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DPO3A - DNA polymerase III subunit alpha
UniProt: P10443 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10238
Length: 1160 (1139)
Sequences: 2252
Seq/Len: 1.98

DPO3A
Paralog alert: 0.20 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
410_K 413_Q 6.316 1.00
13_S 41_I 5.808 1.00
674_K 678_E 5.533 1.00
573_N 583_P 5.157 1.00
92_T 126_E 4.245 1.00
152_D 191_A 4.185 1.00
319_P 323_E 3.889 1.00
1028_V 1067_A 3.684 1.00
30_K 33_A 3.588 1.00
446_G 456_V 3.57 1.00
729_E 733_K 3.57 1.00
600_L 611_L 3.568 1.00
815_D 890_R 3.476 1.00
671_E 674_K 3.466 1.00
89_A 266_R 3.457 1.00
704_G 726_V 3.432 1.00
717_P 721_A 3.269 1.00
294_K 298_E 3.256 1.00
31_A 39_L 3.218 1.00
346_E 417_H 3.149 1.00
585_D 588_A 3.109 1.00
302_E 375_K 3.021 1.00
650_N 659_E 2.996 1.00
286_M 294_K 2.993 1.00
365_G 402_F 2.964 1.00
653_D 658_R 2.944 1.00
89_A 165_R 2.943 1.00
30_K 34_L 2.938 1.00
738_A 742_M 2.937 1.00
349_Q 353_D 2.925 1.00
293_V 326_E 2.89 1.00
852_A 856_G 2.833 1.00
139_V 166_Y 2.806 1.00
598_D 601_Q 2.775 1.00
725_S 729_E 2.695 1.00
595_K 598_D 2.681 1.00
852_A 859_F 2.659 1.00
732_E 738_A 2.657 1.00
700_Y 723_Q 2.59 1.00
286_M 290_D 2.567 1.00
566_N 570_E 2.555 1.00
1000_V 1048_L 2.534 1.00
653_D 659_E 2.469 1.00
259_N 262_E 2.467 1.00
304_L 321_Y 2.455 1.00
209_D 500_K 2.432 1.00
297_K 322_D 2.43 1.00
86_V 130_L 2.429 1.00
395_E 703_G 2.422 1.00
118_R 157_F 2.38 1.00
594_K 598_D 2.373 1.00
356_V 413_Q 2.36 1.00
225_L 448_V 2.347 1.00
600_L 605_T 2.342 1.00
565_I 586_I 2.33 1.00
995_T 1051_S 2.321 1.00
332_I 370_V 2.294 1.00
293_V 297_K 2.281 1.00
596_S 777_H 2.244 1.00
326_E 330_Q 2.232 1.00
472_A 499_R 2.226 1.00
643_L 648_V 2.222 1.00
197_V 263_I 2.204 1.00
168_L 189_A 2.202 1.00
565_I 774_L 2.197 1.00
28_V 57_G 2.187 1.00
899_M 944_W 2.171 1.00
810_K 830_E 2.165 0.99
485_Y 496_D 2.155 0.99
675_P 696_V 2.14 0.99
812_L 832_V 2.139 0.99
334_Q 394_P 2.132 0.99
622_R 649_D 2.119 0.99
431_I 508_A 2.119 0.99
598_D 602_R 2.108 0.99
595_K 777_H 2.098 0.99
676_V 696_V 2.086 0.99
699_G 734_N 2.084 0.99
1058_D 1061_G 2.08 0.99
843_E 847_E 2.077 0.99
356_V 410_K 2.073 0.99
724_R 742_M 2.069 0.99
746_D 749_E 2.063 0.99
293_V 333_N 2.056 0.99
611_L 631_M 2.052 0.99
55_G 548_Y 2.034 0.99
155_V 192_R 2.008 0.99
295_R 298_E 2.004 0.99
441_V 501_L 2.002 0.99
63_K 268_N 2.001 0.99
520_T 524_D 1.994 0.99
292_L 329_L 1.958 0.99
40_A 87_L 1.954 0.99
1008_T 1014_I 1.949 0.99
200_N 241_R 1.943 0.99
883_I 898_L 1.939 0.99
48_C 529_Y 1.928 0.99
247_C 258_A 1.918 0.98
851_E 855_K 1.914 0.98
186_V 196_V 1.909 0.98
416_E 420_D 1.909 0.98
663_Y 674_K 1.883 0.98
