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OPENSEQ.org
DPO2 - DNA polymerase II
UniProt: P21189 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10747
Length: 783 (781)
Sequences: 1004
Seq/Len: 1.29
DPO2
Paralog alert: 0.18 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
672_K 677_E 4.084 1.00
408_R 540_D 3.76 1.00
198_V 207_K 2.769 1.00
434_D 437_G 2.643 1.00
668_E 672_K 2.453 1.00
303_E 341_Q 2.425 0.99
558_S 561_E 2.371 0.99
229_D 335_D 2.319 0.99
561_E 564_K 2.31 0.99
224_N 229_D 2.307 0.99
168_I 208_L 2.299 0.99
212_F 220_I 2.269 0.99
119_F 383_R 2.253 0.99
647_Q 681_R 2.14 0.98
380_R 383_R 2.099 0.98
471_T 475_H 2.084 0.98
165_L 233_L 1.988 0.97
83_C 92_Y 1.972 0.97
201_R 236_H 1.957 0.97
45_I 81_L 1.944 0.97
500_Y 516_A 1.939 0.97
200_S 203_Q 1.937 0.97
432_L 437_G 1.934 0.96
158_E 229_D 1.933 0.96
216_D 248_R 1.928 0.96
673_L 682_L 1.92 0.96
42_V 117_E 1.913 0.96
422_S 494_I 1.868 0.95
156_D 331_Y 1.844 0.95
316_E 319_R 1.843 0.95
202_P 206_E 1.813 0.94
531_K 535_E 1.812 0.94
158_E 335_D 1.808 0.94
224_N 228_F 1.791 0.94
156_D 229_D 1.762 0.93
50_V 54_Q 1.75 0.93
248_R 272_R 1.74 0.93
417_V 550_F 1.726 0.92
228_F 335_D 1.725 0.92
155_I 208_L 1.696 0.91
158_E 224_N 1.682 0.91
224_N 335_D 1.668 0.90
532_A 536_A 1.663 0.90
150_L 219_V 1.651 0.90
218_D 272_R 1.636 0.89
537_Q 572_H 1.623 0.89
156_D 335_D 1.62 0.89
158_E 331_Y 1.591 0.88
771_N 774_T 1.587 0.87
207_K 210_A 1.583 0.87
216_D 272_R 1.556 0.86
113_R 117_E 1.55 0.86
533_L 576_W 1.55 0.86
545_D 615_K 1.533 0.85
110_P 117_E 1.531 0.85
86_H 90_M 1.526 0.84
544_G 548_S 1.52 0.84
360_G 379_P 1.518 0.84
486_K 573_V 1.518 0.84
202_P 240_Y 1.514 0.84
568_A 572_H 1.51 0.84
637_V 702_H 1.484 0.82
541_V 544_G 1.483 0.82
651_E 655_R 1.481 0.82
247_G 498_A 1.477 0.82
422_S 612_G 1.467 0.81
158_E 228_F 1.46 0.81
156_D 228_F 1.459 0.81
422_S 508_C 1.457 0.80
169_G 336_C 1.448 0.80
432_L 435_P 1.446 0.80
222_G 225_V 1.44 0.79
40_E 64_R 1.439 0.79
456_D 522_R 1.438 0.79
751_H 756_Q 1.436 0.79
641_W 701_P 1.428 0.79
497_N 615_K 1.421 0.78
401_G 477_R 1.412 0.77
156_D 224_N 1.408 0.77
422_S 429_R 1.402 0.77
64_R 80_G 1.396 0.76
157_I 168_I 1.394 0.76
560_E 564_K 1.386 0.76
219_V 664_E 1.385 0.76
273_L 363_V 1.385 0.76
320_R 327_A 1.377 0.75
618_A 657_F 1.373 0.75
