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OPENSEQ.org

MOAE - Molybdopterin synthase catalytic subunit
UniProt: P30749 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11598
Length: 150 (147)
Sequences: 1255
Seq/Len: 8.54

MOAE
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_S 112_Q 2.932 1.00
109_E 112_Q 2.873 1.00
62_A 65_E 2.676 1.00
14_S 17_E 2.482 1.00
51_T 87_E 2.472 1.00
67_V 79_V 2.416 1.00
38_V 88_L 2.392 1.00
108_F 111_G 2.372 1.00
49_A 87_E 2.358 1.00
67_V 81_V 2.329 1.00
32_V 111_G 2.182 1.00
12_P 93_E 2.095 1.00
95_V 118_L 2.091 1.00
117_Y 121_R 1.981 1.00
16_G 20_P 1.973 1.00
66_I 114_I 1.941 1.00
32_V 108_F 1.941 1.00
69_E 121_R 1.93 1.00
63_L 81_V 1.854 1.00
8_V 85_I 1.823 1.00
101_S 107_A 1.646 1.00
18_E 82_I 1.641 1.00
97_V 115_M 1.605 1.00
68_D 72_N 1.576 1.00
64_A 68_D 1.557 1.00
70_A 114_I 1.545 1.00
22_L 98_G 1.509 1.00
32_V 107_A 1.508 1.00
95_V 115_M 1.493 1.00
52_L 94_I 1.483 1.00
51_T 127_R 1.47 1.00
74_W 113_F 1.458 0.99
19_Y 33_T 1.409 0.99
76_L 110_A 1.403 0.99
42_N 47_V 1.392 0.99
46_S 131_P 1.347 0.99
144_Q 148_K 1.326 0.99
70_A 113_F 1.324 0.99
57_G 60_E 1.311 0.99
69_E 73_R 1.309 0.99
75_P 106_S 1.298 0.98
79_V 99_V 1.283 0.98
99_V 110_A 1.28 0.98
30_A 99_V 1.268 0.98
73_R 113_F 1.237 0.98
56_P 60_E 1.232 0.98
105_S 109_E 1.207 0.97
62_A 122_A 1.203 0.97
49_A 129_A 1.192 0.97
61_K 64_A 1.191 0.97
121_R 147_A 1.175 0.97
18_E 80_T 1.165 0.96
74_W 110_A 1.158 0.96
88_L 94_I 1.157 0.96
141_E 145_Q 1.149 0.96
61_K 65_E 1.143 0.96
99_V 114_I 1.137 0.96
145_Q 148_K 1.131 0.96
51_T 129_A 1.114 0.95
88_L 92_D 1.111 0.95
28_D 77_G 1.107 0.95
70_A 74_W 1.105 0.95
62_A 121_R 1.098 0.95
22_L 80_T 1.078 0.94
111_G 115_M 1.054 0.93
106_S 109_E 1.038 0.92
60_E 64_A 1.035 0.92
18_E 96_F 1.033 0.92
113_F 117_Y 1.03 0.92
146_A 149_R 1.023 0.91
69_E 72_N 1.02 0.91
39_R 103_H 1.016 0.91
17_E 21_W 1.002 0.90
108_F 115_M 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fm0E111000.066Contact Map0.746
2omdA20.981000.115Contact Map0.895
2q5wE10.981000.12Contact Map0.748
2wp4A20.93331000.132Contact Map0.763
4ap8A40.87331000.184Contact Map0.831
3rpfA20.95331000.213Contact Map0.608
2xexA20.4827.30.938Contact Map0.514
4kiyV10.473324.30.94Contact Map0.309
2id1A20.619.70.942Contact Map0.459
1n0uA10.586715.30.945Contact Map0.251

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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