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OPENSEQ.org
LNT - Apolipoprotein N-acyltransferase
UniProt: P23930 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10168
Length: 512 (483)
Sequences: 1316
Seq/Len: 2.72
LNT
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_M 171_A 6.683 1.00
453_G 457_E 4.585 1.00
462_I 468_E 4.36 1.00
451_V 472_T 4.252 1.00
436_L 484_A 3.656 1.00
426_F 450_A 3.616 1.00
161_K 434_L 3.44 1.00
411_S 444_T 3.368 1.00
229_G 249_Y 3.229 1.00
432_R 435_E 3.004 1.00
316_I 410_I 2.962 1.00
57_A 106_G 2.924 1.00
483_Y 488_N 2.829 1.00
315_T 334_N 2.588 1.00
225_S 471_T 2.452 1.00
253_T 265_W 2.406 1.00
152_G 169_V 2.384 1.00
133_Q 174_F 2.368 1.00
433_A 440_L 2.287 1.00
407_L 440_L 2.26 1.00
125_A 129_P 2.243 1.00
382_L 406_Y 2.235 1.00
226_M 449_T 2.225 1.00
20_F 43_G 2.166 1.00
165_P 437_A 2.117 1.00
71_G 149_L 2.096 1.00
482_P 486_T 2.015 1.00
397_R 487_G 2.014 1.00
225_S 260_S 1.97 0.99
18_L 62_C 1.944 0.99
288_L 295_L 1.935 0.99
25_T 70_S 1.878 0.99
136_E 173_N 1.867 0.99
164_A 172_I 1.833 0.99
413_D 425_H 1.832 0.99
439_P 475_T 1.831 0.99
426_F 458_I 1.802 0.99
248_I 467_R 1.802 0.99
157_D 430_R 1.778 0.99
165_P 434_L 1.776 0.99
253_T 263_I 1.767 0.99
226_M 443_S 1.749 0.98
17_A 21_G 1.744 0.98
337_H 395_Q 1.731 0.98
439_P 454_P 1.695 0.98
24_G 40_S 1.684 0.98
226_M 470_L 1.683 0.98
37_A 155_Q 1.675 0.98
423_W 448_I 1.664 0.98
40_S 63_W 1.652 0.97
38_I 180_S 1.625 0.97
430_R 458_I 1.616 0.97
24_G 63_W 1.615 0.97
348_E 364_S 1.606 0.97
406_Y 474_V 1.601 0.97
350_I 354_L 1.59 0.97
383_T 407_L 1.582 0.96
61_F 99_A 1.576 0.96
390_I 409_T 1.567 0.96
223_Q 473_N 1.552 0.96
65_F 69_G 1.545 0.96
440_L 452_I 1.544 0.96
385_A 396_V 1.538 0.96
78_S 416_F 1.534 0.96
449_T 462_I 1.531 0.95
233_Q 236_K 1.521 0.95
60_G 106_G 1.521 0.95
153_Y 428_M 1.508 0.95
437_A 481_T 1.487 0.94
162_G 165_P 1.477 0.94
236_K 268_S 1.477 0.94
112_L 128_A 1.471 0.94
172_I 175_L 1.47 0.94
72_I 146_F 1.467 0.94
422_P 464_Q 1.467 0.94
163_L 175_L 1.463 0.94
405_D 476_P 1.448 0.93
338_L 388_Y 1.444 0.93
300_V 365_F 1.441 0.93
138_L 142_V 1.437 0.93
164_A 431_M 1.418 0.92
60_G 64_G 1.415 0.92
347_L 351_L 1.41 0.92
249_Y 269_A 1.408 0.92
264_I 441_L 1.402 0.92
68_F 139_R 1.401 0.92
224_V 441_L 1.395 0.92
390_I 440_L 1.394 0.92
409_T 442_R 1.385 0.91
53_P 110_G 1.382 0.91
453_G 459_Q 1.376 0.91
429_A 440_L 1.368 0.91
316_I 384_A 1.362 0.90
62_C 66_G 1.354 0.90
46_A 184_A 1.343 0.89
56_S 109_A 1.342 0.89
413_D 442_R 1.334 0.89
153_Y 431_M 1.333 0.89
155_Q 172_I 1.329 0.89
61_F 102_S 1.327 0.89
299_I 317_I 1.322 0.88
230_D 467_R 1.317 0.88
207_P 210_Y 1.315 0.88
480_L 485_R 1.314 0.88
406_Y 441_L 1.313 0.88
61_F 65_F 1.313 0.88
383_T 404_T 1.294 0.87
129_P 178_M 1.294 0.87
285_D 289_R 1.292 0.87
100_Y 104_Y 1.284 0.86
148_W 424_Q 1.283 0.86
227_V 469_V 1.281 0.86
