02 0.37
61_D 64_S 1.02 0.37
62_P 65_F 1.02 0.37
443_T 446_A 1.02 0.37
95_F 497_V 1.019 0.37
231_L 505_Y 1.019 0.37
126_V 174_F 1.017 0.37
414_F 458_Y 1.017 0.37
125_I 386_N 1.013 0.37
205_A 213_C 1.012 0.37
324_V 327_I 1.01 0.36
385_L 432_L 1.01 0.36
190_I 262_R 1.008 0.36
19_L 181_L 1.002 0.36
167_M 170_E 1.002 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.86171000.831Contact Map0.396
4a01A20.505916.80.984Contact Map0.198
3hd7B20.073115.60.984Contact Map1
2m8rA10.073115.60.984Contact Map0.314
3pjzA20.397212.80.985Contact Map0.224
3u0jB20.11074.20.988Contact Map0.044
1pw4A10.38743.80.988Contact Map0.234
4he8J20.30043.20.988Contact Map0.187
3giaA10.43282.90.989Contact Map0.278
2riqA10.10472.70.989Contact Map0
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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