| UniProt: | P17854 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10189 | ||
| Length: | 244 (226) | ||
| Sequences: | 1811 | ||
| Seq/Len: | 8.01 |
| CYSH
Paralog alert: 0.67 [within 20: 0.27] - ratio of genomes with paralogs |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 201_Y | 206_D | 2.917 | 1.00 | |
| 63_H | 67_Q | 2.903 | 1.00 | |
| 84_P | 88_R | 2.742 | 1.00 | |
| 88_R | 92_E | 2.717 | 1.00 | |
| 37_V | 153_F | 2.48 | 1.00 | |
| 92_E | 96_K | 2.439 | 1.00 | |
| 73_P | 102_K | 2.248 | 1.00 | |
| 107_T | 116_R | 2.203 | 1.00 | |
| 131_Y | 217_T | 2.154 | 1.00 | |
| 138_E | 142_R | 2.106 | 1.00 | |
| 67_Q | 197_H | 2.008 | 1.00 | |
| 96_K | 198_G | 1.976 | 1.00 | |
| 121_W | 127_G | 1.957 | 1.00 | |
| 132_N | 217_T | 1.953 | 1.00 | |
| 47_E | 148_N | 1.89 | 1.00 | |
| 225_M | 229_E | 1.881 | 1.00 | |
| 76_L | 82_L | 1.815 | 1.00 | |
| 75_I | 143_A | 1.806 | 1.00 | |
| 92_E | 200_K | 1.773 | 1.00 | |
| 133_D | 138_E | 1.77 | 1.00 | |
| 93_L | 97_L | 1.73 | 1.00 | |
| 63_H | 66_N | 1.726 | 1.00 | |
| 172_I | 177_F | 1.71 | 1.00 | |
| 78_D | 103_V | 1.672 | 1.00 | |
| 36_R | 169_V | 1.65 | 1.00 | |
| 44_L | 151_T | 1.637 | 1.00 | |
| 120_L | 127_G | 1.636 | 1.00 | |
| 70_P | 99_L | 1.62 | 1.00 | |
| 131_Y | 214_D | 1.617 | 1.00 | |
| 132_N | 214_D | 1.598 | 1.00 | |
| 159_E | 187_N | 1.598 | 1.00 | |
| 56_I | 194_L | 1.576 | 1.00 | |
| 120_L | 126_E | 1.554 | 1.00 | |
| 63_H | 193_Y | 1.547 | 1.00 | |
| 33_A | 64_L | 1.537 | 1.00 | |
| 119_K | 122_E | 1.519 | 1.00 | |
| 130_K | 133_D | 1.499 | 1.00 | |
| 67_Q | 193_Y | 1.492 | 0.99 | |
| 66_N | 97_L | 1.469 | 0.99 | |
| 38_A | 42_D | 1.446 | 0.99 | |
| 78_D | 87_Y | 1.442 | 0.99 | |
| 49_V | 75_I | 1.433 | 0.99 | |
| 122_E | 127_G | 1.428 | 0.99 | |
| 38_A | 68_I | 1.41 | 0.99 | |
| 104_Y | 143_A | 1.405 | 0.99 | |
| 22_A | 26_A | 1.4 | 0.99 | |
| 122_E | 126_E | 1.373 | 0.99 | |
| 207_E | 220_K | 1.368 | 0.99 | |
| 34_E | 64_L | 1.347 | 0.99 | |
| 210_L | 221_W | 1.332 | 0.99 | |
| 192_Q | 196_K | 1.329 | 0.99 | |
| 20_A | 23_E | 1.327 | 0.99 | |
| 62_L | 74_V | 1.322 | 0.98 | |
| 189_T | 192_Q | 1.312 | 0.98 | |
| 59_A | 93_L | 1.312 | 0.98 | |
| 144_L | 152_W | 1.3 | 0.98 | |
| 104_Y | 146_E | 1.298 | 0.98 | |
| 121_W | 126_E | 1.29 | 0.98 | |
| 214_D | 217_T | 1.279 | 0.98 | |
| 102_K | 147_L | 1.273 | 0.98 | |
| 37_V | 65_V | 1.244 | 0.98 | |
| 40_A | 48_Y | 1.241 | 0.97 | |
| 107_T | 138_E | 1.231 | 0.97 | |
| 50_L | 61_S | 1.231 | 0.97 | |
