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OPENSEQ.org
SBCD - Nuclease SbcCD subunit D
UniProt: P0AG76 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11094
Length: 400 (396)
Sequences: 1048
Seq/Len: 2.65
SBCD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_V 257_L 4.694 1.00
44_I 182_T 4.218 1.00
38_H 269_E 3.972 1.00
4_L 40_V 3.584 1.00
254_Y 270_N 3.505 1.00
35_A 43_I 3.354 1.00
6_T 9_W 3.102 1.00
190_A 223_I 3.019 1.00
2_R 259_T 2.804 1.00
34_T 255_V 2.602 1.00
36_Q 73_T 2.417 1.00
257_L 271_L 2.414 1.00
49_V 79_V 2.344 1.00
282_L 309_I 2.324 1.00
29_D 69_N 2.309 1.00
81_A 106_A 2.225 1.00
281_V 308_D 2.223 1.00
3_I 42_A 2.21 1.00
23_E 306_W 2.144 1.00
3_I 44_I 2.077 1.00
252_S 272_N 1.98 0.99
28_L 66_F 1.973 0.99
31_L 241_P 1.967 0.99
30_W 274_P 1.953 0.99
256_H 268_V 1.919 0.99
7_S 238_C 1.905 0.99
27_F 241_P 1.858 0.99
67_V 77_L 1.857 0.99
33_E 37_T 1.847 0.99
246_F 279_M 1.82 0.99
79_V 104_V 1.791 0.99
24_H 244_L 1.766 0.98
34_T 271_L 1.763 0.98
367_N 380_Q 1.762 0.98
43_I 70_L 1.761 0.98
361_S 364_E 1.745 0.98
46_A 182_T 1.715 0.98
35_A 70_L 1.715 0.98
38_H 271_L 1.696 0.98
23_E 277_Q 1.687 0.98
3_I 258_V 1.671 0.98
15_F 20_R 1.652 0.97
285_D 288_S 1.646 0.97
243_P 278_P 1.588 0.96
44_I 126_L 1.586 0.96
34_T 38_H 1.584 0.96
71_Q 102_T 1.575 0.96
38_H 257_L 1.568 0.96
126_L 180_I 1.563 0.96
80_L 182_T 1.559 0.96
180_I 260_F 1.553 0.96
180_I 258_V 1.528 0.95
25_Q 62_L 1.522 0.95
226_A 254_Y 1.515 0.95
93_S 97_M 1.512 0.95
280_A 305_V 1.497 0.94
261_S 264_K 1.496 0.94
249_C 281_V 1.496 0.94
32_L 70_L 1.484 0.94
56_P 59_A 1.483 0.94
360_L 368_R 1.472 0.94
246_F 308_D 1.466 0.94
228_I 233_E 1.461 0.93
46_A 115_L 1.455 0.93
23_E 26_A 1.434 0.93
9_W 66_F 1.431 0.93
78_V 128_P 1.417 0.92
11_L 56_P 1.415 0.92
126_L 182_T 1.411 0.92
114_I 125_V 1.396 0.91
218_I 235_V 1.381 0.91
44_I 258_V 1.38 0.91
4_L 257_L 1.376 0.90
27_F 242_I 1.357 0.90
27_F 31_L 1.355 0.90
309_I 335_V 1.354 0.90
209_A 235_V 1.351 0.89
43_I 66_F 1.344 0.89
9_W 31_L 1.342 0.89
255_V 273_V 1.337 0.89
78_V 126_L 1.335 0.89
63_Y 79_V 1.324 0.88
236_R 256_H 1.319 0.88
155_A 158_T 1.318 0.88
258_V 268_V 1.317 0.88
6_T 31_L 1.312 0.87
65_R 95_D 1.305 0.87
286_L 309_I 1.297 0.87
63_Y 104_V 1.294 0.86
256_H 270_N 1.292 0.86
7_S 46_A 1.284 0.86
66_F 70_L 1.273 0.85
290_T 327_L 1.27 0.85
371_A 374_E 1.268 0.85
25_Q 65_R 1.257 0.84
32_L 73_T 1.253 0.84