1051_S 1069_E 1.878 0.98
97_L 128_L 1.876 0.98
155_V 194_L 1.868 0.98
296_A 325_L 1.86 0.98
14_D 23_K 1.855 0.98
601_Q 624_Q 1.855 0.98
586_I 589_I 1.851 0.98
247_C 257_L 1.846 0.98
852_A 868_R 1.843 0.98
442_I 463_I 1.842 0.98
648_V 761_S 1.839 0.98
724_R 746_D 1.838 0.98
601_Q 626_D 1.835 0.98
70_F 86_V 1.824 0.98
707_M 710_R 1.821 0.98
195_P 262_E 1.81 0.98
297_K 326_E 1.81 0.98
816_I 888_F 1.805 0.98
322_D 326_E 1.796 0.97
618_D 622_R 1.792 0.97
443_R 457_D 1.786 0.97
284_G 291_Y 1.781 0.97
378_D 587_A 1.769 0.97
865_L 888_F 1.758 0.97
330_Q 334_Q 1.755 0.97
187_E 191_A 1.753 0.97
1136_V 1142_L 1.742 0.97
165_R 266_R 1.742 0.97
864_D 868_R 1.74 0.97
147_N 150_L 1.73 0.97
226_D 450_G 1.726 0.96
299_G 373_A 1.726 0.96
345_M 349_Q 1.724 0.96
418_V 556_F 1.724 0.96
132_S 166_Y 1.719 0.96
10_R 69_D 1.716 0.96
289_E 338_P 1.703 0.96
346_E 421_M 1.698 0.96
654_R 659_E 1.693 0.96
14_D 504_V 1.693 0.96
207_S 237_Q 1.69 0.96
85_T 133_G 1.69 0.96
1050_V 1067_A 1.685 0.96
31_A 240_M 1.684 0.96
90_N 127_G 1.683 0.96
159_E 194_L 1.68 0.96
619_L 634_L 1.677 0.96
694_A 708_L 1.677 0.96
30_K 206_D 1.671 0.96
643_L 761_S 1.66 0.95
335_M 397_V 1.659 0.95
131_L 169_E 1.656 0.95
91_N 269_V 1.648 0.95
34_L 240_M 1.647 0.95
563_T 567_W 1.646 0.95
223_F 227_D 1.644 0.95
604_E 807_M 1.641 0.95
611_L 635_V 1.64 0.95
289_E 333_N 1.639 0.95
1105_L 1115_V 1.638 0.95
697_L 744_I 1.636 0.95
304_L 369_L 1.636 0.95
728_A 732_E 1.631 0.95
28_V 56_A 1.629 0.95
122_I 157_F 1.628 0.95
783_M 804_C 1.624 0.95
719_E 723_Q 1.622 0.95
981_R 984_D 1.616 0.94
1017_C 1030_L 1.61 0.94
632_I 762_A 1.606 0.94
684_I 693_I 1.604 0.94
572_I 774_L 1.604 0.94
724_R 749_E 1.604 0.94
215_I 497_M 1.603 0.94
636_A 761_S 1.596 0.94
350_W 354_N 1.592 0.94
699_G 730_G 1.59 0.94
42_T 87_L 1.589 0.94
672_S 736_I 1.588 0.94
480_Q 483_E 1.588 0.94
803_E 807_M 1.582 0.94
1014_I 1031_F 1.582 0.94
102_S 528_L 1.579 0.93
303_R 378_D 1.578 0.93
56_A 59_G 1.576 0.93
645_S 648_V 1.57 0.93
742_M 746_D 1.568 0.93
34_L 242_S 1.565 0.93
894_H 943_P 1.563 0.93
189_A 194_L 1.555 0.93
385_D 692_Q 1.555 0.93
83_H 134_G 1.546 0.93
38_A 264_A 1.544 0.92
973_I 997_A 1.539 0.92
673_L 693_I 1.535 0.92
430_I 514_G 1.53 0.92
196_V 256_A 1.521 0.92
167_F 262_E 1.52 0.92
241_R 249_L 1.518 0.92
945_P 948_V 1.517 0.92
91_N 95_Q 1.516 0.92
963_G 967_N 1.515 0.91
295_R 345_M 1.514 0.91
39_L 240_M 1.508 0.91
560_R 789_A 1.506 0.91
169_E 199_T 1.497 0.91
568_A 785_A 1.493 0.91
695_Q 702_L 1.49 0.91
68_A 101_I 1.485 0.90
300_L 373_A 1.483 0.90
590_P 769_Y 1.481 0.90
138_D 158_Y 1.48 0.90
90_N 126_E 1.479 0.90
457_D 461_K 1.479 0.90
44_F 83_H 1.478 0.90
237_Q 241_R 1.475 0.90
