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OPENSEQ.org
HFLD - High frequency lysogenization protein HflD
UniProt: P25746 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11345
Length: 213 (208)
Sequences: 236
Seq/Len: 1.13
HFLD
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_F 177_A 4.653 1.00
92_L 174_G 3.614 1.00
14_G 177_A 2.734 1.00
25_L 163_V 2.346 0.99
19_A 174_G 2.133 0.98
105_A 141_V 1.954 0.96
15_I 93_M 1.946 0.96
156_A 159_Q 1.822 0.93
25_L 170_T 1.797 0.93
14_G 39_S 1.761 0.92
136_A 140_D 1.742 0.91
46_M 113_I 1.681 0.89
8_I 147_P 1.669 0.88
113_I 206_L 1.581 0.84
112_R 140_D 1.58 0.84
96_E 182_H 1.556 0.83
7_D 51_T 1.544 0.82
49_S 53_A 1.54 0.82
140_D 150_Q 1.483 0.79
99_L 109_L 1.478 0.78
112_R 150_Q 1.456 0.77
16_C 164_Q 1.399 0.73
141_V 144_P 1.384 0.72
40_L 169_A 1.378 0.71
21_L 174_G 1.369 0.71
40_L 116_L 1.349 0.69
56_G 91_S 1.345 0.69
21_L 98_K 1.327 0.67
36_L 73_L 1.266 0.62
69_L 91_S 1.249 0.60
42_S 177_A 1.248 0.60
51_T 184_V 1.237 0.59
112_R 137_I 1.234 0.59
89_T 189_L 1.232 0.59
12_L 90_L 1.227 0.58
124_D 187_G 1.219 0.57
39_S 55_F 1.219 0.57
53_A 66_L 1.218 0.57
25_L 31_C 1.218 0.57
66_L 205_I 1.212 0.57
36_L 40_L 1.199 0.56
36_L 126_Q 1.189 0.55
175_I 197_R 1.184 0.54
91_S 193_F 1.181 0.54
19_A 92_L 1.18 0.54
39_S 64_V 1.178 0.54
155_P 159_Q 1.177 0.53
132_S 136_A 1.165 0.52
23_Q 179_V 1.146 0.50
8_I 90_L 1.144 0.50
43_I 114_N 1.134 0.49
98_K 191_L 1.131 0.49
106_L 109_L 1.127 0.49
143_S 171_L 1.122 0.48
159_Q 191_L 1.113 0.47
27_H 151_V 1.111 0.47
68_T 98_K 1.109 0.47
163_V 170_T 1.103 0.46
135_A 202_A 1.1 0.46
113_I 147_P 1.099 0.46
10_L 197_R 1.095 0.46
88_Y 174_G 1.091 0.45
18_S 133_A 1.089 0.45
33_A 44_I 1.088 0.45
97_R 178_A 1.085 0.45
187_G 190_Q 1.082 0.44
55_F 91_S 1.082 0.44
61_N 203_K 1.079 0.44
27_H 84_E 1.077 0.44
6_Y 205_I 1.073 0.44
92_L 203_K 1.072 0.43
17_Q 145_L 1.068 0.43
35_A 39_S 1.068 0.43
160_S 182_H 1.066 0.43
16_C 144_P 1.063 0.43
127_S 182_H 1.063 0.43
64_V 151_V 1.048 0.41
47_N 57_G 1.045 0.41
72_V 81_L 1.04 0.40
23_Q 84_E 1.038 0.40
45_D 48_P 1.037 0.40
62_L 99_L 1.031 0.40
17_Q 65_G 1.029 0.39
119_Q 195_R 1.028 0.39
45_D 53_A 1.027 0.39
87_R 143_S 1.026 0.39
55_F 203_K 1.024 0.39
173_A 197_R 1.023 0.39
17_Q 113_I 1.021 0.39
47_N 167_V 1.019 0.39
142_I 175_I 1.015 0.38
30_H 60_A 1.015 0.38
43_I 182_H 1.01 0.38
31_C 167_V 1.008 0.38
96_E 179_V 1.006 0.37
36_L 192_M 1.004 0.37
157_V 160_S 1.004 0.37
40_L 77_S 1.003 0.37
73_L 107_D 1.002 0.37
35_A 64_V 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sdiA10.99061000.019Contact Map0.353
3af5A10.511713.80.966Contact Map0.124
2ycbA20.47897.10.97Contact Map0.188
2xr1A20.48836.50.971Contact Map0.197
1zl8A10.2350.972Contact Map0.133
4j8sA10.60564.60.973Contact Map0.238
2ondA20.58223.20.975Contact Map0.237
2gukA20.33332.90.975Contact Map0.004
1uhkA20.28172.90.975Contact Map0.324
2ck3I10.13622.50.976Contact Map0.231
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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