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OPENSEQ.org

RHAM - L-rhamnose mutarotase
UniProt: P32156 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11865
Length: 104 (104)
Sequences: 508
Seq/Len: 4.88

RHAM
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_V 75_R 3.233 1.00
19_Q 45_L 2.645 1.00
5_A 53_F 2.497 1.00
31_A 35_S 2.312 1.00
28_E 72_V 2.254 1.00
70_T 73_C 1.966 1.00
19_Q 23_N 1.921 1.00
40_N 57_E 1.871 1.00
17_E 20_R 1.855 1.00
74_Q 78_K 1.833 1.00
87_N 91_S 1.83 1.00
25_I 30_E 1.824 1.00
3_R 99_E 1.808 1.00
36_H 67_V 1.798 1.00
11_N 85_P 1.683 0.99
17_E 21_R 1.649 0.99
9_Q 51_L 1.588 0.99
20_R 24_P 1.568 0.99
40_N 55_M 1.537 0.99
19_Q 98_Q 1.496 0.98
99_E 102_Y 1.493 0.98
3_R 102_Y 1.481 0.98
21_R 80_M 1.466 0.98
30_E 101_F 1.442 0.98
9_Q 85_P 1.437 0.98
15_H 50_N 1.414 0.97
10_V 15_H 1.408 0.97
52_L 100_V 1.308 0.95
42_A 55_M 1.273 0.94
44_Y 55_M 1.232 0.93
20_R 65_N 1.226 0.93
65_N 68_A 1.219 0.93
39_H 59_E 1.21 0.92
15_H 47_K 1.202 0.92
40_N 102_Y 1.186 0.91
43_I 53_F 1.183 0.91
7_V 51_L 1.157 0.90
3_R 62_E 1.138 0.89
32_V 67_V 1.136 0.89
36_H 66_A 1.12 0.88
73_C 77_W 1.091 0.86
33_L 36_H 1.085 0.86
32_V 70_T 1.076 0.85
62_E 66_A 1.059 0.84
29_L 73_C 1.057 0.83
87_N 90_N 1.051 0.83
25_I 29_L 1.026 0.81
26_W 72_V 1.019 0.80
32_V 36_H 1.014 0.80
77_W 93_V 1.012 0.80
3_R 57_E 1.011 0.80
42_A 99_E 1.006 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qlwA211000.041Contact Map0.73
1x8dA411000.042Contact Map0.762
1y0hA20.923189.40.867Contact Map0.594
1lq9A20.913586.70.873Contact Map0.415
1x7vA30.894285.80.875Contact Map0.753
3gz7A20.903885.10.876Contact Map0.692
2gffA20.932784.50.877Contact Map0.656
4dpoA20.903884.40.877Contact Map0.582
3bm7A10.894282.80.879Contact Map0.536
4hl9A90.913582.30.88Contact Map0.668

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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