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OPENSEQ.org
HMP - Flavohemoprotein
UniProt: P24232 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10456
Length: 396 (396)
Sequences: 763
Seq/Len: 1.93
HMP
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_I 237_A 4.991 1.00
302_H 324_Y 3.051 1.00
279_D 307_E 2.828 1.00
3_D 122_K 2.818 1.00
18_V 66_S 2.815 1.00
32_M 97_I 2.777 1.00
103_L 121_G 2.755 1.00
6_T 122_K 2.727 1.00
172_L 219_I 2.633 1.00
160_K 168_T 2.568 1.00
209_T 220_A 2.503 1.00
192_W 244_K 2.424 1.00
64_Y 127_L 2.41 1.00
158_V 173_E 2.392 1.00
86_T 249_A 2.324 1.00
70_N 73_A 2.297 1.00
263_T 357_M 2.22 1.00
169_S 218_R 2.213 1.00
3_D 6_T 2.197 1.00
191_V 243_V 2.145 0.99
238_N 241_D 2.118 0.99
79_E 134_R 2.096 0.99
266_S 274_M 2.074 0.99
159_A 171_E 1.976 0.99
154_D 244_K 1.95 0.99
159_A 239_V 1.884 0.98
293_F 343_M 1.883 0.98
254_M 277_M 1.876 0.98
156_R 242_V 1.843 0.98
91_K 94_Q 1.825 0.98
154_D 242_V 1.823 0.98
16_L 110_F 1.819 0.98
129_N 133_N 1.798 0.97
173_E 215_K 1.784 0.97
82_A 134_R 1.753 0.97
157_I 172_L 1.749 0.97
223_R 235_N 1.748 0.97
87_S 205_Q 1.73 0.96
136_A 150_E 1.714 0.96
31_R 104_A 1.714 0.96
376_V 382_Q 1.707 0.96
4_A 8_A 1.707 0.96
295_A 343_M 1.696 0.96
35_H 101_H 1.672 0.95
312_G 318_F 1.662 0.95
156_R 175_V 1.657 0.95
210_R 279_D 1.612 0.94
263_T 359_F 1.596 0.94
136_A 140_N 1.594 0.94
27_H 31_R 1.58 0.93
327_P 331_D 1.566 0.93
100_E 104_A 1.532 0.92
16_L 113_G 1.531 0.92
31_R 101_H 1.525 0.91
167_I 269_V 1.518 0.91
17_L 21_G 1.503 0.91
221_V 233_L 1.496 0.90
156_R 173_E 1.493 0.90
107_D 114_Q 1.491 0.90
118_D 122_K 1.474 0.90
237_A 243_V 1.466 0.89
163_R 169_S 1.464 0.89
282_A 318_F 1.46 0.89
193_L 229_V 1.459 0.89
262_V 281_L 1.455 0.89
26_A 30_D 1.453 0.89
24_L 105_T 1.445 0.88
189_L 245_L 1.442 0.88
153_R 178_G 1.442 0.88
14_I 18_V 1.432 0.88
299_G 327_P 1.431 0.88
308_V 320_A 1.423 0.87
185_P 276_A 1.412 0.87
122_K 126_V 1.407 0.86
93_E 96_N 1.399 0.86
5_Q 8_A 1.393 0.86
117_L 121_G 1.387 0.85
27_H 108_E 1.383 0.85
154_D 175_V 1.381 0.85
296_A 301_V 1.368 0.84
331_D 337_F 1.366 0.84
180_V 183_Y 1.361 0.84
61_I 106_L 1.355 0.83
170_F 233_L 1.351 0.83
16_L 19_E 1.342 0.83
163_R 209_T 1.337 0.82
181_A 217_Y 1.333 0.82
137_E 140_N 1.332 0.82
91_K 96_N 1.33 0.82
281_L 286_H 1.303 0.80
6_T 126_V 1.301 0.80
63_A 77_A 1.3 0.80
266_S 294_H 1.3 0.80
161_T 171_E 1.294 0.79
6_T 118_D 1.292 0.79
