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OPENSEQ.org
HIPA - Serine/threonine-protein kinase HipA
UniProt: P23874 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10443
Length: 440 (427)
Sequences: 1010
Seq/Len: 2.37
HIPA
Paralog alert: 0.27 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_D 234_E 4.274 1.00
14_G 26_F 3.824 1.00
207_L 220_A 3.036 1.00
297_K 391_I 2.925 1.00
301_F 305_I 2.736 1.00
32_W 39_R 2.735 1.00
291_D 326_R 2.622 1.00
297_K 394_D 2.598 1.00
318_F 328_T 2.553 1.00
252_Q 331_Y 2.543 1.00
252_Q 316_S 2.505 1.00
206_C 305_I 2.457 1.00
208_L 211_K 2.438 1.00
215_L 330_F 2.354 1.00
121_T 124_R 2.285 1.00
330_F 333_I 2.25 1.00
293_Y 387_Q 2.23 1.00
296_M 388_M 2.143 1.00
201_D 229_R 2.132 1.00
30_P 34_A 2.111 1.00
303_W 374_F 2.063 0.99
210_A 301_F 2.023 0.99
43_L 253_E 2 0.99
13_V 32_W 1.986 0.99
316_S 331_Y 1.984 0.99
252_Q 318_F 1.977 0.99
12_R 29_A 1.973 0.99
180_I 232_A 1.968 0.99
285_S 291_D 1.955 0.99
207_L 231_L 1.953 0.99
371_P 393_S 1.924 0.99
298_F 330_F 1.884 0.99
209_L 402_A 1.862 0.99
16_L 61_F 1.857 0.99
278_I 295_F 1.838 0.99
216_N 294_D 1.807 0.98
7_W 104_I 1.796 0.98
253_E 257_Q 1.782 0.98
204_Y 220_A 1.78 0.98
176_T 234_E 1.777 0.98
210_A 333_I 1.776 0.98
64_L 103_L 1.755 0.98
375_L 388_M 1.745 0.98
178_H 234_E 1.681 0.97
218_P 233_V 1.666 0.97
213_L 398_M 1.649 0.97
72_R 76_V 1.646 0.97
5_V 107_D 1.636 0.96
212_E 406_V 1.632 0.96
223_I 232_A 1.628 0.96
254_D 331_Y 1.611 0.96
319_I 323_G 1.602 0.96
320_Q 326_R 1.573 0.95
293_Y 391_I 1.555 0.95
294_D 298_F 1.553 0.95
126_E 226_G 1.54 0.94
298_F 315_F 1.529 0.94
207_L 217_V 1.509 0.94
204_Y 208_L 1.506 0.93
352_L 356_L 1.505 0.93
6_T 26_F 1.493 0.93
151_V 179_I 1.471 0.92
416_E 420_T 1.465 0.92
151_V 159_A 1.465 0.92
207_L 218_P 1.448 0.92
102_T 249_R 1.441 0.91
379_K 385_E 1.441 0.91
28_Y 47_L 1.441 0.91
213_L 395_F 1.436 0.91
208_L 409_S 1.417 0.90
300_V 391_I 1.412 0.90
150_S 238_R 1.406 0.90
67_D 154_A 1.401 0.90
33_L 47_L 1.399 0.90
4_L 91_S 1.398 0.90
254_D 266_K 1.396 0.90
85_Q 88_D 1.396 0.90
211_K 219_D 1.394 0.89
255_M 278_I 1.389 0.89
43_L 317_V 1.384 0.89
200_V 222_I 1.381 0.89
256_C 312_A 1.38 0.89
100_A 251_P 1.371 0.88
45_L 52_I 1.356 0.88
202_N 206_C 1.35 0.87
213_L 399_I 1.345 0.87
283_M 292_R 1.332 0.86
41_L 101_V 1.324 0.86
282_L 317_V 1.322 0.86
375_L 389_H 1.318 0.86
212_E 405_N 1.316 0.86
282_L 291_D 1.294 0.84
218_P 330_F 1.29 0.84
402_A 405_N 1.288 0.84
152_A 254_D 1.28 0.83
279_M 295_F 1.267 0.82
272_G 275_I 1.266 0.82
275_I 279_M 1.236 0.80
420_T 424_S 1.233 0.80
299_Q 377_T 1.227 0.80
63_N 152_A 1.219 0.79
63_N 310_G 1.217 0.79
288_A 291_D 1.215 0.79