665_Y 669_T 1.368 0.74
199_A 203_Q 1.364 0.74
319_R 323_E 1.363 0.74
686_K 702_H 1.36 0.74
157_I 224_N 1.355 0.73
500_Y 632_K 1.355 0.73
229_D 331_Y 1.353 0.73
546_T 615_K 1.344 0.72
78_V 428_I 1.344 0.72
4_A 26_A 1.342 0.72
530_T 549_T 1.337 0.72
196_E 207_K 1.333 0.72
57_L 92_Y 1.329 0.71
45_I 96_L 1.325 0.71
228_F 305_K 1.319 0.70
61_Q 95_R 1.314 0.70
388_A 422_S 1.311 0.70
671_D 675_A 1.31 0.70
497_N 545_D 1.307 0.69
282_K 291_F 1.304 0.69
153_V 170_L 1.3 0.69
77_P 233_L 1.3 0.69
500_Y 545_D 1.295 0.68
303_E 334_K 1.294 0.68
52_R 55_H 1.293 0.68
19_T 41_S 1.286 0.68
148_P 428_I 1.286 0.68
651_E 671_D 1.282 0.67
83_C 89_L 1.276 0.67
349_M 634_L 1.276 0.67
387_V 521_M 1.274 0.67
493_K 497_N 1.269 0.66
105_E 113_R 1.265 0.66
731_V 747_L 1.264 0.66
648_F 669_T 1.26 0.65
406_D 429_R 1.259 0.65
686_K 730_Y 1.254 0.65
500_Y 614_K 1.253 0.65
550_F 619_G 1.252 0.65
463_K 651_E 1.252 0.65
572_H 575_A 1.251 0.64
421_K 593_E 1.249 0.64
219_V 349_M 1.247 0.64
529_Q 532_A 1.246 0.64
417_V 619_G 1.245 0.64
463_K 471_T 1.245 0.64
482_R 485_N 1.241 0.64
331_Y 335_D 1.24 0.63
497_N 500_Y 1.24 0.63
229_D 305_K 1.239 0.63
654_L 658_R 1.238 0.63
421_K 591_E 1.238 0.63
432_L 487_P 1.237 0.63
280_A 285_F 1.235 0.63
441_G 461_R 1.235 0.63
305_K 338_L 1.233 0.63
140_L 663_Q 1.23 0.63
322_A 629_M 1.229 0.62
618_A 634_L 1.228 0.62
43_A 89_L 1.227 0.62
779_Q 782_L 1.227 0.62
534_I 603_M 1.225 0.62
422_S 605_T 1.224 0.62
500_Y 615_K 1.223 0.62
760_V 766_P 1.22 0.62
656_I 750_E 1.219 0.61
165_L 558_S 1.215 0.61
508_C 511_F 1.21 0.61
672_K 678_L 1.21 0.61
275_I 280_A 1.21 0.61
224_N 331_Y 1.208 0.60
467_P 473_I 1.208 0.60
404_V 614_K 1.207 0.60
598_F 630_V 1.206 0.60
271_G 422_S 1.206 0.60
618_A 644_L 1.205 0.60
347_E 350_P 1.205 0.60
717_G 748_D 1.203 0.60
29_N 47_A 1.202 0.60
306_S 327_A 1.201 0.60
421_K 574_N 1.199 0.60
120_I 126_V 1.197 0.59
503_L 510_F 1.195 0.59
384_A 468_E 1.194 0.59
13_R 20_E 1.193 0.59
427_I 526_I 1.19 0.59
438_L 441_G 1.184 0.58
493_K 501_G 1.183 0.58
502_V 508_C 1.183 0.58
220_I 230_L 1.182 0.58
707_R 710_D 1.18 0.58
635_E 649_Q 1.179 0.58
668_E 671_D 1.179 0.58
429_R 494_I 1.175 0.57
12_W 16_P 1.174 0.57
235_K 238_E 1.172 0.57
388_A 428_I 1.168 0.57
652_L 656_I 1.167 0.57
760_V 763_G 1.164 0.56
209_N 242_L 1.164 0.56
