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OPENSEQ.org
PANC - Pantothenate synthetase
UniProt: P31663 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11746
Length: 283 (281)
Sequences: 1579
Seq/Len: 5.62
PANC
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_A 51_V 4.185 1.00
182_D 198_R 3.6 1.00
39_K 175_V 3.149 1.00
79_C 90_V 3.097 1.00
156_L 174_G 2.907 1.00
180_A 186_L 2.87 1.00
41_V 82_L 2.761 1.00
135_S 168_F 2.752 1.00
48_A 147_C 2.593 1.00
25_A 48_A 2.539 1.00
202_P 205_Y 2.432 1.00
138_F 170_I 2.431 1.00
75_L 92_A 2.411 1.00
47_R 147_C 2.378 1.00
26_L 54_S 2.342 1.00
42_D 85_R 2.342 1.00
4_I 89_L 2.341 1.00
43_E 47_R 2.309 1.00
245_I 263_I 2.226 1.00
35_D 42_D 2.225 1.00
239_R 268_W 2.202 1.00
142_Q 169_D 2.177 1.00
74_T 77_E 2.165 1.00
45_K 88_D 2.148 1.00
110_D 128_R 2.144 1.00
108_Y 128_R 2.14 1.00
192_Y 272_A 2.098 1.00
48_A 145_I 2.075 1.00
41_V 53_V 2.063 1.00
5_E 75_L 1.998 1.00
32_N 74_T 1.976 1.00
53_V 87_V 1.92 1.00
145_I 171_E 1.885 1.00
17_L 50_V 1.884 1.00
13_Q 89_L 1.874 1.00
52_V 141_V 1.869 1.00
153_F 262_V 1.858 1.00
150_E 176_P 1.833 1.00
22_K 50_V 1.824 1.00
135_S 162_M 1.816 1.00
247_D 250_T 1.804 1.00
205_Y 209_S 1.792 1.00
197_Q 271_D 1.79 1.00
147_C 175_V 1.789 1.00
43_E 46_A 1.764 1.00
6_T 97_E 1.732 1.00
150_E 279_M 1.677 1.00
197_Q 270_G 1.674 1.00
6_T 9_L 1.669 1.00
38_M 81_K 1.647 1.00
10_L 14_I 1.638 0.99
10_L 140_L 1.634 0.99
182_D 202_P 1.613 0.99
134_V 159_I 1.612 0.99
53_V 82_L 1.604 0.99
26_L 141_V 1.599 0.99
194_T 197_Q 1.595 0.99
66_E 192_Y 1.568 0.99
146_A 172_I 1.568 0.99
212_A 216_Q 1.522 0.99
211_I 225_I 1.516 0.99
77_E 81_K 1.511 0.99
64_R 192_Y 1.461 0.99
25_A 147_C 1.453 0.98
150_E 262_V 1.447 0.98
131_S 162_M 1.439 0.98
131_S 158_L 1.436 0.98
122_S 241_D 1.431 0.98
47_R 145_I 1.426 0.98
160_R 174_G 1.421 0.98
94_S 97_E 1.421 0.98
254_V 261_A 1.419 0.98
229_A 243_I 1.416 0.98
43_E 175_V 1.41 0.98
119_E 264_L 1.406 0.98
139_N 168_F 1.4 0.98
211_I 243_I 1.393 0.98
163_V 172_I 1.38 0.98
11_R 142_Q 1.372 0.98
114_L 158_L 1.37 0.98
150_E 156_L 1.358 0.97
150_E 174_G 1.353 0.97
63_D 125_G 1.347 0.97
54_S 141_V 1.332 0.97
7_L 140_L 1.331 0.97
63_D 66_E 1.307 0.97
215_L 280_V 1.296 0.96
7_L 97_E 1.288 0.96
159_I 172_I 1.287 0.96
4_I 10_L 1.284 0.96
111_V 131_S 1.278 0.96
156_L 172_I 1.272 0.96
63_D 192_Y 1.269 0.96
211_I 263_I 1.269 0.96
91_F 140_L 1.268 0.96
135_S 166_M 1.25 0.95
200_I 236_K 1.238 0.95
65_P 69_A 1.233 0.95
56_F 95_V 1.228 0.95
204_L 265_V 1.227 0.95
23_R 49_D 1.225 0.94
115_S 158_L 1.212 0.94
43_E 147_C 1.203 0.94
28_P 54_S 1.2 0.94
4_I 13_Q 1.198 0.94
32_N 77_E 1.197 0.94
79_C 92_A 1.191 0.93
3_I 79_C 1.19 0.93
32_N 191_G 1.186 0.93
210_S 232_E 1.168 0.92
202_P 269_L 1.166 0.92
39_K 178_M 1.159 0.92
153_F 246_R 1.159 0.92
101_N 164_A 1.138 0.91
14_I 18_R 1.132 0.91
227_T 231_Q 1.121 0.90
230_G 234_N 1.118 0.90
45_K 51_V 1.118 0.90
226_I 245_I 1.117 0.90
138_F 146_A 1.115 0.90
119_E 244_Q 1.113 0.90
24_V 52_V 1.106 0.89
246_R 264_L 1.097 0.89
109_V 135_S 1.088 0.88
209_S 212_A 1.072 0.87
214_K 228_I 1.069 0.87
266_A 275_I 1.068 0.87
118_L 264_L 1.066 0.87
80_E 84_K 1.063 0.87
7_L 11_R 1.062 0.87
192_Y 271_D 1.059 0.87
99_Y 133_I 1.059 0.87
207_V 211_I 1.058 0.86
241_D 268_W 1.048 0.86
130_V 138_F 1.046 0.86
262_V 279_M 1.043 0.85
3_I 75_L 1.041 0.85
41_V 87_V 1.04 0.85
157_A 160_R 1.023 0.84
38_M 82_L 1.023 0.84
5_E 94_S 1.021 0.84
197_Q 272_A 1.021 0.84
14_I 89_L 1.018 0.83
233_L 240_A 1.017 0.83
211_I 229_A 1.009 0.83
13_Q 17_L 1.009 0.83
35_D 186_L 1.005 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v8fA20.96821000.014Contact Map0.783
3innA40.99291000.053Contact Map0.797
3mxtA10.98941000.056Contact Map0.769
3q12A40.99291000.098Contact Map0.82
2ejcA10.98591000.186Contact Map0.797
3ag6A20.99291000.191Contact Map0.805
3uk2A20.96821000.194Contact Map0.749
3covA20.97531000.233Contact Map0.734
3n8hA20.90811000.239Contact Map0.737
2x0kA20.830499.60.854Contact Map0.318
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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