OPENSEQ.org - SECE - ECOLI GREMLIN

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SECE - Preprotein translocase subunit SecE

UniProt:	P0AG96	Sequence MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVALLTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRLVSFITGLRF	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10939
Length:	127 (127)
Sequences:	321
Seq/Len:	2.53

SECE
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
99_A	103_V	2.125	1.00
19_W	33_N	2.095	1.00
68_T	73_R	1.971	0.99
44_R	59_A	1.885	0.99
24_A	50_I	1.819	0.99
117_R	121_F	1.819	0.99
110_G	113_G	1.723	0.98
45_A	49_V	1.721	0.98
25_L	58_V	1.55	0.95
76_R	80_R	1.534	0.95
28_V	32_G	1.472	0.93
59_A	93_T	1.456	0.93
71_F	123_T	1.45	0.93
71_F	116_V	1.416	0.91
18_K	30_I	1.415	0.91
114_I	121_F	1.397	0.91
71_F	74_E	1.37	0.89
31_V	74_E	1.368	0.89
24_A	86_T	1.366	0.89
41_L	45_A	1.359	0.89
47_A	51_L	1.312	0.87
30_I	83_I	1.301	0.86
21_V	25_L	1.272	0.84
107_I	111_L	1.251	0.83
62_T	93_T	1.245	0.82
111_L	120_S	1.235	0.82
25_L	54_A	1.222	0.81
98_A	102_A	1.214	0.80
29_A	48_V	1.214	0.80
28_V	51_L	1.212	0.80
116_V	123_T	1.212	0.80
2_S	68_T	1.21	0.80
81_K	122_I	1.199	0.79
113_G	116_V	1.198	0.79
35_L	46_L	1.197	0.79
21_V	58_V	1.192	0.78
107_I	110_G	1.186	0.78
15_E	18_K	1.15	0.75
17_M	92_H	1.137	0.74
109_W	113_G	1.134	0.73
34_Y	53_A	1.127	0.73
33_N	71_F	1.117	0.72
106_L	110_G	1.111	0.71
49_V	103_V	1.11	0.71
100_V	105_S	1.095	0.70
75_A	104_M	1.088	0.69
14_L	18_K	1.078	0.68
24_A	91_L	1.075	0.68
50_I	54_A	1.068	0.67
13_G	17_M	1.062	0.66
74_E	119_V	1.057	0.66
53_A	57_G	1.052	0.65
25_L	108_L	1.046	0.65
95_L	99_A	1.043	0.64
43_L	46_L	1.039	0.64
29_A	67_A	1.038	0.64
18_K	43_L	1.032	0.63
22_V	37_R	1.025	0.62
113_G	117_R	1.02	0.62
16_A	98_A	1.008	0.60
67_A	90_T	1.003	0.60
58_V	81_K	1.001	0.60

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3j01B	1	0.9134	100	0.265	Contact Map	0.072
3dinD	2	0.4961	99.7	0.597	Contact Map	0.353
3dl8C	2	0.4961	99.7	0.597	Contact Map	0.018
2zjsE	1	0.4724	99.6	0.622	Contact Map	0.298
3bo0B	1	0.5118	99.4	0.654	Contact Map	0.211
3mp7B	1	0.4803	14.2	0.935	Contact Map	0.26
2wwbB	1	0.5354	12.8	0.936	Contact Map	0.258
2wswA	1	0.5433	7.7	0.942	Contact Map	0.172
3arcL	2	0.2913	5.2	0.946	Contact Map	0.224
3lbwA	4	0.1732	4.4	0.948	Contact Map	0.826

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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