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OPENSEQ.org

MENA - 1,4-dihydroxy-2-naphthoate octaprenyltransferase
UniProt: P32166 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11880
Length: 308 (298)
Sequences: 1308
Seq/Len: 4.39

MENA
Paralog alert: 0.18 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_L 196_V 2.812 1.00
237_L 259_A 2.782 1.00
224_N 227_R 2.411 1.00
152_G 219_R 2.408 1.00
202_L 225_A 2.347 1.00
217_V 225_A 2.343 1.00
220_L 224_N 2.302 1.00
100_I 104_V 2.294 1.00
144_G 147_P 2.294 1.00
93_Q 97_R 2.286 1.00
32_T 46_A 2.159 1.00
97_R 101_I 2.093 1.00
59_L 103_V 2.049 1.00
93_Q 96_K 2.02 1.00
17_R 21_L 1.943 1.00
16_L 62_L 1.934 1.00
223_V 227_R 1.921 1.00
26_A 294_N 1.89 1.00
268_R 272_R 1.873 1.00
149_G 213_K 1.818 1.00
110_G 131_G 1.763 1.00
55_L 105_L 1.762 1.00
142_T 150_Y 1.737 0.99
159_L 164_W 1.733 0.99
20_T 203_R 1.722 0.99
20_T 57_Q 1.673 0.99
152_G 213_K 1.669 0.99
284_E 288_K 1.629 0.99
92_Q 96_K 1.622 0.99
32_T 41_F 1.615 0.99
52_T 109_S 1.603 0.99
192_L 236_S 1.575 0.99
60_S 138_A 1.551 0.98
132_G 136_I 1.545 0.98
66_Y 92_Q 1.509 0.98
32_T 174_Q 1.505 0.98
137_A 148_Y 1.489 0.98
31_G 35_A 1.484 0.98
168_M 183_I 1.471 0.98
213_K 218_V 1.461 0.98
198_N 228_Y 1.44 0.97
217_V 220_L 1.435 0.97
229_H 286_T 1.433 0.97
107_C 135_I 1.432 0.97
29_I 298_V 1.427 0.97
171_W 182_L 1.414 0.97
227_R 231_C 1.413 0.97
139_I 143_V 1.41 0.97
15_S 62_L 1.397 0.97
298_V 301_I 1.39 0.96
23_L 27_A 1.384 0.96
12_W 98_A 1.376 0.96
20_T 201_N 1.374 0.96
96_K 100_I 1.371 0.96
155_D 201_N 1.366 0.96
112_A 127_F 1.357 0.96
275_D 278_A 1.343 0.95
56_L 130_L 1.333 0.95
146_R 151_I 1.33 0.95
21_L 57_Q 1.322 0.95
30_V 189_C 1.319 0.95
8_R 94_E 1.31 0.95
201_N 215_T 1.309 0.94
244_N 254_W 1.308 0.94
153_L 156_I 1.293 0.94
148_Y 151_I 1.283 0.94
43_P 47_L 1.276 0.93
63_A 99_L 1.27 0.93
48_L 109_S 1.262 0.93
103_V 106_I 1.26 0.93
222_E 226_R 1.249 0.92
34_L 171_W 1.245 0.92
118_C 126_G 1.237 0.92
198_N 225_A 1.219 0.91
160_V 165_L 1.214 0.91
62_L 98_A 1.213 0.91
242_L 246_F 1.2 0.90
152_G 218_V 1.195 0.90
206_N 222_E 1.194 0.90
33_A 298_V 1.19 0.90
77_D 207_S 1.187 0.90
42_D 45_V 1.186 0.90
255_L 300_G 1.185 0.90
191_L 232_L 1.183 0.90
237_L 260_A 1.181 0.89
17_R 203_R 1.171 0.89
200_N 203_R 1.162 0.88
155_D 228_Y 1.157 0.88
20_T 200_N 1.154 0.88
57_Q 203_R 1.148 0.88
187_T 239_C 1.143 0.87
99_L 139_I 1.139 0.87
33_A 36_W 1.135 0.87
156_I 209_R 1.133 0.87
137_A 144_G 1.131 0.87
136_I 140_T 1.127 0.86
15_S 95_M 1.126 0.86
32_T 36_W 1.125 0.86
137_A 161_F 1.124 0.86
91_T 94_E 1.119 0.86
21_L 61_N 1.117 0.86
57_Q 61_N 1.116 0.86
33_A 302_F 1.116 0.86
214_N 219_R 1.11 0.85
28_I 53_A 1.109 0.85
205_I 217_V 1.104 0.85
104_V 224_N 1.1 0.84
194_T 198_N 1.098 0.84
202_L 226_R 1.098 0.84
206_N 209_R 1.091 0.84
296_L 300_G 1.088 0.83
250_S 253_G 1.087 0.83
168_M 186_A 1.086 0.83
155_D 194_T 1.084 0.83
30_V 186_A 1.079 0.83
144_G 201_N 1.076 0.83
164_W 186_A 1.074 0.82
193_A 290_A 1.072 0.82
203_R 215_T 1.065 0.82
80_G 83_R 1.064 0.82
25_F 50_L 1.06 0.81
162_F 166_S 1.048 0.80
44_L 231_C 1.047 0.80
205_I 222_E 1.046 0.80
237_L 263_L 1.043 0.80
55_L 106_I 1.043 0.80
158_V 197_L 1.041 0.80
101_I 105_L 1.04 0.80
201_N 204_D 1.034 0.79
83_R 162_F 1.031 0.79
195_A 217_V 1.031 0.79
52_T 169_G 1.025 0.78
81_P 86_Q 1.022 0.78
60_S 196_V 1.022 0.78
133_L 157_S 1.02 0.78
18_P 167_V 1.02 0.78
55_L 102_T 1.019 0.78
254_W 257_L 1.019 0.78
24_A 57_Q 1.016 0.77
16_L 102_T 1.014 0.77
234_M 238_V 1.003 0.76
9_T 13_L 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.31493.40.971Contact Map0.146
1m56D20.11362.50.973Contact Map0.781
1zoyC10.31492.30.973Contact Map0.275
3hd7A20.126620.974Contact Map0.335
2h88C20.31491.80.975Contact Map0.325
3tx3A20.62011.80.975Contact Map0.184
1colA20.25651.80.975Contact Map0.216
1lghA40.18181.30.977Contact Map0.312
3d31C20.33771.20.977Contact Map0.118
1rh1A10.24681.20.978Contact Map0.346

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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