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OPENSEQ.org
TSAA - Probable tRNA (adenine(37)-N6)-methyltransferase
UniProt: P28634 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11503
Length: 235 (234)
Sequences: 417
Seq/Len: 1.78
TSAA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_M 91_T 4.074 1.00
74_T 85_R 3.933 1.00
51_L 110_V 3.669 1.00
59_I 132_V 3.608 1.00
31_S 189_E 3.364 1.00
22_V 127_V 3.124 1.00
36_L 121_L 2.327 1.00
106_E 122_G 2.263 1.00
6_F 99_P 2.214 0.99
13_R 128_D 2.162 0.99
49_R 74_T 2.105 0.99
51_L 57_L 2.093 0.99
11_V 39_I 2.041 0.99
60_L 100_I 1.968 0.98
108_K 122_G 1.9 0.98
17_K 128_D 1.9 0.98
104_L 145_L 1.886 0.98
104_L 143_E 1.877 0.98
140_P 150_A 1.829 0.97
48_V 51_L 1.808 0.97
13_R 37_H 1.783 0.97
6_F 62_V 1.725 0.96
109_E 120_K 1.707 0.95
170_E 184_T 1.684 0.95
111_V 120_K 1.602 0.93
33_N 108_K 1.556 0.91
4_F 62_V 1.53 0.90
62_V 99_P 1.521 0.90
48_V 107_L 1.513 0.90
31_S 185_L 1.501 0.89
19_K 195_P 1.485 0.89
108_K 120_K 1.483 0.89
10_G 38_L 1.478 0.88
32_A 186_F 1.461 0.88
100_I 133_V 1.432 0.86
107_L 119_L 1.43 0.86
60_L 102_M 1.428 0.86
37_H 118_I 1.423 0.86
60_L 133_V 1.381 0.83
14_S 34_G 1.35 0.81
166_T 169_V 1.319 0.79
210_A 219_R 1.308 0.78
14_S 124_L 1.292 0.77
107_L 110_V 1.285 0.77
13_R 35_E 1.266 0.75
83_N 197_P 1.254 0.74
32_A 123_S 1.248 0.74
62_V 133_V 1.246 0.74
95_F 209_Y 1.236 0.73
217_N 233_E 1.235 0.73
144_S 147_D 1.233 0.72
105_V 121_L 1.221 0.71
183_L 187_I 1.2 0.69
6_F 133_V 1.195 0.69
20_F 197_P 1.185 0.68
53_A 144_S 1.182 0.68
152_Y 199_Y 1.177 0.67
38_L 41_P 1.169 0.67
46_D 114_K 1.168 0.66
26_P 61_F 1.165 0.66
61_F 98_N 1.163 0.66
34_G 98_N 1.159 0.66
49_R 95_F 1.156 0.65
59_I 105_V 1.154 0.65
91_T 181_P 1.147 0.64
29_V 189_E 1.147 0.64
18_E 217_N 1.141 0.64
114_K 147_D 1.131 0.63
38_L 48_V 1.123 0.62
12_I 73_P 1.12 0.62
29_V 218_V 1.12 0.62
12_I 34_G 1.116 0.61
113_H 167_A 1.11 0.61
54_F 152_Y 1.096 0.59
104_L 141_F 1.093 0.59
94_T 142_A 1.085 0.58
24_R 79_R 1.078 0.57
35_E 118_I 1.067 0.56
24_R 207_K 1.063 0.56
195_P 199_Y 1.035 0.53
34_G 220_W 1.029 0.52
10_G 133_V 1.026 0.52
36_L 41_P 1.026 0.52
168_E 224_D 1.026 0.52
121_L 124_L 1.024 0.51
13_R 30_K 1.022 0.51
83_N 209_Y 1.021 0.51
231_A 234_P 1.013 0.50
20_F 81_G 1.009 0.50
8_Q 11_V 1.005 0.49
38_L 71_W 1.003 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xqbA211000.159Contact Map0.614
2nv4A20.62551000.429Contact Map0.733
3okxA20.6341000.46Contact Map0.641
1z8mA10.3234940.941Contact Map0.386
2otrA10.319193.90.941Contact Map0.497
3bpqB20.314993.90.941Contact Map0.372
3g5oB20.387293.60.942Contact Map0.494
2a6sA40.314992.30.944Contact Map0.587
2kheA10.327790.80.947Contact Map0.439
1wmiA20.323489.60.948Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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