| 193_Y | 197_H | 1.221 | 0.97 | |
| 50_L | 65_V | 1.215 | 0.97 | |
| 61_S | 153_F | 1.213 | 0.97 | |
| 56_I | 212_V | 1.211 | 0.97 | |
| 205_W | 210_L | 1.203 | 0.97 | |
| 81_Y | 114_E | 1.199 | 0.97 | |
| 94_T | 100_N | 1.19 | 0.97 | |
| 96_K | 200_K | 1.19 | 0.97 | |
| 63_H | 97_L | 1.19 | 0.97 | |
| 226_A | 229_E | 1.186 | 0.96 | |
| 93_L | 96_K | 1.175 | 0.96 | |
| 37_V | 64_L | 1.17 | 0.96 | |
| 222_E | 225_M | 1.165 | 0.96 | |
| 104_Y | 142_R | 1.153 | 0.96 | |
| 170_L | 179_V | 1.143 | 0.95 | |
| 34_E | 68_I | 1.14 | 0.95 | |
| 61_S | 182_I | 1.135 | 0.95 | |
| 86_T | 202_H | 1.133 | 0.95 | |
| 130_K | 134_I | 1.132 | 0.95 | |
| 60_V | 193_Y | 1.131 | 0.95 | |
| 85_E | 88_R | 1.129 | 0.95 | |
| 36_R | 184_D | 1.128 | 0.95 | |
| 159_E | 186_D | 1.12 | 0.95 | |
| 91_D | 94_T | 1.115 | 0.94 | |
| 186_D | 189_T | 1.114 | 0.94 | |
| 228_E | 231_R | 1.113 | 0.94 | |
| 65_V | 72_I | 1.099 | 0.94 | |
| 107_T | 139_P | 1.098 | 0.94 | |
| 35_G | 38_A | 1.098 | 0.94 | |
| 60_V | 190_I | 1.096 | 0.94 | |
| 204_L | 212_V | 1.089 | 0.94 | |
| 66_N | 99_L | 1.078 | 0.93 | |
| 90_I | 103_V | 1.076 | 0.93 | |
| 32_D | 35_G | 1.073 | 0.93 | |
| 170_L | 177_F | 1.072 | 0.93 | |
| 88_R | 91_D | 1.072 | 0.93 | |
| 23_E | 27_E | 1.072 | 0.93 | |
| 63_H | 199_L | 1.065 | 0.93 | |
| 80_G | 105_R | 1.061 | 0.92 | |
| 60_V | 182_I | 1.053 | 0.92 | |
| 44_L | 149_A | 1.052 | 0.92 | |
| 114_E | 118_G | 1.044 | 0.92 | |
| 89_F | 201_Y | 1.04 | 0.91 | |
| 63_H | 197_H | 1.023 | 0.90 | |
| 191_Y | 201_Y | 1.021 | 0.90 | |
| 19_L | 23_E | 1.02 | 0.90 | |
| 158_R | 183_I | 1.018 | 0.90 | |
| 187_N | 191_Y | 1.009 | 0.90 | |
| 64_L | 193_Y | 1.007 | 0.89 | |
| 109_S | 135_N | 1.006 | 0.89 | |
| 117_Y | 130_K | 1.003 | 0.89 | |
| 55_G | 58_A | 1.003 | 0.89 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2oq2A | 4 | 0.9672 | 100 | 0.293 | Contact Map | 0.79 |
| 2o8vA | 1 | 1 | 100 | 0.3 | Contact Map | 0.67 |
| 4bwvA | 2 | 0.959 | 100 | 0.313 | Contact Map | 0.78 |
| 2goyA | 8 | 0.9836 | 100 | 0.331 | Contact Map | 0.744 |
| 1zunA | 1 | 0.9508 | 100 | 0.457 | Contact Map | 0.733 |
| 3fwkA | 1 | 0.8893 | 100 | 0.522 | Contact Map | 0.517 |
| 1surA | 1 | 0.8811 | 100 | 0.528 | Contact Map | 0.714 |
| 2wsiA | 1 | 0.8811 | 100 | 0.542 | Contact Map | 0.508 |
| 3k32A | 6 | 0.7582 | 99.8 | 0.744 | Contact Map | 0.602 |
| 3bl5A | 6 | 0.7664 | 99.8 | 0.746 | Contact Map | 0.605 |
Sequence Conservation (Image Generated using WebLogo v3)