13_T 116_V 1.289 0.79
375_L 380_V 1.281 0.78
163_R 220_A 1.268 0.77
24_L 113_G 1.267 0.77
325_R 370_F 1.262 0.77
334_K 337_F 1.258 0.77
162_P 168_T 1.255 0.76
64_Y 74_L 1.251 0.76
107_D 117_L 1.246 0.76
71_L 130_V 1.237 0.75
212_P 276_A 1.233 0.75
24_L 27_H 1.231 0.74
299_G 331_D 1.225 0.74
389_C 393_H 1.216 0.73
5_Q 10_V 1.214 0.73
39_L 205_Q 1.213 0.73
361_L 385_I 1.212 0.73
11_K 69_E 1.206 0.72
155_F 174_P 1.203 0.72
31_R 108_E 1.195 0.71
62_A 66_S 1.188 0.71
44_N 47_N 1.187 0.71
42_I 94_Q 1.177 0.70
309_K 322_T 1.173 0.69
14_I 62_A 1.16 0.68
275_L 307_E 1.159 0.68
295_A 325_R 1.151 0.67
101_H 104_A 1.146 0.67
364_P 368_M 1.145 0.67
57_L 98_V 1.143 0.66
298_N 326_Q 1.142 0.66
261_P 289_Q 1.136 0.66
278_L 308_V 1.133 0.65
32_M 38_E 1.126 0.65
267_A 370_F 1.126 0.65
74_L 123_A 1.123 0.64
75_L 78_V 1.122 0.64
28_F 99_G 1.122 0.64
261_P 264_L 1.122 0.64
68_I 74_L 1.121 0.64
35_H 100_E 1.121 0.64
271_Q 292_W 1.12 0.64
305_A 336_Q 1.119 0.64
87_S 190_G 1.118 0.64
7_I 77_A 1.116 0.64
67_N 70_N 1.114 0.64
122_K 387_Y 1.109 0.63
169_S 220_A 1.101 0.62
27_H 30_D 1.1 0.62
99_G 103_L 1.094 0.61
171_E 216_G 1.091 0.61
49_R 94_Q 1.09 0.61
293_F 323_W 1.085 0.60
61_I 69_E 1.084 0.60
141_E 283_K 1.083 0.60
130_V 247_A 1.082 0.60
232_W 237_A 1.078 0.60
160_K 238_N 1.078 0.60
78_V 131_F 1.074 0.59
27_H 105_T 1.066 0.58
202_E 205_Q 1.064 0.58
373_K 377_D 1.062 0.58
165_A 300_D 1.062 0.58
183_Y 208_L 1.062 0.58
82_A 131_F 1.061 0.58
20_T 113_G 1.06 0.58
124_Y 128_A 1.054 0.57
173_E 216_G 1.052 0.57
344_D 347_K 1.05 0.57
136_A 143_A 1.041 0.56
312_G 320_A 1.039 0.56
192_W 201_Q 1.039 0.56
264_L 288_A 1.034 0.55
171_E 218_R 1.032 0.55
315_L 318_F 1.028 0.54
39_L 101_H 1.027 0.54
33_F 101_H 1.027 0.54
17_L 68_I 1.025 0.54
32_M 90_I 1.014 0.53
327_P 337_F 1.013 0.53
26_A 54_R 1.008 0.52
17_L 62_A 1.005 0.52
32_M 100_E 1.003 0.52
183_Y 276_A 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gvhA111000.321Contact Map0.636
1cqxA20.99751000.326Contact Map0.666
4g1vA10.95451000.348Contact Map0.673
4eh1A20.5961000.661Contact Map0.84
1krhA20.8031000.681Contact Map0.708
1tvcA10.61361000.682Contact Map0.452
1qfjA40.57831000.682Contact Map0.751
2piaA10.57831000.685Contact Map0.757
2r6hA40.60861000.687Contact Map0.796
2eixA20.60351000.69Contact Map0.772
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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