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YADI - Putative phosphotransferase enzyme IIA component YadI
UniProt: P36881 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12322
Length: 146 (132)
Sequences: 1162
Seq/Len: 8.80

YADI
Paralog alert: 0.66 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
21_E 26_A 3.48 1.00
31_R 54_E 2.928 1.00
11_D 14_Q 2.692 1.00
8_C 92_V 2.519 1.00
108_T 111_E 2.415 1.00
16_I 92_V 2.39 1.00
12_R 16_I 2.342 1.00
39_L 47_M 2.045 1.00
100_M 116_I 1.994 1.00
99_Q 119_L 1.85 1.00
14_Q 34_N 1.846 1.00
15_E 18_D 1.764 1.00
7_T 48_M 1.719 1.00
6_I 92_V 1.687 1.00
63_F 86_C 1.685 1.00
65_T 73_Y 1.541 1.00
45_S 78_L 1.541 1.00
13_A 34_N 1.535 1.00
33_V 51_A 1.51 1.00
46_R 50_D 1.503 1.00
20_L 101_M 1.49 1.00
21_E 27_L 1.485 1.00
48_M 76_A 1.408 0.99
35_F 44_L 1.405 0.99
64_L 96_L 1.401 0.99
6_I 30_C 1.366 0.99
92_V 97_I 1.366 0.99
10_D 19_A 1.361 0.99
64_L 100_M 1.356 0.99
45_S 75_V 1.356 0.99
107_M 111_E 1.347 0.99
17_L 32_A 1.34 0.99
17_L 21_E 1.339 0.99
31_R 51_A 1.3 0.99
17_L 30_C 1.281 0.98
87_E 110_S 1.275 0.98
33_V 40_S 1.27 0.98
3_G 51_A 1.267 0.98
24_H 102_A 1.23 0.98
6_I 17_L 1.225 0.98
19_A 94_L 1.197 0.97
68_A 125_S 1.181 0.97
50_D 53_H 1.173 0.97
72_P 76_A 1.173 0.97
8_C 13_A 1.169 0.97
4_W 100_M 1.162 0.97
56_D 60_G 1.153 0.96
2_L 109_S 1.144 0.96
23_K 94_L 1.128 0.96
64_L 93_T 1.116 0.95
71_P 75_V 1.11 0.95
29_Q 57_S 1.102 0.95
4_W 96_L 1.088 0.95
22_K 37_R 1.082 0.94
119_L 123_E 1.078 0.94
30_C 101_M 1.061 0.94
93_T 124_V 1.048 0.93
77_S 127_L 1.046 0.93
94_L 98_E 1.04 0.93
118_E 121_A 1.034 0.92
64_L 97_I 1.022 0.92
6_I 97_I 1.017 0.91
43_M 46_R 1.014 0.91
7_T 35_F 1.01 0.91
89_I 117_V 1.007 0.91
36_W 39_L 1.004 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lfhA60.96581000.272Contact Map0.729
1pdoA10.91781000.281Contact Map0.658
3iprA60.96581000.302Contact Map0.821
3mtqA20.92471000.308Contact Map0.813
3bedA20.93841000.324Contact Map0.773
3gx1A20.842599.90.396Contact Map0.688
3gdwA20.897399.90.416Contact Map0.734
3ct6A20.856299.90.427Contact Map0.55
3b48A60.842599.90.45Contact Map0.477
1td9A60.787735.50.922Contact Map0.103

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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