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OPENSEQ.org
ODO1 - 2-oxoglutarate dehydrogenase E1 component
UniProt: P0AFG3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10979
Length: 933 (930)
Sequences: 1114
Seq/Len: 1.20
ODO1
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_Q 154_G 4.919 1.00
734_L 776_M 4.231 1.00
665_L 716_M 4.132 1.00
672_A 712_C 3.904 1.00
690_A 737_Y 3.761 1.00
831_Q 835_N 3.748 1.00
749_C 760_M 3.679 1.00
815_K 839_D 3.674 1.00
420_F 433_V 3.55 1.00
259_A 388_I 3.505 1.00
387_V 409_T 3.503 1.00
268_V 278_L 3.451 1.00
697_I 716_M 3.281 1.00
557_L 602_A 3.122 1.00
818_V 872_C 3.025 1.00
824_V 827_D 3.024 1.00
420_F 448_V 2.976 1.00
180_E 446_R 2.962 1.00
859_V 862_Q 2.959 1.00
235_L 388_I 2.937 1.00
613_L 654_V 2.919 1.00
200_K 494_E 2.888 1.00
702_S 746_M 2.873 1.00
741_C 746_M 2.869 1.00
549_V 603_T 2.8 1.00
325_I 700_F 2.782 1.00
259_A 354_I 2.701 1.00
569_E 634_S 2.695 1.00
619_G 656_D 2.667 1.00
232_G 454_C 2.605 1.00
252_R 348_K 2.582 1.00
815_K 867_K 2.559 1.00
499_L 503_T 2.488 1.00
424_A 454_C 2.478 0.99
804_G 859_V 2.472 0.99
187_R 439_D 2.447 0.99
760_M 775_V 2.446 0.99
170_A 188_I 2.435 0.99
475_Q 634_S 2.405 0.99
331_I 380_V 2.394 0.99
197_S 201_K 2.368 0.99
168_I 433_V 2.354 0.99
304_D 313_H 2.339 0.99
817_V 866_V 2.32 0.99
504_E 508_L 2.305 0.99
365_V 662_E 2.285 0.99
481_P 489_D 2.27 0.99
367_Q 616_E 2.261 0.99
242_M 384_V 2.255 0.99
489_D 493_Q 2.254 0.99
177_S 180_E 2.246 0.99
347_N 445_K 2.244 0.99
819_M 856_M 2.23 0.99
741_C 748_V 2.209 0.99
923_Q 927_N 2.207 0.99
734_L 881_A 2.18 0.98
840_V 930_L 2.166 0.98
820_C 824_V 2.141 0.98
503_T 507_N 2.131 0.98
732_A 776_M 2.128 0.98
754_P 788_V 2.122 0.98
922_Q 925_L 2.122 0.98
485_K 489_D 2.11 0.98
813_G 838_H 2.107 0.98
245_H 439_D 2.038 0.97
610_P 650_G 2.035 0.97
179_E 443_T 2.022 0.97
845_I 885_S 2.014 0.97
922_Q 926_V 2.014 0.97
817_V 860_L 2.013 0.97
780_S 823_K 1.988 0.97
468_A 624_F 1.982 0.97
818_V 842_I 1.979 0.97
554_L 791_L 1.958 0.96
490_K 494_E 1.949 0.96
167_P 426_D 1.949 0.96
152_K 155_E 1.948 0.96
747_Q 767_R 1.945 0.96
818_V 929_A 1.941 0.96
325_I 662_E 1.934 0.96
551_M 555_Q 1.933 0.96
426_D 429_A 1.924 0.96
557_L 603_T 1.914 0.96
902_A 928_D 1.912 0.96
830_E 834_K 1.887 0.95
831_Q 834_K 1.879 0.95
609_I 765_A 1.861 0.95
778_P 823_K 1.855 0.95
239_L 266_V 1.853 0.95
644_H 649_Q 1.852 0.94
203_F 431_A 1.846 0.94
701_I 716_M 1.844 0.94
553_R 606_D 1.827 0.94
568_V 630_I 1.823 0.94
365_V 663_A 1.817 0.94
717_L 775_V 1.799 0.93
