May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
UXUA - Mannonate dehydratase
UniProt: P24215 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11066
Length: 394 (390)
Sequences: 461
Seq/Len: 1.18
UXUA
Paralog alert: 0.14 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_L 228_V 4.112 1.00
89_L 100_V 4.064 1.00
90_R 225_E 4.052 1.00
224_E 263_S 3.831 1.00
204_D 207_K 3.308 1.00
83_A 86_Q 3.295 1.00
93_A 226_V 3.27 1.00
212_F 232_V 3.268 1.00
42_V 95_C 3.093 1.00
65_V 88_T 2.798 1.00
4_T 26_G 2.72 1.00
86_Q 218_A 2.66 1.00
101_C 269_T 2.642 1.00
255_Q 289_Q 2.566 1.00
33_H 44_E 2.551 1.00
251_I 285_D 2.527 1.00
282_D 285_D 2.47 0.99
227_G 265_A 2.447 0.99
251_I 289_Q 2.416 0.99
287_I 291_G 2.333 0.99
68_H 81_W 2.243 0.99
15_S 18_D 2.235 0.99
220_I 230_M 2.233 0.99
217_K 261_V 2.193 0.98
383_V 387_I 2.107 0.98
272_T 326_V 2.106 0.98
324_Y 383_V 1.972 0.96
29_T 52_I 1.958 0.96
45_I 92_L 1.958 0.96
65_V 92_L 1.953 0.96
90_R 226_V 1.951 0.96
209_R 256_W 1.939 0.96
297_T 330_I 1.936 0.96
249_S 253_D 1.902 0.95
315_A 318_N 1.899 0.95
79_E 214_V 1.897 0.95
324_Y 387_I 1.887 0.95
254_M 268_F 1.869 0.95
74_H 78_Y 1.858 0.94
49_K 53_E 1.849 0.94
42_V 94_Q 1.832 0.94
222_V 225_E 1.828 0.94
324_Y 390_A 1.793 0.93
213_A 217_K 1.793 0.93
277_V 302_T 1.789 0.93
248_V 257_M 1.761 0.92
219_I 230_M 1.755 0.92
198_E 201_K 1.755 0.92
50_A 54_D 1.747 0.92
79_E 218_A 1.742 0.92
159_A 163_A 1.71 0.91
2_E 60_S 1.651 0.88
213_A 260_T 1.636 0.88
287_I 294_I 1.632 0.88
327_V 380_V 1.624 0.87
359_D 362_K 1.613 0.87
28_V 61_V 1.609 0.87
128_F 239_R 1.59 0.86
383_V 386_A 1.556 0.84
357_L 370_A 1.543 0.83
284_V 325_E 1.536 0.83
267_G 295_Y 1.533 0.83
285_D 289_Q 1.521 0.82
216_L 261_V 1.506 0.81
220_I 263_S 1.494 0.81
65_V 89_L 1.484 0.80
250_T 278_R 1.472 0.79
90_R 222_V 1.458 0.78
1_M 327_V 1.457 0.78
129_D 310_T 1.453 0.78
291_G 333_E 1.451 0.78
34_I 41_S 1.451 0.78
77_N 80_Q 1.445 0.77
251_I 290_F 1.439 0.77
70_D 77_N 1.437 0.77
100_V 228_V 1.431 0.76
8_Y 126_L 1.43 0.76
87_Q 90_R 1.41 0.75
254_M 258_V 1.408 0.75
299_L 327_V 1.396 0.74
132_E 161_R 1.392 0.74
44_E 47_K 1.39 0.73
42_V 46_L 1.389 0.73
46_L 95_C 1.371 0.72
93_A 100_V 1.348 0.70
254_M 275_Y 1.34 0.70
255_Q 259_D 1.334 0.69
29_T 59_W 1.322 0.68
34_I 44_E 1.314 0.67
169_D 172_R 1.309 0.67
17_A 55_A 1.299 0.66
283_L 304_R 1.286 0.65
2_E 58_V 1.285 0.65
250_T 280_D 1.285 0.65
229_R 265_A 1.279 0.64
78_Y 214_V 1.274 0.64
317_L 381_R 1.272 0.64
329_A 332_E 1.269 0.63
185_E 190_L 1.257 0.62
232_V 248_V 1.254 0.62
331_V 387_I 1.253 0.62
39_V 91_N 1.252 0.62
46_L 50_A 1.246 0.61
284_V 288_K 1.241 0.61
74_H 211_N 1.24 0.61
209_R 253_D 1.236 0.60
10_P 51_I 1.229 0.60
258_V 268_F 1.227 0.60
28_V 296_F 1.226 0.59
324_Y 389_R 1.221 0.59
334_E 339_A 1.216 0.58
288_K 325_E 1.213 0.58
118_V 124_K 1.207 0.58
322_D 389_R 1.201 0.57
83_A 218_A 1.2 0.57
4_T 219_I 1.198 0.57
69_E 73_T 1.191 0.56
303_M 320_D 1.183 0.55
305_E 310_T 1.181 0.55
87_Q 91_N 1.174 0.54
238_P 277_V 1.161 0.53
248_V 254_M 1.159 0.53
60_S 98_R 1.156 0.53
139_H 162_F 1.152 0.52
220_I 223_A 1.151 0.52
283_L 286_M 1.147 0.52
39_V 87_Q 1.137 0.51
269_T 296_F 1.135 0.51
284_V 291_G 1.135 0.51
272_T 330_I 1.133 0.51
74_H 214_V 1.133 0.51
161_R 165_M 1.132 0.50
255_Q 290_F 1.127 0.50
54_D 202_D 1.119 0.49
61_V 99_T 1.117 0.49
20_R 120_P 1.1 0.47
101_C 296_F 1.09 0.46
275_Y 284_V 1.089 0.46
231_A 269_T 1.087 0.46
124_K 355_Q 1.079 0.45
365_N 369_S 1.077 0.45
86_Q 219_I 1.076 0.45
287_I 330_I 1.072 0.45
275_Y 286_M 1.072 0.45
73_T 223_A 1.07 0.44
30_A 36_N 1.067 0.44
324_Y 386_A 1.065 0.44
299_L 348_M 1.062 0.44
327_V 383_V 1.058 0.43
259_D 262_N 1.054 0.43
65_V 185_E 1.05 0.43
74_H 79_E 1.046 0.42
378_A 381_R 1.045 0.42
151_T 154_E 1.041 0.42
339_A 346_I 1.041 0.42
261_V 266_N 1.037 0.41
324_Y 328_K 1.034 0.41
231_A 275_Y 1.029 0.41
321_V 326_V 1.028 0.40
270_M 286_M 1.028 0.40
194_R 198_E 1.024 0.40
99_T 347_P 1.024 0.40
139_H 159_A 1.023 0.40
5_W 24_A 1.023 0.40
250_T 253_D 1.021 0.40
54_D 94_Q 1.015 0.39
251_I 255_Q 1.009 0.39
78_Y 82_I 1.007 0.39
86_Q 90_R 1.006 0.38
248_V 268_F 1.005 0.38
303_M 318_N 1.003 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4eacA411000.421Contact Map0.775
3bdkA20.87311000.578Contact Map0.784
1tz9A20.88831000.683Contact Map0.741
3vniA40.695499.90.872Contact Map0.59
3cqjA20.682799.80.879Contact Map0.621
2qulA40.685399.80.88Contact Map0.613
1i60A10.682799.80.88Contact Map0.542
2zdsA60.720899.80.881Contact Map0.647
2hk0A40.685399.80.881Contact Map0.577
3obeA20.657499.80.882Contact Map0.502
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.2222 seconds.