157_F 161_H 1.474 0.90
492_K 496_D 1.467 0.90
22_A 205_I 1.466 0.90
1053_Q 1068_R 1.465 0.90
690_V 712_M 1.463 0.89
883_I 902_L 1.455 0.89
272_R 275_E 1.454 0.89
728_A 742_M 1.454 0.89
298_E 302_E 1.451 0.89
719_E 722_K 1.451 0.89
943_P 949_V 1.447 0.89
628_F 632_I 1.444 0.89
643_L 646_G 1.44 0.88
122_I 161_H 1.439 0.88
635_V 765_A 1.438 0.88
88_A 269_V 1.437 0.88
485_Y 495_I 1.436 0.88
1052_G 1065_M 1.435 0.88
211_D 493_A 1.434 0.88
482_P 486_E 1.434 0.88
44_F 134_G 1.432 0.88
225_L 449_L 1.423 0.88
202_V 240_M 1.415 0.87
27_L 202_V 1.415 0.87
287_S 290_D 1.41 0.87
469_M 473_K 1.407 0.87
297_K 300_L 1.407 0.87
599_M 776_A 1.406 0.87
350_W 414_V 1.406 0.87
628_F 766_L 1.406 0.87
170_L 256_A 1.403 0.87
723_Q 726_V 1.402 0.87
846_I 849_I 1.397 0.86
25_A 56_A 1.396 0.86
446_G 494_L 1.396 0.86
896_A 900_N 1.395 0.86
251_A 254_P 1.392 0.86
852_A 855_K 1.388 0.86
56_A 60_A 1.385 0.86
717_P 753_G 1.385 0.86
23_K 26_P 1.385 0.86
654_R 657_G 1.382 0.86
604_E 806_R 1.375 0.85
7_V 261_V 1.374 0.85
1028_V 1050_V 1.374 0.85
643_L 649_D 1.373 0.85
901_S 939_A 1.371 0.85
52_K 545_D 1.371 0.85
357_P 407_C 1.366 0.85
129_I 167_F 1.362 0.84
847_E 851_E 1.36 0.84
544_S 716_K 1.36 0.84
283_T 290_D 1.358 0.84
783_M 807_M 1.353 0.84
615_G 638_F 1.352 0.84
596_S 776_A 1.348 0.84
221_D 231_P 1.347 0.84
53_F 64_P 1.346 0.84
672_S 734_N 1.343 0.83
818_S 826_N 1.338 0.83
325_L 373_A 1.334 0.83
996_A 1019_L 1.332 0.83
882_L 887_A 1.332 0.83
623_L 652_I 1.326 0.82
296_A 369_L 1.324 0.82
321_Y 369_L 1.322 0.82
607_A 786_V 1.321 0.82
453_Y 457_D 1.321 0.82
1086_I 1150_I 1.31 0.81
50_L 66_V 1.308 0.81
1014_I 1029_M 1.307 0.81
884_M 952_G 1.305 0.81
88_A 128_L 1.305 0.81
982_L 1023_S 1.305 0.81
1008_T 1032_T 1.305 0.81
215_I 445_V 1.304 0.81
598_D 626_D 1.302 0.81
838_I 885_S 1.302 0.81
679_P 758_K 1.298 0.80
134_G 203_R 1.298 0.80
702_L 710_R 1.298 0.80
644_Q 649_D 1.297 0.80
866_C 905_A 1.293 0.80
296_A 373_A 1.293 0.80
103_K 123_E 1.291 0.80
740_L 743_K 1.289 0.80
122_I 160_E 1.288 0.80
826_N 832_V 1.286 0.79
261_V 265_K 1.285 0.79
129_I 266_R 1.283 0.79
243_E 247_C 1.282 0.79
691_M 759_S 1.279 0.79
138_D 154_C 1.278 0.79
409_E 567_W 1.277 0.79
189_A 195_P 1.277 0.79
605_T 611_L 1.276 0.79
172_R 252_D 1.272 0.78
333_N 338_P 1.271 0.78
156_A 192_R 1.27 0.78
100_L 128_L 1.268 0.78
1000_V 1017_C 1.268 0.78
950_L 962_T 1.261 0.78
443_R 460_S 1.258 0.77
46_N 105_Y 1.258 0.77
262_E 266_R 1.257 0.77
998_G 1028_V 1.256 0.77
292_L 374_L 1.252 0.77
982_L 1026_L 1.251 0.77
29_K 60_A 1.251 0.77
186_V 253_I 1.25 0.77
823_F 833_Y 1.249 0.77
820_L 854_N 1.249 0.77
1006_M 1016_I 1.246 0.76
207_S 236_P 1.244 0.76
354_N 413_Q 1.239 0.76
