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OPENSEQ.org
GLMS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
UniProt: P17169 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10382
Length: 609 (608)
Sequences: 1775
Seq/Len: 2.92
GLMS
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_E 152_Q 5.323 1.00
115_R 134_W 4.397 1.00
294_E 341_N 4.075 1.00
22_R 56_A 3.837 1.00
264_I 445_I 3.817 1.00
224_D 228_A 3.637 1.00
298_I 308_G 3.605 1.00
373_A 386_S 3.49 1.00
402_S 405_A 3.444 1.00
211_D 232_R 3.381 1.00
141_T 144_E 3.284 1.00
51_K 598_Q 3.262 1.00
361_R 385_E 3.058 1.00
146_V 171_L 3.018 1.00
181_I 213_A 2.842 1.00
17_L 69_G 2.841 1.00
262_N 266_N 2.813 1.00
172_A 190_I 2.805 1.00
128_I 153_L 2.731 1.00
264_I 411_T 2.657 1.00
446_E 450_S 2.652 1.00
172_A 213_A 2.609 1.00
117_Y 134_W 2.601 1.00
132_V 149_A 2.592 1.00
117_Y 133_N 2.58 1.00
166_H 169_T 2.548 1.00
48_R 58_A 2.497 1.00
452_D 587_H 2.492 1.00
181_I 220_V 2.355 1.00
447_Q 550_Q 2.306 1.00
84_V 122_E 2.3 1.00
267_T 392_T 2.288 1.00
96_V 125_T 2.25 1.00
347_L 413_L 2.242 1.00
184_G 187_E 2.187 1.00
160_V 170_L 2.162 1.00
132_V 161_I 2.158 1.00
142_L 171_L 2.156 1.00
346_T 360_L 2.144 1.00
203_R 236_E 2.114 1.00
221_N 229_E 2.106 1.00
169_T 214_E 2.103 1.00
294_E 339_R 2.082 1.00
93_H 165_R 2.046 1.00
109_R 113_K 2.003 1.00
315_F 420_L 1.983 1.00
143_R 223_F 1.98 1.00
406_F 479_I 1.974 1.00
132_V 146_V 1.967 1.00
447_Q 450_S 1.958 1.00
315_F 417_V 1.952 0.99
308_G 347_L 1.943 0.99
445_I 579_V 1.94 0.99
463_S 591_I 1.92 0.99
96_V 129_A 1.917 0.99
135_E 152_Q 1.911 0.99
128_I 159_T 1.905 0.99
53_Q 57_Q 1.903 0.99
11_R 187_E 1.899 0.99
430_I 433_D 1.889 0.99
546_V 559_N 1.884 0.99
293_V 343_L 1.881 0.99
142_L 163_D 1.869 0.99
48_R 83_E 1.869 0.99
538_R 560_M 1.864 0.99
258_Y 452_D 1.853 0.99
484_A 495_A 1.851 0.99
18_L 34_L 1.846 0.99
183_L 205_I 1.845 0.99
172_A 181_I 1.841 0.99
565_M 577_Y 1.827 0.99
146_V 161_I 1.795 0.99
19_E 199_P 1.785 0.99
547_F 565_M 1.783 0.99
392_T 408_T 1.783 0.99
117_Y 130_H 1.783 0.99
183_L 220_V 1.781 0.99
93_H 164_S 1.773 0.99
481_L 497_A 1.76 0.99
19_E 22_R 1.753 0.99
441_L 575_I 1.749 0.99
418_A 434_I 1.743 0.99
251_H 586_Y 1.735 0.99
154_R 528_E 1.723 0.98
327_I 499_A 1.721 0.98
551_D 564_E 1.72 0.98
17_L 71_A 1.706 0.98
47_R 83_E 1.669 0.98
135_E 148_R 1.669 0.98
500_A 530_L 1.668 0.98
590_L 596_V 1.665 0.98
249_Y 258_Y 1.664 0.98
518_I 584_L 1.643 0.98
150_I 153_L 1.641 0.98
338_V 369_L 1.636 0.98
