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OPENSEQ.org
HEM6 - Coproporphyrinogen-III oxidase, aerobic
UniProt: P36553 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12189
Length: 299 (298)
Sequences: 855
Seq/Len: 2.87
HEM6
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
172_Y 177_N 4.086 1.00
101_Y 137_F 3.439 1.00
141_A 182_I 3.416 1.00
149_R 153_L 3.276 1.00
102_V 217_V 3.275 1.00
49_L 58_A 3.105 1.00
203_Q 207_K 2.916 1.00
152_C 201_F 2.86 1.00
24_T 30_E 2.829 1.00
165_K 169_E 2.627 1.00
155_F 204_A 2.602 1.00
187_F 202_M 2.543 1.00
17_D 45_R 2.496 1.00
105_S 209_Y 2.49 1.00
137_F 220_R 2.392 1.00
22_Q 210_T 2.358 1.00
11_F 207_K 2.327 1.00
14_N 18_T 2.321 1.00
55_F 217_V 2.311 1.00
101_Y 229_E 2.291 1.00
55_F 58_A 2.223 1.00
151_L 208_G 2.164 1.00
7_Q 196_D 2.13 1.00
226_G 229_E 2.107 1.00
48_V 61_N 2 1.00
229_E 285_P 1.989 1.00
9_K 13_L 1.979 1.00
54_V 221_K 1.972 1.00
26_V 218_E 1.962 0.99
220_R 223_M 1.947 0.99
138_E 288_A 1.939 0.99
33_E 47_R 1.936 0.99
15_L 206_G 1.923 0.99
194_D 197_R 1.913 0.99
134_F 272_V 1.909 0.99
146_R 150_D 1.885 0.99
136_G 179_Q 1.872 0.99
234_L 271_L 1.855 0.99
18_T 207_K 1.837 0.99
33_E 45_R 1.782 0.99
163_Y 201_F 1.781 0.99
151_L 204_A 1.768 0.99
159_V 190_L 1.721 0.98
101_Y 228_R 1.711 0.98
137_F 223_M 1.705 0.98
146_R 149_R 1.672 0.98
156_G 159_V 1.648 0.98
159_V 163_Y 1.626 0.97
179_Q 294_K 1.621 0.97
285_P 288_A 1.62 0.97
59_G 266_M 1.62 0.97
21_Q 24_T 1.613 0.97
17_D 33_E 1.613 0.97
23_L 95_V 1.597 0.97
231_N 273_R 1.583 0.97
98_H 225_Y 1.576 0.97
194_D 198_C 1.568 0.97
129_F 148_A 1.547 0.96
190_L 201_F 1.546 0.96
154_P 204_A 1.502 0.95
12_L 202_M 1.486 0.95
26_V 214_L 1.466 0.94
50_R 57_Q 1.463 0.94
230_R 234_L 1.458 0.94
38_R 43_G 1.442 0.94
143_H 147_T 1.421 0.93
38_R 41_G 1.404 0.93
35_S 46_S 1.403 0.93
288_A 291_E 1.385 0.92
94_V 266_M 1.375 0.92
5_A 87_E 1.365 0.91
58_A 95_V 1.361 0.91
143_H 215_P 1.352 0.91
129_F 208_G 1.338 0.90
27_D 53_G 1.322 0.89
101_Y 223_M 1.315 0.89
291_E 294_K 1.28 0.87
158_D 162_R 1.278 0.87
93_L 107_A 1.275 0.87
179_Q 272_V 1.262 0.86
109_V 205_V 1.26 0.86
61_N 266_M 1.256 0.86
129_F 144_W 1.255 0.86
173_L 247_W 1.252 0.86
11_F 203_Q 1.25 0.86
26_V 54_V 1.249 0.85
227_E 231_N 1.246 0.85
20_C 47_R 1.245 0.85
230_R 271_L 1.234 0.84
252_L 256_Q 1.219 0.84
84_R 119_A 1.205 0.83
8_V 12_L 1.195 0.82
284_S 287_A 1.182 0.81
178_E 236_R 1.177 0.80
17_D 47_R 1.168 0.80
19_I 93_L 1.162 0.79
149_R 299_V 1.151 0.78
24_T 31_F 1.131 0.77
107_A 185_L 1.124 0.76
169_E 174_K 1.121 0.76
65_V 88_A 1.113 0.75
152_C 185_L 1.11 0.75
70_M 77_H 1.11 0.75
162_R 169_E 1.109 0.75
131_L 182_I 1.103 0.74
34_D 187_F 1.102 0.74
29_A 53_G 1.098 0.74
290_S 294_K 1.09 0.73
19_I 206_G 1.087 0.73
70_M 74_A 1.085 0.72
65_V 86_F 1.083 0.72
268_M 272_V 1.081 0.72
35_S 45_R 1.081 0.72
178_E 239_R 1.079 0.72
78_R 81_L 1.076 0.71
212_A 215_P 1.071 0.71
11_F 206_G 1.064 0.70
259_G 264_I 1.063 0.70
51_N 98_H 1.062 0.70
231_N 275_E 1.057 0.70
152_C 159_V 1.055 0.69
136_G 295_V 1.046 0.68
192_T 198_C 1.045 0.68
136_G 141_A 1.034 0.67
214_L 218_E 1.033 0.67
138_E 292_F 1.028 0.66
34_D 262_E 1.023 0.66
34_D 263_S 1.021 0.66
7_Q 203_Q 1.019 0.65
204_A 208_G 1.013 0.65
18_T 22_Q 1.012 0.65
153_L 156_G 1.008 0.64
153_L 157_E 1.005 0.64
135_Y 232_F 1.004 0.64
40_A 86_F 1 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vjuA21100-0.002Contact Map0.638
1txnA211000.007Contact Map0.705
2aexA111000.013Contact Map0.693
2z15A40.3478170.979Contact Map0.238
3b8iA60.49513.80.98Contact Map0.174
2m4yA10.0978.70.982Contact Map0.153
1jlxA20.21748.10.982Contact Map0
3eooA160.51517.70.982Contact Map0.208
1dx8A10.11047.30.983Contact Map0.421
3e9vA10.32786.50.983Contact Map0.237
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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