148_S 191_A 1.238 0.76
167_F 266_R 1.238 0.76
1002_A 1018_T 1.237 0.76
721_A 749_E 1.237 0.76
591_L 766_L 1.235 0.76
876_R 906_L 1.232 0.75
657_G 660_E 1.231 0.75
852_A 857_G 1.23 0.75
626_D 655_K 1.23 0.75
28_V 60_A 1.23 0.75
143_L 188_L 1.227 0.75
12_H 19_D 1.227 0.75
663_Y 678_E 1.225 0.75
684_I 747_L 1.223 0.75
19_D 44_F 1.222 0.74
12_H 16_S 1.222 0.74
635_V 761_S 1.221 0.74
170_L 253_I 1.22 0.74
451_H 494_L 1.219 0.74
644_Q 648_V 1.218 0.74
45_T 71_N 1.216 0.74
865_L 879_L 1.213 0.74
25_A 59_G 1.21 0.73
560_R 790_D 1.207 0.73
647_M 761_S 1.205 0.73
347_F 418_V 1.205 0.73
47_L 94_Y 1.204 0.73
1142_L 1146_L 1.204 0.73
43_D 49_G 1.202 0.73
125_N 161_H 1.201 0.73
1034_A 1038_Y 1.2 0.73
700_Y 726_V 1.2 0.73
595_K 776_A 1.199 0.72
92_T 127_G 1.199 0.72
327_T 330_Q 1.199 0.72
224_T 450_G 1.196 0.72
425_D 521_K 1.196 0.72
998_G 1019_L 1.194 0.72
561_T 782_F 1.193 0.72
172_R 179_E 1.189 0.72
152_D 192_R 1.184 0.71
288_T 339_G 1.181 0.71
606_T 617_K 1.18 0.71
150_L 153_E 1.179 0.71
648_V 685_L 1.177 0.70
198_A 256_A 1.176 0.70
327_T 389_E 1.175 0.70
34_L 243_E 1.173 0.70
818_S 858_Y 1.17 0.70
472_A 476_E 1.169 0.70
262_E 265_K 1.166 0.69
412_D 416_E 1.166 0.69
71_N 83_H 1.165 0.69
185_A 196_V 1.165 0.69
646_G 649_D 1.164 0.69
280_Q 519_P 1.161 0.69
579_N 778_Y 1.16 0.69
685_L 753_G 1.158 0.69
385_D 679_P 1.158 0.69
702_L 707_M 1.157 0.69
214_E 225_L 1.157 0.69
624_Q 656_H 1.157 0.69
1107_P 1145_D 1.156 0.68
483_E 487_A 1.156 0.68
99_L 524_D 1.156 0.68
178_E 182_L 1.155 0.68
485_Y 492_K 1.155 0.68
103_K 107_R 1.155 0.68
643_L 647_M 1.153 0.68
852_A 869_T 1.153 0.68
131_L 197_V 1.152 0.68
65_I 87_L 1.151 0.68
70_F 116_I 1.151 0.68
646_G 761_S 1.15 0.68
32_A 60_A 1.149 0.68
432_T 512_A 1.144 0.67
12_H 69_D 1.141 0.67
542_D 545_D 1.14 0.67
579_N 582_P 1.137 0.67
645_S 761_S 1.136 0.67
697_L 736_I 1.134 0.66
600_L 635_V 1.129 0.66
47_L 98_T 1.127 0.66
620_I 634_L 1.126 0.66
624_Q 658_R 1.123 0.65
849_I 865_L 1.118 0.65
741_A 745_F 1.118 0.65
23_K 504_V 1.117 0.65
649_D 761_S 1.117 0.65
65_I 264_A 1.116 0.64
417_H 421_M 1.115 0.64
783_M 800_L 1.115 0.64
568_A 774_L 1.115 0.64
597_F 769_Y 1.115 0.64
300_L 325_L 1.114 0.64
132_S 168_L 1.112 0.64
886_G 962_T 1.11 0.64
387_L 759_S 1.11 0.64
739_E 743_K 1.11 0.64
89_A 167_F 1.107 0.64
479_P 482_P 1.106 0.63
701_T 704_G 1.105 0.63
293_V 329_L 1.105 0.63
1105_L 1142_L 1.102 0.63
19_D 134_G 1.101 0.63
565_I 569_L 1.099 0.63
69_D 203_R 1.099 0.63
787_M 797_V 1.099 0.63
351_S 406_F 1.098 0.63
189_A 256_A 1.097 0.63
1151_G 1155_V 1.095 0.62
303_R 375_K 1.095 0.62
69_D 83_H 1.095 0.62
593_D 596_S 1.092 0.62
19_D 83_H 1.089 0.62
589_I 770_Q 1.089 0.62