188_N 219_S 1.633 0.98
143_R 214_E 1.623 0.97
448_M 576_F 1.622 0.97
54_M 57_Q 1.617 0.97
49_L 82_S 1.614 0.97
188_N 220_V 1.606 0.97
105_H 109_R 1.604 0.97
461_D 561_H 1.603 0.97
320_G 337_A 1.602 0.97
94_I 136_L 1.6 0.97
182_G 201_T 1.581 0.97
315_F 323_C 1.571 0.97
453_K 456_E 1.558 0.97
331_F 338_V 1.557 0.97
107_P 154_R 1.556 0.96
296_I 345_I 1.549 0.96
144_E 147_L 1.545 0.96
437_G 444_R 1.544 0.96
43_M 95_V 1.528 0.96
205_I 220_V 1.526 0.96
161_I 171_L 1.525 0.96
94_I 163_D 1.514 0.96
49_L 81_P 1.51 0.96
14_A 34_L 1.504 0.96
483_G 581_L 1.503 0.95
371_S 386_S 1.497 0.95
207_L 213_A 1.492 0.95
419_K 423_L 1.491 0.95
58_A 83_E 1.484 0.95
348_S 382_L 1.483 0.95
548_A 564_E 1.476 0.95
326_E 334_R 1.47 0.95
519_V 534_I 1.466 0.95
427_D 430_I 1.461 0.95
320_G 335_K 1.45 0.94
135_E 149_A 1.444 0.94
468_A 518_I 1.442 0.94
36_V 66_G 1.427 0.94
362_L 365_E 1.424 0.93
163_D 166_H 1.419 0.93
344_M 363_S 1.413 0.93
527_L 552_A 1.411 0.93
183_L 188_N 1.407 0.93
208_E 232_R 1.402 0.93
214_E 221_N 1.397 0.93
339_R 342_S 1.397 0.93
587_H 591_I 1.393 0.92
317_S 335_K 1.39 0.92
222_I 232_R 1.389 0.92
422_R 431_E 1.387 0.92
354_A 358_A 1.386 0.92
145_A 149_A 1.385 0.92
305_Y 309_M 1.382 0.92
263_A 408_T 1.379 0.92
205_I 222_I 1.377 0.92
477_Y 481_L 1.371 0.92
239_L 244_G 1.371 0.92
194_Q 206_F 1.37 0.92
295_H 324_D 1.366 0.92
149_A 153_L 1.364 0.91
203_R 234_D 1.361 0.91
374_I 416_L 1.36 0.91
11_R 189_F 1.357 0.91
8_I 68_T 1.353 0.91
471_L 519_V 1.353 0.91
143_R 147_L 1.347 0.91
136_L 163_D 1.346 0.91
37_V 162_M 1.343 0.91
471_L 537_V 1.329 0.90
150_I 173_A 1.319 0.90
344_M 369_L 1.317 0.89
466_H 592_K 1.314 0.89
160_V 190_I 1.314 0.89
49_L 80_E 1.297 0.88
551_D 567_H 1.287 0.88
35_A 45_R 1.283 0.88
169_T 216_T 1.283 0.88
110_E 114_A 1.281 0.88
136_L 165_R 1.279 0.88
289_L 370_G 1.279 0.88
46_L 58_A 1.278 0.87
68_T 168_D 1.268 0.87
418_A 421_S 1.268 0.87
142_L 161_I 1.268 0.87
568_V 576_F 1.264 0.87
373_A 382_L 1.264 0.87
168_D 217_R 1.252 0.86
451_Q 454_R 1.251 0.86
202_R 236_E 1.251 0.86
144_E 148_R 1.25 0.86
392_T 409_Q 1.247 0.86
216_T 219_S 1.245 0.86
96_V 128_I 1.238 0.85
375_C 383_V 1.234 0.85
460_E 591_I 1.232 0.85
246_K 598_Q 1.23 0.85
373_A 389_A 1.222 0.84
443_S 446_E 1.209 0.83
548_A 562_I 1.202 0.83
223_F 229_E 1.202 0.83
511_I 542_G 1.198 0.82
162_M 170_L 1.198 0.82
53_Q 56_A 1.189 0.82
111_E 134_W 1.186 0.82
7_A 13_V 1.185 0.81
35_A 95_V 1.181 0.81
548_A 555_V 1.171 0.80
18_L 59_A 1.17 0.80
