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OPENSEQ.org
GLF - UDP-galactopyranose mutase
UniProt: P37747 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11981
Length: 367 (364)
Sequences: 4153
Seq/Len: 11.41
GLF
Paralog alert: 0.46 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_D 26_K 4.11 1.00
5_I 224_A 3.725 1.00
5_I 30_I 3.713 1.00
356_A 360_V 3.702 1.00
16_C 228_I 3.664 1.00
32_K 212_D 3.587 1.00
9_S 36_I 3.478 1.00
28_L 208_K 3.333 1.00
3_D 225_H 3.312 1.00
30_I 224_A 3.208 1.00
141_E 145_Q 3.17 1.00
34_N 210_G 2.952 1.00
129_E 137_S 2.891 1.00
226_R 336_I 2.821 1.00
18_N 22_K 2.679 1.00
5_I 222_S 2.678 1.00
30_I 222_S 2.623 1.00
136_I 141_E 2.545 1.00
19_E 357_L 2.507 1.00
7_V 231_G 2.484 1.00
7_V 229_Y 2.462 1.00
63_K 67_D 2.422 1.00
200_K 203_E 2.393 1.00
26_K 206_D 2.386 1.00
22_K 71_D 2.385 1.00
229_Y 236_Y 2.375 1.00
3_D 28_L 2.275 1.00
6_I 27_V 2.272 1.00
196_K 199_E 2.236 1.00
17_A 29_V 2.216 1.00
9_S 29_V 2.21 1.00
132_E 161_K 2.189 1.00
195_T 199_E 2.164 1.00
4_Y 25_K 2.161 1.00
74_E 191_V 2.128 1.00
36_I 202_L 2.115 1.00
257_E 292_H 2.091 1.00
29_V 36_I 2.087 1.00
231_G 236_Y 2.077 1.00
338_G 359_Q 2.037 1.00
36_I 209_L 2.028 1.00
208_K 211_I 2.024 1.00
324_K 327_E 1.983 1.00
130_N 133_E 1.922 1.00
228_I 363_I 1.866 1.00
15_V 353_I 1.822 1.00
4_Y 20_L 1.772 1.00
6_I 17_A 1.738 1.00
28_L 224_A 1.729 1.00
19_E 22_K 1.726 1.00
6_I 13_G 1.712 1.00
19_E 68_Y 1.708 1.00
62_D 354_S 1.706 1.00
64_Y 361_K 1.667 1.00
11_L 349_M 1.664 1.00
354_S 358_Y 1.659 1.00
202_L 207_V 1.64 1.00
208_K 222_S 1.631 1.00
30_I 208_K 1.628 1.00
12_F 352_V 1.621 1.00
216_D 229_Y 1.603 1.00
3_D 25_K 1.59 1.00
35_H 41_Y 1.582 1.00
36_I 207_V 1.572 1.00
19_E 361_K 1.562 1.00
18_N 71_D 1.555 1.00
12_F 355_A 1.54 1.00
230_T 338_G 1.533 1.00
30_I 213_F 1.517 1.00
356_A 359_Q 1.495 1.00
159_S 162_E 1.491 1.00
231_G 239_Y 1.484 1.00
217_K 221_A 1.471 1.00
135_A 144_Y 1.469 1.00
16_C 359_Q 1.463 1.00
208_K 220_L 1.462 1.00
16_C 356_A 1.462 1.00
16_C 20_L 1.438 1.00
245_E 315_D 1.434 1.00
76_N 191_V 1.427 1.00
232_P 235_Q 1.427 1.00
114_N 118_A 1.422 1.00
2_Y 28_L 1.405 0.99
28_L 225_H 1.398 0.99
69_V 190_P 1.391 0.99
21_K 27_V 1.387 0.99
336_I 359_Q 1.359 0.99
44_D 195_T 1.333 0.99
65_I 69_V 1.332 0.99
64_Y 357_L 1.327 0.99
72_L 201_M 1.32 0.99
23_L 364_M 1.316 0.99
6_I 228_I 1.31 0.99
42_T 50_I 1.303 0.99
11_L 40_A 1.299 0.99
4_Y 226_R 1.295 0.99
341_L 344_Y 1.286 0.99
2_Y 226_R 1.285 0.99
21_K 205_V 1.279 0.99
192_G 196_K 1.275 0.99
39_N 340_R 1.275 0.99
129_E 133_E 1.249 0.99
108_D 111_E 1.247 0.99
136_I 144_Y 1.235 0.98
226_R 334_K 1.235 0.98
332_E 335_V 1.235 0.98
40_A 198_I 1.231 0.98
65_I 353_I 1.226 0.98
9_S 31_E 1.223 0.98
25_K 364_M 1.206 0.98
69_V 353_I 1.184 0.98
20_L 360_V 1.182 0.98
12_F 338_G 1.182 0.98
196_K 200_K 1.181 0.98
110_Q 114_N 1.173 0.98
240_R 328_L 1.168 0.97
114_N 117_N 1.167 0.97
145_Q 149_K 1.167 0.97
29_V 207_V 1.165 0.97
152_T 163_L 1.155 0.97
157_G 249_L 1.155 0.97
142_D 146_A 1.151 0.97
19_E 356_A 1.134 0.97
5_I 28_L 1.13 0.97
136_I 161_K 1.124 0.97
358_Y 362_N 1.123 0.97
12_F 230_T 1.119 0.96
10_G 13_G 1.115 0.96
247_R 313_V 1.112 0.96
198_I 202_L 1.109 0.96
21_K 204_G 1.108 0.96
9_S 209_L 1.1 0.96
2_Y 225_H 1.094 0.96
2_Y 206_D 1.09 0.96
43_E 52_K 1.083 0.96
326_R 330_S 1.077 0.95
24_N 27_V 1.077 0.95
343_E 355_A 1.073 0.95
352_V 355_A 1.073 0.95
37_G 198_I 1.071 0.95
2_Y 26_K 1.07 0.95
236_Y 239_Y 1.067 0.95
336_I 362_N 1.067 0.95
336_I 363_I 1.064 0.95
113_Q 116_I 1.063 0.95
228_I 359_Q 1.056 0.95
338_G 355_A 1.053 0.95
58_F 66_W 1.051 0.94
132_E 136_I 1.045 0.94
6_I 10_G 1.044 0.94
44_D 50_I 1.043 0.94
6_I 16_C 1.039 0.94
132_E 144_Y 1.038 0.94
25_K 28_L 1.036 0.94
68_Y 72_L 1.033 0.94
19_E 23_L 1.032 0.94
11_L 353_I 1.029 0.94
233_I 244_L 1.027 0.94
199_E 203_E 1.023 0.93
360_V 363_I 1.023 0.93
14_A 29_V 1.022 0.93
4_Y 224_A 1.008 0.93
320_E 323_K 1.007 0.93
28_L 206_D 1.002 0.92
18_N 72_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1i8tA20.99731000.208Contact Map0.685
1v0jA40.99731000.221Contact Map0.701
2bi7A10.98371000.241Contact Map0.713
3hdqA100.97821000.258Contact Map0.746
4gdeA40.97821000.331Contact Map0.683
4dsgA20.97821000.345Contact Map0.676
2ivdA20.98641000.35Contact Map0.731
3i6dA20.98911000.352Contact Map0.731
1sezA20.98371000.372Contact Map0.755
3lovA10.98091000.376Contact Map0.757
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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