816_R 868_D 1.799 0.93
238_M 386_I 1.795 0.93
358_A 402_A 1.783 0.93
239_L 354_I 1.782 0.93
327_S 353_T 1.779 0.93
596_A 794_L 1.772 0.93
325_I 696_V 1.755 0.92
196_N 199_E 1.749 0.92
302_S 710_R 1.725 0.91
734_L 821_S 1.724 0.91
235_L 354_I 1.718 0.91
211_E 482_T 1.717 0.91
614_S 664_V 1.712 0.91
358_A 393_G 1.707 0.91
824_V 872_C 1.707 0.91
583_A 588_E 1.694 0.90
360_V 449_F 1.694 0.90
533_W 770_R 1.677 0.90
498_T 501_D 1.673 0.90
924_D 928_D 1.666 0.89
757_V 760_M 1.666 0.89
716_M 774_V 1.654 0.89
334_V 351_P 1.65 0.89
824_V 925_L 1.647 0.89
42_R 46_Q 1.645 0.88
723_E 780_S 1.645 0.88
829_L 842_I 1.642 0.88
740_L 746_M 1.632 0.88
790_S 793_E 1.632 0.88
575_A 579_G 1.628 0.88
180_E 440_F 1.625 0.88
108_N 167_P 1.617 0.87
692_G 695_V 1.61 0.87
596_A 787_A 1.607 0.87
139_F 153_L 1.604 0.87
33_D 36_S 1.595 0.86
705_E 771_R 1.594 0.86
465_E 468_A 1.59 0.86
578_Y 630_I 1.59 0.86
790_S 794_L 1.585 0.86
371_N 658_V 1.584 0.86
424_A 452_L 1.582 0.86
372_M 658_V 1.581 0.86
628_A 652_F 1.566 0.85
666_A 696_V 1.56 0.85
915_M 919_Q 1.556 0.84
801_P 855_A 1.549 0.84
112_L 473_M 1.547 0.84
208_T 484_R 1.546 0.84
428_E 487_Y 1.538 0.83
125_P 135_F 1.534 0.83
370_L 415_V 1.534 0.83
823_K 922_Q 1.534 0.83
378_Y 614_S 1.521 0.83
618_S 654_V 1.513 0.82
366_V 616_E 1.512 0.82
417_A 449_F 1.51 0.82
786_L 833_R 1.51 0.82
613_L 681_I 1.51 0.82
92_V 139_F 1.508 0.82
845_I 848_L 1.505 0.82
723_E 823_K 1.503 0.81
353_T 385_R 1.498 0.81
750_V 874_E 1.488 0.81
138_T 152_K 1.473 0.80
29_D 36_S 1.472 0.80
831_Q 930_L 1.469 0.79
584_M 595_G 1.466 0.79
662_E 692_G 1.459 0.79
549_V 554_L 1.447 0.78
751_P 760_M 1.438 0.77
235_L 266_V 1.438 0.77
187_R 443_T 1.436 0.77
372_M 663_A 1.433 0.77
872_C 929_A 1.43 0.77
610_P 678_T 1.43 0.77
727_P 909_S 1.423 0.76
235_L 386_I 1.422 0.76
818_V 870_V 1.418 0.76
350_L 384_V 1.416 0.76
246_A 438_L 1.416 0.76
239_L 452_L 1.414 0.76
480_H 486_I 1.41 0.75
184_I 420_F 1.408 0.75
184_I 433_V 1.408 0.75
176_T 416_Q 1.404 0.75
807_D 833_R 1.403 0.75
200_K 490_K 1.403 0.75
681_I 717_L 1.395 0.74
397_S 656_D 1.395 0.74
926_V 930_L 1.394 0.74
835_N 927_N 1.384 0.73
239_L 386_I 1.382 0.73
132_E 154_G 1.381 0.73
213_L 278_L 1.372 0.73
432_F 436_L 1.372 0.73
492_E 502_A 1.365 0.72
723_E 778_P 1.363 0.72
110_D 114_L 1.363 0.72
601_Y 757_V 1.352 0.71
259_A 325_I 1.349 0.71
238_M 434_T 1.345 0.70
598_N 601_Y 1.344 0.70
236_I 270_V 1.333 0.69
829_L 833_R 1.327 0.69
741_C 849_Y 1.321 0.68
717_L 777_S 1.319 0.68
579_G 582_Q 1.314 0.68
153_L 156_L 1.304 0.67