841_V 878_V 1.088 0.62
896_A 944_W 1.087 0.61
712_M 745_F 1.087 0.61
44_F 71_N 1.086 0.61
804_C 811_I 1.085 0.61
856_G 868_R 1.085 0.61
167_F 259_N 1.084 0.61
214_E 230_R 1.084 0.61
611_L 765_A 1.084 0.61
319_P 322_D 1.082 0.61
70_F 101_I 1.081 0.61
675_P 678_E 1.081 0.61
7_V 38_A 1.08 0.61
894_H 897_A 1.078 0.61
671_E 678_E 1.075 0.60
263_I 267_C 1.075 0.60
863_F 905_A 1.073 0.60
455_F 490_E 1.073 0.60
99_L 521_K 1.073 0.60
379_L 762_A 1.071 0.60
85_T 131_L 1.071 0.60
159_E 163_P 1.071 0.60
611_L 620_I 1.07 0.60
444_D 506_R 1.07 0.60
783_M 831_I 1.069 0.60
296_A 300_L 1.069 0.60
820_L 824_H 1.068 0.59
325_L 369_L 1.068 0.59
6_F 9_L 1.064 0.59
712_M 720_M 1.064 0.59
629_E 679_P 1.063 0.59
441_V 498_A 1.061 0.59
227_D 230_R 1.061 0.59
132_S 139_V 1.06 0.59
214_E 232_R 1.059 0.58
130_L 162_F 1.059 0.58
619_L 622_R 1.058 0.58
148_S 187_E 1.058 0.58
989_E 992_K 1.058 0.58
475_F 495_I 1.056 0.58
291_Y 295_R 1.056 0.58
456_V 494_L 1.056 0.58
11_V 27_L 1.055 0.58
654_R 661_I 1.054 0.58
135_R 181_Y 1.052 0.58
103_K 124_L 1.051 0.58
703_G 710_R 1.046 0.57
348_I 404_V 1.046 0.57
731_A 736_I 1.045 0.57
239_Y 245_E 1.044 0.57
457_D 460_S 1.044 0.57
44_F 203_R 1.044 0.57
438_A 502_E 1.044 0.57
513_G 543_K 1.044 0.57
803_E 806_R 1.042 0.57
601_Q 761_S 1.042 0.57
37_P 261_V 1.04 0.56
1085_A 1118_Y 1.037 0.56
83_H 203_R 1.036 0.56
163_P 194_L 1.032 0.56
407_C 563_T 1.032 0.56
283_T 287_S 1.03 0.55
643_L 685_L 1.028 0.55
651_F 681_Y 1.026 0.55
593_D 777_H 1.026 0.55
720_M 749_E 1.025 0.55
431_I 529_Y 1.025 0.55
470_T 473_K 1.025 0.55
1055_S 1066_T 1.024 0.55
453_Y 456_V 1.023 0.55
181_Y 185_A 1.022 0.54
967_N 1022_R 1.022 0.54
77_L 119_D 1.022 0.54
635_V 768_S 1.02 0.54
1012_N 1036_D 1.02 0.54
586_I 770_Q 1.02 0.54
32_A 62_I 1.019 0.54
826_N 830_E 1.019 0.54
321_Y 382_L 1.014 0.54
90_N 93_G 1.013 0.53
716_K 719_E 1.012 0.53
355_G 570_E 1.012 0.53
77_L 120_W 1.011 0.53
242_S 245_E 1.01 0.53
495_I 499_R 1.009 0.53
619_L 648_V 1.008 0.53
201_D 213_H 1.007 0.53
645_S 649_D 1.007 0.53
449_L 497_M 1.006 0.53
616_M 638_F 1.004 0.52
86_V 128_L 1.002 0.52
611_L 768_S 1.001 0.52
644_Q 647_M 1 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hpiA10.97241000.108Contact Map0.726
2hnhA10.7811000.224Contact Map0.709
3f2bA10.69481000.398Contact Map0.599
4gx8A40.23281000.84Contact Map0.688
3e38A20.24141000.888Contact Map0.379
2yxoA20.197499.90.946Contact Map0.544
3o0fA10.201799.80.949Contact Map0.684
3b0xA10.196699.80.95Contact Map0.502
4gc3A10.213899.80.951Contact Map0.527
2w9mA20.206999.80.951Contact Map0.381

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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