440_A 444_R 1.169 0.80
478_P 507_P 1.167 0.80
293_V 342_S 1.164 0.80
184_G 188_N 1.161 0.80
296_I 321_I 1.159 0.79
462_F 561_H 1.153 0.79
503_L 508_L 1.141 0.78
9_A 13_V 1.14 0.78
318_L 571_V 1.139 0.78
437_G 569_E 1.13 0.77
479_I 578_T 1.128 0.77
254_Q 258_Y 1.128 0.77
556_S 564_E 1.127 0.77
316_E 334_R 1.125 0.77
444_R 576_F 1.124 0.76
406_F 478_P 1.12 0.76
190_I 215_I 1.119 0.76
457_A 460_E 1.117 0.76
543_Q 561_H 1.116 0.76
364_K 387_D 1.115 0.76
143_R 212_I 1.109 0.75
195_L 198_L 1.107 0.75
35_A 43_M 1.107 0.75
194_Q 198_L 1.105 0.75
583_L 587_H 1.104 0.75
298_I 323_C 1.104 0.75
476_Q 520_V 1.104 0.75
471_L 480_A 1.101 0.74
110_E 113_K 1.097 0.74
181_I 190_I 1.097 0.74
51_K 595_D 1.094 0.74
529_K 609_E 1.094 0.74
112_L 119_F 1.091 0.73
271_R 415_M 1.09 0.73
113_K 122_E 1.09 0.73
461_D 543_Q 1.09 0.73
14_A 66_G 1.086 0.73
262_N 446_E 1.085 0.73
191_A 196_A 1.084 0.73
37_V 68_T 1.072 0.72
49_L 83_E 1.069 0.71
534_I 544_L 1.068 0.71
190_I 213_A 1.065 0.71
383_V 389_A 1.064 0.71
378_P 391_M 1.062 0.71
142_L 146_V 1.061 0.70
441_L 576_F 1.057 0.70
303_T 402_S 1.054 0.70
103_E 529_K 1.053 0.70
537_V 544_L 1.051 0.69
421_S 426_L 1.05 0.69
18_L 56_A 1.05 0.69
7_A 16_I 1.049 0.69
51_K 246_K 1.048 0.69
511_I 517_V 1.048 0.69
136_L 141_T 1.044 0.69
282_L 290_L 1.044 0.69
462_F 584_L 1.042 0.68
320_G 323_C 1.042 0.68
80_E 122_E 1.041 0.68
311_S 413_L 1.041 0.68
418_A 431_E 1.04 0.68
175_S 210_G 1.036 0.68
440_A 443_S 1.035 0.68
479_I 576_F 1.035 0.68
584_L 588_V 1.034 0.68
8_I 217_R 1.032 0.67
260_Q 407_T 1.032 0.67
346_T 386_S 1.027 0.67
451_Q 563_I 1.027 0.67
68_T 170_L 1.026 0.67
94_I 142_L 1.025 0.67
296_I 343_L 1.022 0.66
345_I 416_L 1.019 0.66
444_R 568_V 1.018 0.66
357_L 361_R 1.018 0.66
254_Q 452_D 1.014 0.65
147_L 223_F 1.012 0.65
433_D 569_E 1.012 0.65
548_A 552_A 1.008 0.65
310_V 479_I 1.007 0.65
469_L 515_M 1.007 0.65
287_D 291_S 1.004 0.64
1_M 4_I 1.004 0.64
411_T 438_L 1.002 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bplA30.99671000.35Contact Map0.847
2zj3A10.61251000.595Contact Map0.791
1moqA10.60431000.602Contact Map0.728
3tbfA80.60761000.602Contact Map0.802
2pocA40.59611000.606Contact Map0.837
3knzA60.58291000.656Contact Map0.702
2amlA20.59111000.658Contact Map0.623
1j5xA10.5551000.662Contact Map0.647
3g68A20.55991000.662Contact Map0.675
3fj1A40.55991000.665Contact Map0.701
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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