752_S 787_A 1.298 0.66
367_Q 414_M 1.298 0.66
218_G 228_S 1.297 0.66
564_V 567_A 1.295 0.66
135_F 603_T 1.291 0.66
912_V 921_Q 1.29 0.66
221_F 283_A 1.289 0.66
619_G 629_V 1.288 0.66
108_N 161_K 1.287 0.65
475_Q 479_K 1.286 0.65
609_I 766_L 1.283 0.65
632_N 635_N 1.277 0.65
511_D 515_A 1.274 0.64
825_Y 829_L 1.272 0.64
902_A 925_L 1.269 0.64
331_I 369_T 1.268 0.64
823_K 874_E 1.268 0.64
800_L 803_I 1.267 0.64
106_H 161_K 1.266 0.64
30_F 46_Q 1.265 0.64
302_S 313_H 1.261 0.63
817_V 843_V 1.261 0.63
97_N 101_F 1.261 0.63
405_T 411_I 1.261 0.63
313_H 710_R 1.261 0.63
559_K 582_Q 1.26 0.63
837_Q 930_L 1.258 0.63
238_M 430_V 1.249 0.62
306_Q 311_L 1.246 0.62
568_V 578_Y 1.245 0.62
912_V 925_L 1.243 0.62
492_E 498_T 1.242 0.61
665_L 690_A 1.241 0.61
805_E 829_L 1.24 0.61
679_L 715_V 1.238 0.61
810_D 813_G 1.235 0.61
144_F 156_L 1.228 0.60
199_E 435_R 1.227 0.60
386_I 452_L 1.225 0.60
363_Q 692_G 1.218 0.59
585_A 595_G 1.216 0.59
282_F 296_K 1.213 0.59
230_E 458_H 1.211 0.59
851_F 885_S 1.209 0.58
245_H 435_R 1.206 0.58
697_I 702_S 1.203 0.58
405_T 414_M 1.203 0.58
828_L 842_I 1.201 0.58
276_Q 516_G 1.199 0.57
241_E 435_R 1.199 0.57
232_G 388_I 1.199 0.57
26_L 38_D 1.196 0.57
255_V 334_V 1.194 0.57
213_L 268_V 1.19 0.57
228_S 573_R 1.189 0.56
818_V 843_V 1.189 0.56
837_Q 840_V 1.188 0.56
126_S 132_E 1.187 0.56
377_G 655_W 1.186 0.56
412_G 449_F 1.182 0.56
594_G 625_H 1.181 0.56
341_L 348_K 1.18 0.56
559_K 586_A 1.179 0.55
273_K 281_E 1.176 0.55
562_S 582_Q 1.173 0.55
607_E 766_L 1.172 0.55
302_S 533_W 1.172 0.55
564_V 570_M 1.169 0.55
425_D 480_H 1.167 0.54
646_H 649_Q 1.165 0.54
569_E 632_N 1.164 0.54
251_T 350_L 1.163 0.54
39_A 43_S 1.161 0.54
343_E 346_S 1.16 0.54
206_E 209_A 1.155 0.53
877_L 903_G 1.154 0.53
489_D 499_L 1.154 0.53
240_K 270_V 1.151 0.53
465_E 823_K 1.148 0.52
786_L 829_L 1.148 0.52
848_L 881_A 1.147 0.52
713_G 770_R 1.145 0.52
751_P 756_Q 1.144 0.52
292_T 743_E 1.14 0.52
484_R 502_A 1.139 0.52
307_T 310_G 1.138 0.51
552_K 555_Q 1.136 0.51
235_L 452_L 1.133 0.51
465_E 478_K 1.133 0.51
549_V 553_R 1.133 0.51
507_N 511_D 1.133 0.51
570_M 630_I 1.128 0.51
467_S 478_K 1.128 0.51
158_E 162_Q 1.127 0.50
232_G 424_A 1.126 0.50
754_P 826_Y 1.122 0.50
819_M 889_F 1.122 0.50
819_M 869_F 1.121 0.50
439_D 596_A 1.121 0.50
919_Q 923_Q 1.119 0.50
224_A 228_S 1.118 0.50
27_Y 31_L 1.118 0.50
411_I 616_E 1.118 0.50
665_L 774_V 1.118 0.50
812_K 865_H 1.115 0.49
246_A 442_N 1.114 0.49
705_E 763_R 1.113 0.49
781_L 826_Y 1.113 0.49
297_Y 300_G 1.11 0.49