218_D 248_R 1.163 0.56
527_M 549_T 1.163 0.56
158_E 305_K 1.162 0.56
641_W 759_P 1.162 0.56
29_N 95_R 1.159 0.56
500_Y 523_G 1.158 0.56
431_F 434_D 1.157 0.56
92_Y 542_I 1.154 0.55
179_Y 211_W 1.154 0.55
199_A 625_D 1.153 0.55
153_V 212_F 1.151 0.55
545_D 614_K 1.15 0.55
433_I 515_L 1.149 0.55
497_N 546_T 1.149 0.55
523_G 546_T 1.148 0.55
41_S 86_H 1.145 0.54
23_F 41_S 1.144 0.54
282_K 340_T 1.143 0.54
634_L 649_Q 1.14 0.54
539_Y 544_G 1.14 0.54
156_D 305_K 1.138 0.54
655_R 658_R 1.138 0.54
676_G 680_A 1.134 0.53
294_E 304_G 1.134 0.53
596_T 630_V 1.133 0.53
417_V 596_T 1.133 0.53
293_L 335_D 1.13 0.53
305_K 331_Y 1.13 0.53
641_W 645_A 1.128 0.53
222_G 548_S 1.128 0.53
220_I 272_R 1.127 0.53
180_M 184_E 1.125 0.52
22_S 36_L 1.122 0.52
546_T 614_K 1.117 0.52
98_E 101_V 1.116 0.51
7_I 23_F 1.115 0.51
123_P 353_L 1.115 0.51
374_G 505_T 1.115 0.51
206_E 571_Q 1.114 0.51
525_Q 677_E 1.112 0.51
404_V 615_K 1.112 0.51
433_I 629_M 1.111 0.51
385_G 461_R 1.111 0.51
374_G 509_R 1.11 0.51
23_F 114_Y 1.11 0.51
228_F 331_Y 1.108 0.51
290_S 295_T 1.107 0.51
279_E 282_K 1.106 0.50
425_P 547_D 1.102 0.50
105_E 108_V 1.099 0.50
640_D 686_K 1.098 0.50
229_D 615_K 1.097 0.50
341_Q 592_L 1.097 0.50
12_W 15_T 1.094 0.49
502_V 516_A 1.094 0.49
520_T 591_E 1.094 0.49
88_Q 91_N 1.093 0.49
731_V 773_A 1.093 0.49
195_L 246_L 1.09 0.49
431_F 437_G 1.09 0.49
154_S 169_G 1.09 0.49
592_L 646_Q 1.088 0.49
209_N 213_A 1.088 0.49
118_R 383_R 1.088 0.49
443_A 540_D 1.088 0.49
55_H 63_F 1.088 0.49
591_E 634_L 1.086 0.48
497_N 543_Y 1.085 0.48
500_Y 546_T 1.085 0.48
219_V 324_D 1.084 0.48
372_A 502_V 1.084 0.48
467_P 679_D 1.084 0.48
500_Y 520_T 1.083 0.48
406_D 422_S 1.082 0.48
103_V 106_A 1.081 0.48
206_E 241_R 1.079 0.48
133_G 136_V 1.078 0.48
692_L 707_R 1.077 0.48
119_F 382_H 1.077 0.48
406_D 754_T 1.077 0.48
714_Q 720_L 1.077 0.48
449_H 461_R 1.075 0.47
355_R 359_N 1.074 0.47
430_T 487_P 1.074 0.47
42_V 93_E 1.073 0.47
224_N 615_K 1.071 0.47
281_L 705_A 1.067 0.47
674_M 750_E 1.065 0.46
289_S 646_Q 1.065 0.46
544_G 619_G 1.06 0.46
543_Y 615_K 1.059 0.46
571_Q 575_A 1.058 0.46
539_Y 543_Y 1.057 0.46
213_A 575_A 1.057 0.46
131_H 134_T 1.057 0.46
691_P 724_N 1.055 0.45
49_Q 451_T 1.054 0.45
234_Q 238_E 1.051 0.45
380_R 384_A 1.05 0.45
37_A 56_I 1.049 0.45