125_V 177_L 1.249 0.84
194_D 247_D 1.235 0.83
125_V 179_I 1.23 0.82
27_F 66_F 1.223 0.82
381_Q 385_H 1.218 0.82
42_A 180_I 1.218 0.82
35_A 40_V 1.217 0.82
21_E 24_H 1.214 0.81
162_Q 166_A 1.213 0.81
3_I 180_I 1.206 0.81
259_T 269_E 1.195 0.80
50_F 93_S 1.194 0.80
364_E 367_N 1.19 0.80
6_T 45_V 1.184 0.79
11_L 28_L 1.183 0.79
167_D 171_L 1.179 0.79
5_H 219_A 1.178 0.79
283_K 310_E 1.178 0.79
30_W 273_V 1.173 0.78
42_A 126_L 1.173 0.78
209_A 229_I 1.171 0.78
27_F 30_W 1.166 0.78
194_D 245_S 1.165 0.77
127_C 181_A 1.164 0.77
283_K 312_T 1.163 0.77
117_R 178_P 1.162 0.77
31_L 40_V 1.16 0.77
181_A 218_I 1.151 0.76
321_Q 325_Q 1.149 0.76
51_D 90_L 1.148 0.76
35_A 75_C 1.148 0.76
91_N 106_A 1.142 0.75
193_S 245_S 1.141 0.75
105_V 128_P 1.14 0.75
259_T 267_S 1.136 0.75
89_T 203_T 1.129 0.74
116_P 121_T 1.129 0.74
363_E 388_T 1.128 0.74
203_T 245_S 1.127 0.74
193_S 196_V 1.125 0.74
36_Q 69_N 1.117 0.73
54_S 64_N 1.116 0.73
52_T 133_R 1.114 0.73
63_Y 102_T 1.112 0.73
319_D 322_R 1.105 0.72
20_R 23_E 1.1 0.72
92_E 134_P 1.097 0.71
247_D 277_Q 1.091 0.71
161_Y 185_L 1.087 0.70
212_F 235_V 1.086 0.70
24_H 50_F 1.084 0.70
9_W 27_F 1.084 0.70
249_C 308_D 1.082 0.70
377_E 380_Q 1.079 0.69
46_A 210_Q 1.077 0.69
6_T 240_S 1.075 0.69
13_Q 20_R 1.07 0.69
308_D 337_L 1.066 0.68
49_V 90_L 1.065 0.68
26_A 276_T 1.061 0.68
197_R 223_I 1.06 0.67
42_A 78_V 1.051 0.67
128_P 182_T 1.05 0.66
225_R 252_S 1.05 0.66
201_I 289_I 1.05 0.66
33_E 36_Q 1.049 0.66
367_N 384_Q 1.048 0.66
129_I 183_G 1.044 0.66
63_Y 92_E 1.036 0.65
223_I 251_K 1.035 0.65
158_T 210_Q 1.034 0.65
9_W 45_V 1.033 0.65
7_S 183_G 1.033 0.65
5_H 217_Y 1.031 0.64
5_H 12_G 1.028 0.64
7_S 165_Y 1.022 0.63
7_S 14_N 1.02 0.63
141_Q 259_T 1.019 0.63
69_N 72_Q 1.013 0.62
43_I 77_L 1.012 0.62
124_A 180_I 1.009 0.62
217_Y 258_V 1.006 0.62
187_T 229_I 1.006 0.62
23_E 27_F 1.005 0.61
117_R 120_G 1.003 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3thoB10.9051000.414Contact Map0.657
2q8uA20.7651000.487Contact Map0.704
1ii7A20.7451000.526Contact Map0.691
3av0A10.85251000.539Contact Map0.61
3t1iA40.8351000.565Contact Map0.594
4fbwA20.841000.578Contact Map0.641
4fbkA20.821000.581Contact Map0.644
3d03A60.632599.90.782Contact Map0.606
2yvtA10.552599.90.783Contact Map0.608
1uf3A80.517599.80.793Contact Map0.661
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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