271_T 445_N 1.28 0.86
268_S 445_N 1.273 0.86
21_G 66_G 1.262 0.85
155_Q 176_L 1.261 0.85
161_K 431_M 1.259 0.85
426_F 452_I 1.257 0.85
352_R 359_D 1.252 0.85
53_P 57_A 1.251 0.84
68_F 102_S 1.249 0.84
296_V 318_T 1.245 0.84
458_I 461_M 1.243 0.84
248_I 251_N 1.239 0.84
27_A 37_A 1.238 0.84
301_D 334_N 1.234 0.83
139_R 145_G 1.224 0.83
31_Y 420_I 1.223 0.83
229_G 245_T 1.215 0.82
42_M 180_S 1.2 0.81
167_M 175_L 1.198 0.81
425_H 442_R 1.197 0.81
243_L 247_K 1.197 0.81
94_V 97_L 1.194 0.80
154_S 172_I 1.187 0.80
441_L 449_T 1.182 0.80
415_W 442_R 1.179 0.79
233_Q 237_W 1.176 0.79
422_P 448_I 1.175 0.79
225_S 469_V 1.175 0.79
235_L 241_Q 1.166 0.78
245_T 271_T 1.165 0.78
296_V 408_L 1.165 0.78
20_F 62_C 1.164 0.78
162_G 434_L 1.162 0.78
24_G 151_F 1.157 0.77
235_L 238_D 1.155 0.77
407_L 436_L 1.151 0.77
247_K 251_N 1.15 0.77
266_P 414_A 1.146 0.77
413_D 421_G 1.145 0.76
339_V 386_I 1.14 0.76
263_I 293_S 1.139 0.76
385_A 390_I 1.139 0.76
104_Y 108_F 1.138 0.76
150_Q 153_Y 1.137 0.76
439_P 474_V 1.136 0.76
380_I 405_D 1.134 0.75
75_V 269_A 1.132 0.75
486_T 490_P 1.127 0.75
397_R 436_L 1.121 0.74
452_I 458_I 1.119 0.74
269_A 297_T 1.115 0.74
133_Q 173_N 1.115 0.74
439_P 451_V 1.115 0.74
365_F 417_G 1.114 0.74
411_S 464_Q 1.104 0.73
66_G 71_G 1.102 0.72
388_Y 442_R 1.094 0.72
65_F 99_A 1.092 0.72
381_E 405_D 1.082 0.71
186_A 198_A 1.077 0.70
226_M 451_V 1.075 0.70
439_P 477_T 1.073 0.70
35_P 38_I 1.069 0.69
451_V 474_V 1.066 0.69
72_I 75_V 1.063 0.69
63_W 108_F 1.063 0.69
227_V 265_W 1.062 0.68
265_W 393_G 1.061 0.68
224_V 451_V 1.059 0.68
73_N 419_S 1.054 0.68
87_G 90_N 1.053 0.68
40_S 47_L 1.05 0.67
421_G 442_R 1.048 0.67
172_I 431_M 1.048 0.67
65_F 102_S 1.046 0.67
236_K 239_E 1.044 0.67
438_R 480_L 1.043 0.66
268_S 415_W 1.041 0.66
165_P 482_P 1.035 0.66
460_A 470_L 1.035 0.66
100_Y 105_T 1.034 0.65
72_I 149_L 1.033 0.65
18_L 496_A 1.029 0.65
83_G 86_P 1.029 0.65
413_D 422_P 1.028 0.65
404_T 436_L 1.022 0.64
201_L 205_P 1.022 0.64
224_V 406_Y 1.022 0.64
27_A 154_S 1.022 0.64
264_I 296_V 1.018 0.64
47_L 59_I 1.017 0.64
156_I 430_R 1.017 0.64
108_F 135_T 1.01 0.63
348_E 352_R 1.009 0.63
151_F 177_M 1.007 0.62
110_G 114_R 1.005 0.62
166_I 482_P 1.004 0.62
87_G 91_I 1.004 0.62
233_Q 365_F 1.003 0.62
403_D 438_R 1.002 0.62
222_I 262_L 1.001 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1uf5A20.51761000.685Contact Map0.683
2w1vA20.49221000.708Contact Map0.743
3p8kA20.49021000.709Contact Map0.725
1f89A20.5021000.712Contact Map0.715
4f4hA20.50591000.716Contact Map0.74
2e11A40.46091000.717Contact Map0.726
3ivzA20.44731000.72Contact Map0.811
3hkxA10.4981000.72Contact Map0.672
4lf0A10.52931000.721Contact Map0.67
1emsA20.5411000.727Contact Map0.748
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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