367_G 466_L 1.048 0.45
62_G 84_R 1.048 0.45
532_A 535_E 1.047 0.45
177_I 194_E 1.046 0.45
195_L 220_I 1.045 0.44
11_H 23_F 1.045 0.44
220_I 428_I 1.044 0.44
690_R 703_V 1.042 0.44
501_G 520_T 1.041 0.44
199_A 393_E 1.041 0.44
361_L 371_A 1.039 0.44
218_D 271_G 1.039 0.44
688_L 703_V 1.037 0.44
335_D 520_T 1.037 0.44
105_E 158_E 1.037 0.44
425_P 501_G 1.036 0.44
209_N 237_A 1.035 0.43
305_K 335_D 1.035 0.43
439_V 532_A 1.033 0.43
650_Q 654_L 1.032 0.43
156_D 296_V 1.032 0.43
240_Y 473_I 1.031 0.43
288_F 595_E 1.031 0.43
571_Q 664_E 1.03 0.43
23_F 115_L 1.029 0.43
98_E 238_E 1.027 0.43
519_I 669_T 1.027 0.43
178_V 329_A 1.026 0.43
56_I 61_Q 1.025 0.42
10_R 23_F 1.025 0.42
204_L 406_D 1.024 0.42
754_T 758_Q 1.024 0.42
224_N 305_K 1.023 0.42
427_I 632_K 1.021 0.42
153_V 711_E 1.02 0.42
771_N 776_M 1.02 0.42
504_G 544_G 1.02 0.42
280_A 349_M 1.019 0.42
210_A 468_E 1.019 0.42
666_V 775_L 1.018 0.42
566_G 570_V 1.017 0.42
224_N 293_L 1.017 0.42
401_G 501_G 1.017 0.42
485_N 531_K 1.014 0.41
442_M 732_W 1.014 0.41
4_A 11_H 1.013 0.41
520_T 523_G 1.013 0.41
489_S 493_K 1.012 0.41
451_T 522_R 1.012 0.41
299_E 564_K 1.012 0.41
321_F 370_V 1.011 0.41
591_E 701_P 1.011 0.41
101_V 387_V 1.01 0.41
351_F 428_I 1.009 0.41
501_G 547_D 1.009 0.41
120_I 534_I 1.008 0.41
411_L 656_I 1.008 0.41
480_A 483_Q 1.008 0.41
226_V 274_I 1.007 0.41
435_P 438_L 1.007 0.41
351_F 616_R 1.007 0.41
86_H 89_L 1.006 0.41
247_G 467_P 1.006 0.41
497_N 523_G 1.006 0.41
535_E 682_L 1.006 0.41
551_V 764_I 1.004 0.40
83_C 96_L 1.003 0.40
386_Y 456_D 1.003 0.40
548_S 551_V 1.003 0.40
91_N 683_V 1.003 0.40
548_S 619_G 1.002 0.40
293_L 297_A 1.002 0.40
158_E 293_L 1.002 0.40
305_K 334_K 1.001 0.40
648_F 652_L 1.001 0.40
497_N 614_K 1 0.40
447_P 558_S 1 0.40
151_K 573_V 1 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k59A111000.092Contact Map0.426
3iayA10.94641000.225Contact Map0.466
1qhtA10.90421000.23Contact Map0.429
2gv9A20.95791000.245Contact Map0.386
4fvmA10.94381000.274Contact Map0.404
4m8oA10.96171000.277Contact Map0.381
1s5jA10.91571000.281Contact Map0.376
3qexA10.91951000.293Contact Map0.343
2py5A20.57731000.68Contact Map0.248
1noyA20.44321000.712Contact Map0.46
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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