304_L 395_F 1.214 0.79
61_F 103_L 1.213 0.78
177_T 247_L 1.21 0.78
308_T 336_A 1.209 0.78
385_E 389_H 1.209 0.78
126_E 227_N 1.208 0.78
371_P 374_F 1.205 0.78
254_D 257_Q 1.2 0.77
202_N 335_S 1.197 0.77
63_N 298_F 1.197 0.77
67_D 74_R 1.197 0.77
64_L 257_Q 1.194 0.77
5_V 104_I 1.193 0.77
5_V 12_R 1.19 0.77
63_N 254_D 1.189 0.77
207_L 233_V 1.188 0.76
378_A 388_M 1.188 0.76
63_N 257_Q 1.185 0.76
220_A 233_V 1.182 0.76
308_T 334_I 1.18 0.76
387_Q 390_E 1.176 0.75
62_D 72_R 1.173 0.75
96_D 257_Q 1.173 0.75
279_M 292_R 1.173 0.75
28_Y 45_L 1.164 0.74
271_G 274_G 1.163 0.74
155_Q 310_G 1.157 0.74
118_E 124_R 1.154 0.73
6_T 103_L 1.154 0.73
417_N 424_S 1.144 0.73
39_R 182_L 1.144 0.73
259_F 281_F 1.143 0.72
64_L 202_N 1.141 0.72
416_E 419_V 1.141 0.72
42_S 257_Q 1.138 0.72
26_F 61_F 1.134 0.72
178_H 232_A 1.129 0.71
6_T 61_F 1.127 0.71
300_V 392_L 1.125 0.71
127_E 131_A 1.124 0.71
210_A 305_I 1.122 0.70
103_L 120_L 1.117 0.70
67_D 155_Q 1.102 0.68
294_D 297_K 1.099 0.68
302_Q 310_G 1.098 0.68
236_F 252_Q 1.09 0.67
267_Y 313_K 1.087 0.67
67_D 152_A 1.085 0.67
155_Q 266_K 1.081 0.66
218_P 231_L 1.081 0.66
40_P 47_L 1.079 0.66
225_A 230_A 1.072 0.65
306_G 366_I 1.07 0.65
310_G 325_Y 1.069 0.65
205_Y 406_V 1.065 0.65
215_L 301_F 1.064 0.65
60_F 257_Q 1.061 0.64
155_Q 195_D 1.06 0.64
296_M 378_A 1.06 0.64
370_Y 373_H 1.058 0.64
160_L 232_A 1.057 0.64
212_E 402_A 1.054 0.63
415_P 418_V 1.052 0.63
28_Y 46_P 1.046 0.63
200_V 231_L 1.044 0.62
7_W 12_R 1.041 0.62
94_G 331_Y 1.04 0.62
250_L 318_F 1.04 0.62
38_A 47_L 1.039 0.62
178_H 200_V 1.036 0.61
209_L 305_I 1.036 0.61
296_M 300_V 1.032 0.61
45_L 60_F 1.03 0.61
238_R 257_Q 1.03 0.61
297_K 395_F 1.029 0.61
278_I 282_L 1.028 0.61
240_W 247_L 1.027 0.60
202_N 205_Y 1.027 0.60
11_Q 35_S 1.026 0.60
359_S 373_H 1.025 0.60
63_N 155_Q 1.02 0.60
5_V 105_P 1.02 0.60
406_V 410_L 1.015 0.59
423_E 426_V 1.015 0.59
271_G 312_A 1.015 0.59
64_L 254_D 1.013 0.59
227_N 300_V 1.012 0.59
61_F 154_A 1.011 0.59
6_T 101_V 1.009 0.58
67_D 195_D 1.006 0.58
254_D 310_G 1.005 0.58
155_Q 254_D 1.004 0.58
258_T 317_V 1.004 0.58
48_Q 52_I 1 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tpdA10.99551000.178Contact Map0.758
3akjA20.61821000.625Contact Map0.63
1cjaA20.6795910.95Contact Map0.448
3ezqA80.188634.40.969Contact Map0.815
3ezqB80.181829.90.97Contact Map0.732
3oq9A50.161420.10.972Contact Map0.699
1nd4A20.5159170.973Contact Map0.457
1ichA10.213615.80.973Contact Map0.881
1fadA10.197713.60.974Contact Map0.349
2of5A70.1659130.974Contact Map0.743
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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