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OPENSEQ.org
FECR - Protein FecR
UniProt: P23485 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10292
Length: 317 (308)
Sequences: 2143
Seq/Len: 6.96
FECR
Paralog alert: 0.45 [within 20: 0.12] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
132_N 154_E 4.835 1.00
162_D 166_R 3.867 1.00
129_L 137_A 3.728 1.00
40_Y 47_Q 3.597 1.00
178_T 203_E 2.94 1.00
29_S 32_Q 2.897 1.00
197_V 218_A 2.79 1.00
183_E 199_Q 2.575 1.00
154_E 185_T 2.379 1.00
147_T 171_L 2.216 1.00
156_A 183_E 2.174 1.00
134_Q 152_Y 2.16 1.00
138_D 149_R 2.146 1.00
158_T 183_E 2.11 1.00
249_F 257_V 2.11 1.00
251_D 279_R 2.087 1.00
252_K 256_E 2.065 1.00
39_W 46_N 2.039 1.00
116_G 133_T 1.994 1.00
253_P 256_E 1.989 1.00
252_K 257_V 1.988 1.00
158_T 199_Q 1.968 1.00
204_V 222_L 1.939 1.00
12_A 46_N 1.927 1.00
22_V 32_Q 1.912 1.00
261_L 292_I 1.885 1.00
138_D 151_W 1.875 1.00
118_V 287_K 1.863 1.00
45_D 48_W 1.861 1.00
246_I 283_T 1.851 1.00
28_V 32_Q 1.843 1.00
90_L 93_G 1.838 1.00
195_L 202_V 1.833 1.00
182_T 202_V 1.826 1.00
120_R 128_L 1.812 1.00
195_L 216_V 1.799 1.00
255_G 276_A 1.78 1.00
187_R 260_T 1.78 1.00
297_A 302_V 1.769 1.00
177_L 195_L 1.758 1.00
47_Q 51_Q 1.752 1.00
28_V 36_W 1.74 1.00
177_L 186_V 1.74 1.00
115_K 134_Q 1.71 1.00
180_L 215_I 1.694 1.00
194_Q 221_S 1.653 1.00
128_L 158_T 1.648 1.00
241_S 248_S 1.645 1.00
265_R 290_D 1.625 1.00
260_T 263_R 1.586 1.00
111_Y 121_Q 1.563 1.00
133_T 264_Y 1.555 1.00
169_R 178_T 1.548 0.99
127_S 146_R 1.526 0.99
217_N 220_E 1.52 0.99
180_L 201_A 1.51 0.99
33_E 37_Q 1.493 0.99
220_E 232_V 1.489 0.99
149_R 171_L 1.485 0.99
175_G 224_F 1.48 0.99
197_V 202_V 1.48 0.99
130_T 158_T 1.445 0.99
203_E 215_I 1.438 0.99
154_E 187_R 1.433 0.99
19_W 36_W 1.432 0.99
179_A 182_T 1.428 0.99
120_R 130_T 1.414 0.99
173_R 188_Q 1.381 0.99
156_A 243_T 1.375 0.99
125_D 146_R 1.371 0.98
42_Q 46_N 1.365 0.98
23_L 28_V 1.363 0.98
136_A 152_Y 1.361 0.98
157_I 168_F 1.357 0.98
278_L 301_P 1.352 0.98
159_T 182_T 1.349 0.98
11_Q 15_S 1.343 0.98
201_A 215_I 1.332 0.98
129_L 155_I 1.327 0.98
26_E 32_Q 1.325 0.98
196_D 221_S 1.323 0.98
113_T 116_G 1.322 0.98
51_Q 54_E 1.322 0.98
172_T 193_T 1.316 0.98
288_N 291_A 1.306 0.98
133_T 260_T 1.298 0.98
113_T 117_T 1.286 0.97
253_P 279_R 1.283 0.97
203_E 213_K 1.275 0.97
184_F 202_V 1.271 0.97
146_R 168_F 1.269 0.97
180_L 203_E 1.266 0.97
177_L 184_F 1.249 0.97
179_A 200_H 1.247 0.97
43_D 46_N 1.244 0.97
257_V 280_L 1.244 0.97
20_Y 24_S 1.232 0.96
17_S 21_A 1.221 0.96
200_H 218_A 1.219 0.96
181_G 202_V 1.202 0.96
249_F 260_T 1.198 0.96
127_S 141_F 1.197 0.96
201_A 217_N 1.191 0.95
25_G 28_V 1.184 0.95
180_L 200_H 1.177 0.95
265_R 289_T 1.173 0.95
159_T 168_F 1.168 0.95
248_S 283_T 1.168 0.95
132_N 242_W 1.163 0.95
148_V 157_I 1.16 0.95
111_Y 139_V 1.153 0.94
297_A 304_I 1.152 0.94
114_A 117_T 1.151 0.94
258_I 262_T 1.15 0.94
258_I 271_C 1.145 0.94
141_F 146_R 1.14 0.94
196_D 235_L 1.135 0.94
140_R 149_R 1.132 0.94
220_E 234_P 1.127 0.93
87_L 90_L 1.125 0.93
130_T 243_T 1.125 0.93
146_R 181_G 1.123 0.93
20_Y 53_V 1.12 0.93
127_S 159_T 1.112 0.93
127_S 160_A 1.109 0.93
32_Q 35_R 1.107 0.93
118_V 130_T 1.106 0.93
160_A 179_A 1.106 0.93
129_L 148_V 1.101 0.92
109_A 136_A 1.094 0.92
171_L 176_Q 1.092 0.92
37_Q 41_E 1.091 0.92
169_R 176_Q 1.09 0.92
40_Y 43_D 1.084 0.92
129_L 157_I 1.082 0.91
132_N 185_T 1.08 0.91
116_G 263_R 1.077 0.91
146_R 182_T 1.073 0.91
271_C 276_A 1.069 0.91
118_V 245_D 1.067 0.91
134_Q 263_R 1.061 0.90
265_R 312_I 1.06 0.90
157_I 184_F 1.057 0.90
185_T 196_D 1.055 0.90
258_I 314_I 1.047 0.90
167_P 178_T 1.047 0.90
23_L 36_W 1.046 0.90
148_V 168_F 1.046 0.90
145_Q 169_R 1.046 0.90
112_R 136_A 1.042 0.89
253_P 258_I 1.042 0.89
271_C 275_V 1.042 0.89
249_F 252_K 1.035 0.89
161_K 199_Q 1.028 0.88
137_A 148_V 1.022 0.88
133_T 263_R 1.02 0.88
142_D 145_Q 1.016 0.88
273_P 276_A 1.011 0.87
44_Q 47_Q 1.011 0.87
186_V 195_L 1.011 0.87
262_T 293_L 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4m0nA10.69091000.315Contact Map0.738
2y3mA20.239797.60.89Contact Map0.281
4g08A10.261897.40.894Contact Map0.744
3gr5A10.26597.20.896Contact Map0.72
3ezjA40.246196.50.906Contact Map0.738
3ossD10.249296.40.907Contact Map0.761
4jtmA20.239796.30.908Contact Map0.778
4ar0A10.318696.10.91Contact Map0.7
4e9jA20.287195.20.916Contact Map0.7
2w16A20.227187.60.932Contact Map0.707
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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