372_M 576_K 1.108 0.49
411_I 414_M 1.106 0.48
330_V 353_T 1.104 0.48
373_S 415_V 1.104 0.48
591_F 790_S 1.103 0.48
845_I 856_M 1.102 0.48
551_M 795_A 1.1 0.48
155_E 158_E 1.099 0.48
602_A 642_L 1.096 0.47
372_M 380_V 1.094 0.47
596_A 790_S 1.093 0.47
341_L 349_V 1.092 0.47
551_M 792_E 1.092 0.47
750_V 821_S 1.092 0.47
216_Y 557_L 1.092 0.47
564_V 578_Y 1.092 0.47
820_C 842_I 1.09 0.47
786_L 830_E 1.088 0.47
352_I 434_T 1.088 0.47
673_T 712_C 1.087 0.47
181_K 419_I 1.085 0.46
603_T 611_V 1.081 0.46
584_M 591_F 1.08 0.46
35_D 39_A 1.079 0.46
662_E 695_V 1.077 0.46
570_M 578_Y 1.075 0.45
211_E 485_K 1.071 0.45
449_F 616_E 1.064 0.44
842_I 925_L 1.063 0.44
742_A 849_Y 1.062 0.44
581_R 585_A 1.062 0.44
749_C 775_V 1.061 0.44
174_H 419_I 1.061 0.44
754_P 784_H 1.058 0.44
877_L 887_H 1.056 0.44
236_I 774_V 1.054 0.43
148_K 155_E 1.054 0.43
831_Q 927_N 1.053 0.43
628_A 654_V 1.052 0.43
649_Q 907_S 1.051 0.43
780_S 784_H 1.05 0.43
455_Y 482_T 1.049 0.43
245_H 248_N 1.049 0.43
457_R 482_T 1.048 0.43
37_V 42_R 1.048 0.43
723_E 742_A 1.047 0.43
229_L 269_N 1.047 0.43
242_M 438_L 1.046 0.43
162_Q 192_R 1.046 0.43
791_L 794_L 1.041 0.42
560_R 563_T 1.04 0.42
227_F 297_Y 1.04 0.42
556_E 603_T 1.04 0.42
591_F 595_G 1.037 0.42
877_L 901_Y 1.037 0.42
224_A 331_I 1.035 0.42
95_L 99_Y 1.031 0.41
784_H 788_V 1.031 0.41
88_K 130_L 1.028 0.41
872_C 902_A 1.028 0.41
242_M 434_T 1.026 0.41
870_V 902_A 1.026 0.41
425_D 455_Y 1.026 0.41
614_S 654_V 1.026 0.41
555_Q 586_A 1.026 0.41
275_P 509_Y 1.025 0.41
30_F 42_R 1.025 0.41
501_D 737_Y 1.022 0.40
917_V 921_Q 1.022 0.40
559_K 563_T 1.021 0.40
631_H 816_R 1.018 0.40
554_L 599_L 1.017 0.40
678_T 765_A 1.017 0.40
247_G 309_G 1.016 0.40
755_A 800_L 1.016 0.40
760_M 899_L 1.016 0.40
233_D 483_P 1.013 0.39
557_L 606_D 1.012 0.39
419_I 892_V 1.012 0.39
228_S 371_N 1.011 0.39
419_I 449_F 1.01 0.39
699_Q 728_E 1.009 0.39
843_V 859_V 1.007 0.39
723_E 777_S 1.007 0.39
676_P 770_R 1.004 0.39
365_V 588_E 1.003 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jgdA111000.409Contact Map0.711
2xt6A20.96361000.421Contact Map0.714
2yicA40.90251000.423Contact Map0.72
3rimA40.67421000.859Contact Map0.407
4kxvA10.64631000.862Contact Map0.431
3uk1A20.68061000.865Contact Map0.423
1itzA30.64951000.866Contact Map0.398
3mosA10.64421000.867Contact Map0.424
2bfdA10.42231000.867Contact Map0.462
3m49A20.68491000.869Contact Map0.389
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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